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erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

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World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： Pui-Yin Leung Wenjing Chen Anissa n sari Poojitha Sitaram Pui-Kei Wu Susan Tsai Jong-In Park Department of Biochemistry Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUnD Pancreatic cancer is a leading cause of cancer-related *** activity of the epidermal growth factor receptor(eGFR)is often observed in pancreatic cancer,and the small molecule eGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential(Δψm),facilitate tumor cell uptake ofΔψm-sensitive agents,disrupt mitochondrial homeostasis,and subsequently trigger tumor cell *** has not been tested for this *** To determine whether erlotinib can elevateΔψm and increase tumor cell uptake ofΔψm-sensitive agents,subsequently triggering tumor cell ***Δψm-sensitive fluorescent dye was used to determine how erlotinib affectsΔψm in pancreatic adenocarcinoma(PDAC)cell *** viability of conventional and patient-derived primary PDAC cell lines in 2D-and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone(MitoQ),aΔψm-sensitive *** synergy between erlotinib and MitoQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug combination was determined using immune-compromised nude mice bearing PDAC cell line *** erlotinib elevatedΔψm in PDAC cells,facilitating tumor cell uptake and mitochondrial enrichment ofΔψm-sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatment potentiated low doses of *** suggested that these drugs synergistically induced tumor cell *** with in vitro data,erlotinib and MitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each *** Our findings suggest tha

关键词： Pancreatic cancer erlotinib Mitochondria-targeted ubiquinone Mitochondria Combination therapy

Solid-state nMR of the retinal protonated Schiff base in microbial rhodopsins

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Magnetic Resonance Letters 2024年第3期4卷 11-18页

作者： sari Kumagai Izuru Kawamura Graduate School of engineering Science Yokohama National UniversityYokohama240-8501Japan

Rhodopsin is a seven-helical transmembrane protein with a retinal chromophore covalently bound to a conserved lysine in helix G via a retinal protonated Schiff base(RPSB).Microbial rhodopsins absorb light through chromophore and play a fundamental role in *** microbial rhodopsins have been discovered,contributing to diverse functions and ***-state nMR spectroscopy has been instrumental in elucidating the conformation of chromophores and the three-dimensional structure of microbial *** review focuses on the 15n chemical shift values of RPSB and summarizes recent progress in the *** displayed the correlation between the 15n isotropic chemical shift values of RPSB and the maximum absorption wavelength of rhodopsin using solid-state nMR spectroscopy.

关键词： Membrane proteins Microbial rhodopsin Retinal Solid-state nMR Protonated Schiff base

Implementing and evaluating an automatic centroid moment tensor procedure for the Indonesia region and surrounding areas

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earth and Planetary Physics 2024年第4期8卷 609-620页

作者： Madlazim Muhammad nurul Fahmi Dyah Permata sari ella Meilianda Sorja Koesuma Physics Department Faculty of Mathematics and Natural SciencesUniversitas Negeri SurabayaSurabaya 60231Indonesia Science education Study Program Faculty of Mathematics and Natural SciencesUniversitas Negeri Surabaya 60231SurabayaIndonesia Disaster Science Department Faculty of Mathematics and Natural SciencesUniversitas Syiah KualaAceh 23126Indonesia Physics Department Faculty of Mathematics and Natural SciencesUniversitas Sebelas MaretSolo 57126Indonesia

The purpose of this research was to suggest an applicable procedure for computing the centroid moment tensor(CMT)automatically and in real time from earthquakes that occur in Indonesia and the surrounding *** software was used to estimate the CMT solution by selecting the velocity model that best suited the local and regional geological conditions in Indonesia and the surrounding *** data used in this study were earthquakes with magnitudes of 5.4 to ***-quality,real-time broadband seismographic data were provided by the International Federation of Digital Seismograph networks Web Services(FDSnWS)and the european Integrated Data Archive(eIDA)Federation in Indonesia and the surrounding ***,the inversion process and filter adjustment were carried out on the seismographic data to obtain good CMT *** CMT solutions from Gisola provided good-quality solutions,in which all earthquake data had A-level quality(high quality,with good variant reduction).The Gisola CMT solution was justified with the Global CMT(GCMT)solution by using the Kagan angle value,with an average of approximately 11.2°.This result suggested that the CMT solution generated from Gisola was trustworthy and *** Gisola CMT solution was typically available within approximately 15 minutes after an earthquake *** it met the quality requirement,it was automatically published on the *** catalog of local and regional earthquake records obtained through this technology holds great promise for improving the current understanding of regional seismic activity and ongoing tectonic *** accurate and real-time CMT solution generated by implementing the Gisola algorithm consisted of moment tensors and moment magnitudes,which provided invaluable insights into earthquakes occurring in Indonesia and the surrounding areas.

