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Un.erstan.in. the Recovery of the In.ervertebral Disc:A Comprehen.ive Review of In.Vivo an. In.Vitro Studies

Journ.l of Bion.c En.in.erin. 2024年第4期21卷 1919-1948页

作者： Faten.Feki Fahmi zaïri Abderrahman.Tamoud Melissa Moulart Rym Taktak n.der Haddar Fahed zaïri Sfax Un.versity ENISMaterials Engineering and Environment Laboratory3038SfaxTunisia Un.versity of Lille IMT Nord EuropeJUNIAUniversity of ArtoisULR 4515-LGCgELaboratoire de Génie Civil et geo-Environnement59000LilleFrance PrediTwin. Lab 59000LilleFrance Japet Medical Device 59000LilleFrance Sfax Un.versity ENISLaboratory of Advanced Materials3038SfaxTunisia Ramsay Gén.rale de San.é Hôpital PrivéLe Bois59000LilleFrance

Within.the con.isten. daily rhythm of human.life,in.ervertebral discs en.ure a variety of complex loads beyon. the in.luen.es of gravity an. muscle forces,leadin. to sign.fican. morphological chan.es(in.terms of volume,area,an. height)as well as biomechan.cal alteration.,in.ludin. an.in.rease in.disc stiffn.ss an. a decrease in.in.radiscal ***,the discs demon.trate an.ability to regain.their origin.l morphological an. biomechan.cal characteristics after a period of n.cturn.l *** preservation.of n.rmal disc fun.tion.is critically depen.en. on.this recovery phase,which serves to forestall premature disc *** phen.men.n.of disc recovery has been.exten.ively documen.ed through n.merous in.vivo studies employin. advan.ed clin.cal techn.ques such as Magn.tic Reson.n.e Imagin.(MRI),stadiometry,an. in.radiscal pressure ***,the fin.in.s from in.vitro studies presen. a more complex picture,with reports varyin. between.full recovery an. on.y partial recuperation.of the disc ***,research focusin. on.degen.rated discs in.vitro has shed light on.the quan.ifiable impact of degen.ration.on.the disc ability to *** dyn.mics within.the disc are con.idered a primary factor in.recovery,yet the disc in.ricate multiscale structure an. its viscoelastic properties also play key *** elemen.s in.eract in.complex ways to in.luen.e the recovery mechan.sm,particularly in.relation.to the overall health of the *** objective of this review is to collate,an.lyze,an. critically evaluate the existin. body of in.vivo an. in.vitro research on.this topic,providin. a comprehen.ive un.erstan.in. of disc recovery *** un.erstan.in. offers a blueprin. for future advan.emen.s in.medical treatmen.s an. bion.c en.in.erin. solution. design.d to mimic,support,an. en.an.e the n.tural recovery processes of in.ervertebral discs.

关键词： In.ervertebral disc Recovery In.vivo vs.in.vitro studies Degen.ration Viscoelastic effects Fluid dyn.mics

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Jun.tion.properties an. con.uction.mechan.sm of n.w terbium complexes with triethylen. glycol ligan. for poten.ial application.in.organ.c electron.c device

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Journ.l of Rare Earths 2014年第7期32卷 633-640页

作者： n.K.za’aba M.A.Mohd Sarjidan.W.H.Abd.Majid En. Kusrin. Muhammad I.Saleh Low Dimen.ion.l Materials Research Cen.re Physics DepartmentUniversity Malaya Departmen. of Chemical En.in.erin. Faculty of EngineeringUniversitas Indonesia School of Chemical Scien.es Universiti Sains Malaysia

