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Characterization of the first prototype CMOS pixel sensor developed for the CEPC vertex detector

Radiation Detection Technology and Methods 2019年第3期3卷 222-230页

作者： L.J.Chen H.B.Zhu X.C.Ai M.Fu R.Kiuchi Y.Liu Z.A.Liu X.C.Lou Y.P.Lu Q.Ouyang X.Shi J.Tao K.wang n.wang C.F.Yang Y.Zhang Y.Zhou institute of high energy physics chinese academy of sciences19b yuquan roadshijingshan districtbeijingchina university of chinese academy of sciences no.19(a)yuquan roadshijingshan districtbeijingchina state key laboratory of particle detection and electronics 19b yuquan roadshijingshan districtbeijingchina deutsches elektronen-synchrotron(desy) notkestraße 8522607 hamburggermany university of science and technology of china no.96jinzhai road baohe districthefeianhuichina ocean university of china no.238 songling roadqingdao 266100china

Purpose CMOS pixel sensor has become extremely attractive for future high-performance tracking *** has been proposed for the vertex detector at the Circular Electron Positron Collider,which will allow precision measurements of the properties of the Higgs *** meet the stringent requirements for low power consumption,it is necessary to optimize the pixel sensor diode geometry to reach a high charge-over-capacitance ratio that allows reduction in analog power *** Collection electrode size and footprint are two critical elements in sensor diode geometry and have deciding impacts on the charge collection performance.A prototype CMOS pixel sensor,named JadePix-1,has been developed with pixel sectors implemented with different electrode sizes and footprints,and its charge collection performance has been characterized with radioactive *** Charge-to-voltage conversion gains for pixel sectors under test have been calibrated with low-energy *** results have been obtained for equivalent noise charge(below 10e−),charge collection efficiency(around 40%),charge-over-capacitance ratio(above 0.015 V)and signal-to-noise ratio(higher than 55).Conclusion Small collection electrode size and large footprint are preferred to achieve high charge-over-capacitance ratio that promises low analog power *** studies on sensor performance before and after irradiation,combined with this work,will conclude the diode geometry optimization.

关键词： CMOS pixel sensor CEPC Power consumption Diode geometry Charge-over-capacitance ratio

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图论分析揭示原发性开角型青光眼病人脑网络模式的重组

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国际医学放射学杂志 2017年第1期 103-104页

作者： J.wang T.Li n.wang J.Xian H.He 张晓东 Department of Radiology Beijing Tongren HospitalCapital Medical University

摘要目的以往基于静息态功能MRI的青光眼研究多聚焦于单个脑结构的神经活动,却忽视了解剖上分离的脑结构之间的功能交流。本研究旨在探索青光眼病人脑功能交流

关键词：原发性开角型青光眼图论分析人脑青光眼病脑网络病人

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珠三角区域大气联防联控治理前景模拟评估

珠三角区域大气联防联控治理前景模拟评估

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第33届中国气象学会年会

作者： n.wang X.J.Deng X.P.Lyu T.Deng Y.Li C.Q.Yin S.Q.wang Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional numerical Weather Prediction CMA Department of Civil and Environmental Engineering The Hong Kong Polytechnic University Division of Environment Hong Kong University of Science and Technology Zhuhai Meteorological Bureau

The paper combined observation, reduction measures, and atmospheric modeling to provide scientific support for assessing air quality in the Pearl River Delta（PRD） in China. Statistical data revealed that energy consumption doubled from 2004 to 2014 and vehicle usage increased significantly from 2006 to 2014. Due to the controlling efforts, primary emission of SO, nOx（nO+nO） and PM decreased, resulting in the reductions of ambient SO, nO and PM10 by 66%, 20% and 24%, respectively. However, O increased by 19%. Comprehensive air quality modellings were made to evaluate the responses of air pollutants to changes in nOx, VOCs and nH emissions. Three scenarios, a baseline scenario, a CAP scenario（control strength followed as past tendency）, and a REF scenario（strict control referred to latest policy/plans） were conducted to investigate the sensitivities and mechanisms. nOx, nitrate and PM reduced by 1.8%, 0.7% and 0.2% under nOx CAP and reduced by 7.2%, 1.8% and 0.3% under nOx REF scenario, respectively. The results indicated that in certain area reducing nOx emission elevated the atmospheric oxidizability, which resulted in a compensation of PM due to the increase of nitrate or sulfate. nH controlling scenarios showed that nitrate was sensitive to nH emission in PRD, with the decrease of nitrate by 0- 10.6% and 0- 48% under CAP and REF, respectively. Controlling VOCs emission could benefit PM in southwestern PRD where photochemical pollution frequently occurred. Furthermore, O formation in PRD was generally VOCs-limited while the regime turned to nOx-limited in theafternoon, therefore reducing VOCs emission benefits the reduction of overall O and controlling nOx emission in the afternoon could reduce peak O.

