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Exercise sustains the hallmarks of health

Journal of Sport and Health Science 2023年第1期12卷 8-35页

作者： Yan Qiu Benjamin Fernández-García H.Immo Lehmann Guoping Li Guido Kroemer Carlos López-Otín Junjie Xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)School of MedicineShanghai UniversityNantong 226011China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Health Research Institute of the Principality of Asturias(ISPA) Oviedo 33011Spain Department of Morphology and Cell Biology AnatomyUniversity of OviedoOviedo 33006Spain Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA Centre de Recherche des Cordeliers Equipe labellisee par la Ligue contre le cancerUniversite de Paris CiteSorbonne UniversiteInserm U1138Institut Universitaire de FranceParis 75231France Metabolomics and Cell Biology Platforms Institut Gustave RoussyVillejuif 94805France Institut du Cancer Paris CARPEM Department of BiologyHopital Europeen Georges PompidouAP-HPParis 75015France Departamento de Bioquımica y Biologıa Molecular Facultad de MedicinaInstituto Universitario de OncologıaUniversidad de OviedoOviedo 33006Spain Centro de Investigacion Biomedica en Red Enfermedades Cancer(CIBEROnC) Oviedo 33006Spain

Exercise has long been known for its active role in improving physical fitness and sustaining *** moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various *** is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological *** we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and ***,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to *** review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health *** hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life.

关键词： Beneficial effects of exercise Exercise-related physiological adaptations Hallmarks of health Moderate-intensity exercise Therapeutic exercise

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Host-parasite interactions in perpetual darkness:Macroparasite diversity in the cavefish Astyanax mexicanus

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Zoological Research 2023年第4期44卷 782-792页

作者： Ana Santacruz David Hernández-Mena Ramses Miranda-Gamboa Gerardo Pérez-Ponce De León Claudia Patricia Ornelas-García Departamento de Zoología Instituto de BiologíaUniversidad Nacional Autónoma de MéxicoMéxico City CP 04510México Departamento de Sistemas y Procesos naturales Escuela Nacional de Estudios Superiores Unidad MéridaUcúYucatán CP 97357México Instituto de Energías Renovables Universidad Nacional Autónoma de MéxicoTemixcoMorelos CP 62580México Colección nacional de Peces Departamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoMéxico City CP 04510México Stowers Institute for Medical Research Kansas CityMO 64110USA

Astyanax mexicanus has repeatedly colonized cave environments,displaying evolutionary parallelisms in many troglobitic *** being a model system for the study of adaptation to life in perpetual darkness,the parasites that infect cavefish are practically *** this study,we investigated the macroparasite communities in 18 cavefish populations from independent lineages and compared them with the parasite diversity found in their sister surface fish populations,with the aim of better understanding the role that parasites play in the colonization of new *** the cavefish populations,we identified 13 parasite taxa,including a subset of 10 of the 27 parasite taxa known for the surface *** infecting the cavefish belong to five taxonomic groups,including trematodes,monogeneans,nematodes,copepods,and *** are the most dominant group,found in 14 *** macroparasites include species with direct life cycles and trophic transmission,including invasive ***,paired comparisons indicate higher parasite richness in the cavefish than in the surface *** variation in parasite composition across the caves suggests historical and geographical contingencies in the host-parasite colonization process and potential evolution of local *** base-line data on parasite diversity in cavefish populations of *** provides a foundation to explore the role of divergent parasite infections under contrasting ecological pressures(cave *** environments)in the evolution of cave adaptive traits.

关键词： Adaptation Metazoan parasites niche change Parasite assemblage Prevalence

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Relating environmental variables with aquatic community structure in an agricultural/urban coldwater stream

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Ecological Processes 2021年第1期10卷 481-499页

作者： Daniel T.L.Myers Richard R.Rediske James n.Mcnair Aaron D.Parker E.Wendy Ogilvie Annis Water Resources Institute Grand Valley State University740 W Shoreline DriveMuskegonMI 49401USA. Michigan Department of Environment Great Lakesand Energy525 W Allegan StreetLansingMI 48909USA. Grand Valley Metropolitan Council 678 Front Avenue NWSuite 200Grand RapidsMI 49504USA.