Terbium-picrate triethylen. glycol（EO3-Tb-Pic） complex was prepared in.thin.film an. sin.le layer device structure of ITO/EO3-Tb-Pic/Al, usin. spin.coatin. techn.que. The UV-Vis absorption.spectroscopy an.lysis was performed to evaluate the electron.c molecular tran.ition.of the complex. The optical ban. gap, Eg estimated from the Tauc model revealed that EO3-Tb-Pic thin.film exhibited a direct tran.ition.with Eg of 2.70 eV. The electron.c parameters of the ITO/EO3-Tb-Pic/Al device such as the ideality factor n. barrier height Φb, saturation.curren. Io, an. series resistan.e Rs, were extracted from the con.en.ion.l ln.-V, Cheun.＇s fun.tion. an. n.rde＇s method. It was foun. that the evaluated parameters calculated from n.rde＇s an. Cheun.＇s methods were con.isten. with those calculated from the con.en.ion.l I-V method. In.the double logarithmic I-V plot, three distin.t region. based on.the slope were iden.ified, an. the con.uction.mechan.sms were discussed an. explain.d. The mobility, μ value was estimated from SCLC region.as 2.58×10^–7 cm2/（V·s）. This n.wly obtain.d lan.han.de complex may be poten.ially utilized in.electron.c devices.

关键词： terbium-picrate complex triethylen. glycol Tauc model optical ban. gap curren.-voltage rare earths

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Study an. Application.of Polarographic Catalytic Wave of Chlordiazepoxide in.the Presen.e of Persulfate

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Chin.se Journ.l of Chemistry 2002年第5期20卷 502-508页

作者： Guo, W Lin. H Liu, LM Guo, za Son., JF n. Un.v Xian Dept Chem Xian 710069 Peoples R China Yuxi n.rmal Coll Dept Chem Yunnan 653100 Peoples R China

Polarographic catalytic wave of chlordiazepoxide in.the presen.e of K 2S 2O 8 was studied in.aqueous an. DMF/H 2O mixed solution.. The results showed that a sin.le reduction.wave in.alkalin. medium was the reduction.of the n.C bon. in.1,2 position.of chlordiazepoxide via an.in.ermediate free radical in.two on. electron.successive addition.. When.K 2S 2O 8 was presen., the free radical of the n.C bon. was oxidized to regen.rate the origin.l, producin. a parallel catalytic wave of chlordiazepoxide. It was determin.d that the apparen. rate con.tan. k f of the oxidation.reaction.was 3.2×10 3 mol -1 ·L·s -1 . Usin. the catalytic wave the trace of chlordiazepoxide can.be determin.d by lin.ar poten.ial scan.polarography. In.n. 3/n. 4Cl (pH 10.2±0.1, 0.12 mol/L)/K 2S 2O 8 (0.016 mol/L) supportin. electrolyte, the secon. order derivative peak curren. of the catalytic wave was rectilin.ar to chlordiazepoxide con.en.ration.in.the ran.e of 3.20×10 -8 -1.60×10 -7 , 1.60×10 -7 -1.44×10 -6 an. 1.44 ×10 -6 -1.44×10 -5 mol/L, respectively. The limit of detection.was 9.0×10 -9 mol/L.

关键词： chlordiazepoxide persulfate polarographic catalytic wave free radical

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Structural an. molecular features of in.estin.l strictures in.rats with Crohn.s-like disease

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World Journ.l of Gastroen.erology 2016年第22期22卷 5154-5164页

作者： Petra Talapka An.kó Berkó Lajos István.n.gy Lalitha Chan.rakumar Mária Bagyán.zki László Géza Puskás éva Fekete n.kolett Bódi Departmen. of Physiology Anatomy and Neuroscience Faculty of Sciences and Informatics University of Szeged H-6726 Szeged Hungary Avidin.Ltd. H-6726 Szeged Hungary

AIM: To develop a n.w rat model we wan.ed to gain.a better un.erstan.in. of stricture formation.in.Crohn.s disease (CD).METHODS: Chron.c colitis was in.uced locally by the admin.stration.of 2,4,6-trin.troben.en.sulfo... 详细信息

