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国际医学放射学杂志 2015年第4期 384-384页

作者： M.Kanematsu S.Goshima n.kawai H.Kondo T.Miyoshi H.Watanabe 张冰 Department of Radiology Gifu University Hospital

摘要目的低管电压低碘对比剂负荷下CT肾血管成像的可行性研究,并与高管电压和碘对比剂中等负荷技术比较X线衰减情况和影像质量。材料与方法本研究经机构伦理委

关键词：碘对比剂平均低管电压团注追踪生理盐水 CT

Effects of General Anesthesia on the Results of Cardiac Catheterization in Pediatric Patients with Ventricular Septal Defect

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Congenital Heart Disease 2023年第2期18卷 235-243页

作者： Kiyotaka Go Taichi Kato Machiko Kito Yoshihito Morimoto Satoru kawai Hidenori Yamamoto Yoshie Fukasawa Kazushi Yasuda Department of Pediatric Cardiology Aichi Children’s Health and Medical CenterObu474-8710Japan Department of Pediatrics Nagoya University Graduate School of MedicineNagoya466-8560Japan

Background:There is no gold standard sedation method for pediatric cardiac *** congenital heart diseases with intracardiac shunts,hemodynamic parameters are prone to change depending on the ventilation conditions and anesthetics,although few studies have examined these *** purpose of this study was to investigate the effects of two different sedation methods on the hemodynamic ***:This study retrospectively evaluated consecutive patients with ventricular septal defect(VSD)below 1 year of age who underwent cardiac catheterization at Aichi Children’s Health and Medical Center,who were divided into age-and VSD diameter-matched general anesthesia(GA)and monitored anesthesia care(MAC)under the natural airway groups(n=40 each),for comparison of hemodynamic ***:In the GA group,arterial blood pH and arterial partial pressure of oxygen were significantly higher(pn dioxide was significantly lower than in the MAC group(pn pulmonary artery pressure(pnd systemic blood pressure(pn the GA *** vascular resistance index(pnd systemic vascular resistance index(pnificantly lower in the GA group than the MAC *** were no significant differences in pulmonary blood flow index,systemic blood flow index,and pulmonary/systemic blood flow ratio between the two ***:Cardiac catheterization under GA in VSD patients results in different hemodynamic parameters compared to that under *** particular,when using pulmonary artery pressure and pulmonary vascular resistance measured under GA for judgment regarding the surgical indications or perioperative management,consideration should be given to the fact that these parameters might be lower compared to those measured under MAC.

关键词： Ventricular septal defect cardiac catheterization general anesthesia monitored anesthesia care

Long-Term Outcomes of Systemic-to-Pulmonary Artery Shunt in Patients with Functional Single Ventricle and Heterotaxy Syndrome

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Congenital Heart Disease 2023年第4期18卷 399-411页

作者： Shota kawai Takashi Kido Yuta Teguri Koji Miwa Tomomitsu Kanaya Yoichiro Ishii Hisaaki Aoki Futoshi Kayatani Sanae Tsumura Department of Cardiovascular Surgery Osaka Women’s and Children’s HospitalIzumiOsakaJapan Department of Pediatric Cardiology Osaka Women’s and Children’s HospitalIzumiOsakaJapan

Objectives: We sought to determine the long-term outcomes and mortality-associated factors after systemic-topulmonaryartery shunt (SPS) in patients with heterotaxy syndrome. Methods: We retrospectively analyzed allpatients with a functional single ventricle and heterotaxy syndrome who underwent SPS at our center from January2001 to April 2022. Results: This study involved 84 patients. Restrictive pulmonary blood flow requiringearly modulation was presented in 34 (40%) patients. Compared with patients without restrictive pulmonaryblood flow (n = 50 [60%]), the postnatal survival of these 34 patients was significantly lower at 10 years (log rank:p = 0.04), but the statistical significance disappeared at 20 years (log rank: p = 0.18). Among 31 patients whounderwent SPS, 11 (35%) had extracardiac total anomalous pulmonary venous connection (TAPVC). The survivalrate after SPS was 80% at 10 years. Cox regression analysis showed that extracardiac TAPVC (hazard ratio6.44, 95% confidence interval 1.23–33.7, p = 0.03) and pulmonary venous obstruction (PVO) at TAPVC repair(hazard ratio 11.2, 95% confidence interval 2.13–58.5, p = 0.004) were significantly associated with death. In25 patients who underwent bidirectional cavopulmonary shunt (BCPS), surgical interventions on the pulmonaryartery (PA) were performed after SPS in 7 of 9 patients with PA coarctation, 3 of 4 with non-confluent PAs, and4 of 12 with normal PAs. At SPS, primary central PA plasty was performed in three patients with PA coarctationand 2 with non-confluent PAs. There was no significant difference in the PA index before BCPS between patientswith and without primary central PA plasty (p = 0.49). Among 20 patients who underwent total cavopulmonaryconnection (TCPC), adverse events occurred in 7 (35%) patients, including death in 1 (5%), intervention for pulmonaryarteriovenous malformation (PAVM) in 3 (15%), and surgical intervention for PVO in 3 (15%). TheB-type natriuretic peptide concentration was significant

