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第二讲牙周治疗展望

口腔医学研究 1987年第4期 243-245页

作者： R.n.powell 韩乃明

流行病学研究表明:牙龈炎是流行性极高的疾病。在澳大利亚和中国的情况也是如此。在澳大利亚,牙科医生与总人口的比例为1:2100。即便这样也不可能使每个患有牙龈炎的人得到治疗。在中国,牙科医生与人口的比例为1:250000,要治疗每个龈炎... 详细信息

流行病学研究表明:牙龈炎是流行性极高的疾病。在澳大利亚和中国的情况也是如此。在澳大利亚,牙科医生与总人口的比例为1:2100。即便这样也不可能使每个患有牙龈炎的人得到治疗。在中国,牙科医生与人口的比例为1:250000,要治疗每个龈炎患者就更不可能了。因此,需要适当集中地使用牙科医生。牙科医生的责任可能就在于:选择最可能发生破坏性牙周病的患者,提供预防或早期治疗措施。这一部分只占人群中较小的比例。许多国家是有人力给这部分人作预防和治疗工作的。为了能恰当地选择病人,应很好地理解整个疾病过程。这主要包括:①牙菌斑的致病力;②局部免疫反应;③个体对疾病的易感性。

关键词：牙周治疗活动性螺旋体青少年牙周炎牙周病牙周疾病探诊出血菌斑牙周致病菌

Silencing-specific methylation and single nucleotide polymorphism of hMLH1 promoter in gastric carcinomas

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World Journal of Gastroenterology 2003年第1期9卷 26-29页

作者： Da-JunDeng JinZhou Bu-DongZhu Jia-FuJi JeffreyC.Harper StevenM.powell PekingUniversityHealthScienceCenterandBei.jingInstituteforCancerResearch Beijing100034China UniversityofVirginiaHealthScicnceCenter.Charlottesville.VA22908-0708.USA

AIM:To investigate CpG methylation and single nucleotide polymorphism(SnP)of a specific promoter region of hMLH1 in primary gastric carcinoma. METHODS:Primary gastric carcinomas(n=80),their corresponding normal mucosal samples,and gastric mucosal biopsies from normal/gastritis control patients(n=54)were *** at-253 nt and-251 nt in relation with the translational start site and SnP of a silencing specific region(-339 nt-46 nt)in the hMLH1 promoter were analyzed by BstUI-combined bisulfite assay(COBRA),denaturing high performance liquid chromatogram(DHPLC),and sequencing. RESULTS:(A)The specific methylation at-253 nt and-251 nt was observed in 2 of 60 primary gastric carcinomas,but neither in all of the corresponding mucosa nor in normal/ gastritis samples,by Bst UI-COBRA and DHPLC.(B)The hMLH1 promoter was methylated homogeneously in the xenograft of the primary gastric carcinoma with the methylated and unmethylated hMLH1.(C)The pattern of SnP at-93 nt of the hMLH1 promoter in 54 Chinese patients with gastric carcinoma was the same as that in the control patients:51% was A/G heteroalleles,34% and 15% were A/A and G/G homoalleles,respectively. COnCLUSIOn:Biallelic inactivation of hMLH1 by epigenetic silencing existed in human primary gastric carcinoma *** of hMLH1 may play a role in the early stage of development of a few gastric *** SnP at-93 nt is not related to the susceptibility of gastric carcinomas.

关键词：原发性胃癌单核苷酸基因多态性聚合酶链反应甲基化

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金省之共性

国外花岗岩类地质与矿产 1994年第2期 1-8页

作者： G.n.Phillips R.powell 胡雄伟

许多太古代绿岩金矿、维特瓦特斯兰德金矿、板岩带金矿及浅成热液金矿的形成与低盐度、高温(>200℃)还原流体有关。这种含金流体出现在不同时空、岩石序列及构造背景中,是镁铁质岩和/或杂砂岩变质去挥发分作用的产物。绿泥石-钠长石-方... 详细信息

许多太古代绿岩金矿、维特瓦特斯兰德金矿、板岩带金矿及浅成热液金矿的形成与低盐度、高温(>200℃)还原流体有关。这种含金流体出现在不同时空、岩石序列及构造背景中,是镁铁质岩和/或杂砂岩变质去挥发分作用的产物。绿泥石-钠长石-方解石-石英组合(如镁铁质岩或杂砂岩),在绿片岩-角闪岩相边界发生的变质作用(约480℃±20°,3～5kbar)产生大量低盐度H_2O-CO_2流体,其成分与许多金矿床已查明的流体相似。流体含还原硫(由黄铁矿溶解提供),具备Au呈Au-S络合分子搬运的理想条件。金的沉淀可以因温度、硫活度降低及氧活度变化实现。变质去挥发分流体模式解释了主要金省之共性(如高地热梯度、低盐度以及与变质作用大致同时),也说明了容矿岩石与构造、具体时序关系、蚀交组合以及不同矿床地质年龄之多变性。相似性是由深部过程产生,而差异性则是由沉淀位置或其附近的作用造成。