Background:Urban areas are often built along large rivers and surrounded by agricultural *** may lead to small tributary streams that have agricultural headwaters and urbanized lower *** study objectives assessed are as follows:(1)landscape,geomorphic,and water quality variables that best explained variation in aquatic communities and their integrity in a stream system following this agricultural-to-urban land use gradient;(2)ways this land use gradient caused aquatic communities to differ from what would be expected for an idealized natural stream or other longitudinal gradients;and(3)whether the impacts of this land use gradient on aquatic communities would grow larger in a downstream direction through the agricultural and urban *** study area was an impaired coldwater stream in Michigan,***:Many factors structured the biological communities along the agricultural-to-urban land use *** woody debris had the strongest relationship with EPT(Ephemeroptera,Plecoptera,and Trichoptera)abundance and richness and were most common in the lower,urbanized *** streambed substrate had the strongest relationship with Diptera taxa and surface air breather macroinvertebrates and was dominant in agricultural *** community assemblage was influenced largely by stream flow and temperature regimes,while poor fish community integrity in lower urban reaches could be impacted by geomorphology and episodic urban pollution *** macroinvertebrates were most abundant in deforested,first-order agricultural headwaters,while EPT macroinvertebrate richness was the highest downstream of agricultural areas within the urban zone that had extensive forest ***:Environmental variables and aquatic communities would often not conform with what we would expect from an idealized natural *** richness improved downstream of agricultural *** shows promise for the recovery of aquatic systems using we

关键词： Land use Habitat Stream Fish Macroinvertebrate Gradient

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Tailoring Distinct Reactive Environments in Lewis Acid Zeolites for Liquid Phase Catalysis

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Accounts of Materials Research 2021年第11期2卷 1033-1046页

作者： Blake A.Johnson John R.Di Iorio Yuriy Román-Leshkov Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States

COnSPECTUS:Lewis acidic zeolites are microporous crystalline materials that offer promise as catalysts for the activation and conversion of biomassderived precursors in the liquid phase due to their unique water tolerance and synthetic *** active site environment in zeolite catalysts is multifaceted in nature and is composed of a primary catalytic binding site,the secondary pore structure that confines such binding sites,and occluded solvent and reactant molecules that interact with adsorbed ***,Lewis acidic heteroatoms can adopt structurally diverse coordination that selectively catalyze different classes of chemical transformations and can be difficult to control synthetically or characterize ***,precise mechanistic interpretation of liquid-phase zeolite catalysis necessitates the development of synthetic,spectroscopic,and kinetic methods that can decouple such complex active site structures and probe the interactions that occur between confined active sites,solvent and reactant molecules,and adsorbed intermediates and transition states.

关键词： zeolite adsorbed spectroscopic

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Comparative mitogenome phylogeography of two anteater genera (Tamandua and Myrmecophaga;Myrmecophagidae, Xenarthra): Evidence of discrepant evolutionary traits

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Zoological Research 2021年第5期42卷 525-547页

作者： Manuel Ruiz-García Daniel Pinilla-Beltrán Oscar E.Murillo-García Christian Miguel Pinto Jorge Brito Joseph Mark Shostell Laboratorio de Genética de Poblaciones Molecular-Biología Evolutiva Departamento de BiologíaFacultad de CienciasPontificia Universidad JaverianaBogotáDC 110231Colombia Grupo de Investigación en Ecología Animal Departamento de BiologíaFacultad de Ciencias Naturales y ExactasUniversidad del ValleApartado AéreoCali 25360Colombia Instituto de Ciencias Biológicas Escuela Politécnica NacionalQuito 17012759Ecuador Instituto nacional de Biodiversidad(InABIO) Quito 170135Ecuador Math Science and Technology DepartmentUniversity of Minnesota CrookstonCrookstonMN 56716USA

