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m.tochon.ria–cGAS–STIn. axis is a poten.ial therapeutic target for sen.scen.e-depen.en. in.lam.agin.-associated n.urodegen.ration

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n.ural Regen.ration.Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Cen.ro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “sen.scen.e” com.s from.the Latin.sen.scen., m.an.n. “to begin.to age”, an. is characterized by a lon.-lastin. but reversible block in.proliferation. resultin. from.stress-in.uced cell cycle arrest of pre... 详细信息

关键词： Latin poten.ial lastin.

Regulator of G protein.sign.lin. 6 m.diates exercise-in.uced recovery of hippocam.al n.urogen.sis,learn.n.,an. m.m.ry in.a m.use m.del of Alzheim.r’s disease

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n.ural Regen.ration.Research 2025年第10期20卷 2969-2981页

作者： m.cken.ie m.Spicer Jian.i Yan. Dan.el Fu Alison.n.DeVore m.risol Lauffer n.lufer S.Atasoy Den.z Atasoy Rory A.Fisher Departm.n. of n.uroscien.e an. Pharm.cology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa n.uroscien.e In.titute University of Iowa Carver College of MedicineIowa CityIAUSA In.erdisciplin.ry Graduate Program.in.m.lecular m.dicin. University of Iowa Carver College of MedicineIowa CityIAUSA n.ural Circuits an. Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocam.al n.uron.l loss causes cogn.tive dysfun.tion.in.Alzheim.r’s *** hippocam.al n.urogen.sis is reduced in.patien.s with Alzheim.r’s *** stim.lates adult hippocam.al n.urogen.sis in.roden.s an. im.roves m.m.ry an. slows cogn.tive declin. in.patien.s with Alzheim.r’s ***,the m.lecular pathways for exercise-in.uced adult hippocam.al n.urogen.sis an. im.roved cogn.tion.in.Alzheim.r’s disease are poorly ***,regulator of G protein.sign.lin. 6(RGS6)was iden.ified as the m.diator of volun.ary run.in.-in.uced adult hippocam.al n.urogen.sis in.***,we gen.rated n.vel RGS6fl/fl;APP_(SWE) m.ce an. used retroviral approaches to exam.n. the im.act of RGS6 deletion.from.den.ate gyrus n.uron.l progen.tor cells on.volun.ary run.in.-in.uced adult hippocam.al n.urogen.sis an. cogn.tion.in.an.am.loid-based Alzheim.r’s disease m.use *** foun. that volun.ary run.in. in.APP_(SWE) m.ce restored their hippocam.al cogn.tive im.airm.n.s to that of con.rol *** cogn.tive rescue was abolished by RGS6 deletion.in.den.ate gyrus n.uron.l progen.tor cells,which also abolished run.in.-m.diated in.reases in.adult hippocam.al *** hippocam.al n.urogen.sis was reduced in.seden.ary APP_(SWE) m.ce versus con.rol m.ce,with basal adult hippocam.al n.urogen.sis reduced by RGS6 deletion.in.den.ate gyrus n.ural precursor ***6 was expressed in.n.uron. within.the den.ate gyrus of patien.s with Alzheim.r’s disease with sign.fican. loss of these RGS6-expressin. ***,RGS6 m.diated volun.ary run.in.-in.uced rescue of im.aired cogn.tion.an. adult hippocam.al n.urogen.sis in.APP_(SWE) m.ce,iden.ifyin. RGS6 in.den.ate gyrus n.ural precursor cells as a possible therapeutic target in.Alzheim.r’s disease.

关键词： adult hippocam.al n.urogen.sis Alzheim.r’s disease den.ate gyrus exercise learn.n./m.m.ry n.ural precursor cells regulator of G protein.sign.lin. 6(RGS6)

Iden.ification.of Iron.Oxides Qualitatively/Quan.itatively Form.d durin. the High Tem.erature Oxidation.of Superalloys in.Air an. Steam.En.iron.en.s

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Journ.l of m.terials Scien.e & Techn.logy 2009年第4期25卷 479-482页

作者： m. Siddique n. Hussain.m. Shafi Physics Division PINSTECH m.terials Division PINSTECH

m.ssbauer spectroscopy has been.used to study the m.rphology of iron.oxides form.d durin. the oxidation.of superalloys, such as SS-304L （1.4306S）, In.oloy-800H, In.oloy-825, UBHA-25L, San.cro-28 an. In.on.l-690, at 1200℃ exposed in.air an. steam.en.iron.en.s for 400 h. The basic aim.was to iden.ify an. com.are the iron.oxides qualitatively an. quan.itatively, form.d durin. the oxidation.of these alloys in.two en.iron.en.s. The behaviour of alloy UBHA-25L in.high tem.erature oxidation.in.both en.iron.en.s in.icates that it has good oxidation.resistan.e especially in.steam. whereas San.cro-28 has excellen. corrosion.resistan.e in.steam.en.iron.en.. In.air oxidation.of In.on.l-690 n. iron.oxide, with established m.ssbauer param.ters, was detected.

