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Impacts of PI3K/protein.kin.se B pathway activation.in.reactive astrocytes: from detrimen.al effects to protective fun.tion.

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n.ural Regen.ration.Research 2025年第4期20卷 1031-1041页

作者： Ramón.Pérez-n.ñez María Fern.n.a Gon.ález An. María Avalos Lisette Leyton Cellular Commun.cation.Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advan.ed Cen.er for Chron.c Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile In.tituto de Cien.ias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abun.an. type of glial cell in.the cen.ral n.rvous *** in.ury an. in.lammation.astrocytes become reactive an. un.ergo morphological an. fun.tion.l *** on.their phen.typic classification.as A1 or A2,reactive astrocytes con.ribute to both n.urotoxic an. n.uroprotective respon.es,***,this bin.ry classification.does n.t fully capture the diversity of astrocyte respon.es observed across differen. diseases an. *** an.lysis has revealed that reactive astrocytes have a complex lan.scape of gen. expression.profiles,which emphasizes the heterogen.ous n.ture of their *** actively participate in.regulatin. cen.ral n.rvous system in.lammation.by in.eractin. with microglia an. other cell types,releasin. cytokin.s,an. in.luen.in. the immun. *** phosphoin.sitide 3-kin.se(PI3K)/protein.kin.se B(AKT)sign.lin. pathway is a cen.ral player in.astrocyte reactivity an. impacts various aspects of astrocyte behavior,as eviden.ed by in.silico,in.vitro,an. in.vivo *** astrocytes,in.lammatory cues trigger a cascade of molecular even.s,where n.clear factor-κB serves as a cen.ral mediator of the pro-in.lammatory ***,we review the heterogen.ity of reactive astrocytes an. the molecular mechan.sms un.erlyin. their *** highlight the in.olvemen. of various sign.lin. pathways that regulate astrocyte reactivity,in.ludin. the PI3K/AKT/mammalian.target of rapamycin.mTOR),αvβ3 in.egrin.PI3K/AKT/con.exin.43,an. n.tch/PI3K/AKT *** targetin. the in.ctivation.of the PI3K/AKT cellular sign.lin. pathway to con.rol reactive astrocytes an. preven. cen.ral n.rvous system damage,eviden.e suggests that activatin. this pathway could also yield ben.ficial *** dual fun.tion.of the PI3K/AKT pathway un.erscores its complexity in.astrocyte reactivity an. brain.fun.tion.*** review emphasizes the importan.e of employin. astrocyte-exclusive models to un.erst

关键词： in.lammation in.egrin. n.uroprotective n.urotoxic phosphatidylin.sitol 3-kin.se reactive astrocytes sign.l tran.duction Thy-1(CD90)

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Faster Region.Con.olution.l n.ural n.twork(FRCn.)Based Facial Emotion.Recogn.tion

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Computers, Materials & Con.in.a 2024年第5期79卷 2427-2448页

作者： J.Sheril An.el A.Dian. An.rushia TMary n.ebha Oussama Accouche Louai Saker n.An.n. Departmen. of Electron.cs an. Commun.cation.En.in.erin. Karunya Institute of Technology and SciencesCoimbatore641114India College of En.in.erin. an. Techn.logy American University of the Middle EastEgaila54200Kuwait Departmen. of Civil En.in.erin. Karunya Institute of Technology and SciencesCoimbatore641114India

Facial emotion.recogn.tion.FER)has become a focal poin. of research due to its widespread application.,ran.in. from human.computer in.eraction.to affective *** tradition.l FER techn.ques have relied on.han.crafted features an. classification.models train.d on.image or video datasets,recen. strides in.artificial in.elligen.e an. deep learn.n.(DL)have ushered in.more sophisticated *** research aims to develop a FER system usin. a Faster Region.Con.olution.l n.ural n.twork(FRCn.)an. design.a specialized FRCn. architecture tailored for facial emotion.recogn.tion.leveragin. its ability to capture spatial hierarchies within.localized region. of facial *** proposed work en.an.es the accuracy an. efficien.y of facial emotion.*** proposed work comprises twomajor key compon.n.s:In.eption.v3-based feature extraction.an. FRCn.-based emotion.*** experimen.ation.on.Kaggle datasets validates the effectiven.ss of the proposed strategy,showcasin. the FRCn. approach’s resilien.e an. accuracy in.iden.ifyin. an. categorizin. facial *** model’s overall performan.e metrics are compellin.,with an.accuracy of 98.4%,precision.of 97.2%,an. recall of 96.31%.This work in.roduces a perceptive deep learn.n.-based FER method,con.ributin. to the evolvin. lan.scape of emotion.recogn.tion.*** high accuracy an. resilien.e demon.trated by the FRCn. approach un.erscore its poten.ial for real-world *** research advan.es the field of FER an. presen.s a compellin. case for the practicality an. efficacy of deep learn.n. models in.automatin. the un.erstan.in. of facial emotion..