关键词： centroid moment tensor Gisola International Federation of Digital Seismograph networks Web Services(FDSnWS) real time Indonesia

Investigating the future study area on VR technology implementation in safety training: A systematic literature review

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Journal of Safety Science and Resilience 2024年第2期5卷 235-248页

作者： Adithya Sudiarno Ratna sari Dewi Retno Widyaningrum Ahmad Murtaja Dzaky Ma'arij Aldi Yustisia Supriatna Industrial and Systems engineering Department Institut Teknologi Sepuluh NopemberSurabaya60111Indonesia Occupational Safety and Health Councilof east Java Province(Dewan K3 Provinsi Jawa Timur) Surabaya60234Indonesia

Safety training is the exercise normally conducted for all the current and future employees of a company to identify and recognize occupational hazards and diseases as well as determine the appropriate controlling ***,virtual reality(VR)is a technology developed to virtually simulate the surrounding envi-ronment to ensure immersive experience and interaction through artificial three-dimensional(3D)*** devices have been developed to be more compact,easy to use,and affordable to enable people to enjoy immersive virtual experiences and provide interactive and realistic *** has made technology one of the most popular forms of media for different kinds of training,such as safety-related ***,this study aimed to review the use of VR in safety training through the systematic literature review(SLR)*** process focused on developing 4 primary questions(PQs)classified into 11 systematic research questions(SRQs)for discussion points concerning current developments in VR technology *** were further combined with the preferred reporting items for systematic reviews and meta-analyses(PRISMA)flow diagrams in selecting the relevant *** questions were also used to investigate the scenarios,methods,objectives,and outcomes of previous *** results showed the need for further studies on the application of VR technology in safety training in other fields such as firefighting,chemical industry,maritime,***,several scenarios such as construction design,disaster response,rescue procedures,and others need to be *** study also provides information on the gaps for future study,including the exploration of a broader range of industries and VR scenarios.

关键词： Virtual reality Safety training VRfuture development Systematic literaturereview

Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil engineering 2024年第2期18卷 309-318页

作者： Ayşe e.ÖZSOYÖZBAY Işıl SAnRI KARAPInAR Zehra n.KUTLU İsmail e.KILIÇ Department of Civil engineering Maltepe UniversityIstanbul 34857Turkey School of engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

In vivo astrocyte reprogramming following spinal cord injury

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neural Regeneration Research 2024年第3期19卷 487-488页

作者： Yannick n.Gerber Florence e.Perrin MMDn University of MontpellierEPHEINSERMMontpellierFrance Institut Universitaire de France(IUF) ParisFrance

Harmful and helpful roles of astrocytes in spinal cord injury(SCI):SCI induce gradable sensory,motor and autonomic impairments that correlate with the lesion severity and the rostro-caudal location of the injury *** absence of spontaneous axonal regeneration after injury results from neuron-intrinsic and neuron-extrinsic ***,not only adult neurons display limited capability to regrow axons but also the injury environment contains inhibitors to axonal regeneration and a lack of growth-promoting *** other cell populations that respond to the lesion,reactive astrocytes were first considered as only detrimental to spontaneous axonal ***,astrocytes.

关键词： injury impairment programming

nanomotion of bacteria to determine metabolic profile

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nanotechnology and Precision engineering 2024年第1期7卷 1-9页

作者： S.n.Pleskova e.V.Lazarenko n.A.Bezrukov R.n.Kriukov A.V.Boryakov M.e.Dokukin S.I.Surodin Research Laboratory of Scanning Probe Microscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Department of nanotechnology and Biotechnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov Physics and Technology Institute National Research Nuclear University MEPhISarov 607186Russia

In addition to their visible motion such as swimming(e.g.,with the help ofﬂagella),bacteria can also exhibit nanomotion that is detectable only with highly sensitive instruments,and this study shows that it is possible to detect bacterial nanomotion using an AFM detection *** results show that the nanomotion characteristics depend on the bacterial strain,and that nanomotion can be used to sense the metabolic activity of bacteria because the oscillations are sensitive to the food preferences of the bacteria and the type of surrounding medium.