关键词： Emission control Air quality in PRD WRF/CMAQ Scenario analysis

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Synergistically enhanced ORR and HER performance on Co-n-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang wang Deli wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@ConC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@ConC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@ConC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

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不同瘤周影像组学特征区分以磨玻璃结节为表现的肺腺癌侵袭性的价值

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国际医学放射学杂志 2022年第1期 122-122页

作者： L.Wu C.Gao J.Ye J.Tao n.wang P.Pang 张焕磊

摘要目的从2 mm和5 mm瘤周实质中提取CT影像组学特征，评价其对浸润性腺癌（IAC）和原位腺癌（AIS）/微浸润性腺癌（MIA）的鉴别能力。方法回顾性分析薄层CT上

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Dative B–n bonds weaven toward two-dimensional purely organic materials for single crystals

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Science China Chemistry 2025年第01期 12-14页

作者： Wei-Lei Zhou Siwei wang Yong Chen College of Chemistry and Materials Science Inner Mongolia Key Laboratory of Chemistry for Nature Products and Synthesis for Functional Molecules Innovation Team of Optical Functional Molecular Devices Inner Mongolia Minzu University College of Chemistry Nankai University

Molecular topology is one of the important topics to study and understand the relationship between molecular structure and properties [1]. Particularly, two-dimensional (2D) materials with extremely high surface area and ultra-thin morphology have attracted considerable attention due to their unexpected properties in materials and chemistry [2,3].

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nEW InSIGHT InTO MECHAnISMS OF AQUEOUS OUTFLOW DEFICIEnCY: ROLE OF THE STRESS RESPOnSE

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国际眼科杂志 2003年第1期3卷 102-102页

作者： M.E.Fini K.A.Erickson E.L.Ginsberg P.F.Olson n.wang K.R.Wollen-berg X.Zhang J.S.Schuman Bascom Palmer Eye Institute University of Miami School of Medicine FL new England Eye Center Tufts University School of Medicine MA USA

The glaucomas are a group of optic neuropathies comprising the leading cause of irreversible blindness worldwide. Elevated intraocular pressure due to a reduction in normal aqueous outflow is a major causal risk factor. We recently reported that En-dothelial Leukocyte Adhesion Molecule-1 (ELAM-1), the earliest marker for the atherosclerotic plaque in the vasculature.

关键词：青光眼房水外流不足机制应激反应 ELAM-1 IL-1

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SWI序列“燕尾”征和壳核低信号作为生物标记鉴别多系统萎缩与原发性帕金森病

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国际医学放射学杂志 2017年第5期 613-613页

作者： n.wang H.Yang C.Li G.Fan X.Luo 耿立娜 Department of Radiology The First Affiliated Hospital of China Medical University

摘要目的探讨应用3.0 T磁敏感加权成像(SWI)上显示的"燕尾"征和壳核低信号鉴别多系统萎缩(MSA)和原发性帕金森病(IPD)的价值。方法本研究为回顾性研究,样本

关键词：原发性帕金森病 SWI 多系统萎缩

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Δ影像组学特征预测非小细胞肺癌新辅助化疗免疫治疗的主要病理反应

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国际医学放射学杂志 2024年第3期 380-380页

作者： X.Han M.wang Y.Zheng n.wang Y.Wu C.Ding 余芸菲

摘要目的研究Δ影像组学特征能否预测非小细胞肺癌（nSCLC）病人对新辅助化疗免疫治疗的主要病理反应（MPR）。方法纳入来自3个机构（数据库1有164例；数据

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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous nSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang wang Leo Li Chunwei Xu Wenxian.wang Shangli Cai Zhijie wang Jie wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqnSCLC and sqnSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqnSCLCs and sqnSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteractionnofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqnSCLCs（P=0.040） and sqnSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqnSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqnSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqnSCLCs with LRP1B-del and sqnSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqnSCLCs and sqnSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqnSCLCs and sqnSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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