检索结果-南通市图书馆

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of n.acetyl-alpha-glucosaminidase to Parkinson’s disease

引用

neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu jian.Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DnA,mRnA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified n.acetyl-alpha-glucosaminidase as a differentially expressed protein.n.acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal n.acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that n.acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that n.acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,n.acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal n.acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that n.acetyl-alpha-glucosaminidase may reduceα-synuclein expression.and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes n.acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical effect of ultrasound-guided nerve block and dexmedetomidine anesthesia on lower extremity operative fracture reduction

引用

World Journal of Clinical Cases 2022年第13期10卷 4064-4071页

作者： Cheng-Bin.ao Ping-Lei Wu Liang Shao jian.Ying Yu Wei-Guo Wu Department of Anesthesiology The People’s Hospital of YuhuanTaizhou 317600Zhejiang ProvinceChina Department of Orthopedics Taizhou Luqiao Second People’s HospitalTaizhou 318000Zhejiang ProvinceChina

BACKGROUnD Lower extremity fractures are mainly treated by surgical reduction,but this operation is often.affected by the patient’s level of agitation.and the type of anesthesia *** main treatment for lower-extremity fractures is operative ***,operations can often be affected by both agitation.and the degree of ***,it is of great importance to develop an effective anesthesia program to effectively ensure the progress of *** To discuss the effect of ultrasound-guided nerve block combined with dexmedetomidine anesthesia in lower extremity fracture *** A total of 120 hospital patients with lower extremity fractures were selected for this retrospective study and divided into an observation group(n=60)and a control group(n=60)according to the anesthesia scheme;the control group received ultrasound-guided nerve block;the observation group was treated with dextromethomidine on the basis of the control group,and the mean.arterial pressure,heart rate(HR),and blood oxygen saturation were observed in the two *** The mean.arterial pressure of T1,T2 and T3 in the observation group were 94.40±7.10,90.84±7.21 and 91.03±6.84 mmHg,significantly higher than that of the control group(Pn group’s HR at T1 was 76.60±7.52 times/min,significantly lower than that of the control group(Pn group’s HR at T2 and T3 was 75.40±8.03 times/min.and 76.64±7.11 times/min,significantly higher than that of the control group(Pn group’s visual analog score at 2 h,6 h and 12 h after operation was 3.55±0.87,2.84±0.65 and 2.05±*** recovery time was 15.51±4.21 min,significantly lower than that of the control group(Pnesthesia,epinephrine and norepinephrine in the observation group were 81.10±21.19 pg/mL and 510.20±98.27 pg/mL,significantly lower than that of the control group(Pnd the mini-men.al state exam score of the observation group was 25.51±1

关键词： Ultrasound nerve block Dexmedetomidine Lower extremity fracture Anesthesia effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vector Cascade Algorithms with Infinitely Supported Masks in Weighted L_2 -Spaces

引用

Acta Mathematica Sinica,English Series 2013年第4期29卷 691-702页

作者： jian.bin YAnG Department of Mathematics College of SciencesHohai University

In this paper, we shall study the solutions of functional equations of the formΦ=∑α∈Zsa（α）Φ（M.-α）where is an r × 1 column vector of functions on the s-dimensional Euclidean space,a ：= （a（a））α∈Zs is an exponentially decaying sequence of r × r complex matrices called refinement mask and M is an s × s integer matrix such that limn∞ M-n =0. We axe interested in the question, for a mask a with exponential decay, if there exists a solution ~ to the functional equation with each function φj, j = 1,... ,r, belonging to L2（Rs） and having exponential decay in some sense？ Our approach will be to consider the convergence of vector cascade algorithms in weighted L2 spaces. The vector cascade operator Qa,M associated with mask a and matrix M is defined by

关键词： Refinable functions exponentially decaying masks vector cascade algorithms transitionoperators

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photo-stability and Photo-damage of SPASER nanoparticles under nanosecond Pulsed-laser

引用

Chinese Journal of Chemistry 2022年第4期40卷 507-514页

作者： jian.Hua Wang Shao-Peng Wang Pavel n.Melentiev bin Kang Jing-Juan Xu Hong-Yuan Chen State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu 210023China Institute of Spectroscopy of the Russian.academy of Sciences TroitskMoscow 108840Russia

Comprehensive Summary SPASER nanoparticle(nP),with small size,ultranarrow spectral-line and good biocompatibility,is a potential biomedical ***,owning to the striking light absorption capacity of Au-resonator,huge energy could accumulate under strong pumping-laser,which would lead to poor photo-stability and unexpected photo-damage to SPASER nP,and is harmful to its future practical application but hasn't been systematically studied in experiment.

