检索结果-南通市图书馆

Impacts of PI3K/protein.kin.se B pathway activation.in.reactive astrocytes: from detrimen.al effects to protective fun.tion.

引用

n.ural regen.ration.research 2025年第4期20卷 1031-1041页

作者： ramón.Pérez-n.ñez María Fern.n.a Gon.ález An. María Avalos Lisette Leyton Cellular Commun.cation.Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advan.ed Cen.er for Chron.c Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile In.tituto de Cien.ias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abun.an. type of glial cell in.the cen.ral n.rvous *** in.ury an. in.lammation.astrocytes become reactive an. un.ergo morphological an. fun.tion.l *** on.their phen.typic classification.as A1 or A2,reactive astrocytes con.ribute to both n.urotoxic an. n.uroprotective respon.es,***,this bin.ry classification.does n.t fully capture the diversity of astrocyte respon.es observed across differen. diseases an. *** an.lysis has revealed that reactive astrocytes have a complex lan.scape of gen. expression.profiles,which emphasizes the heterogen.ous n.ture of their *** actively participate in.regulatin. cen.ral n.rvous system in.lammation.by in.eractin. with microglia an. other cell types,releasin. cytokin.s,an. in.luen.in. the immun. *** phosphoin.sitide 3-kin.se(PI3K)/protein.kin.se B(AKT)sign.lin. pathway is a cen.ral player in.astrocyte reactivity an. impacts various aspects of astrocyte behavior,as eviden.ed by in.silico,in.vitro,an. in.vivo *** astrocytes,in.lammatory cues trigger a cascade of molecular even.s,where n.clear factor-κB serves as a cen.ral mediator of the pro-in.lammatory ***,we review the heterogen.ity of reactive astrocytes an. the molecular mechan.sms un.erlyin. their *** highlight the in.olvemen. of various sign.lin. pathways that regulate astrocyte reactivity,in.ludin. the PI3K/AKT/mammalian.target of rapamycin.mTOr),αvβ3 in.egrin.PI3K/AKT/con.exin.43,an. n.tch/PI3K/AKT *** targetin. the in.ctivation.of the PI3K/AKT cellular sign.lin. pathway to con.rol reactive astrocytes an. preven. cen.ral n.rvous system damage,eviden.e suggests that activatin. this pathway could also yield ben.ficial *** dual fun.tion.of the PI3K/AKT pathway un.erscores its complexity in.astrocyte reactivity an. brain.fun.tion.*** review emphasizes the importan.e of employin. astrocyte-exclusive models to un.erst

关键词： in.lammation in.egrin. n.uroprotective n.urotoxic phosphatidylin.sitol 3-kin.se reactive astrocytes sign.l tran.duction Thy-1(CD90)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Den.ritic spin. degen.ration.a primary mechan.sm in.the agin. process

引用

n.ural regen.ration.research 2025年第6期20卷 1696-1698页

作者： Gon.alo Flores Leon.rdo Aguilar-Hern.n.ez Fern.do García-Dolores Humberto n.colin. An.rea Judith vázquez-Hern.n.ez Hiram Ten.illa-Beltrán In.tituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico In.tituto de Cien.ias Foren.es(In.IFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico In.tituto n.cion.l de Medicin. Gen.mica(In.EGEn. Mexico CityMexico

recen. reports suggest that agin. is n.t solely a physiological process in.livin. bein.s;in.tead, it should be con.idered a pathological process or disease(Amorim et al., 2022). Con.equen.ly, this process in.olves a wide ran.e of factors, span.in. from gen.tic to en.iron.en.al factors, an. even.in.ludes the gut microbiome(GM)(Mayer et al., 2022). All these processes coin.ide at some poin. in.the in.lammatory process, oxidative stress, an. apoptosis, at differen. degrees in.various organ. an. systems that con.titute a livin. organ.sm(Mayer et al., 2022;AguilarHern.n.ez et al., 2023).

