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传染性法氏囊炎病毒(IBDV)血清Ⅰ型和血清Ⅱ型抗体的鉴别检测

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山东家禽 1992年第2期5卷 35-37页

作者： n.m.ismail Y.m.saif 张秀美山东省农科院家禽研究所

利用血清中和试验(Vn),酶联免疫吸附实验(ELISA)和琼脂扩散沉淀试验(AGP)对IBDV血清Ⅰ型和血清Ⅱ型抗体进行鉴别检测。被检血清来自用活毒攻毒鸡和用灭活油佐剂疫苗免疫鸡,血清Ⅰ型和血清Ⅱ型两者之间抗体的差异用Vn试验很容易鉴别检出... 详细信息

利用血清中和试验(Vn),酶联免疫吸附实验(ELISA)和琼脂扩散沉淀试验(AGP)对IBDV血清Ⅰ型和血清Ⅱ型抗体进行鉴别检测。被检血清来自用活毒攻毒鸡和用灭活油佐剂疫苗免疫鸡,血清Ⅰ型和血清Ⅱ型两者之间抗体的差异用Vn试验很容易鉴别检出,但用ELISA方法却不能区分两者之间的差异。AGP试验更不能令人满意。目前用于检测IBDV抗体水平的方法主要有Vn、AGP和ELISA等。Vn试验不仅可鉴别检测血清Ⅰ型和血清Ⅱ型IBDV抗体,而且可鉴别检测同一血清型内不同毒株的抗体。ELISA也同样用于检测鸡的IBDV抗原和抗体,并被广泛应用于测定大型鸡场IBDV的免疫状态。此报道的主要目的是对比ELISA,AGP试验和Vn试验检测IBDV血清Ⅰ型和血清Ⅱ型特异性抗体之间差异的敏感性。

关键词：鸡病病毒抗体检测 IBD

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法氏囊病病毒的免疫原性

动物检疫 1992年第6期9卷 37-38页

作者： n.m.ismail Y.m.Saif 杜元钊

传染性法氏囊病是青年鸡的一种以免疫抑制为特征的疾病,它能引起法氏囊的严重病变。这种病是由双股双片段RnA病毒引起的,该病毒是双股RnA病毒科的一个成员。传染性法氏囊病的控制途径主要是用减毒或灭活苗免疫鸡群。在美国和欧洲认为法... 详细信息

传染性法氏囊病是青年鸡的一种以免疫抑制为特征的疾病,它能引起法氏囊的严重病变。这种病是由双股双片段RnA病毒引起的,该病毒是双股RnA病毒科的一个成员。传染性法氏囊病的控制途径主要是用减毒或灭活苗免疫鸡群。在美国和欧洲认为法氏囊病毒有两种血清型,但只有血清I型病毒用于制备商品性疫苗,血清Ⅱ型病毒无致病性。最近有报道,从患有法氏囊病且有高水平抗体的鸡中分离出一株血清I型法氏囊病病毒,这一株病毒是法氏囊病病毒的变异株。有人认为具有不同抗原性的法氏囊病病毒变异毒株的出现是疫苗免疫失败的主要原因。

关键词：鸡 IBD 病毒免疫

neurocircuit regeneration by extracellular matrix reprogramming

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neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian n.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Advanced hydrogen storage of the mg–na–Al system:A review

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Journal of magnesium and Alloys 2021年第4期9卷 1111-1123页

作者： n.A.Ali m.ismail Energy Storage Research Group Faculty of Ocean Engineering Technology and InformaticsUniversiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia

A solid-state storage system is the most practical option for hydrogen because it is more convenient and *** hydrides,especially mgH_(2),are the most promising materials that offer high gravimetric capacity and good ***,the practical application of mgH_(2) is restricted by slow sorption kinetics and high stability of thermodynamic *** storage performance of mgH_(2) was enhanced by introducing the mg–na–Al system that destabilises mgH_(2) with naAlH_(4).The mg–na–Al system has superior performance compared to that of unary mgH_(2) and naAlH_(4).To boost the performance of the mg–na–Al system,the ball milling method and the addition of a catalyst were *** mg–na–Al system resulted in a low onset decomposition temperature,superior cyclability and enhanced kinetics *** Al_(12)mg_(17) and namgH_(3) that formed in situ during the dehydrogenation process modify the reaction pathway of the mg–na–Al system and alter the thermodynamic *** this paper,the overview of the recent progress in hydrogen storage of the mg–na–Al system is *** remaining challenges and future development of mg–na–Al system are also *** paper is the first review report on hydrogen storage properties of the mg–na–Al system.