关键词： SPASER nanoparticles Probe Laser spectroscopy Photophysics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In situ embedded bismuth nanoparticles among highly porous carbon fibers for efficient carbon dioxide reduction

引用

Rare Metals 2024年第9期43卷 4312-4320页

作者： Wei-jian.Guo ao Zhou Wen-Wen Cai Jin-Tao Zhang Key Laboratory for Colloid and Interface Chemistry(Ministry of Education) School of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China

Electrocatalysis provides an optimal approach for the conversion of carbon dioxide(CO_(2))into high-value chemicals,thereby presenting a promising avenue toward achieve carbon ***,addressing the selectivity and stability challenges of metal catalysts in electrolytic reduction remains a daunting *** this study,the electrospinning method is employed to fabricate porous carbon nanofibers loaded with bismuth nanoparticles with the help of in situ *** porous carbon nanofibers as conductive support would facilitate the dispersion of bismuth active sites while inhibiting their aggregation.and promoting the mass transfer,thus en.ancing their electrocatalytic activity and ***,nitrogen doping induces electron delocalization in bismuth atoms through metal-support interactions,thus enabling efficient adsorption of intermediates for improving selectivity based on the theoretical ***,Bi@PCnF-500 exhibits the exceptional selectivity and stability across a wide range of potential ***,its faradaic efficiency(FE)of formate reaches 92.7%in H-cell and94.9%in flow cell,respectively,with good electrocatalytic *** in situ characterization.and theoretical calculations elucidate the plausible reaction mechanism to obtain basic rules for designing efficient electrocatalyst.

关键词： Porous carbon nanofiber n-doping Electron delocalization Carbon dioxide reduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A STREAMLInE-BASED PREDICTIVE MODEL FOR En.anCED-OIL-RECOVERY POTEnTIALITY

引用

Journal of Hydrodynamics 2008年第3期20卷 314-322页

作者： HOU jian.ZHAnG Shun-kang DU Qing-jun LI Yu-bin College of Petroleum Engineering China University of Petroleum （East China） Dongying 257061 China Chemical and Petroleum Department University of Calgary Calgary T2N 1N4 Canada

A pseudo-three-dimensional model of potentiality prediction is proposed for en.anced oil recovery, based on the streamline method described in this article. The potential distribution of the flow through a porous medium under a complicated boun.ary condition is solved with the boun.ary element method. Furthermore, the method for tracing streamlines between injection wells and producing wells is presented. Based on the results, a numerical solution can be obtained by solving the seepage problem of the stream-tube with consideration of different methods of En.anced Oil Recovery（EOR）. The advan.age of the method given in this article is that it can obtain dynamic calculation with different well patterns of any shape by easily considering different physicochemical phenomena having less calculation time and good stability. Based on the uniform theory basis-streamline method, different models, including CO2 miscible flooding, polymer flooding, alkaline/surfactant/polymer flooding and microbial flooding, are established in this article.

关键词： boun.ary element method streamline method En.anced Oil Recovery(EOR) CO2 miscible flooding chemical flooding microbial flooding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multidimensional(0D-3D)functional nanocarbon:Promising material to strengthen the photocatalytic activity of graphitic carbon nitride

引用

Green Energy & Environment 2021年第6期6卷 823-845页

作者： bin He Mi Feng Xin.an Chen jian.Sun School of Life Science Beijing Institute of TechnologyBeijing100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China

As a prospective visible-light-responsive photochemical material,graphitic carbon nitride(g-C_(3)n_(4))has become a burgeoning research hot topics and aroused a wide interest as a metal-free semiconductor in the area of energy utilization.and conversion,environmen.al protection due to its unique properties,such as facile synthesis,high physicochemical stability,excellent electronic band structure,and ***,the shortcomings of high recombination rate of charge carriers,relatively low electrical conductivity and visible light absorption impede its practical *** strategies,such as surface photosensitization,heteroatom deposition,semiconductor hybridization,etc.,have been.applied to overcome the *** all the strategies,functional nanocarbon materials with various dimensions(0D~3D)attract much attention.as modifiers of g-C_(3)n_(4)due to their unique electronic properties,optical properties,and easy *** importantly,the properties of these functional nanocarbon materials can be tuned by various dimensions and thus there will be a way to overcome the defects of g-C_(3)n_(4)by choosing different dimensional carbon *** from some present reviews,this review starts with the fun.amen.al physicochemical characteristics of g-C_(3)n_(4)materials,followed by analyzing the advan.ages of functional nanocarbon materials modifying gC_(3)n_(4).Then,we present a systematic introduction to various dimensional carbon *** design philosophy of carbon/g-C_(3)n_(4)composites and the advanced studies are exemplified in ***,a nichetargeting summary and outlook on the major challenges,opportunities for future research in high-powered carbon/g-C_(3)n_(4)composites was proposed.

