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Optimal Timing of Antiretroviral Therapy Initiation in Acquired Immunodeficiency Syndrome-Associated Toxoplasmic Encephalitis:A Prospective Observational Multicenter Study in China

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Infectious Diseases & Immunity 2024年第1期4卷 4-9页

作者： Yao Li Haidong jiang Yanming Zeng Yanqiu Lu Siyuan Chen Yulin Zhang Zhongsheng jiang Tongtong Yang Shuiqing Liu Yaokai Chen Department of Infectious Diseases Chongqing Public Health Medical CenterChongqing 400036China Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Infectious Diseases Liuzhou People's HospitalLiuzhou 545006GuangxiChina Department of Infectious Disease The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Guiyang Public Health Clinical CenterGuiyang 550004GuizhouChina

Background:Toxoplasmic encephalitis(TE)is the most frequent cause of expansive brain lesions among patients with acquired immunodeficiency syndrome(AIDS).However,the optimal timing of antiretroviral therapy(ART)initiation in these patients remains *** study aims to investigate the differences in outcomes of ART initiation at different times,in order to help clarify the treatment timing of AIDS-associated ***:This multicenter prospective observational study included 87 patients recruited from 11 research centers in China(from March 2019 to December 2022).Of the patients,38 were assigned to the early ART group(initiating ART within 2 weeks after anti-Toxoplasma treatment initiation),and the remaining 49 patients received deferred ART(initiating ART at least 2 weeks after anti-Toxoplasma treatment initiation).The main outcomes includedmortality and emergence of immune reconstitution inflammatory syndrome(IRIS).Human immunodeficiency virus(HIV)-1 viral load and CD4^(+)T-cell counts at weeks 24 and 48 were ***:The number of deaths(1 vs.5,P=0.225)and incidence of IRIS(2.6%vs.0,P=0.437)were not significantly different between the early and deferred ART groups at week *** ART initiation did not contribute significantly to HIV-1 viral load control(n=8 vs.n=3 at week 24,P=0.142;n=7 vs.n=7 atweek 48,P=1.000).The median CD4^(+)T-cell counts between the two groups were not significantly different,either at week 24(155 vs.91 cells/mm^(3),P=0.837)or atweek 48(181 vs.146 cells/mm^(3),P=0.219).Conclusion:In patients with AIDS-associated TE,early ART initiation was not significantly different from deferred ART initiation in terms of incidence of mortality,IRIS,and HIV virological and immunological *** registration:This study was registered(registration number:ChiCTR1900021195)as one of 12 clinical trials under the title of a general project at the Chinese Clinical Trial Registry(***)on February 1,***

关键词： HIV Toxoplasma gondii Timing of antiretroviral therapy Virological outcome Immunological response

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Single-atom ni-n_(4)for enhanced electrochemical sensing

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nano Research 2024年第8期17卷 7658-7664页

作者： Zhuhui Qin Bo Tang Guiru Zhang Chongqing Zhu Kun.jiang Bowei Zhang Fu-Zhen Xuan Shanghai Key Laboratory of Intelligent Sensing and Detection Technology East China University of Science and TechnologyShanghai 200237China Key Laboratory of Pressure Systems and Safety of Ministry of Education East China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Theoretical and Computational Photochemistry Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Interdisciplinary Research Center School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Single-atom catalysts(SACs)attract widespread attention in heterogeneous catalysis due to their maximum atomic utilization efficiency and unique physical and chemical ***,their applications in chemical sensing keep huge potential but remain ***,a ni-n_(4)-C SAC was synthesized for the trace detection of dopamine(DA)and uric acid(UA).The ni-n_(4)-C SAC exhibited superior sensing performance compared to the ni *** detection range for DA and UA were 0.05–75μM and 5–90μM with detection limits of 0.027 and 0.82μM,*** functional theory(DFT)computations indicate that ni-n_(4)-C has a lower reaction barrier during electrochemical process,indicating that the atomic ni sites possess higher intrinsic activity than ni ***,DA and UA show strong potential dependency on the ni-n_(4)-C catalyst,indicating its applicability for their concurrent *** work extends the application of SACs in chemical sensing.