关键词： Heterotaxy syndrome single ventricle total anomalous of pulmonary venous connection pulmonary artery coarctation

Gamete Dialogs in Green Lineages

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Molecular Plant 2015年第10期8卷 1442-1454页

作者： Toshiyuki Mori Hiroko kawai-Toyooka Tomoko Igawa Hisayoshi nozaki Department of Biological Sciences Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Graduate School of Horticulture Chiba University 648 Matsudo Matsudo Chiba 271-8510 Japan

Gamete fusion is a core process of sexual reproduction and, in both plants and animals, different sex gametes fuse within species. Although most of the molecular factors involved in gamete interaction are still unknown in various sex-possessing eukaryotes, reports of such factors in algae and land plants have been increasing in the past decade. In particular, knowledge of gamete interaction in flowering plants and green algae has increased since the identification of the conserved gamete fusion factor GEnERATIVE CELL SPECIFIC 1/HAPLESS 2 （GCS1/HAP2）. GCSl was first identified as a pollen generative cell-specific transmembrane protein in the lily （Lilium Iongiflorum）, and was then shown to function not only in flowering plant gamete fusion but also in various eukaryotes, including unicellular protists and metazoans. In addition, although initially restricted to Chlamydomonas, knowledge of gamete attachment in flowering plants was also acquired. This review focuses on recent progress in the study of gamete interaction in volvocine green algae and flowering plants and discusses conserved mechanisms of gamete recognition, attachment, and fusion leading to zygote formation.

关键词： sexual reproduction gamete fusion flowering plants green algae evolution

Molecular Cloning and Functional Characterization of Porcine MyD88 Essential for TLR Signaling

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Cellular & Molecular Immunology 2007年第5期4卷 369-376页

作者： Masanori Tohno Tomoyuki Shimazu Hisashi Aso Yasushi kawai Tadao Saito Haruki Kitazawa Food Immunology Group Laboratory of Animal Products ChemistryGraduate School of Agricultural ScienceTohoku UniversityAobakuSendai 981-8555Japan Research Fellow of the Japan Society for the Promotion of Science Food Immunology Group Laboratory of Animal Products ChemistryGraduate School of Agricultural ScienceTohoku UniversityAobakuSendai 981-8555Japan Laboratory of Functional Morphology Graduate School of Agricultural ScienceTohoku UniversityAobakuSendai 981-8555Japan

We isolated cDnA encoding porcine MyD88 （poMyD88） from Peyer＇s patches （Pps） of GALT. The complete open reading frame （ORF） of poMyD88 contains 879 bp encoding a deduced 293 aa residues. The amino acid sequence of poMyD88 was characterized by n-terminal death, intermediate and C-terminal Toll/IL-1 receptor （TIR） domains. The putative poMyD88 protein shares a higher level of homology with its human （87.2% amino acid identity） than with its mouse （77.4% amino acid identity） counterpart. Overexpression of poMyD88 participated in the further enhanced activation of nF-w.B in human embryonic kidney （HEK） 293 cells expressing porcine TLR2 and porcine TLR4/MD-2, but not porcine RP105/MD-1 after stimulation with the corresponding ligands. The expression levels of MyD88 were highest in the spleen and mesenteric lymph nodes （MLns）, and lower in digestive tissues of newborn swine. In adult swine, the expression levels in the digestive tissues were lower than those in MLns and the spleen. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals.

关键词： MyD88 TLR2 TLR4/MD-2 RP105/MD-1 cDnA cloning swine

High-pressure phase transitions of anorthosite crust in the Earth's deep mantle

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Geoscience Frontiers 2018年第6期9卷 1859-1870页

作者： Masayuki nishi Steeve Gréaux Shigehiko Tateno Yasuhiro Kuwayama Kenji kawai Tetsuo Irifune Shigenori Maruyama Geodynamics Research Centre Ehime UniversityEhime 790-8577Japan Earth-Life Science Institute Tokyo Institute of TechnologyTokyo 152-8550Japan Institute for Planetary Materials Okayama UniversityMisasaTottori 682-0193Japan Department of Earth Planetary Science School of ScienceUniversity of Tokyo113-0033 Hongo 7-3-1BunkyoTokyoJapan novosibirsk State University Pirogova 1630090Russia