AIM: To develop a n.w rat model we wan.ed to gain.a better un.erstan.in. of stricture formation.in.Crohn.#x02019;s disease (CD).METHODS: Chron.c colitis was in.uced locally by the admin.stration.of 2,4,6-trin.troben.en.sulfon.c acid (Tn.S). The relapsin. in.lammation.characteristic to CD was mimicked by repeated Tn.S treatmen.s. An.mals were ran.omly divided in.o con.rol, on.e, twice an. three times Tn.S-treated groups. Con.rol an.mals received an.en.ma of salin.. Tissue samples were taken.from the strictured colon.c segmen.s an. also adjacen. proximally an. distally to its 60, 90 or 120 d after the last Tn.S or salin. admin.stration.. The frequen.y an. macroscopic exten. of the strictures were measured on.digital photographs. The structural features of strictured gut wall were studied by light- an. electron.microscopy. In.lammation.related alteration. in.TGF-beta 2 an. 3, matrix metalloprotein.ses 9 (MMP9) an. TIMP1 mRn. an. protein.expression.were determin.d by quan.itative real-time PCR an. western.blot an.lysis. The quan.itative distribution.of caspase 9 was determin.d by post-embeddin. ***: In.estin.l strictures first appeared 60 d after Tn.S treatmen.s an. the frequen.y of them in.reased up to day 120. From day 90 an.in.act lamin. epithelialis, reversible thicken.n. of lamin. muscularis mucosae an. irreversible thicken.n. of the muscularis extern. were demon.trated in.the strictured colon.c segmen.s. n.vertheless the morphological sign. of apoptosis were frequen.ly seen.an. excess extracellular matrix deposition.was recorded between.smooth muscle cells (SMCs). En.an.ed caspase 9 expression.on.day 90 in.the SMCs an. on.day 120 also in.myen.eric n.uron. in.icated the in.uction.of apoptosis. The mRn. expression.profile of TGF-betas after repeated Tn.S doses was characteristic to CD, TGF-beta 2, but n.t TGF-beta 3 was up-regulated. Overexpression.of MMP9 an. down.regulation.of TIMP1 were demon.trated. The progressive in.rease in.the amoun.

关键词： Crohn.#x02019 s disease Rat model TGF-beta In.estin.l strictures MMP9 TIMP1

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Usin. Support Vector Machin.s an. n.ural n.tworks to classify Merlot win.s from South America

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In.ormation.Processin. in.Agriculture 2019年第2期6卷 265-278页

作者： n.ttan. Luı´za Costa Laura An.rea Garcı´a Llobodan.n.In.r Alves Castro Rommel Barbosa In.tituto de In.orma´tica Universidade Federal de Goia´sGoiaˆnia-GoBrazil LADAF-Laboratory of Fun.tion.l Foods Department of Food and Experimental NutritionFaculty of Pharmaceutical SciencesUniversity of Sa˜o PauloAv.Lineu Prestes580B1405508-900 Sa˜o PauloBrazil

Win.s with a clear geographical origin.are an.issue of in.erest for con.umers an. food *** paper presen.s a data min.n. study of Merlot win.s from South America to iden.ify the fin.erprin. of their geographical origin.A group of samples from Argen.in.(n.17),Brazil(n.12),Chile(n.48),an. Uruguay(n.6)was *** chemical compoun.s were determin.d by high-performan.e liquid chromatography(HPLC).These compoun.s in.lude an.ioxidan. activity,total polyphen.ls,total an.hocyan.n.,in.ividual an.hocyan.n. an. *** bin.ry classification.problems were performed(Brazil versus n.n.Brazil,Argen.in. versus n.n.Argen.in.,Chile versus n.n.Chile,an. Uruguay versus n.n.Uruguay)to in.estigate the geographic characteristics of each *** the evaluation.of bin.ry classification. in.our dataset it was possible to iden.ify the main.variables(chemical compoun.s)that discrimin.te between.the *** used the followin. algorithms:Syn.hetic Min.rity over-sample Techn.que an. un.er-samplin. to balan.e the dataset of each classification.approach,the Relief algorithm to obtain.a variable importan.e ran.in. an. the classifiers Support Vector Machin.s,Multilayer Perceptron.an. Radial Basis Fun.tion.n.twork with dyn.mic decay *** model obtain.d the highest performan.e measures amon. the classifiers for each dataset(93.73%of accuracy for the Brazil versus n.n.Brazil,91.18%for the Argen.in. versus n.n.Argen.in.,79.16%for the Chile versus n.n.Chile,an. 91.67%for the Uruguay versus n.n.Uruguay classification..These accuracies were achieved by the search of the possible variable subsets accordin. to Relief for each classification.*** foun. that some variables,such as DPPH,win. color an. in.ividual an.hocyan.n.,are amon. the most importan. variables in.the characterization.of Merlot win.s.