关键词： Facial emotion. FRCn. deep learn.n. emotion.recogn.tion face Cn.

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等离子体技术制备具有亚微米颗粒结构的球化W-Cu伪合金微粉

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Tran.action. of n.n.errous Metals Society of Chin. 2024年第2期34卷 592-603页

作者： A.v.SAMOKHIn.n.v.ALEKSEEv A.A.DOROFEEv A.A.FADEEv M.A.SIn.YSKIY I.D.ZAvERTIAEv Y.v.GRIGORIEv In.titute of Metallurgy an. Materials Scien.e Russian Academy of SciencesMoscow 119334Leninsky prospect 49Russian Federal Scien.ific Research Cen.er“Crystallography an. Photon.cs” Russian Academy of SciencesMoscow 119334Leninsky prospect 59Russian

采用复杂多级方法研究并证实制备具有亚微米/纳米级内部结构的球形W-Cu复合微粉的可能性。首先,采用等离子体化学合成法制备具有核壳结构的W-Cu纳米粉末(W核及Cu壳)。然后,将W-Cu纳米粉末与蔗糖的水悬浮液进行喷雾干燥,形成25~63μm的微... 详细信息

采用复杂多级方法研究并证实制备具有亚微米/纳米级内部结构的球形W-Cu复合微粉的可能性。首先,采用等离子体化学合成法制备具有核壳结构的W-Cu纳米粉末(W核及Cu壳)。然后,将W-Cu纳米粉末与蔗糖的水悬浮液进行喷雾干燥,形成25~63μm的微粒,收率为50%。最后,用热等离子体射流处理由纳米粉末组成的微粒,形成致密的球形W-Cu颗粒。成品粉末的球化度为90%~95%,体积密度为8.1 g/cm^(3),流动性约为12 s/50 g,杂质中O、C和H的含量(质量分数)分别为0.7%、0.02%~0.2%和0.03%~0.05%。

关键词： W-Cu复合材料等离子体化学合成造粒等离子体球化纳米颗粒微粒微粉

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Outcomes of lon.-actin. in.ectable an.ipsychotics use in.pregn.n.y:A literature review

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World Journ.l of Psychiatry 2024年第4期14卷 582-599页

作者： An. v Pejčić Srdjan.M Stefan.vić Milošn.Milosavljević vladimir S Jan.ić Marko M Folić n.ven. D Folić Jovan. Z Milosavljević Departmen. of Pharmacology an. Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Departmen. of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Departmen. of Clin.cal Pharmacology University Clinical Center KragujevacKragujevac 34000Serbia Departmen. of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clin.c for Psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Cen.er for Pharmaceutical an. Pharmacological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Departmen. of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric Clin.c University Clinical Center KragujevacKragujevac 34000Serbia Departmen. of An.tomy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUn. Women.with a history of serious psychotic disorders are at in.reased risk of disease relapse durin. ***-actin. in.ectable(LAI)an.ipsychotics have been.widely used to improve adheren.e an. preven. relapse in.patien.s with various severe psychotic disorders,but there is a lack of high-quality data from previous research on.the safety of LAI an.ipsychotics durin. *** To summarize relevan. data on.matern.l,pregn.n.y,n.on.tal,an. developmen.al outcomes from published cases of LAI an.ipsychotic use in.*** A literature search was performed through n.vember 11,2023,usin. three on.in. databases:PubMed/MEDLIn.,Scopus,an. Web of *** reports or case series that reported in.ormation.about the outcomes of pregn.n.y in.women.who used LAI an.ipsychotics at an. poin. in.pregn.n.y,with available full texts,were *** statistics,n.rrative summation.an. tabulation.of the extracted data were *** A total of 19 publication. satisfied the in.lusion.criteria:3 case series,15 case reports,an. 1 con.eren.e *** reported the outcomes of LAI an.ipsychotic use in.74 women.an. 77 *** use of secon.gen.ration.LAI an.ipsychotics was reported in.the majority(n.47;61.0%)of ***-gen.ration.LAI an.ipsychotics were admin.stered durin. 30 pregn.n.ies(39.0%).Most of the women.approximately 64%)had either satisfactory con.rol of symptoms or n. in.ormation.about relapse,while approximately 12%of them had developed gestation.l diabetes mellitus.A min.rity of cases reported adverse outcomes such as stillbirth,spon.an.ous abortion.preterm birth,low birth weight,con.en.tal an.malies,an. n.urological man.festation. in.***,there were n. reports of n.gative lon.-term developmen.al *** Curren.ly available data seem reassurin.,but further well-design.d studies are required to properly evaluate the risks an. ben.fits of LAI an.ipsychotic use durin. pregn.n.y.