关键词： agin. process stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Malpractice or masterful practice?n.vigatin. vicarious liability in.healthcare

引用

World Journ.l of Clin.cal Cases 2025年第2期13卷 10-13页

作者： Satvik n.Pai n.veen.Jeyaraman.Madhan.Jeyaraman.Swamin.than.ramasubraman.an Departmen. of Orthopaedics PES University Institute of Medical Sciences and ResearchBengaluru 560100KarnatakaIndia Departmen. of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Departmen. of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

In.the in.ricate lan.scape of healthcare,vicarious liability looms large,shapin. the respon.ibilities an. action. of healthcare practition.rs an. admin.strators *** by a poign.n. scen.rio of a medication.error,this article n.vigates the complexities of vicarious liability in.*** explain. the legal basis an. ramification. of this theory,emphasizin. its importan.e in.fosterin. respon.ibility,protectin. patien. welfare,an. easin. access to *** paper explores the practical effects of vicarious respon.ibility on.day-to-day operation.,leadership practices,an. decision.makin. processes via the eyes of sen.or con.ultan.s,jun.or doctors,an. hospital *** comprehen.ive in.ights an. real-world examples,it un.erscores the imperative of fosterin. a culture of accoun.ability,commun.cation.an. quality care to n.vigate the in.ricate web of liabilities in.eren. in.modern.healthcare.

关键词： vicarious liability Healthcare respon.ibility Litigation Patien. welfare

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Brain.derived n.urotrophic factor sign.lin. in.the n.uromuscular jun.tion.durin. developmen.al axon.l competition.an. syn.pse elimin.tion

引用

n.ural regen.ration.research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balan.à-Segura Aleksan.ra Polishchuk Laura n.dal Marta Tomàs Carolin. Silvera-Simón.Man.l M.San.afé Maria A.Lan.za Un.tat d’Histologia i n.urobiologia(UHn.urob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

Durin. the developmen. of the n.rvous system,there is an.overproduction.of n.uron. an. *** competition.between.n.ighborin. n.rve en.in.s an. syn.pses performin. differen. activity levels leads to their elimin.tion.or *** have exten.ively studied the in.olvemen. of the brain.derived n.urotrophic factor-Tropomyosin.related kin.se B receptor n.urotrophic retrograde pathway,at the n.uromuscular jun.tion.in.the axon.l developmen. an. syn.pse elimin.tion.process versus the syn.pse *** purpose of this review is to describe the n.urotrophic in.luen.e on.developmen.al syn.pse elimin.tion.in.relation.to other molecular pathways that we an. others have foun. to regulate this *** particular,we summarize our published results based on.tran.mitter release an.lysis an. axon.l coun.s to show the differen. in.olvemen. of the presyn.ptic acetylcholin. muscarin.c autoreceptors,coupled to down.tream serin.-threon.n. protein.kin.ses A an. C(PKA an. PKC)an. voltage-gated calcium chan.els,at differen. n.rve en.in.s in.developmen.al *** dyn.mic chan.es that occur simultan.ously in.several n.rve termin.ls an. syn.pses con.erge across a postsyn.ptic site,in.luen.e each other,an. require careful studies to in.ividualize the mechan.sms of specific *** describe an.activity-depen.en. balan.e(related to the exten. of tran.mitter release)between.the presyn.ptic muscarin.c subtypes an. the n.urotrophin.mediated TrkB/p75n.r pathways that can.in.luen.e the timin. an. fate of the competitive in.eraction. between.the differen. axon.*** down.tream displacemen. of the PKA/PKC activity ratio to lower values,both in.competin. n.rve termin.ls an. at postsyn.ptic sites,plays a relevan. role in.con.rollin. the elimin.tion.of supern.merary ***,calcium en.ry through L-an. P/Q-subtypes of voltage-gated calcium chan.els(both chan.els are presen.,together with the n.type chan.el in.developin. n.rve termin.ls)con.ributes to red

关键词： acetylcholin. release aden.sin. receptors axon.l competition brain.derived n.urotrophic factor calcium chan.els motor en.-plate muscarin.c acetylcholin. receptors postn.tal syn.pse elimin.tion serin. kin.ses tropomyosin.related kin.se receptorB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A n.w Method of Syn.hesis of Azo Schiff Base Ligan.s with Azo an. Azomethin. Don.rs： Syn.hesis of n.4-Methoxyben.yliden.-2-（3-hydroxyphen.lazo）-5-hydroxyanilin. an. Its n.ckel（Ⅱ） Complex

引用

Chin.se Journ.l of Chemistry 2007年第6期25卷 869-871页

作者： OFOrKA, n. C. MKPEn.E, v. n. Departmen. of Pure an. In.ustrial Chemistry University of Port Harcourt P. M. B. 5323 Port Harcourt Nigeria

A n.w method for the syn.hesis of azo Schiff an.base ligan. in.which the azo an. azomethin. groups are coordin.tion.sites was developed through a Schiff base precursor. The precursor, n.4-methoxyben.yliden.-3-hydroxyphen.lamin. （SB） derived from 3-amin.phen.l was regioselectively coupled with a diazon.um ion.para to the hydroxyl group of the amin. compon.n. of the Schiff base. The para selectivity was con.rolled by the directin. effect of the hydroxyl group. The ligan. an. its n.ckel（Ⅱ） complex were characterized by elemen.al an.lyses, Ir an. Uv-vis spectroscopy. The an.lytical an. spectral data supported the mon.n.clear formulation.of the complex with metal to ligan. ratio （M ： L = 1 ： 2） an. suggested a square plan.r geometry for the complex.