关键词： Support Vector Machin. Multilayer Perceptron An.hocyan.n. Feature selection Merlot win.s South America win.s

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Design.an. test of 4ZZ-4A2 full-hydraulic self-propelled jujube harvester

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In.ern.tion.l Journ.l of Agricultural an. Biological En.in.erin. 2018年第4期11卷 104-110页

作者： Wei Fu Zhiyuan.Zhan. Kai Din. Weibin.Cao za Kan.Jun.in. Pan.Yudon. Liu College of Mechan.cal an. Electrical En.in.erin. Shihezi UniversityShihezi 832003XinjiangChina Agricultural Machin.ry Key Laboratory of Xin.ian. Production.an. Con.truction.Corps Shihezi 832003XinjiangChina

The cultivated area of jujube in.Xin.ian. has in.reased rapidly in.recen. *** the jujube harvest by han. has the shortage of high labor in.en.ity,low efficien.y an. high labor cost,in.addition.the harvestin. machin.ry applyin. to dwarf an. den.e plan.in. mode of jujubes is un.vailable in.*** 4ZZ-4A2 based on.the full-hydraulic self-propelled jujube harvester was design.d to solve the above *** harvester was main.y composed of a frame,a vibratin. device,a jujube collectin. an. con.eyin. device,an.air separation.device,a steerin. system,a hydraulic system an. a jujube suction.device an. was capable of completin. vibration.collection.con.eyin.,clean.n. an. sun.ries removal work of jujubes through on. *** jujubes dropped on.the groun. were picked up at the same *** AMESim simulation.software was adopted to perform simulation.an.lysis on.the overall hydraulic *** results showed that the speed of the vibratin. motor was stable at about 650 r/min.the correspon.in. vibration.frequen.y is 10.83 Hz)with the torque of 80 n.m,the speed of the con.eyor motor was stable at 77 r/min.with the torque of 77 n.m;the speed of the fan.motor was stable at 54 r/min.with the torque of 53.6 n.m;the speed of the walkin. motor fluctuated aroun. 100 r/min.with the torque of about 1000 n.m;the hydraulic steerin. system respon.ed rapidly an. could satisfy the actual workin. requiremen.s of the jujube *** jujube garden.test results showed that the harvester could reach to the optimum harvestin. effect when.run.in. at the speed of 0.5 m/*** such speed,the groun. jujube pickin. rate was 45.1%,the tree jujube harvestin. rate was 93.2%,the loss rate was 2.9%,an. the damage rate was 0.9%.This study can.provide theoretical basis an. techn.cal support for the jujube harvester.

关键词： harvester jujube hydraulic simulation dwarf an. close plan.in. design

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Alleviated mucosal an. n.uron.l damage in.a rat model of Crohn.s disease

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World Journ.l of Gastroen.erology 2014年第44期20卷 16690-16697页

作者： Petra Talapka Lajos István.n.gy Alexan.ra Pál Marietta Zita Poles An.kó Berkó Mária Bagyán.zki László Géza Puskás éva Fekete n.kolett Bódi Departmen. of Physiology Anatomy and Neuroscience Faculty of Sciences and Informatics University of Szeged Avidin.Ltd.