We investigated phase relations, mineral chemistry, and density of lunar highland anorthosite at conditions up to 125 GPa and 2000 K. We used a multi-anvil apparatus and a laser-heated diamond-anvil cell for this purpose. In-situ X-ray diffraction measurements at high pressures and composition analysis of recovered samples using an analytical transmission electron microscope showed that anorthosite consists of garnet,CaAl_4Si_2O_(11)-rich phase(CAS phase), and SiO_2 phases in the upper mantle and the mantle transition *** lower mantle conditions, these minerals transform to the assemblage of bridgmanite, Ca-perovskite,corundum, stishovite, and calcium ferrite-type aluminous phase through the decomposition of garnet and CAS phase at around 700 km depth. Anorthosite has a higher density than PREM and pyrolite in the upper mantle, while its density becomes comparable or lower under lower mantle conditions. Our results suggest that ancient anorthosite crust subducted down to the deep mantle was likely to have accumulated at660-720 km in depth without coming back to the Earth's surface. Some portions of the anorthosite crust might have circulated continuously in the Earth's deep interior by mantle convection and potentially subducted to the bottom of the lower mantle when carried within layers of dense basaltic rocks.

关键词： Anorthosite Phase transformation Multi-anvil apparatus Diamond-anvil cell Mantle dynamics

Spontaneous regression of hepatocellular carcinoma: A mini-review

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World Journal of Gastroenterology 2017年第21期23卷 3797-3804页

作者： Akira Sakamaki Kenya Kamimura Satoshi Abe Atsunori Tsuchiya Masaaki Takamura Hirokazu kawai Satoshi Yamagiwa Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

Spontaneous tumor regression is an extremely rare phenomenon in the oncology field. However, there are several case reports resulted in the regression of hepatocellular carcinoma(HCC) and the accumulation of clinical information and analyses of the mechanism can contribute to the development of a novel therapy. For this purpose, we have carefully reviewed 23 cases of spontaneously regressed HCC published in recent 5 years and our case. The information regarding the tumor size, tumor marker, treatments, etc., have been summarized. The mechanism of spontaneous regression has been discussed to date and presumed to be due to many factors, including hypoxia and immunological reactions. In this careful review of the 24 cases based on the clinical information, hypoxia, systemic inflammation, and both upon spontaneous regression were seen in 3, 8, and 4 cases, respectively amo ng t he 15 c as e s f or w hic h t he inf o r mat io n regarding the proposed mechanisms are available. Recent development of immunotherapeutic approaches in oncology shows promising results, therefore, accumulation of additional cases and analysis of mechanisms underlying the spontaneous regression of HCC are essential and could lead to the development of a new generation of immunotherapies including antibodies directed against immune reactions.

关键词：自发的回归 Hepatocellular 癌免疫学的反应免疫疗法组织缺氧

nAD＋ Accumulation during Pollen Maturation in Arabidopsis Regulating Onset of Germination

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Molecular Plant 2013年第1期6卷 216-225页

作者： Shin-nosuke Hashida Hideyuki Takahashi Kentaro Takahara Maki kawai-Yamada Kazuyoshi Kitazaki Kazuhiro Shoji Fumiyuki Goto Toshihiro Yoshihara Hirofumi Uchimiya Institute of Molecular and Cellular Biosciences (IMCB) University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-0032 Japan Environmental Science Research Laboratory Central Research Institute of Electric Power Industry (CRIEPI) 1646 Abiko Chiba 270-1194 Japan Iwate Biotechnology Research Center (IBRC) Kitakami Iwate 024-0003 Japan Department of Environmental Science and Human Engineering Saitama University Sakura-ku Saitama 338-0825 Japan Institute for Environmental Science and Technology Saitama University 255 Shimo-Okubo Sakura-ku Saitama 338-8570 Japan

Although the nicotinamide nucleotides nAD（H） and nADP（H） are essential for various metabolic reactions that play major roles in maintenance of cellular homeostasis, the significance of nAD biosynthesis is not well under- stood. Here, we investigated the dynamics of pollen nicotinamide nucleotides in response to imbibition, a representative germination cue. Metabolic analysis with capillary electrophoresis electrospray ionization mass spectrometry revealed that excess amount of nAD＊ is accumulated in freshly harvested dry pollen, whereas it dramatically decreased immedi- ately after contact with water, importantly, excess of nAD~ impaired pollen tube growth. Moreover, nAD~ accumulation was retained after pollen was imbibed in the presence of nAD^-consuming reaction inhibitors and pollen germination was greatly retarded. Pollen deficient in the nicotinate/nicotinamide mononucleotide adenyltransferase （nMnAT） gene, encoding a key enzyme in nAD biosynthesis, and a lack of nAD＊ accumulation in the gametophyte, showed precocious pollen tube germination inside the anther Iocule and vigorous tube growth under high-humidity conditions. Hence, the accumulation of excess nAD＊ is not essential for pollen germination, but instead participates in regulating the timing of germination onset. These results indicate that nAD＋ accumulation acts to negatively regulate germination and a decrease in nAD＋ plays an important role in metabolic state transition.

关键词： Arabidopsis nicotinamide adenine dinucleotide (nAD) nAD biosynthesis nAD consumption nMnAT pollengermination pollen longevity.