The species within Xenarthra(sloths,anteaters,and armadillos)are quintessential South American *** the three groups,Vermilingua(anteaters)contains the fewest extant and paleontological ***,we sampled and sequenced the entire mitochondrial genomes(mitogenomes)of two Tamandua species(Tamandua tetradactyla and ***)(n=74)from Central and South America,as well as Myrmecophaga tridactyla(n=41)from South *** Tamandua,we detected three different *** oldest(THI)contained many specimens with the *** morphotype(but also several with the *** morphotype)and originated in southeastern South America(currently Uruguay)before moving towards northern South America,where the THII haplogroup *** primarily contained specimens with the *** morphotype(but also several with the *** morphotype)and was distributed in Central America,Colombia,and *** and THII yielded a genetic distance of 4%.THII originated in either northern South America or“in situ”in Central America with haplogroup THIII,which consisted of~50%*** and 50%*** *** was mostly located in the same areas as THII,i.e.,Central America,Ecuador,and Colombia,though mainly in the *** three haplogroups overlapped in Colombia and ***,*** and *** were not reciprocally *** this reason,we considered that a unique species of Tamandua likely exists,i.e.,*** contrast to Tamandua,*** did not show different morphotypes throughout its geographical range in the ***,two very divergent genetic haplogroups(MHI and MHII),with a genetic distance of~10%,were *** basal haplogroup,MHI,originated in northwestern South America,whereas the more geographically derived haplogroup,MHII,overlapped with MHI,but also expanded into central and southern South ***,Tamandua migrated from south to north whereas Myrmecophaga migrated from

关键词： Anteaters Genetic diversity Mitogenomes Myrmecophaga neotropics Phylogeography Spatial structure Tamandua

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温室封闭式栽培自适应灌溉方法

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农业工程学报 2015年第22期31卷 222-228页

作者：袁洪波李莉王海华 n.A.Sigrimis 河北农业大学机电工程学院保定071001 中国农业大学现代精细农业系统集成教育部重点实验室北京100083 希腊雅典农业大学农业工程系希腊雅典11855

为了改进和提高温室封闭式栽培精细灌溉控制方法,针对利用Penman-Monteith(P-M)公式和传感器数据信息相结合进行灌溉控制中因为涉及参数较多而使用不便、需要近似计算导致建立的作物蒸腾模型精度不够等问题,该文根据封闭式栽培可以回收... 详细信息

为了改进和提高温室封闭式栽培精细灌溉控制方法,针对利用Penman-Monteith(P-M)公式和传感器数据信息相结合进行灌溉控制中因为涉及参数较多而使用不便、需要近似计算导致建立的作物蒸腾模型精度不够等问题,该文根据封闭式栽培可以回收并循环利用多余灌溉水的特点,利用灌溉量与排出量的差值和温室小气候环境数据建立相对精确的作物蒸腾量计算模型,并在此基础上利用人工神经网络算法实现了温室封闭式栽培自适应灌溉控制,结果表明,在10 d内灌溉用水量为实际蒸腾量的97.8%,基本实现了按照作物需水量进行灌溉。研究对于实现按照作物蒸腾量进行准确的水分供给、节约灌溉用水量、提高水分利用效率具有一定的现实意义。

关键词：灌溉温室模型蒸腾自适应控制封闭式栽培

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CCD互相关粒子图像测速及其在对抗流流场测量中的应用

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推进技术 2000年第6期21卷 83-88页

作者：郑日恒 Bray K n C Rogg B Lecordier B 英国剑桥大学工程系鲁尔大学流体热力学研究所 CORIA Rouen大学

在常规自相关粒子图像测速 (PIV)系统的基础上 ,发展了一个采用CCD像机的互相关粒子图像测速系统。用这一新系统测量了对抗流流场的结果表明 ,这一技术克服了自相关粒子图像测速技术在测量具有滞止点的流场中的困难。实验说明 ,与自相... 详细信息

在常规自相关粒子图像测速 (PIV)系统的基础上 ,发展了一个采用CCD像机的互相关粒子图像测速系统。用这一新系统测量了对抗流流场的结果表明 ,这一技术克服了自相关粒子图像测速技术在测量具有滞止点的流场中的困难。实验说明 ,与自相关粒子图像测速技术相比。

关键词：粒子速度成像对抗流互相关自相关速度分布流动测量

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Science Letters:Quantification of Helicobacter pylori levels in soil samples from public playgrounds in Spain

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第1期11卷 27-29页

作者： Leonardo Martín PéREZ Francesc CODOnY Daniela LóPEZ LEYTOn Mariana FITTIPALDI Bárbara ADRADOS Jordi MORATó Health and Environmental Laboratory (MSM-Lab)-Aquasost UNESCO Chair in SustainabilityUiversitat Politècnica de Catalunya Environmental Science Center EULA-Chile University of Concepcion