关键词：金矿床变质流体成因盐度流体

无临床心血管疾病成人中冠状动脉钙负荷与社会心理因素的关系

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 6-7页

作者： Diez Roux A.V. Ranjit n. powell L. 罗亮 Department of Epidemiology School of Public HealthUniversity of MichiganAnn ArborMI 48103United States Dr.

背景:社会心理因素与冠状动脉事件存在关联,但是这种关联的潜在机制仍然不明确。关于社会心理因素与亚临床冠状动脉粥样硬化之间相关性的证据常为混杂的。目的:观察4个社会心理因素(抑郁症状、愤怒、焦虑、持续紧张)

关键词：社会心理因素冠状动脉亚临床冠状动脉粥样硬化

神经功能恢复良好的动脉瘤性蛛网膜下腔出血患者18个月后的心理状况调查

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 17-18页

作者： powell J. Kitchen n. Heslin J. Greenwood R. 李锐 Goldsm iths College Lewisham WayNewCrossLondonSE146N W United K ing-dom Dr.

Objectives: To evaluate functioning, 18 m onths after surgery,of 49patients with good neurological recovery following aneurysm alsubarachnoid haem orrhage (SAH ), and to determ ine the extent of any im provem ents in dis- turbances of m ood,cognitive functioning,and levels of activity and participation previously observed at 9m onth follow up.M ethods: SAH patients, m atched for age, gender,and occupation with healthy control participants, com pletely quantitative m easures ofm ood (H A D S,FIES, BD I)and activity /participation (BICR O -39scales),and a briefcognitive assessmentbattery (verbalfluency,digit span,prose recall).Controls com pleted theH A D S and the BICRO -***:Patients showed som e recovery of cognitive functioning,though im pairm ents of prose recall persisted.A nxiety and depression sym ptom s were higher in patients than in controls,butfewerthan 20% scored in the clinical range on any questionnaires except for RIES-Intrusive thoughts (22%);only three showed signs of full blown post-traum atic stress *** ost half showed elevated dependence on others for dom estic activi- ties and organisation and abnorm ally low levels ofem ploy- *** little variance in outcom e was predicted by dem ographic variables,neurological or cognitive im pair- m ent,prior life stress,orm ood.H owever,levels ofsocial activity and self-organisation were related to persisting fa- tigue. Conclusions: The observed decline in intrusive thoughts and avoidance over tim e is consistent with that seen after life threatening illness or traum *** persistent reductions in independence and levels of em ploym ent m ay in som e casesreflectconsidered lifestyle adjustm ents rather than adverse and unwanted changes butin others indicate a need forfocused rehabilitation.

关键词：心理状况调查功能恢复认知功能康复治疗情绪障碍认知损害记忆障碍流畅性职业与健康应激状态

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有热配合的激光/前视红外测距机

应用光学 1990年第1期11卷 39-42页

作者： Thomas R.Patrick Richardson Richard powell Barry n.Berdanier 蒋鸿旺

本发明论及一个由前视红外(FLIR)系统和激光系统组成的设备,前视红外系统用于目标定位和识别,激光系统用于测定目标距离。过去,典型的测距仪系统有一个相干辐射源,如nd:YAG激光器,它所产生的脉冲能量发射到目标上,经目标反射,然后在发... 详细信息

本发明论及一个由前视红外(FLIR)系统和激光系统组成的设备,前视红外系统用于目标定位和识别,激光系统用于测定目标距离。过去,典型的测距仪系统有一个相干辐射源,如nd:YAG激光器,它所产生的脉冲能量发射到目标上,经目标反射,然后在发射点接收。整个传输时间可用来测量目标距离。测距机一般是用热成象传感器,例如前视红外,提供的信息来对准目标。以前的装置存在的问题很多,尤其是在恶劣气侯下。

关键词：红外测距测距机激光系统探测器阵列脉冲能量前视红外系统激光大气传输激光发射传输时间目标反射

Effects of target pre-heating and expansion on terahertz radiation production from intense laser-solid interactions

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High Power Laser Science and Engineering 2014年第1期2卷 13-17页

