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Thermo-and pH-sensitive Polymer with Pendant Spacer-linked Imidazole Cycles

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Chinese Journal of Polymer Science 2024年第4期42卷 437-445页

作者： natalya V.Zakharova Stanislav n.Zelinskiy Mariya S.Strelova Elena n.danilovtseva Vadim V.Annenkov Institute of Macromolecular Compounds of the Russian Academy of Sciences Saint Petersburg199004Russia Limnological Institute of Siberian Branch of the Russian Academy of Sciences Irkutsk664033Russia

By the reaction of poly(acryloyl chloride) with n-(3-aminopropyl)imidazole, poly(n-(3-(1H-imidazol-1-yl)propyl)acrylamide) was synthesized. The new polymer contains an imidazole ring removed from the main chain by a spacer of five bonds. The structure and purity, molecular weight, hydrodynamic and thermosensitive properties of the obtained sample were studied by1H-and13C-nMR, FTIR spectroscopy, acid-base titration, light scattering, turbidimetry and viscometry. The observed ability of the imidazole-containing polymer to form and destroy associates in water-salt solutions at pH 6.6-7.4 and temperatures of 29-48℃ indicates that these are promising candidates for designing complex biomedical systems. The new polymer is able to form complexes with oligo-dnA more actively than poly(1-vinylimidazole), which is of interest for gene delivery applications. The polymer cross-linked with epichlorohydrin gives micro-relief coatings on the plastic surface, and the modified surface is able to attach negatively charged objects. This thermo-and pH-sensitive polymer modification can be applied to create finely controlled surfaces for cell culturing.

关键词： Imidazole-containing polymer Thermolability pH-sensitivity The modified surface dnA immobilization

Outcomes of long-acting injectable antipsychotics use in pregnancy:A literature review

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World Journal of Psychiatry 2024年第4期14卷 582-599页

作者： Ana V Pejčić Srdjan M Stefanović Milošn Milosavljević Vladimir S Janjić Marko M Folić nevena d Folić Jovana Z Milosavljević department of Pharmacology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia department of Clinical Pharmacology University Clinical Center KragujevacKragujevac 34000Serbia department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for Psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pharmaceutical and Pharmacological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia department of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric Clinic University Clinical Center KragujevacKragujevac 34000Serbia department of Anatomy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUnd Women with a history of serious psychotic disorders are at increased risk of disease relapse during ***-acting injectable(LAI)antipsychotics have been widely used to improve adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from previous research on the safety of LAI antipsychotics during *** To summarize relevant data on maternal,pregnancy,neonatal,and developmental outcomes from published cases of LAI antipsychotic use in *** A literature search was performed through november 11,2023,using three online databases:PubMed/MEdLInE,Scopus,and Web of *** reports or case series that reported information about the outcomes of pregnancy in women who used LAI antipsychotics at any point in pregnancy,with available full texts,were *** statistics,narrative summation,and tabulation of the extracted data were *** A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference *** reported the outcomes of LAI antipsychotic use in 74 women and 77 *** use of secondgeneration LAI antipsychotics was reported in the majority(n=47;61.0%)of ***-generation LAI antipsychotics were administered during 30 pregnancies(39.0%).Most of the women(approximately 64%)had either satisfactory control of symptoms or no information about relapse,while approximately 12%of them had developed gestational diabetes mellitus.A minority of cases reported adverse outcomes such as stillbirth,spontaneous abortion,preterm birth,low birth weight,congenital anomalies,and neurological manifestations in ***,there were no reports of negative long-term developmental *** Currently available data seem reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAI antipsychotic use during pregnancy.

关键词： Antipsychotic agents Long-acting injectable Pregnancy Outcome Review

Imprints of a gravitational wave through the weak field deflection of photons

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Chinese Physics C 2024年第8期48卷 240-245页

作者： Reggie C.Pantig AliÖvgün Physics department Mapúa University658 Muralla St.IntramurosManila 1002Philippines Physics department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkiye

In this study,we investigate the novel phenomenon of gravitational lensing experienced by gravitational waves traveling past a Schwarzschild black hole perturbed by a specific,first-order,polar gravitational *** apply the Gauss-Bonnet theorem,finding a topological contribution to the deflection of light rays passing near the black *** demonstrate that the deflection angle can be determined by analyzing a region entirely outside the path of the light ray,leading to a calculation based solely on the parameters of the perturbing wave(Legendre polynomial order,l;frequency,σ).This approach offers a unique perspective on gravitational lensing and expands our understanding of black hole interactions with gravitational waves.