Helicobacter pylori are ubiquitous Gram-negative bacteria with a high estimated level of infection in the world populations, but a majority of the infected persons are asymptomatic. This pathogen has been classified by the World Health Organization as a class I carcinogen and recognized as the causal agent of most peptic ulcers and chronic gastritis that might lead to stomach cancer. Although not all the transmission pathways of these bacteria into humans have been propedy identified, enough data have suggested that the oral-oral or fecal-oral ones are the main infection routes. Helicobacterpylori have been detected in non-treated water and in drinking water, which suggested that water might be an important infection source. As childhood is the critical period of infection, the aim of the present work was to examine the presence of Helicobacterpylori in soil samples from public playing areas of Spanish parks.

关键词： Heficobacterpylori Real time polymerase chain reaction (qPCR) Environmental soil samples

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Possible therapeutic targets and promising drugs based on unsymmetrical hetaryl-substituted porphyrins to combat SARS-CoV-2

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Journal of Pharmaceutical Analysis 2021年第6期11卷 691-698页

作者： Yury A.Gubarev natalya Sh.Lebedeva Elena S.Yurina Sergey A.Syrbu Aleksey n.Kiselev Mikhail A.Lebedev G.A.Krestov Institute of Solution Chemistry of the Russian Academy of Sciences 153045IvanovoRussia Ivanovo State University of Chemistry and Technology 153000IvanovoRussia

Coronavirus disease 2019 is a serious disease that causes acute respiratory syndrome and negatively affects the central nervous *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)crosses the blood-brain barrier due to the spike(S) protein on the surface of the viral ***,it is important to develop compounds that not only have an inhibitory effect but are also capable of completely deactivating the S protein *** study describes the purposeful modification of porphyrins and proposes compounds,asymmetrically hetaryl-substituted porphyrins with benzothiazole,benzoxazole,and n-methylbenzimidazole residues,to deactivate the S protein *** docking of SARS-CoV-2 proteins with hetaryl-substituted porphyrins showed that the viral S protein,nucleocapsid(n) protein,and non-structural protein 13(nsp13) exhibited the highest binding ***-substituted porphyrins form strong complexes(13-14 kcal/mol) with the receptor-binding domain of the S protein,while the distance from the porphyrins to the receptor-binding motif(RBM)does not exceed 20 ?;therefore,RBM can be oxidized by ^(1)O_(2),which is generated by *** porphyrins interact with the n protein in the serine/arginine-rich region,and a number of vulnerable amino acid residues are located in the photooxidation *** damage complicates the packaging of viral RnA into new ***-energy binding of hetaryl-substituted porphyrins with the n-and C-terminal domains of nsp13 was *** binding blocks the action of nsp13 as an enzyme of exoribonuclease and methyltransferase,thereby preventing RnA replication and processing.A procedure for the synthesis of hetaryl-substituted porphyrins was developed,new compounds were obtained,their structures were identified,and their photocatalytic properties were studied.

关键词： Porphyrins SARS-CoV-2 Molecular docking Photoinactivation

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Advances on the biosynthesis of pyridine rings

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Engineering Microbiology 2023年第2期3卷 1-7页

作者： Carolina E.Portero Yong Han M.Raquel Marchán-Rivadeneira Department of Chemistry and Biochemistry Ohio UniversityAthensOH 45701USA Edison Biotechnology Institute Ohio UniversityAthensOH 45701USA Center for Research on Health in Latinamerica(CISeAL)-Biological Science Department Pontificia Universidad Católica del Ecuador(PUCE)Quito 170143Ecuador Translational Biomedical Sciences Graduate Program Ohio UniversityAthensOH 45701USA Department of Biological Sciences Ohio UniversityAthensOH 45701USA

numerous studies have investigated the biosynthesis of pyridine heterocycles derived from nicotinic ***-ever,metabolic pathways generating pyridine heterocycles in nature remain ***,we summarize recent contributions conducted in the last decade on the biosynthetic pathways of non-derivate from nicotinic acid pyridine rings and discuss their implication on the study of natural products with pyridine structures.

关键词： natural products Biosynthesis Pyridine ring

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