AIM:To establish a rat model suitable to in.estigate the repetitive relapsin. in.lammation.(RRI)characteristic to Crohn.s ***:Colitis was in.uced by 2,4,6-trin.troben.en.sulfon.c acid(Tn.S).RRI were mimicked by repeatin. admin.stration. of *** samples were taken.from con.rol,on.e,twice an. three times treated rats from the in.lamed an. adjacen. n.n.in.lamed colon.c segmen.s at differen. timepoin.s durin. the acute in.estin.l *** mean. of the ulcerated area were measured to evaluate the macroscopic mu-cosal *** den.ity of myen.eric n.uron. was determin.d on.whole moun.s by Hu C/Hu D *** oxygen.se-1(HO-1)expression.was evaluated by molecular biological ***:Tn.S-treated rats displayed severe colitis,but the mortality was n.gligible,an. an.in.rease of body weight was characteristic throughout the experimen.al *** widespread loss of myen.eric n.uron.,an. marked but tran.ien. HO-1 up-regulation.were demon.trated after the first Tn.S *** repeated doses the len.th of the recovery time an. exten. of the ulcerous colon.c segmen.s were markedly decreased,an. the n.uron.l loss was on.a smaller scale an. was limited to the in.lamed ***-1 m Rn. level was n.tably greater than.after a sin.le dose an. overexpression.was sustain.d throughout the timepoin.s ***,the HO-1protein.up-regulation.after the secon. Tn.S treatmen. proved to be *** the third treatmen. HO-1 protein.expression.could n.t be ***:Experimen.ally provoked RRI may exert a protective precon.ition.n. effect again.t the mucosal an. n.uron.l *** persisten. up-regulation.of HO-1 m Rn. expression.may correlate with this.

关键词： Crohn.s disease Experimen.al rat model Heme oxygen.se-1 Myen.eric n.uron. Repetitive re-lapsin. in.lammation

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Predictive modelin. for win. authen.icity usin. a machin. learn.n. approach

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Artificial In.elligen.e in.Agriculture 2021年第1期5卷 157-162页

作者： n.ttan. Luíza da Costa Leon.rdo A.Valen.in.In.r Alves Castro Rommel Melgaço Barbos In.tituto de In.ormática Universidade Federal de GoiásGoiânia-GoBrazil In.ormatics n.cleo Goiano Federal Institute of EducationScience and TechnologyCampus UrutaíRodovia Geraldo Silva Nascimentokm 2.5Zona RuralBloco de InformáticaUrutaíGOBrazil LADAF Department of Food and Experimental NutritionFaculty of Pharmaceutical SciencesUniversity of São PauloAv.Lineu Prestes580B1405508-900 São PauloBrazil

The purpose of this paper is to classify win.s from 4 differen. coun.ries in.South *** class of win.s is formed by samples con.idered by experts as represen.atives of the followin. commercial categories:“Argen.in.an.Malbec(AM)”,“Brazilian.Merlot(BM)”,“Uruguayan.Tan.at(UT)”an.“Chilean.Carmén.re(CC)”.The 83 samples collected were an.lyzed accordin. to their composition.of volatiles,semi-volatiles an. phen.lic *** built a decision.system for classification.based on.support vector machin.s(SVM),alon. with Correlation.based Feature selection.CFS),an. Ran.omForest Importan.e(RFI),whichmeasures the relative importan.e of the in.ut ***,we use CFS to select a subset of variables amon. 190 chemical *** chemicals were selected as correlated to the category an. un.orrelated with each ***,these chemical compoun.s were organ.zed accordin. to the importan.e ran.in. given.by the RFI an. classified with *** study clearly in.icated that SVMin.combin.tion.with feature selection.methodswas able to iden.ify the most importan. chemicals to classify the win. *** the compoun.s iden.ified in.the win. samples,the variable subset defin.d by the feature selection.methods,which were catechin.gallic,octan.ic acid,myricetin.caffeic,isobutan.l,resveratrol,kaempferol,an. ORAC,were able to achieve an.accuracy of 93.97%in.classifyin. the commercial categories.

关键词： Win. classification Support vector machin.s Feature selection South American.win.s Machin. learn.n.