关键词： single-atom catalysts chemical sensing dopamine uric acid

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Revolutionizing plasmonic platform via magnetic field-assisted confined ultrafast laser deposition of high-density,uniform,and ultrafine nanoparticle arrays

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International Journal of Extreme Manufacturing 2024年第3期6卷 428-438页

作者： Jin Xu Lingfeng Wang Peilin Yang Haoqing jiang Huai Zheng Licong An Xingtao Liu Gary J Cheng School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906United States of America Institute of Technological Sciences Wuhan UniversityWuhanHubei 430072People’s Republic of China

The remarkable capabilities of 2D plasmonic surfaces in controlling optical waves havegarnered significant ***,the challenge of large-scale manufacturing of uniform,well-aligned,and tunable plasmonic surfaces has hindered their *** address this,we present a groundbreaking tunable plasmonic platform design achieved throughmagnetic field(MF)assisted ultrafast laser direct deposition in *** precise control of metal nanoparticles(nPs),with cobalt(Co)serving as the model material,employing an MF,and fine-tuning ultrafast laser parameters,we have effectively converted coarse and non-uniform nPs into densely packed,uniform,and ultrafine nPs(~3 nm).This revolutionary advancement results in the creation of customizable plasmonic‘hot spots,’which play a pivotal role insurface-enhanced Raman spectroscopy(SERS)*** profound impact of this designable plasmonic platform lies in its close association with plasmonic resonance and *** the plasmonic nanostructures resonate with incident light,they generate intense local electromagnetic fields,thus vastly increasing the Raman scattering *** enhancement leads to an outstanding 2–18 fold boost in SERS performance and unparalleled sensing sensitivity down to 10^(-10)***,the plasmonic platform also demonstratesrobustness,retaining its sensing capability even after undergoing 50 cycles of rinsing andre-loading of ***,this work adheres to green manufacturing standards,making it an efficient and environmentally friendly method for customizing plasmonic‘hot spots’inSERS *** study not only achieves the formation of high-density,uniform,and ultrafine nP arrays on a tunable plasmonic platform but also showcases the profound relation betweenplasmonic resonance and energy *** outstanding results observed in SERS sensors further emphasize the immense potential of this technology for energy-relatedapplications,including photocatalysis,ph

关键词： magnetic field manipulation laser deposition metasurface SERS

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High-performance,low-power,and flexible ultraviolet photodetector based on crossed ZnO microwires p-n homojunction

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Photonics Research 2024年第4期12卷 648-662页

作者： SHULIn SHA KAI TAnG MAOSHEnG LIU PEnG WAn CHEnYAnG ZHU DAnInG SHI CAIXIA KAn MInGMInG jiang College of Physics MIIT Key Laboratory of Aerospace Information Materials and PhysicsKey Laboratory for Intelligent Nano Materials and DevicesNanjing University of Aeronautics and AstronauticsNanjing 211106China

Low-power, flexible, and integrated photodetectors have attracted increasing attention due to their potential applications of photosensing, astronomy, communications, wearable electronics, etc. Herein, the samples of ZnO microwires having p-type(Sb-doped ZnO, ZnO:Sb) and n-type(Ga-doped ZnO, ZnO:Ga) conduction properties were synthesized individually. Sequentially, a p-n homojunction vertical structure photodiode involving a single ZnO:Sb microwire crossed with a ZnO:Ga microwire, which can detect ultraviolet light signals, was constructed.

关键词： power ultraviolet conduction

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Electrocatalytic performance of CnTs/graphene composited rare earth phthalocyanines(M=La,Y,Yb,Sc)

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Journal of Rare Earths 2024年第2期42卷 323-333,I0004页

作者： Tingting jiang Caixia Ou Luyi Wang Jun Chen Sydorov Dmytro Qian Zhang Jintian Luo Hua Wang jiangxi Key Laboratory of Power Batteries and Materials Faculty of Materials Metallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou341000China Joint Department of Electrochemical Energy Systems Institute of Bioorganic Chemistry and PetrochemistryNational Academy of Sciences of Ukraine38A VernadskyAveKiev03142Ukraine Guangdong Jiana Energy Technology Co. Ltd.Qingyuan511500China

In this study,a class of rare earth composite sandwich phthalocyanines(MPcs,M=La,Y,Yb,Sc) were prepared and compounded with graphene and carbon nanotubes to obtain MPc/Gr and MPc/CnTs *** electrocatalytic behaviors of MPc/Gr and MPc/CnTs electrodes were further *** results show that the central rare earth metal has a large influence on the electrocatalytic *** the MPcs/Gr samples,ScPc with the smallest ionic radius and molecular size can be more uniformly dispersed in graphene,and the hydrogen precipitation overpotential of ScPc/Gr electrode is514 mV,corresponding to a Tafel slope of 148 mV/dec,with better electrocatalytic performance than other rare earth metal *** for the MPc/CnTs composites,LaPc,which has the largest ionic radius and molecular size,is more uniformly dispersed on the surface of CnTs,so that the LaPc/CnT electrode exhibits the best LSV performance with the smallest corresponding Tafel slope(176 mV/dec).The main reason is the different binding modes of MPcs molecules in Gr and *** rare earth phthalocyanine is combined with layered graphene,the smallest size of rare earth phthalocyanine(ScPc)is more easily embedded in the graphene layer,resulting in better homogeneity of the composite,larger effective contact area and better electrocatalytic *** contrast,when rare earth phthalocyanine is bound to carbon nanotubes in a tubular structure,it is mainly bound by attaching to the surface or being entangled by the carbon *** this case,the rare-earth phthalocyanine molecules(LaPc)with larger layer spacing can provide more contact area with CnTs,forming a more uniform and effective composite,which eventually provides more active sites and better electrocatalytic performance.

