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56 Years of the m.rburg Virus—A Review.of Therapeutics

Open.Journ.l of Epidem.ology 2024年第2期14卷 273-283页

作者： m.chael m. Toza Em.an.el Im.n.olw. n.talia Shakela Ferdin.n. n.ubi Han.om. Hatw.ko Christabel n. Hikaam.o Departm.n. of Pharm.cy School of Health Sciences University of Zambia Lusaka Zambia Departm.n. of Biology Chemistry and Physics School of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia Departm.n. of Pharm.ceutical Chem.stry an. Pharm.ceutics School of Pharmacy Kabarak University Nakuru Kenya Departm.n. of Physiological Scien.es School of Medicine and Health Sciences Mulungushi University Livingstone Zambia

Backgroun.: The m.rburg virus (m.RV) is the causative agen. of m.rburg virus disease (m.D). This filovirus first appeared in.1967 an. has sin.e caused several outbreaks w.th case fatality rates betw.en.23% an. 90%. The earliest cases of m.D are thought to be caused by exposure to an.in.ected an.m.l, either a reservoir host (som. bat species, e.g., Rousettus aegyptiacus) or a spill-over host, such as n.n.hum.n.prim.tes. The virus is spread betw.en.people by direct con.act w.th blood or other bodily fluids (in.ludin. saliva, sw.at, faeces, urin., tears, an. breast m.lk) from.in.ected in.ividuals. Despite the high fatality rate, the m.rburg virus has n. vaccin. or drug treatm.n.. Recen. outbreaks of the virus in.2023 in.Tan.an.a an. Equatorial Guin.a have reign.ted the n.ed to develop effective therapeutics, especially in.the w.ke of the COVID-19 pan.em.c. Purpose: This review.seeks to highlight the drug discovery efforts aim.d at developin. vaccin.s or possible treatm.n.s as poten.ial therapeutics. Several existin. an.iviral agen.s are bein. probed, an. vaccin.s are in.pre-clin.cal an. clin.cal stages. n.tural products are also an.im.ortan. source of possible drugs or lead com.oun.s an. w.en.coupled w.th com.utation.l techn.ques, these strategies offer possible therapeutics for the m.rburg virus, especially in.Africa, w.ich has a high disease burden. m.thods: Usin. the search en.in.s Google Scholar an. Pubm.d;keyw.rds e.g. m.rburg virus, m.rburg treatm.n.s, m.rburg virus drug discovery w.re utilized. Several results w.re yielded, an. articles published in.recen. years w.re accepted in.o the fin.l *** an. Con.lusion. This study show. there is a grow.n. in.erest in.therapeutics for the m.rburg virus, especially w.th the recen. outbreaks an. pan.em.c preparedn.ss. In.tiatives that to support vaccin. developm.n. an. access like the m.RVAC con.ort tim. are critical to fightin. this public health threat.

关键词： m.rburg Virus Vaccin.s An.ivirals Viruses Drug Discovery

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Em.irical m.del for fusion.cross section. of Ca-in.uced reaction.

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Chin.se Physics C 2024年第3期48卷 126-132页

作者： Reddi Ran..L n.Sow.ya K.n.Sridhar H C.m.n.un.tha m.m.Arm.tron. Arasu Departm.n. of Physics St.Joseph's College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirappalli620002TNIndia Departm.n. of Physics Govt.First.Grade CollegeChikkaballapur-562101KarnatakaIndia Departm.n. of Physics Govt.First.Grade CollegeMalur-563160KarnatakaIndia Departm.n. of Physics Govt.First.Grade CollegeDevanahalli-562110KarnatakaIndia

A n.w.em.irical form.la for the astrophysical S-factor has been.suggested as a fun.tion.of the Coulom. in.eraction.param.ter,cen.er of m.ss en.rgy,an. barrier *** 22 fusion.reaction. w.th ^(40,48)Ca as projectiles w.re con.idered for differen. targets,leadin. to com.oun. n.clei w.th atom.c an. m.ss n.m.ers varyin. betw.en.40≤Z≤≤Z≤112 an. 88≤A≤27888≤A≤278,*** fusion.cross-section. have been.estim.ted usin. the geom.tric factor,the Gam.w.Som.erfield factor,an. the em.irical form.la for the *** study's fin.in.s show.d better agreem.n. w.th those of available experim.n.s w.en.com.ared to w.n.'s *** presen. w.rk leads to a sm.ller stan.ard deviation.value than.w.n.'s form.la w.en.used to correlate the experim.n.al data of calcium.in.uced fusion.***'s form.la provides a good approxim.tion.of fusion.cross-section. w.en.the cen.er of m.ss en.rgy is below.the fusion.barrier w.en.com.ared to above the fusion.barrier.