关键词： An.ipsychotic agen.s Lon.-actin. in.ectable Pregn.n.y Outcome Review

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Some Mean.Con.ergen.e Theorems for the Maximum of n.rmed Double Sums of Ban.ch Space valued Ran.om Elemen.s

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Acta Mathematica Sin.ca,En.lish Series 2024年第7期40卷 1727-1740页

作者： An.rew ROSALSKY Le van.THAn. n.uyen.Thi THUY Departmen. of Statistics University of FloridaGainesvilleFL 32611-8545USA Departmen. of Mathematics Vinh UniversityVinhNghe AnViet Nam High School for Gifted Studen.s Vinh UniversityVinhNghe AnViet Nam

In.this correspon.en.e,we establish mean.con.ergen.e theorems for the maximum of n.rmed double sums of Ban.ch space valued ran.om *** of the results pertain.to ran.om elemen.s which are *** expan. an. improve a n.mber of particular cases in.the literature on.mean.con.ergen.e of ran.om elemen.s in.Ban.ch *** of the main.con.ribution. of the paper is to simplify an. improve a recen. result of Li,Presn.ll,an. Rosalsky[Journ.l of Mathematical In.qualities,16,117–126(2022)].A n.w maximal in.quality for double sums of M-depen.en. ran.om elemen.s is proved which may be of in.epen.en. *** sharpn.ss of the results is illustrated by four examples.

关键词： Double sum mean.con.ergen.e Rademacher type p Ban.ch space Ban.ch space valued ran.om elemen. M-depen.en. ran.om elemen.s

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Old-growth mixed dipterocarp forests show variable losses an. gain. in.abovegroun. biomass an. stan.in. carbon.over forty years

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Forest Ecosystems 2024年第1期11卷 14-23页

作者： Sisira Ediriweera Champika Ban.ara Tithira Lakkan. Shan.ka Jayasin.he David Woodbury Arun.Dayan.n.an.B.M.P.Sin.hakumara Xian.chen. Mi I.A.U.n.Gun.tilleke C.v.S.Gun.tilleke Mark SAshton Departmen. of Scien.e an. Techn.logy Uva Wellassa UniversityBadullaSri Lanka The Forest School Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Departmen. of Forestry an. En.iron.en.al Scien.e University of Sri JayewardenepuraNugegodaSri Lanka State Key Laboratory of vegetation.an. En.iron.en.al Chan.e Institute of BotanyChinese Academy of SciencesBeijing100093China Botan. Departmen. University of PeradeniyaPeradeniyaSri Lanka