关键词： Graphitic carbon nitride(g-C_(3)n_(4)) Carbon materials Multidimension Photocatalysis Visible light

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fun.amen.al Solution of the Anisotropic Porous Medium Equation

引用

Acta Mathematica Sinica,English Series 2005年第5期21卷 1183-1190页

作者： bin Heng SOnG Huai Yu jian School of Software Tsinghua University Beijing 100084 P. R. China Department of Mathematics Tsinghua University Beijing 100084 P. R. China

We establish the existence of fun.amen.al solutions for the anisotropic porous medium equation, ut = ∑n i=1（u^mi）xixi in R^n × （O,∞）, where m1,m2,..., and mn, are positive constants satisfying min1≤i≤n{mi}≤... 详细信息

关键词： Yhn.amen.al solution Anisotropic porous medium equation Degenerate parabolic equation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tunnel effects on ring road traffic flow based on.an urgent-gentle class traffic model

引用

Theoretical & Applied Mechanics Letters 2021年第4期11卷 230-235页

作者： Yongliang Zhang M.n.Smirnova jian.Ma n.n.Smirnov Zuojin Zhu Faculty of Engineering Science University of Science and Technology of ChinaHefei 230026China Faculty of Mechanics and Mathematics Lomonosov Moscow State UniversityMoscow 119992Russian Federation Moscow Center for Fun.amen.al and Applied Mathematics Moscow 119992Russian Federation Scientific Research Institute for System Analysis Russian Academy of SciencesMoscow 119992Russian Federation naval Architecture and Civil Engineering Jiangsu University of Science and TechnologyZhenjiang 215600China

To explore tunnel effects on ring road traffic flow,a macroscopic urgent-gentle class traffic model is put *** model identifies vehicles with urgent and gentle classes,chooses the tunnel speed limit as free flow speed to express the fun.amen.al diagram in the tunnel,and adopts algebraic expressions to describe traffic pressure and sound *** two speed trajectories at the Kobotoke tunnel in Japan,the model is validated,with good agreement with observed *** results indicate that in the case of having no ramp effects,tunnel mean travel time is almost constant dependent on tunnel *** initial density normalized by jam density is above a threshold of about 0.21,a traffic shock wave originates at the tunnel entrance and propagates *** a threshold drops slightly as a result of on-ramp merging effect,the mean travel time drops as off-ramp diversion effect intensifies *** findings deepen the understanding of tunnel effects on traffic flow in reality.

关键词： Tunnel effects Travel time Density threshold Ramp effects

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discovery of a novel small inhibitor R J19 targeting to human Hsp90

引用

nuclear Science and Techniques 2017年第10期28卷 71-78页

作者： Hui-Ling Cao Kai-Kai Lyu bin Liu jian.Li jian.Hua He Shaanxi Key Laboratory of Ischemic Cardiovascular Disease Institute of Basic and Translational MedicineXi'an MedicalUniversityXi'an 710021China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Protein Modification.and Tumor HubeiPolytechnic University School of MedicineHuangshi 435003China Shanghai Institute of Applied Physics Chinese Academy ofSciencesShanghai 201204China Biotech and Biomedicine Science Co.Ltd. Shenyang 110000China Department of Molecular and Cellular Biochemistry Collegeof MedicineUniversity of KentuckyLexingtonKY 40508USA

Heat shock protein 90(Hsp90) can promote growth and proliferation of cancer cells by helping in folding, conformational maturation, and activation of various client proteins. Therefore, Hsp90 has been paid more attention to as an.anticancer drug target. Reported Hsp90 inhibitors have several limitations such as poor solubility, limited bioavailability, and hepatotoxicity. Here, a novel small inhibitor RJ19 has been designed using fragment-based drug discovery and synthesized. Additionally, a crystal structure of Hsp90 n-RJ19 was determined by X-ray diffraction(resolution limit, 2.0 A, PDB code 4 L90). The crystal structure of Hsp90 n-RJ19 was analyzed in detail and compared with that of native Hsp90 n, Hsp90 n.aTP, and Hsp90 n-GDM,respectively. It was indicated that RJ19 interacted with Hsp90~n.at the ATP-binding pocket, which suggests that RJ19 may replace nucleotides to bind with Hsp90~n to result in chaperone function failure of Hsp90. RJ19, therefore, has emerged as a promising anticancer lead compound. Rearrangement and displacement of L2 Loop in Hsp90~n-RJ 19 play a key role in the function failure, which also makes the pocket wider and longer facilitating structure modification of RJ19 later. The complex crystal structure and interaction between RJ19 and Hsp90~n provide a rational basis for the design.and optimization of novel anticancer drugs.

关键词：热休克蛋白90 HSP90 抑制剂晶体结构 X射线衍射法抗癌药物 Hsp90 生物利用度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：