关键词： fusion.cross-section. w.n. form.la Gam.w.Som.erfield-factor Geom.tric-factor S-factor

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Predictin. effects of tun.el throttlin. of an.ular freew.y vehicular flow.by a con.in.um.m.del

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Journ.l of Traffic an. Tran.portation.En.in.erin.(En.lish Edition. 2024年第4期11卷 733-746页

作者： Zhon.m.n.huan. m.n.Sm.rn.va n.n.Sm.rn.v Zuojin.Zhu Faculty of En.in.erin. Scien.e University of Science and Technology of China In.titute of Plasm. Physics Hefei Institutes of Physical Science Chinese Academy of Sciences Faculty of m.chan.cs an. m.them.tics Lomonosov Moscow State University

Fluid flow.throttlin. is com.on.in.in.ustrial an. buildin. services en.in.erin.. Sim.lar tun.el throttlin. of vehicular flow.is caused by the abrupt n.m.er reduction.of roadw.y lan., as the tun.el has a low.r lan. n.m.er than.in.the roadw.y n.rm.l segm.n.. To predict the effects of tun.el throttlin. of an.ular freew.y vehicular flow. a three-lan. con.in.um.m.del is developed. Lan. Ⅲ of the tun.el is com.letely blocked due to the n.ed of tun.el rehabilitation. etc. There exists m.n.atory n.t lan.-chan.in. rate from.lan. Ⅲ to lan. Ⅱ just upstream.of the tun.el en.ran.e, w.ich is described by a m.del of ran.om.n.m.er gen.rated through a golden.section.an.lysis. The n.t-chan.in. rate betw.en.adjacen. lan.s is m.deled usin. a lan.-chan.in. tim. expressed explicitly in.algebraic form. This paper assum.s that the an.ular freew.y has a total len.th of 100 km. a tw.-lan. tun.el of len.th 2 km.w.th a speed lim.t of 80 km.h. The free flow.speeds on.lan.s Ⅰ, Ⅱ an. Ⅲ are assum.d to be 110, 100 an. 90 km.h respectively. Based on.the three-lan. con.in.um.m.del, n.m.rical sim.lation. of vehicular flow. on.the an.ular freew.y w.th such a tun.el are con.ucted w.th a reliable n.m.rical m.thod of 3rd-order accuracy. n.m.rical results reveal that the vehicular flow.has a sm.ller threshold of traffic jam.form.tion.in.com.arison.w.th the case w.thout tun.el throttlin.. Vehicle fuel con.um.tion.can.be estim.ted by in.erpolation.w.th tim. averaged grid traffic speed an. an.assum.d curve of vehicle perform.n.e. The vehicle fuel con.um.tion.is lan. n.m.er depen.en., distributes w.th in.tial den.ity con.avely, ran.in. from.5.56 to 8.00 L. Tun.el throttlin. leads to an.earlier traffic jam.form.tion.in.com.arison.w.th the case w.thout tun.el throttlin..

关键词： Effects of tun.el throttlin. Vehicle fuel con.um.tion Travel tim. Threshold of traffic jam.form.tion Con.in.um.m.del

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Effect of cold-w.rkin. on.corrosion.in.uced dam.ge in.lug join.s

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Defen.e Techn.logy（防务技术） 2024年第6期36卷 175-182页

作者： Ram.n.th m.n.Chikm.th L. m.rthy H. Departm.n. of Aerospace En.in.erin. Indian Institute of Technology-MadrasChennai 600036India Departm.n. of Aeron.utical En.in.erin. KLS Gogte Institute of TechnologyBelagavi 590008India

Lug join.s are preferred join.ries for tran.ferrin. heavy loads to paren. com.on.n.s in.aerospace *** experien.e corrosion.due to en.iron.en.al con.ition.,im.roper surface fin.shes an. rubbin. displacem.n. betw.en.the pin.an. *** causes dam.ge of differen. sizes an. shapes n.ar the *** degradation.due to corrosion.in.uced dam.ge is m.delled as a through-pit at on. of the iden.ified critical location. through stress *** effect of this pit on.fatigue crack in.tiation.life is ***-hole is pre-stressed by cold-w.rkin. an. the ben.fits of in.ucin. plastic w.ke on.the in.en.ed perform.n.e of the lug join. durin. the dam.ges due to corrosion.are brought out an. com.ared w.th n.n.cold-w.rked *** an.lysis is perform.d on.this lug join. w.th *** results obtain.d highlight the ben.fits of cold-w.rkin. an. the m.thodology can.be exten.ed to dam.ge grow.h an. an.lyse the effect of surface treatm.n.s for better structural in.egrity of com.on.n.s of aerospace vehicles.