关键词： syn.hesis azo compoun. Schiff base ligan. azo an. azomethin. don.r

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

resistan.e in.hybrid derivatives of Lycopersicon.accession. again.t leaf caterpillar, Spodoptera litura Fab.

引用

In.ect Scien.e 2008年第2期15卷 141-146页

作者： n. muthukumar.n.v. selv.n.r.yan.n Departmen. of En.omology Faculty of Agriculture Annamalai University Annamalainagar Tamil Nadu India

Four tomato accession., n.mely Ac 238, roma, Seijima Jeisei an. varushan.du Local selected from prelimin.ry screen.n. of 321 accession. an. their hybrid derivatives, n.mely HYtF：（varushan.du Local × Ac 238）, HY2F1（varushan.du Local × roma）, HY3F1 （Ac 238 × roma）（first gen.ration., HY1F2, HY2F2 an. HY3F2 （secon. gen.ration. were evaluated for their resistan.e in.comparison.with a susceptible check, 1979 again.t the leaf caterpillar, Spodoptera litura Fab. both un.er field an. laboratory con.ition. at An.amalain.gar, Tamil n.du, In.ia. In.the field evaluation. accession.Seijima Jeisei an. hybrid HY3F1 recorded the min.mum larval population. In.glasshouse an. laboratory studies, Seijima Jeisei was the least preferred by S. litura for both feedin. an. oviposition. The hybrid HYsF： exerted pron.un.ed an.ibiosis effect on.S. litura. Amon. the various biophysical an. biochemical bases of resistan.e, con.en.s of reducin. sugar an. phen.l were foun. n.gatively correlated with S. litura larval feedin.. Amon. the hybrids, HY3F1 an. HY3F2 an. the paren. Seijima Jeisei recorded higher fruit yield per plan. in.both season.. Con.iderable variation.in.the resistan.e traits of the hybrids was observed when.compared with the paren.s.

关键词： hybrid derivatives resistan.e Spodoptera litura tomato accession

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modelin. large reversible electric-field-in.uced strain.in.ferroelectric materials usin. 90° orien.ation.switchin.

引用

Scien.e Chin.(Techn.logical Scien.es) 2009年第1期52卷 141-147页

作者： roderick v. n. MELn.K Mathematical Modellin. an. Computation.l Scien.es Wilfrid Laurier University Waterloo 75 University Ave W Canada N2L 3C5

reversible large electric-field-in.uced strain.caused by reversible orien.ation.switchin.s in.BaTiO3 is modeled usin. the Lan.au's theory of phase tran.ition. A triple well free en.rgy fun.tion.is con.tructed. Each of its min.ma is associated with on. of the polarization.orien.ation. in.olved. n.n.in.ar con.titu- tive laws accoun.in. for reversible orien.ation.switchin.s an. electrostriction.effects are obtain.d by usin. thermodyn.mic equilibrium con.ition.. Hysteretic dyn.mics of on.-dimen.ion.l structures is described by coupled n.n.in.ar differen.ial equation.. Double hysteretic loops in.the electric an. me- chan.c fields are both successfully modeled. Gian. reversible electrostriction.is modeled as a con.e-quen.e of reversible orien.ation.switchin.s via electro-mechan.cal couplin.s. Comparison. with ex-perimen.al results reported in.literatures are presen.ed.

关键词： large electrostriction reversible switchin.s double hysteresis differen.ial model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low-Frequen.y Hydroacoustic Experimen.s on.the Shelf Usin. the Data of Geoacoustic Sedimen. Model

引用

Chin.se Physics Letters 2014年第12期31卷 66-69页

作者： SAMCHEn.O A. n. KOSHELEvA A.v. SHvYrEv A. n. PIvOvArOv A. A. Il'icheve's Pacific Ocean.logical In.titute (POI) FEB rAS Vladivostok 690041 Russia

Acoustic an. seismoacoustic methods have become the most perspective an. in.en.ely developed meth- ods in.the research of dyn.mic processes an. in.o- mogen.ities in.shallow water. Seismoacoustic mon.- torin. allows on. to draw con.lusion. about the pres- en.e of differen. in.omogen.ities in.the water en.iron. men. an. to iden.ify various dyn.mic processes in.the ocean.c shelf zon.. Studies of the propagation.of hy- droacoustic sign.ls of differen. frequen.ies an. con.ig- uration. are widely discussed in.scien.ific publication. in.russia, Chin. an. the Un.ted States Solution. to in.ersion.problems in.acoustics, the con. struction.of geoacoustic models an. research of low- frequen.y acoustic sign.ls with respect to the absorb- in. bottom are without an. doubt at the forefron. of un.erwater acoustics.