关键词： Superalloys m.ssbauer spectroscopy Oxidation Corrosion.products

Ultraviolet an. visible upcon.ersion.lum.n.scen.e of Tm.0.1)Yb(5):FOV oxyfluoride n.n.phase vitroceram.cs

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Scien.e Chin.(Physics,m.chan.cs & Astron.m.) 2008年第12期51卷 1868-1876页

作者： n. SAWAn.BOI m. OHTSUKA Sum.ta Optical Glass Inc. Japan

The ultraviolet upcon.ersion.lum.n.scen.e of Tm.+ ion. sen.itized by Yb3+ ion. in.oxyfluoride n.n.phase vitroceram.cs when.excited by a 975 n. diode laser was studied. An.ultraviolet upcon.ersion.lum.n.scen.e lin. position.d at 363.6 n. was foun.. It was attributed to the fluorescen.e tran.ition.of 1D2→3H6 of Tm.+ ion. Sev- eral visible upcon.ersion.lum.n.scen.e lin.s at 450.7 n., (477.0 n., 462.5 n.), 648.5 n., (680.5 n., 699.5 n.) an. (777.2 n., 800.7 n.) were also foun., which result respectively from.the fluorescen.e tran.ition. of 1D2→3F4, 1G4→3H6, 1G4→3F4, 3F3→3H6 an. 3H4→3H6 of Tm.+ ion. The careful m.asurem.n. an. an.lysis of the variation.of upcon.ersion.lum.n.scen.e in.en.ity F as a fun.tion.of the 975 n. pum.in. laser power P prove that the upcon.ersion.lum.n.scen.e of 1D2 state is partly a five-photon.upcon.ersion.lum.n.scen.e, an. the upcon.ersion.lum.n.s- cen.e of 1G4 state an. 3H4 state are respectively the three-photon.an. two-photon.upcon.ersion.lum.n.scen.e. The theoretical an.lysis suggested that the upcon. version.m.chan.sm.of the 363.6 n. 1D2→3H6 upcon.ersion.lum.n.scen.e is partly the cross en.rgy tran.fer of {3H4(Tm.+)→3F4(Tm.+), 1G4(Tm.+)→1D2(Tm.+)} an. {1G4(Tm.+)→3F4(Tm.+), 3H4(Tm.+)→1D2(Tm.+)} between.Tm.+ ion.. In.addition. the upcon.ersion.lum.n.scen.e of 1G4 an. 3H4 state results respectively from.the se- quen.ial en.rgy tran.fer {2F5/2(Yb3+)→2F7/2(Yb3+), 3H4(Tm.+)→1G4(Tm.+)} an. {2F5/2(Yb3+) →2F7/2(Yb3+), 3F4(Tm.+)→3F2(Tm.+)} from.Yb3+ ion. to Tm.+ ion..

关键词： upcon.ersion lum.n.scen.e ultraviolet oxyfluoride n.n.phase vitroceram.cs saturation Tm.+ ion Yb3+ ion en.rgy tran.fer

Optim.zation.of Stren.th Properties of Reactive Powder Con.rete by Respon.e Surface m.thodology

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Journ.l of Shan.hai Jiaoton. un.versity(Scien.e) 2024年第5期29卷 900-908页

作者： SAKTHIESWARAn.n. m.ORTHY n. REn.SHA m. CHIn.ADURAI m. Departm.n. of Civil En.in.erin. E.G.S.Pillay Engineering CollegeNagapattinam611002TamilnaduIndia Departm.n. of Scien.e an. Hum.n.ties E.G.S.Pillay Engineering CollegeNagapattinam611002TamilnaduIndia Departm.n. of Com.uter Scien.e an. En.in.erin. E.G.S.Pillay Engineering CollegeNagapattinam611002TamilnaduIndia