关键词： supermassive black holes gravitational waves chaos weak deflection angle Gauss-Bonnet theorem

design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana n.nekrasova Andrei I.Fischer natalia A.nesterova Anatoliy V.dobrodumov Anzhelika V.Garshinina Olga d.Shuvaeva natalya V.Zakharova Evgenii F.Panarin Institute of Macromolecular Compounds Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorodintsev Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamidobenzoic acid(MABA)with neutral comonomers(n-vinylpyrrolidone(VP),n-methyl-n-vinylacetamide(MVAA),n-methacryloyl glucosamine(MAG))and anionic comononer sodium styrene sulfonate(naSS)were synthesized by radical *** interactions between the prepared copolymers and Tb^(3+)ions in aqueous solutions were studied;the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing n-vinylamide units(VP,MVAA)is three times more intense than that observed for the complexes between Tb^(3+)and MAG-containing *** the case of naSS-containing copolymers,the luminescence intensity is controlled by the values of binding constants between Tb^(3+)and MABA and the content of MABA units in a *** studied copolymers and their complexes with Tb^(3+)have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanide complexes Antiviral activity Cytotoxicity

The impact of maternal immune activation on the morphology and electrophysiological properties of postnatally-born neurons in the offspring

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neural Regeneration Research 2024年第2期19卷 399-400页

作者： Emilio J.Galván Angelica Zepeda departamento de Farmacobiología CINVESTAV Unidad Sur CdMxMéxico、Centro de Investigaciones sobre el EnvejecimientoCIE-CinvestavCdMxMéxico departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoUNAMCdMxMéxico

Pregnancy comes with a combination of physical changes and physiological immunosuppression that increases the susceptibility of women to pathogens and in turn,rises the prevalence of infectious diseases.

关键词： prevalence activation impact

Implications of regional identity for neural stem and progenitor cell transplantation in the injured or diseased nervous system

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neural Regeneration Research 2024年第4期19卷 715-716页

作者： Prakruthi Amar Kumar Jennifer n.dulin department of Biology Texas A&M UniversityCollege Station Texas A&M Institute for neuroscience Texas A&M UniversityCollege Station

neural stem and progenitor cell(nSPC)transpla ntation has emerged as a promising therapeutic strategy for replacing lost neuronal populations and repairing damaged neural circuits following nervous system injury and disease.A great deal of experimental work has investigated the biology of nSPC grafting in preclinical animal models;more recently.

关键词： neural system injured

Targeting muscle to treat Charcot-Marie-Tooth disease

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neural Regeneration Research 2024年第8期19卷 1653-1654页

作者： david Villarroel-Campos James n.Sleigh department of neuromuscular diseases and UCL Queen Square Motor neuron disease Centre UCL Queen Square Institute of NeurologyUniversity College LondonLondonUK UK dementia Research Institute University College LondonLondonUK

Charcot-Marie-Tooth disease(CMT)is a hereditary peripheral neuropathy causing muscle weakness/wasting and sensory dysfunction predominantly in limb *** patients display gait abnormalities,foot deformities,loss of sens... 详细信息

关键词： Marie sensation neuropathy

Morphology of crater and caldera lakes in the Far Eastern region of Russia and the features of their development

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Journal of Mountain Science 2024年第4期21卷 1246-1258页

作者： dmitrii n.KOZLOV Ekaterina V.LEBEdEVA Institute of Marine Geology and Geophysics Far Eastern Branch of the Russian Academy of SciencesYuzhno-Sakhalinsk 693022Russia Institute of Geography Russian Academy of SciencesMoscow 119017Russia