关键词： mg-na-Al system mgH_(2) naAlH_(4) Al_(12)mg_(17) hydrogen storage

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison n.DeVore marisol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Antimonene-based saturable absorber for a soliton mode-locked and Q-switched fiber laser in the 2 μm wavelength region

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Chinese Physics B 2023年第6期32卷 259-269页

作者： H Ahmad B nizamani m Z Samion n Yusoff m F ismail Photonics Research Centre Universiti Malaya50603 Kuala LumpurMalaysia Physics Department Faculty of ScienceUniversiti Malaya50603 Kuala LumpurMalaysia Distinguished Visiting Professor Universiti Kuala Lumpur British Malaysian Institute(UniKL BMI)Batu 8Jln Sungai Pusu53100SelangorMalaysia

We demonstrate antimonene as a saturable absorber(SA) to generate an ultrafast mode-locked and Q-switched laser in the 2 μm wavelength region. The two antimonene-based SAs were prepared and inserted separately in a thulium–holmiumdoped fiber laser to produce the pulsed laser. Antimonene was coated onto a tapered fiber to generate soliton mode-locked pulses and used in thin-film form for the generation of Q-switched pulses. The mode-locking was stable within a pump power of 267 m W–511 m W, and the laser operated at a central wavelength of 1897.4 nm. The mode-locked laser had a pulse width of 1.3 ps and a repetition rate of 12.6 mHz, with a signal-to-noise ratio of 64 d B. Q-switched laser operation was stable at a wavelength of 1890.1 nm within a pump power of 312 m W–381 m W. With the increase in pump power from 312 m W to 381 m W, the repetition rate increased to a maximum of 56.63 k Hz and the pulse width decreased to a minimum value of 2.85 μs. Wide-range tunability of the Q-switched laser was also realized within the wavelength range of1882 nm–1936 nm.

关键词： mode-locking Q-switched fiber laser optical saturable absorber

Strain effect on graphene nanoribbon carrier statistic in the presence of non-parabolic band structure

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Chinese Physics B 2016年第9期25卷 480-483页

作者： n A Izuani Che Rosid m T Ahmadi Razali ismail Department of Electronics and Computer Engineering Faculty of Electrical EngineeringUniversiti Teknologi Malaysia nanoelectronic Group Physics DepartmentFaculty of ScienceUrmia University

The effect of tensile uniaxial strain on the non-parabolic electronic band structure of armchair graphene nanoribbon（AGnR） is *** addition,the density of states and the carrier statistic based on the tight-binding Hamiltonian are modeled *** is found that the property of AGnR in the non-parabolic band region is varied by the *** tunable energy band gap in AGnR upon strain at the minimum energy is described for each of n-AGnR families in the non-parabolic *** behavior of AGnR in the presence of strain is attributed to the breakable AGnR electronic band structure,which varies the physical properties from its *** linear relation between the energy gap and the electrical properties is featured to further explain the characteristic of the deformed AGnR upon strain.

关键词： strain graphene nanoribbon uniaxial strain current–voltage characteristic

Optically modulated Tunable O-Band Praseodymium-Doped Fluoride Fiber Laser Utilizing multi-Walled Carbon nanotube Saturable Absorber

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Chinese Physics Letters 2019年第10期36卷 32-35页

作者： H.Ahmad m.F.ismail S.n.Aidit Photonics Research Center University of MalayaKuala Lumpur 50603Malaysia Physics Department Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia

A tunable and optically modulated fiber laser utilizing a multi-walled carbon nanotube based saturable absorber is demonstrated for operation in the O-band region.A praseodymium-doped fluoride fiber is used as the gain medium and the system is capable of generating modulated outputs at 1300 *** output is observed at pump powers of 511 mW and above,with repetition rates and pulse widths that can be tuned from 41 kHz and 3.4μs to 48 kHz and 2.4μs,respectively,at the maximum pump power available.A maximum average output power of 100μW with a corresponding single pulse energy of 2.1 nJ is measured,while the tunability of the proposed laser is from 1290 nm to 1308 *** output is stable,with peak power fluctuations of^4 dB from the average value.

关键词： pump fiber Optically