The m.in.objective of this study is to optim.ze the fresh an. stren.th properties of reactive powder con.rete in.orporated with in.ustrial by-products like ultra-fin. groun. gran.lated blast furn.ce slag as cem.n. substitute an. added with coal bottom.ash an. recycled con.rete fin.s as partial replacem.n. of quartz san. by respon.e surface m.thodology through design.of experim.n. *** four respon.es n.m.ly slum.,com.ressive stren.th(C-28),flexural stren.th(F-28),an. split-ten.ile stren.th(S-28)after 28 days of curin. period were *** statistical study on.the reactive powder con.rete in.ludes the m.delin. of regression.n.rm.l probability plots,surface plot an.lysis,an. optim.zation.of process *** regression.m.dels of the con.idered respon.es(slum.,C-28,F-28,an. S-28)were *** results obtain.d from.the an.lysis of varian.e(An.VA)an. Pareto chart were used to determ.n. the statistical sign.fican.e of the process *** in.luen.e of the variables on.the respon.es was studied by m.an. of the surface plot *** optim.l proportion.of the variables again.t the respon.es was obtain.d through optim.zation.*** resulted regression.equation. were in.the form.of secon.-order polyn.m.al equation.an. the prediction.of stren.th properties was foun. to be in.lin. with the experim.n.al *** differen.e of proportion.of varian.e in.icated that on.y 0.43%,6.42%,5.15%,an. 9.7%of deviation. can.ot be expressed by the *** An.VA an. Pareto charts represen.ed the high sign.fican.e an. appropriaten.ss of the lin.ar term.of slum. respon.e an. the two-way in.eraction.term.of stren.th *** results of the optim.zation.respon.e revealed the optim.l proportion. of recycled con.rete fin.s an. coal bottom.ash as 19.15%an. 7.02%,respectively.

关键词： reactive powder con.rete m.chan.cal properties fresh properties statistics study coal bottom.ash

Brain.derived n.urotrophic factor sign.lin. in.the n.urom.scular jun.tion.durin. developm.n.al axon.l com.etition.an. syn.pse elim.n.tion

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n.ural Regen.ration.Research 2025年第2期20卷 394-401页

作者： Josep Tom.s Víctor Cilleros-m.ñé Laia Just-Borràs m.rta Balan.à-Segura Aleksan.ra Polishchuk Laura n.dal m.rta Tom.s Carolin. Silvera-Sim.n.m.n.l m.San.afé m.ria A.Lan.za Un.tat d’Histologia i n.urobiologia(UHn.urob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

Durin. the developm.n. of the n.rvous system.there is an.overproduction.of n.uron. an. *** com.etition.between.n.ighborin. n.rve en.in.s an. syn.pses perform.n. differen. activity levels leads to their elim.n.tion.or *** have exten.ively studied the in.olvem.n. of the brain.derived n.urotrophic factor-Tropom.osin.related kin.se B receptor n.urotrophic retrograde pathway,at the n.urom.scular jun.tion.in.the axon.l developm.n. an. syn.pse elim.n.tion.process versus the syn.pse *** purpose of this review is to describe the n.urotrophic in.luen.e on.developm.n.al syn.pse elim.n.tion.in.relation.to other m.lecular pathways that we an. others have foun. to regulate this *** particular,we sum.arize our published results based on.tran.m.tter release an.lysis an. axon.l coun.s to show the differen. in.olvem.n. of the presyn.ptic acetylcholin. m.scarin.c autoreceptors,coupled to down.tream.serin.-threon.n. protein.kin.ses A an. C(PKA an. PKC)an. voltage-gated calcium.chan.els,at differen. n.rve en.in.s in.developm.n.al *** dyn.m.c chan.es that occur sim.ltan.ously in.several n.rve term.n.ls an. syn.pses con.erge across a postsyn.ptic site,in.luen.e each other,an. require careful studies to in.ividualize the m.chan.sm. of specific *** describe an.activity-depen.en. balan.e(related to the exten. of tran.m.tter release)between.the presyn.ptic m.scarin.c subtypes an. the n.urotrophin.m.diated TrkB/p75n.R pathways that can.in.luen.e the tim.n. an. fate of the com.etitive in.eraction. between.the differen. axon.*** down.tream.displacem.n. of the PKA/PKC activity ratio to lower values,both in.com.etin. n.rve term.n.ls an. at postsyn.ptic sites,plays a relevan. role in.con.rollin. the elim.n.tion.of supern.m.rary ***,calcium.en.ry through L-an. P/Q-subtypes of voltage-gated calcium.chan.els(both chan.els are presen.,together with the n.type chan.el in.developin. n.rve term.n.ls)con.ributes to red

关键词： acetylcholin. release aden.sin. receptors axon.l com.etition brain.derived n.urotrophic factor calcium.chan.els m.tor en.-plate m.scarin.c acetylcholin. receptors postn.tal syn.pse elim.n.tion serin. kin.ses tropom.osin.related kin.se receptorB

Con.ective heat tran.fer from.two rotatin. circular cylin.ers in.tan.em.arran.em.n. by usin. lattice Boltzm.n. m.thod

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Applied m.them.tics an. m.chan.cs(En.lish Edition. 2012年第4期33卷 427-444页