Volcanic lakes in the Kuril-Kamchatka region are difficult to access,and for this reason,they remain poorly studied,with only scattered and brief data *** authors have conducted a study of 10 lake basins using modern digital echolocation survey techniques and have also compiled and summarized published data for 15 lakes in the region,calculating their main morphometric *** has been established that many caldera lake basins are modified by young explosive funnels,extrusive or effusive domes,and exhibit traces of hydrothermal *** lakes of the same genetic type in the Kuril-Kamchatka region are similar in depth and depression forms,the group of caldera lakes shows less homogeneity across all morphometric *** was found that the absolute heights of the reservoirs on Kamchatka Peninsula are generally greater than those on the Kuril Islands,as is often the case with the size of their *** volcanic lakes under study can rapidly change their volume and shape under the influence of endogenous *** the first time for this region,on the base of repeated observations,underwater extrusive dome rate growth and the approximate rates of 2 lake level changes were *** observations of lakes in the Ksudach calderas(Kamchatka)and on Simushir Island indicate approximate rates of level changes:a decrease ranging within 0.5-0.6 m per year(over a 27-year observation interval)and an increase reaching up to 0.26 m per year(over a 48-year interval).The growth rate of the underwater extrusive dome in Lake Shtyubel has averaged 1-1.6 m per year over the past 25 *** analysis has facilitated the first generalization regarding the morphology and developmental features of crater and caldera lakes in the Kuril-Kamchatka region of Russia,representing an important step in their *** results obtained will provide a solid foundation for subsequent research in this region and may be of interest to researchers studying

关键词： Volcanic lakes Echolocation survey Volcanism Gashydrotherms Kamchatka Kuril Islands

Integrative Analysis of Transcriptome and Phenolic Compounds Profile Provides Insights into the Quality of Soursop (Annona muricata L.) Fruit

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1717-1732页

作者： Yolotzin Apatzingán Palomino-Hermosillo Ángel Elpidio díaz-Jasso Rosendo Balois-Morales Verónica AlhelíOchoa-Jiménez Pedro Ulises Bautista-Rosales Guillermo Berumen-Varela Unidad de Tecnología de Alimentos-Secretaría de Investigación y Posgrado Universidad Autónoma de Nayarit.Ciudad de la Cultura SNTepic63000NayaritMéxico Programa Académico de Biología Unidad Académica de AgriculturaUniversidad Autónoma de NayaritKm.9.Carretera Tepic-CompostelaXalisco63780NayaritMéxico Estancias Posdoctorales-Consejo nacional de Humanidades Ciencias y TecnologíasCoordinación de Apoyos a Becarios e InvestigadoresDirección de PosgradoCiudad de México03940México

Soursop(Annona muricata L.)is a tropical fruit highly valued for its uniqueﬂavor,nutritional value,and health-promoting *** ripening process of soursop involves complex changes in gene expression and metabo-lite accumulation,which have been studied using various omics *** analysis has provided insights into the regulation of key genes involved in ripening,while metabolic compound analysis has revealed the presence of numerous bioactive compounds with potential health beneﬁ***,the integration of transcrip-tome and metabolite compound data has not been extensively explored in ***,in this paper,we present a comprehensive analysis of the transcriptome and phenolic compound proﬁles of soursop during *** integration analysis showed that the genes and phenolic compounds were mainly involved in the starch and sucrose metabolism pathways during soursop ***,the phenolic compounds Kaempferol 3-Q-galactoside,Procyanidin C1,Procyanidin trimmer C1,and m-Coumaric,as well as the genes Ubiquitin-like protein 5(UBL5_ARATH),ATP-dependent zinc metalloprotease FTSH8(FTSH8_ORYSJ),Zinc transporter 4(ZIP4_AR-ATH),Thioredoxin-like 3-1(TRL31_ORYSJ),Mitogen-activated protein kinase YOdA(YOdA_ARATH),R-man-delonitrile lyase-like(MGL_ARATH),26s protease regulatory subunit 6A homolog(PRS6_SOLLC),Cytochrome P45072A13(C7A13ARATH),Cytochrome P45084A1(C84A1_ARATH)and Homoserine O-trans-acetylase(MET2-ORYSJ)were correlated and differentially accumulated and expressed,*** study provides new insights into the molecular mechanisms underlying soursop ripening and may contribute to the development of strategies for improving the nutritional quality and shelf life of this important fruit.

关键词： Bioinformatics data integration genes metabolites postharvest storage ripening