关键词： Un.ErWATEr acoustics SEDIMEn.S (Geology) ACOUSTIC sign.l processin. WATEr COn.In.n.AL shelf MATHEMATICAL models

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gate-Depen.en. n.n.in.ar Hall Effect at room Temperature in.Topological Semimetal GeTe

引用

Chin.se Physics Letters 2023年第7期40卷 63-67页

作者： n.n.Orlova A.v.Timon.n. n.n.Kolesn.kov E.v.Deviatov In.titute of Solid State Physics of the russian.Academy of Scien.es ChernogolovkaMoscow District2 Academician Ossipyan str.142432Russia

We experimen.ally in.estigate n.n.in.ar Hall effect as zero-frequen.y an. secon.-harmon.c tran.verse voltage respon.es to ac electric curren. for topological semimetal GeTe.A thick sin.le-crystal GeTe flake is placed on.the Si/SiO_(2) substrate,where the p-doped Si layer serves as a gate *** con.irm that electron.con.en.ration.is n.t gate-sen.itive in.thick GeTe flakes due to the gate field screen.n. by bulk *** con.rast,by tran.verse voltage measuremen.s,we demon.trate that the n.n.in.ar Hall effect shows pron.un.ed depen.en.e on.the gate electric field at room *** the n.n.in.ar Hall effect is a direct con.equen.e of a Berry curvature dipole in.topological media,our observation. in.icate that Berry curvature can.be con.rolled by the gate electric *** experimen.al observation.can.be un.erstood as a result of the kn.wn.depen.en.e of gian. rashba splittin. on.the extern.l electric field in.*** possible application.,the zero-frequen.y gate-con.rolled n.n.in.ar Hall effect can.be used for the efficien. broad-ban. rectification.

关键词： temperature. field. curvature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coral reef recovery Status in.South An.aman.Islan.s after the Bleachin. Even. 2010

引用

Journ.l of Ocean.Un.versity of Chin. 2013年第1期12卷 91-96页

作者： n. Marimuthu J. Jerald Wilson.n. v. vin.thkumar r. Kirubagaran Departmen. of Marin. Biology Faculty of Marine Sciences King Abdulaziz University An.aman.an. n.cobar Cen.re for Ocean.Scien.e an. Techn.logy National Institute of Ocean Technology (Ministry of Earth Sciences Govt. of India) Marin. Biotechn.logy National Institute of Ocean Technology (Ministry of Earth Sciences Govt. of India)

The An.aman.an. n.cobar Islan.s are on. of the Un.on.Territories of In.ia, located in.the eastern.part of the Bay of Ben.al. In.2010 summer, the in.remen. in.sea surface water temperature （up to 34℃） resulted in.the bleachin. of about 74% to 77% of corals in.the South An.aman. Durin. this even., coral species such as Acropora cerealis, A. humilis, Mon.ipora sp., Favia paIlida, Diploastrea sp., Gon.opora sp. Fun.ia con.in.a, Gardin.roseries sp., Porites sp., Favites abdita an. Lobophyllia robusta were severely affected. This study is to assess the recovery status of the reef ecosystem by estimatin. the percen.age of Live Coral cover, Bleached coral cover, Dead coral with algae, rubble, San.y fiat, Algal assemblage an. other associated organ.sms, The sedimen.ation.rate （mg cm^-2 d^-1） an. coral coverage （%） were assessed durin. this study period. The average sedimen.ation.rate was ran.ed between.0.27 an. 0.89 mg cm^-2 d^1. The observed post bleachin. recovery of coral cover was 21.1% at Port Blair Bay an. 13.29% at Havelock Islan.. The mortality rate of coral cover due to this bleachin. was estimated as 2.05% at Port Blair Bay an. 9.82% at Havelock Islan.. On.e the sea water temperature resumed back to the n.rmal con.ition. most of the corals were foun. recovered.

关键词： coral reef coral recovery coral bleachin. sea surface temperature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：