作者： X.H.Yuan Y.Fang D.C.Carroll D.A.MacLellan F.Du n.Booth M.Burza M.Chen R.J.Gray Y.F.Jin Y.T.Li Y.Liu D.neely H.powell G.Scott C.-G.Wahlstrm J.Zhang P.McKenna Z.M.Sheng Key Laboratory for Laser Plasmas (Ministry of Education) and Department of Physics and Astronomy Shanghai Jiao Tong University Beijing national Laboratory of Condensed Matter Physics Institute of Physics Chinese Academy of Sciences SUPA Department of Physics University of Strathclyde Central Laser Facility Rutherford Appleton Laboratory Department of Physics Lund University

The first experimental measurements of intense(～7 × 1019 W cm-2) laser-driven terahertz(THz) radiation from a solid target which is preheated by an intense pulse of laser-accelerated protons is reported. The total energy of the THz radiation is found to decrease by approximately a factor of 2 compared to a cold target reference. This is attributed to an increase in the scale length of the preformed plasma, driven by proton heating, at the front surface of the target,where the THz radiation is generated. The results show the importance of controlling the preplasma scale length for THz production.

关键词： target heating terahertz radiation

卵巢癌患者临终前的资源消费:“太多“有多少?

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 40-41页

作者： Lewin S.n. Buttin B.M. powell M.A. T.J. Herzog 马超 Division of Gynecologic Oncology Columbia University School of Physicians and Surgeons 161 Ft Washington Avenue New York NY 10032 United States

Objective. End-of-life (EOL) medical care consumes 10-12%of national health care expenditures and 27%of Medicare dollars annually. Studies suggest that hospice services decrease EOL expenditures by 25-40%. The goal of this study was to compare the total cost of hospital-based resources utilized in ovarian cancer patients during their last 60 days of life for those enrolled in hospice versus those not on hospice. Methods. Study eligibility included patients who expired from ovarian cancer from 1999 to 2003. Medical records were reviewed for demographic data as well as treatment, response and recurrence rates, histologic type, grade and stage. Billing records were analyzed for costs of inpatient and outpatients visits, including radiologic, laboratory and pharmacy charges. Total cost of hospital resources was compared between patients managed on hospice for >10 days (hospice group) versus nonhospice group) using the following methods: Mann-Whitney U, Kruskal-Wallis and Student’s t tests. Overall survival was compared using Kaplan-Meier statistics. Results. Of the 84 patients analyzed, 67 (79.8%) were in the non-hospice group and 17 (20.2%) were in the hospice group. Demographic, histologic and staging characteristics as well as platinum sensitivity were similar between the two groups before the last 60 days of life. Mean number of chemotherapy cycles before the study period was also similar (20.4 and 21.0, respectively). However, during the study period, the mean total cost per patient in the non-hospice group was ＄59,319 versus ＄15,164 in the hospice group (P = 0.0001). A significant difference in cost was noted for mean inpatient days (＄6584 vs ＄1629, P = 0.0007), radiology (＄6063 vs ＄2343, P = 0.003), laboratory (＄12,281 vs ＄2026, P = 0.0004) and pharmacy charges (＄13,650 vs ＄4465, P = 0.0017) as well as for treating physician per patient (＄112,707 vs ＄34,677, P = 0.04). Overall survival for the two groups was the same. Conclusions. Our findings demonstr

关键词：资源消费医疗记录医院成本医院资源检验科复发率人口数据存活数药剂科有显著性差异

更迭镧系元素螯合物稳定常数序列改进离子交换法分离锕-镧系元素的研究

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高等学校化学学报 1987年第10期8卷 923-926页

作者：凌达仁 powell J.E. 兰州大学现代物理系 Ames Lab.DOE.USA

本文提出了以双(2-氨基乙基)醚为骨架的氨羧螯合剂类作为选择性螯合剂,更迭镧系元素的螯合物稳定常数序列,改进用阳离子交换法分离锕-镧系混合物的新设想。报道了该类络合剂DETAP n,n,n′-三乙酸-n′-3-丙酸-双-2-氨基乙基醚的合成方法... 详细信息

本文提出了以双(2-氨基乙基)醚为骨架的氨羧螯合剂类作为选择性螯合剂,更迭镧系元素的螯合物稳定常数序列,改进用阳离子交换法分离锕-镧系混合物的新设想。报道了该类络合剂DETAP n,n,n′-三乙酸-n′-3-丙酸-双-2-氨基乙基醚的合成方法、阴离子质子常数、它和镧系元素的络合物稳定常数。讨论了该离子交换法在分离锕-镧系元素上应用的可能性。

关键词：稳定常数镧系元素氨羧螯合剂离子交换法螯合物络合剂乙基醚