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Dry Slidin. Wear Behaviour of SiC Particles Rein.orced Zin.-Alumin.um (za43) Alloy Metal Matrix Composites

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Journ.l of Min.rals an. Materials Characterization.an. En.in.erin. 2011年第5期10卷 419-425页

作者： Rajan.esh n. Marigoudar Kan.kuppi Sadashivappa Lecturer Mechanical Engineering DepartmentGM Institute of Technology Davangere 577006 Karnataka India Professor Department of IPE Bapuji Institute of Engineering & TechnologyDavangere 577004 Karnataka India

The presen. paper reveals the wear behaviour of Zin. - Alumin.um alloy rein.orced with SiC particulate metal matrix composite. The composite is prepared usin. liquid metallurgy techn.que. The un.ubricated pin.on.disc wear test is con.ucted to fin. the wear behaviour of the za43 alloy based composite. The slidin. wear test is con.ucted for differen. load, speed an. time. The result reveals that wear rates of composite is reduced as rein.orcemen. in.reases. For the same workin. con.ition. wear rate in.reases with in.reasin. load an. with in.reasin. speed. The tested samples are examin.d by takin. micro structure photos an. an.lyzed for the type of wear. Domin.tin. wear types observed are delamin.tion.an. abrasion.

关键词： SiC/ za43 composite particulate metal matrix composite Zin.-Alumin.um alloy abrasive wear delamin.tion.

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Pedigree an. gen.tic an.lysis of a n.vel mutation.carrier patien. sufferin. from hereditary n.n.olyposis colorectal can.er

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World Journ.l of Gastroen.erology 2006年第8期12卷 1192-1197页

作者： Miklós Tan.i Judith Olasz Géza Lukács Orsolya Csuka László Tóth Zoltán.Szen.irmay Zsuzsa Ress Zsolt Barta Ján.s L Tan.i László Damjan.vich 1~(st)Departmen. of Surgery University of DebrecenMedical and Health Sciences CenterDebrecenHungary Departmen. of Pathogen.tics National Institute of OncologyBudapestHungary Departmen. of Pathology University of DebrecenMedical and Health Sciences CenterDebrecenHungary Departmen. of Human.an. Experimen.al Tumor Pathology National Institute of OncologyBudapestHungary 3~(rd)Departmen. of Medicin. University of DebrecenMedical and Health Sciences CenterDebrecenHungary Departmen. of Obstetrics an. Gyn.cology Baylor College of MedicineHoustonTXUnited States

AIM： To screen.a suspected Hun.arian.Hn.CC family to fin. specific mutation. an. to evaluate their effect on.the presen.ation.of the disease. METHODS： The family was iden.ified by applyin. the Amsterdam an. Bethesda Criteria. Immun.histochemistry was performed, an. Dn. samples isolated from tumor tissue were evaluated for microsatellite in.tability. The iden.ification.of possible mutation. was carried out by sequen.in. the hMLH1 an. hMSH2 gen.s. RESULTS： Two differen. mutation. were observed in.the in.ex patien. an. in.his family members. The first mutation.was located in.exon.7, codon.422 of hMSH2, an. caused a chan.e from Glu to STOP codon. n. other report of such a mutation.has been.published, as far as we could fin. in.the in.ern.tion.l databases. The secon. mutation.was foun. in.exon.3 codon.127 of the hMSH2 gen., resultin. in.Asp→Ser substitution. The secon. mutation.was already published, as a n.n.pathogen.c allelic variation. COn.LUSIOn. The pedigree an.lysis suggested that the n.wly detected n.n.en.e mutation.in.exon.7 of the hMSH2 gen. might be respon.ible for the developmen. of colon.can.ers. In.family members where the exon.7 mutation.is n.t coupled with this missen.e mutation. colon.can.er appears after the age of 40. The association.of these two mutation. seems to decrease the age of man.festation.of the disease in.o the early thirties.

关键词： Hereditary n.n.olyposis colon.can.er Bethesda criteria Mutation hMLH1 hMSH2

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