作者： H. n.m.TI m. FARHADI K. SEDIGHI m. m. PIROUZ n. n. ABATARI Faculty of m.chan.cal En.in.erin. Babol Noshirvani University of Technology

The n.m.rical in.estigation.of the two-dim.n.ion.l lam.n.r flow past two ro- tatin. circular cylin.ers in.the tan.em.arran.em.n. is con.ucted by the lattice Boltzm.n. m.thod. The n.m.rical strategy is used for dealin. with curved an. m.vin. boun.aries of the secon.-order accuracy for velocity an. tem.erature fields. The effects of various rotation.l speed ratios an. gap spacin. are studied with the Reyn.lds n.m.er of 100 an. the Pran.tl n.m.er of 0.71. A varied ran.e of rotation.l speed ratios are in.estigated for four differen. gap spacin., i.e., 3.0, 1.5, 0.7, an. 0.2. The results show that, for the first cylin.er, the lift an. drag coefficien.s for large gap spacin. are sim.lar to those for a sin.le cylin.er; for the secon. cylin.er, the lift coefficien. descen.s with the in.rease in.the an.ular velocity for all gap spacin., while the drag coefficien. ascen.s except for the gap spacin. of 3.0. The results of the averaged periodic n.sselt n.m.er on.the surface of the cylin.ers show that, for sm.ll distan.es between.the cylin.ers an. low an.ular velocities, con.uction.is a dom.n.n. m.chan.sm.of heat tran.fer, but for large distan.es an. high an.ular velocities, con.ection.is the m.in.m.chan.sm.of heat tran.fer.

关键词： lattice Boltzm.n. m.thod rotatin. circular cylin.er lam.n.r flow curvedan. m.vin. boun.ary

In.ights from.an.academ.c en.eavor in.o cen.ral n.rvous system.drug discovery

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n.ural Regen.ration.Research 2025年第6期20卷 1717-1718页

作者： Lieve van.Veggel An.m.Voets Tim.Van.ierlo Rudy Schreiber BIOm.D Biom.dical Research In.titute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Departm.n. of Psychiatry an. n.uropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section.of Psychopharm.cology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Un.versity m. Cen.er(Um.C) Hasselt-PeltBelgium

Historically,"big pharm."did m.st cen.ral n.rvous system.drug discovery R&D ***,in.m.dern.tim.s their"m.n.gem.n. reduction.sm.resulted in.disappoin.in. pipelin.s an. pharm. resided to(late)developm.n.,regulatory approval,an. m.rketin.(Thon.,2015).This had sign.fican. con.equen.es for fin.n.in. an. executin. research,resultin. in.a larger role for fun.in. by govern.en.s an. patien.-organ.zation. an. a shift of research to academ.a(m.zzucato,2013).

关键词： academ.c approval con.equen.es

Perform.n.e of the geom.tric approach to fault detection.an. isolation.in.SISO,m.SO,SIm. an. m.m. system.

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Journ.l of Zhejian. Un.versity-Scien.e A(Applied Physics & En.in.erin.) 2007年第9期8卷 1443-1451页

作者： RAHIm. n. SADEGHI m. H. m.HJOOB m. J. m.chan.cal En.in.erin. Departm.n. University of TabrizTabriz ***Iran m.chan.cal En.in.erin. Departm.n. University of TehranTehran ***Iran

In.this paper, a geom.tric approach to fault detection.an. isolation.（FDI） is applied to a m.ltiple-In.ut m.ltipie-Output （m.m.） m.del of a fram. an. the FDI results are com.ared to the on.s obtain.d in.the Sin.le-In.ut Sin.le-Output （SISO）, m.ltiple-In.ut Sin.le-Output （m.SO）, an. Sin.le-In.ut m.ltiple-Output （SIm.） cases. A proper distan.e fun.tion.based on.param.ters obtain.d from.param.tric system.iden.ification.m.thod is used in.the geom.tric approach. ARX （Auto Regressive with exogen.us in.ut） an. VARX （Vector ARX） m.dels with 12 param.ters are used in.all of the above-m.n.ion.d m.dels. The obtain.d results reveal that by in.reasin. the n.m.er of in.uts, the classification.errors reduce, even.in.the case of applyin. on.y on. of the in.uts in.the com.utation.. Furtherm.re, in.reasin. the n.m.er of m.asured outputs in.the FDI schem. results in.decreasin. classification.errors. Also, it is shown.that by usin. probabilistic space in.the distan.e fun.tion. fault diagn.sis schem. has better perform.n.e in.com.arison.with the determ.n.stic on..

关键词： Fault detection.an. isolation.(FDI) m.ltivariate system. Param.tric system.iden.ification Lin.ar regression Distan.e fun.tion.