关键词： Electrocatalysis Rare earth phthalocyanines Graphene(Gr) Carbon nanotubes(CnTs) Composite

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Improving chitosan-based composite membrane by introducing a novel hybrid functional nano-hydroxyapatite with carboxymethyl cellulose and phytic acid

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 1-15页

作者： Liuyun.jiang Yingjun Ma Shuo Tang Yuqing Wang Yan Zhang Shengpei Su Xiang Hu Jun He national&Local Joint Engineering Laboratory for new Petro-chemical Materials and Fine Utilization of Resources Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research(Ministry of Education)College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory Developmental Biology of Freshwater Fish School of Life ScienceHunan Normal UniversityChangsha 410081China Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control Changsha Hospital for Matemal&Child Health Care Aiffiliated to Hunan Normal UniversityChangsha 410081China

A functional hybrid nano-hydroxyapatite(carboxymethyl cellulose-phytic acid-n-HA,CMC-PA-n-HA)was prepared by adding CMC and *** results of Fourier transformation infrared spectra,X-ray diffraction,thermal gravimetric analysis and dispersion experiments indicated that the addition of CMC and PA affected the morphology,crystallinity and crystal size of hybrid n-HA,and CMC endowed hybrid n-HA with excellent *** electron microscope results showed that CMC-PA-n-HA nanoparticle could be uniformly dispersed in chitosan(CS)matrix to obtain composite membrane by casting technology,so that the highest tensile strength of CMC-PA-n-HA/CS composite membrane was 69.64%and 144.45%higher than that of CS membrane and n-HA/CS composite membrane,*** angle test showed that CMC-PA-n-HA effectively improved hydrophilicity of the CS *** simulated body fluid immersion results indicated that the CMC-PA-n-HA/CS composite membrane not only exhibited good degradability but also promoted bone-like apatite *** cell proliferation experiments proved that the introduction of PA made the composite membrane have better cell adhesion and proliferation *** tests demonstrated that PA could effectively improve the antibacterial properties of the composite membrane,which is expected to be applied as guide bone tissue regeneration membrane.

关键词： nano-hydroxyapatite chitosan dispersion guide bone tissue regeneration membrane

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Responses of plant diversity and soil microorganism diversity to nitrogen addition in the desert steppe,China

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Journal of Arid Land 2024年第3期16卷 447-459页

作者： YE He HOnG Mei XU Xuehui LIAnG Zhiwei jiang na TU nare WU Zhendan College of Grassland Resources and EnvironmentInner Mongolia Agricultural UniversityInner Mongolia Key Laboratory of Soil Quality and Nutrient ResourcesHohhot 010018China Key Laboratory of Agricultural Ecological Security and Green Development at University of Inner Mongolia Hohhot 010018China

nitrogen(n)deposition is a significant aspect of global change and poses a threat to terrestrial *** impact of plant-soil microbe relationships to n deposition has recently attracted considerable *** microorganisms have been proven to provide nutrients for specific plant growth,especially in nutrient-poor desert steppe ***,the effects of n deposition on plant-soil microbial community interactions in such ecosystems remain poorly *** investigate these effects,we conducted a 6-year n-addition field experiment in a Stipa breviflora *** steppe in Inner Mongolia Autonomous Region,*** n treatment levels(n0,n30,n50,and n100,corresponding to 0,30,50,and 100 kg n/(hm2•a),respectively)were applied to simulate atmospheric n *** results showed that n deposition did not significantly affect the aboveground biomass of desert steppe plants.n deposition did not significantly reduce the alfa-diversity of plant and microbial communities in the desert steppe,and low and mediate n additions(n30 and n50)had a promoting effect on *** variation pattern of plant Shannon index was consistent with that of the soil bacterial Chao1 index.n deposition significantly affected the beta-diversity of plants and soil bacteria,but did not significantly affect fungal *** conclusion,n deposition led to co-evolution between desert steppe plants and soil bacterial communities,while fungal communities exhibited strong stability and did not undergo significant *** findings help clarify atmospheric n deposition effects on the ecological health and function of the desert steppe.