关键词： nanomotion Bacteria Cantilever Oscillation Atomic force microscopy Metabolism

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紫外光直接光氧化浸出铜渣

Journal of Central South University 2024年第5期31卷 1476-1493页

作者： Zeynel Abidin sari M.Deniz TURAn Department of Metallurgy-Iskenderun Vocational School of Higher education Iskenderun Technical University31200HatayTurkey Department of Metallurgy and Materials engineering Fırat University23119ElazığTurkey

采用光化学反应研究了铜渣中Cu和Fe的溶解行为。实验采用石英玻璃夹套,在玻璃反应釜中间歇进行,在反应釜下埋入紫外线灯,并采用玻璃管作为送风装置。研究了不同波长UVA(365 nm)、UVB(311 nm)、UVC(254 nm)和真空UV光(185 nm)在浸出液中... 详细信息

采用光化学反应研究了铜渣中Cu和Fe的溶解行为。实验采用石英玻璃夹套,在玻璃反应釜中间歇进行,在反应釜下埋入紫外线灯,并采用玻璃管作为送风装置。研究了不同波长UVA(365 nm)、UVB(311 nm)、UVC(254 nm)和真空UV光(185 nm)在浸出液中的行为。所有实验在相同条件下,在有和没有紫外线灯的情况下进行比较。研究了自由基形成机制对浸出环境的适应性及其在氧化溶液介质浸出中的可用性。在紫外光(185 nm)和非紫外光条件下,铜的提取率分别为85.1%和70.7%。综上所述,在紫外(185 nm)光反应器体系中,铜渣在最佳条件下的金属溶解率比无紫外光反应器体系效率更高。光化学反应器是使其适应湿法冶金应用和检验工艺的新途径。

关键词：浸出铜炉渣光化学氧化紫外线灯氧化自由基

Overview of the Synthesis, Characterization, and Application of Tannin-Glyoxal Adhesive for Wood-Based Composites

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Journal of Renewable Materials 2024年第7期12卷 1165-1186页

作者： Awanda Wira Anggini Rita Kartika sari efri Mardawati Tati Karliati Apri Heri Iswanto Muhammad Adly Rahandi Lubis Research Center for Biomass and Bioproducts National Research and Innovation AgencyCibinong16911Indonesia Department of Forest Products Faculty of Forestry and EnvironmentIPB UniversityBogor16680Indonesia Department of Agro-Industrial Technology Universitas PadjadjaranBandung45363Indonesia Research Collaboration Center for Biomass and Biorefinery BRIN and Universitas PadjadjaranBandung45363Indonesia School of Life Sciences and Technology Institut Teknologi BandungBandung40132Indonesia Department of Forest Products Technology Faculty of ForestryUniversitas Sumatera UtaraMedan20355Indonesia

More than a century after its initial synthesis,urea-formaldehyde(UF)resins still have dominant applications as adhesives,paints,and ***,formaldehyde in this industry produces formaldehyde emissions that are dangerous to *** have spent the last decade replacing formaldehyde and phenol with environmentally friendly substances such as glyoxal and tannin to create bio-based *** review covers recent advances in synthesizing glyoxal tannin-based resins,especially those made from sustainable raw material substitutes and changes made to synthetic processes to improve mechanical *** efficacy of using tannin-glyoxal adhesives in producing wood-based composites has been *** glyoxylate reaction forms cross-linked bridges between the aromatic sites of the tannin and glyoxal molecular *** tannin adhesive with a greater percentage of glyoxal than tannin will produce an adhesive with better *** gel time reduces as the hardener concentration rises from 7.5%to 15%when glyoxal is used in ***,excessive amounts of glyoxal will result in a decrease in viscosity *** exhibits faster delivery degradation when it reaches a maximum temperature of approximately 130°C,although it initiates the curing process slightly slower at 110°*** glyoxal to tannin-based adhesives can improve the mechanical properties of composite *** wet shear strength of the resulting plywood is increased by 105.4%with the addition of 5-weight percent tannin-based resin with glyoxal as a cross-linker in Soy Protein *** glyoxal as a hardener,the panels produced showed good internal bond strengths(>0.35 MPa)and met the international standard specifications for interior-grade panels.

关键词： Bio-based adhesives glyoxal tannin wood adhesives wood-based composites