Backgroun.:n. studies have documen.ed lon.-term tren.s in.abovegroun. biomass(AGB)for mixed-dipterocarp forests(MDF),the domin.n. rain.forest type in.tropical wet equatorial *** our study,we sought to documen. such tren.s over forty years across three sites represen.in. lowlan. to lower mon.an. ***:To do this,we established fifty 100 m×25 m plots in.1978 across three sites sampled alon. an.elevation.gradien.,iden.ified as mature old-growth *** measured trees for diameter at breast height that we iden.ified to species an. *** took wood samples to calculate species wood-specific *** re-measured plots in.1998 an. again.in.***:We show stan.in. AGB for all sites combin.d to be 517.52 Mg·ha^(-1)in.1978,but this declin.d by 17%over 40 years to 430.11 Mg·ha^(-1).n. differen.es exist amon. sites in.AGB primarily because of con.iderable within.site variation.but in.eraction. of time with site show declin.s across sites were n.t un.form,on. remain.d about the *** few species represen.ed a high proportion.of the AGB with the top five species comprisin. between.34%an. 65%,depen.in. upon.site an. year *** species,Mesua n.gassarium,represen.ed a disproportion.tely large amoun. of AGB an. declin. over time,particularly at the low elevation.***:Our results are directly relevan. to estimatin. AGB an. stan.in. carbon.sequestered in.*** study is the first to demon.trate varyin. but overall,declin.n. tren.s in.amoun.s of AGB amon. forests makin. prediction. of biomass an. stan.in. carbon.in.MDF difficult over wide region..

关键词： Western.ghats Shorea spp. Southeast Asia Sri Lan.a Tropical rain.forest Wood specific gravity

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Cr-in.uced fusion.reaction. to syn.hesize superheavy elemen.s

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n.clear Scien.e an. Techn.ques 2024年第5期35卷 122-130页

作者： S.Madhu H.C.Man.un.tha n.Sowmya B.M.Rajesh L.Seen.ppa R.S.Susheela Departmen. of Physics R V College of EngineeringBangalore 560074India visvesvaraya Techn.logical Un.versity BelagaviKarnataka 590018India Departmen. of Physics Government First Grade CollegeSrinivasapurKarnataka 563135India Departmen. of Physics Government First Grade CollegeDevanahallyKarnataka 562110India Departmen. of Physics Government First Grade CollegeMulbagalKarnataka 563131India Departmen. of Physics Government First Grade collegeNanjangudOoty RoadMysore 571301India

We in.estigated ^(50,52-54)Cr-in.uced fusion.reaction. for the syn.hesis of the superheavy elemen. in.the 104≤Z≤122 *** cross section. produced in.this in.estigation.usin. ^(54)Cr projectiles were compared with those obtain.d in.prior *** estimated cross section. from this an.lysis are con.isten. with the fin.in.s of prior *** the curren. study,the predicted cross section.was foun. to be 42fb at 236 Mev for ^(53)Cr+^(243)Am,23.2 fb at 236 Mev for ^(54)Cr+^(247)Cm,95.6 fb at 240 Mev for ^(53)Cr+248Bk,an. 1.33 fb at 242 Mev for ^(53)Cr+***,these projected cross section. with excitation.en.rgy an. beam en.rgy will be useful in.future Cr-in.uced fusion.reaction.in.estigation..

关键词： Fusion.cross section. Compoun. n.cleus formation.probability Survival probability Evaporation.residue cross section.

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A value for Games Defin.d on.Graphs

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Applied Mathematics 2024年第5期15卷 331-348页

作者： n.stor Bravo Departamen.o de Matemá ticas Universidad de Guanajuato Guanajuato Mexico

Given.a graph g=( v,A ) , we defin. a space of subgraphs M with the bin.ry operation.of un.on.an. the un.que decomposition.property in.o blocks. This space allows us to discuss a n.tion.of min.mal subgraphs (min.mal coalition.) that are of in.erest for the game. Addition.lly, a partition.of the game is defin.d in.terms of the gain.of each block, an. subsequen.ly, a solution.to the game is defin.d based on.distributin. to each player (n.de an. edge) presen. in.each block a paymen. proportion.l to their con.ribution.to the coalition.

关键词： Graph Theory values for Graphs Cooperation.Games Poten.ial Fun.tion

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Prompt n.utron.emission.in.^(250)n. spon.an.ous fission.associated with groun. an. isomeric state decays

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Chin.se Physics C 2024年第6期48卷 112-117页

作者： R.S.Mukhin.A.v.Isaev A.v.An.reev M.L.Cheln.kov v.I.Chepigin.H.M.Devaraja I.n.Izosimov A.A.Kuzn.tsova O.n.Malyshev A.G.Popeko Yu.A.Popov A.Rahmatin.jad B.Sailaubekov T.M.Shn.idman.E.A.Sokol A.I.Svirikhin.M.S.Tezekbayeva M.A.Bychkov A.v.Yeremin.O.Dorvaux B.Gall K.Kessaci K.Hauschild A.Lopez-Marten. Join. In.titute for n.clear Research Dubna141980Russia Dubn. State Un.versity Dubna141982Russia In.titute of n.clear Physics Almaty050032Kazakhstan L.n.Gumilyov Eurasian.n.tion.l Un.versity Astana010008Kazakhstan Kazan.Federal Un.versity Kazan420008Russia Un.versitéde Strasbourg CNRSStrasbourg67000France IJCLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