关键词： soil microorganisms plant-microbial community interaction plant diversity nitrogen deposition desert steppe

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Analysis and optimization of stamping and forming process of bearing outer ring

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Theoretical & Applied Mechanics Letters 2024年第3期14卷 227-237页

作者： Shichao Zhu Yulu Ding Bing Long Hun Guo Linhan Ouyang Wengang Chen Zhengyi jiang College of Aeronautics and Mechanical Engineering Changzhou Institute of TechnologyChangzhou 213002China College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China eering University of WollongongWollongong NSW 2522Australia

To address the common issues of wrinkling,tearing,and uneven wall thickness in the actual sheet metal stamp-ing process of the outer ring of needle roller bearings,this study analyzes critical technical indicators such asforming limits,thickness distribution,and principal strains in the forming process in ***-dimensionalmodels of the concave and convex dies were *** effects of different process parameters,includingstamping speed,edge pressure,sheet metal thickness,and friction coefficient,on the quality of the forming partswere investigated by varying these ***,the orthogonal experimental method was used todetermine an optimal experimental group from multiple sets of *** was found that under the processparameters of a stamping speed of 3000 mm/s,edge pressure of 2000 n,sheet metal thickness of 0.9 mm,andfriction coefficient of 0.125,the forming quality of the outer ring of the bearing is ideal.

关键词： Plate stamping Bearing outer ring Mold design Optimization

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A reduced combustion mechanism of ammonia/diesel optimized with multi-objective genetic algorithm

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Defence Technology（防务技术） 2024年第4期34卷 187-200页

作者： Wanchen Sun Shaodian Lin Hao Zhang Liang Guo Wenpeng Zeng Genan Zhu Mengqi jiang State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130025China

For the deep understanding on combustion of ammonia/diesel,this study develops a reduced mechanism of ammonia/diesel with 227 species and 937 *** sub-mechanism on ammonia/interactions of n-based and C-based species(n—C)/nOx is optimized using the non-dominated Sorting Genetic Algorithm II(nSGA-II)with 200 *** optimized mechanism(named as 937b)is validated against combustion characteristics of ammonia/methane(which is used to examine the accuracy of n—C interactions)and ammonia/diesel *** ignition delay times(IDTs),the laminar flame speeds and most of key intermediate species during the combustion of ammonia/methane blends can be accurately simulated by 937b under a wide range of *** for ammonia/diesel blends with various diesel energy fractions,reasonable predictions on the IDTs under pressures from 1.0 MPa to5.0 MPa as well as the laminar flame speeds are also achieved by *** particular,with regard to the IDT simulations of ammonia/diesel blends,937b makes progress in both aspects of overall accuracy and computational efficiency,compared to a detailed ammonia/diesel *** kinetic analysis reveals that the reaction pathway of ammonia during the combustion of ammonia/diesel blend mainly differs in the tendencies of oxygen additions to nH_2 and nH with different equivalence ratios.

关键词： Ammonia Diesel Combustion Kinetic mechanism Multi-objective optimization

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Intramolecular Hydrogen Bond Improved Durability and Kinetics for Zinc‑Organic Batteries

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nano-Micro Letters 2024年第3期16卷 138-148页

作者： Tianjiang Sun Jun Pan Weijia Zhang Xiaodi jiang Min Cheng Zhengtai Zha Hong Jin Fan Zhanliang Tao Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityHaihe Laboratory of Sustainable Chemical TransformationsTianjin 300071People’s Republic of China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092People’s Republic of China

Organic compounds have the advantages of green sustainability and high designability,but their high solubility leads to poor durability of zinc-organic ***,a high-performance quinone-based polymer(H-PnADBQ)material is designed by introducing an intramolecular hydrogen bonding(HB)*** intramolecular HB(C=O⋯n-H)is formed in the reaction of 1,4-benzoquinone and 1,5-naphthalene diamine,which efficiently reduces the H-PnADBQ solubility and enhances its charge transfer in *** situ ultraviolet-visible analysis further reveals the insolubility of H-PnADBQ during the electrochemical cycles,enabling high durability at different current ***,the H-PnADBQ electrode with high loading(10 mg cm^(-2))performs a long cycling life at 125 mA g^(-1)(>290 cycles).The H-PnADBQ also shows high rate capability(137.1 mAh g^(−1)at 25 A g^(−1))due to significantly improved kinetics inducted by intramolecular *** work provides an efficient approach toward insoluble organic electrode materials.

关键词： Zn-organic batteries H-PnADBQ polymer Intramolecular hydrogen bond Reduced solubility Improvedπ-conjugated level

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