The complete-fusion.reaction.(204)Pb(^(48)Ca,2n.^(250)n. was used to study two activities of^(250)n. with distin.t half-lives.A total of 1357 even.s were observed in.the SFin. n.utron.detection.*** average n.mber of n.utron. emitted per spon.an.ous fission.of^(250)n. was determin.d to be(4.1±0.1).The un.sually symmetrical shape of the prompt n.utron.multiplicity distribution.was restored an. presen.ed for the first *** tests were performed to compare the prompt n.utron.multiplicity distribution. associated with the groun. state an. K-isomer state decays.

关键词： spon.an.ous fission prompt n.utron. actin.de

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Elucidatin. elusive quatern.ry selen.de EuCeCuSe3:Syn.hesis,crystal structure,properties an. theoretical studies

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Journ.l of Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim v.Grigoriev An.a v.Ruseikin. Maxim S.Molokeev vladimir A.Chern.shev Aleksan.r S.Aleksan.rovsky Alexan.er S.Krylov Svetlan. n.Krylova n.kolai P.Shestakov Dmitriy A.velikan.v Alexan.er A.Garmon.v Alexey v.Matigorov Evgen. A.Ostapchuk Thomas Schleid Damir A.Safin Laboratory of Theory an. Optimization.of Chemical an. Techn.logical Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kiren.ky In.titute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Departmen. of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation In.titute of n.tural Scien.es an. Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Departmen. of Photon.cs an. Laser Techn.logy Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation In.titute of Physics an. Techn.logy University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation In.titute for In.rgan.c Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scien.ific an. Education.l an. In.ovation.Cen.er for Chemical an. Pharmaceutical Techn.logies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation Un.versity of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on.the n.vel heterometallic quatern.ry selen.de EuCeCuSe3,the fabrication.of which has been.a challen.e un.il this *** structure of the reported selen.de was elucidated from the powder X-ray diffraction.data,which revealed the formation.of EuCeCuSe3with excellen. yield(96.7%)accompan.ed with a min.r fraction.of CeSe2(3.3%),an. was best solved in.orthorhombic space group Pn.a with the BaLaCuS3structural ***,the crystal structure of the title compoun. completes the row of the heterometallic quatern.ry selen.des EuRECuSe3(RE=La,Pr,n.,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belon.s to the BaLaCuS3structural *** distortion.of the CuSe4polyhedron.was compared for the whole series of EuRECuSe3compoun.s usin. theτ4-descriptor for four coordin.ted ion.,which revealed the highest degree of distortion.for the Ce3+-con.ain.n. selen.de,followed by the La3+-based ***,the crystallographic an. geometrical parameters of the reported selen.de were discussed in.comparison.to the Ce3+-based sulfides SrCeCuS3an. *** in.tio calculation. of the crystal structure,a phon.n.spectrum an. elastic con.tan.s for the crystal of EuCeCuSe3were also *** types an. waven.mbers of fun.ame n.al modes were determin.d an. the in.olvemen. of ion. participatin. in.the phon.n.modes was *** experimen.al IR spectrum of the reported selen.de was in.erpreted an. foun. to be in.agreemen. with the calculated *** experimen.al direct ban. gap of EuCeCuSe3was measured to be 1.36 ev that is con.isten. with the con.ept of its origin.due to in.erban. tran.ition. between.orbitals emergin. main.y from 4f(valen.e ban.)an. 5d(con.uction.ban.)levels of the Eu2+*** depen.en.e of the Youn.’s modulus on.the direction.demon.trates the an.sotropy of the elastic properties,while the vickers hardn.ss for EuCeCuSe3was calculated to be 5.2 ***,the title compoun. is paramagn.tic above 4 K.

关键词： Quatern.ry selen.de Syn.hesis Crystal structure Ab in.tio calculation. Magn.tic measuremen.s Spectroscopy

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