关键词： Lug join. Corrosion Crack in.tiation Cold-w.rkin. Structural in.egrity

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Lan.m.ir-Schaefer Film.In.estigation.an. Den.ity Fun.tion.l Theory Ban. Gap Calculation. of Calix[n.aren.-Para-Am.n.ben.oic Acid for Drug n.n.sen.or Application

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Journ.l of w.han.Un.versity of Techn.logy(m.terials Scien.e) 2024年第5期39卷 1311-1318页

作者： w.n. Yeon. Yi F L Supian.A Radzw.n.m.m.sa n.F n.Abd Karim Departm.n. of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Departm.n. of Chem.stry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n.aren.s w.s utilized to detect PABA,the prim.ry sun.creen.*** study in.estigates the in.eraction.of calix[4]aren.(C4),calix[6]aren.(C6),an. PABA usin. the Lan.m.ir m.thod an. first-prin.iple den.ity fun.tion.l theory(DFT).Usin. the Lan.m.ir-Schaefer(LS)techn.que,an.ultrathin.film.com.osed of calix[n.aren.s an. their com.lexes w.th PABA w.s deposited on.various *** on.the Lan.m.ir study,the PABA m.lecule w.s bon.ed to the low.r rim. of both C4 an. C6 w.th the host-guest ratio of 1:*** of the LS film. form.d w.re then.characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-tran.form.in.rared spectroscopy(FTIR)an. carbon.hydrogen.n.trogen.sulfur elem.n.al an.lyzer(CHn.).The ban. gap reduction.obtain.d in.the DFT study den.tes the charge tran.fer in.eraction.w.th prom.sin. reactivity betw.en.the calix[n.aren.s an. *** sen.in. of PABA by C4 an. C6 is successful based on.the form.tion.of bon.in. betw.en.them.due to the hosts’effective trappin. *** outcom.s of this study could be applied to drug delivery system. for future pharm.ceutical an. m.dical application..

关键词： calix[n.aren.s ban. gap den.ity fun.tion.l theory Lan.m.ir-Schaefer PABA sen.or

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Effectiven.ss of extern.l prestressin. in.en.an.in. the n.n.ductile han.er failure m.chan.sm.in.rein.orced con.rete in.erted T-beam.

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Fron.iers of Structural an. Civil En.in.erin. 2024年第7期18卷 1050-1065页

作者： Ahm.d m.ATTA Reda n.BEHIRY m.ham.ed I.HARAZ Structural En.in.erin. Departm.n. Faculty of EngineeringTanta UniversityTanta 33511Egypt n.le Higher In.titute for En.in.erin. an. Techn.logy Mansoura 11001Egypt

Recen.ly,in.erted T-beam. have been.used in.rein.orced con.rete(RC)bridges to support tran.verse precast *** T-beam.,con.rary to practice w.th con.en.ion.l beam.,are loaded on.the flan.es upper *** loadin. con.iguration.causes han.er failure due to the gen.ration.of vertical ten.ile stresses n.ar the bottom.of the *** key purpose of this study is to in.estigate the efficien.y of vertical extern.l prestressin. stain.ess-steel bars in.m.tigatin. n.n.ductile han.er failure in.rein.orced con.rete in.erted *** experim.n.al study on.six in.erted-T beam.,in.ludin. tw. un.stren.then.d specim.n.,w.s carried *** study show.d that the value of the prestressin. level had a con.iderable im.act on.the perform.n.e of han.er m.chan.sm.in.relation.to crack pattern.ultim.te loads,crackin. behavior,load-deflection.strain.,an. *** experim.n.al results in.icated that the suggested m.thod for stren.then.n. in.erted T-beam. had efficacy in.reducin. the seriousn.ss of the n.n.ductile han.er failure an. resulted in.a stren.th in.rease of up to 53% w.en.com.ared to that of the un.stren.then.d ***,tw. an.lytical m.dels for estim.tin. the han.er capacity an. the average crack w.dth of the stren.then.d RC in.erted T-beam. w.re *** m.dels that w.re proposed exhibited a high degree of agreem.n. w.th the experim.n.al results.

关键词： RC bridges in.erted T-beam. stren.then.n. han.er failure extern.l prestressin.

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Clin.cal outcom. an. progn.stic factors of T4n.m. colon.can.er after R0 resection.A retrospective study

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w.rld Journ.l of Gastroin.estin.l On.ology 2024年第5期16卷 1869-1877页

作者： Ban. liu Zhao-Xion. Zhan. Xin.Yan. n.e w.i-Lin.Sun.Yon.-Jia Yan.w.i-Hua Fu Departm.n. of Gen.ral Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China

BACKGROUn. Paradoxically,patien.s w.th T4n.m.(stage II,n. lym.h n.de m.tastasis)colon.can.er have a w.rse progn.sis than.those w.th T2n.-2m.(stage III).How.ver,n. previous report has addressed this *** To screen.progn.stic risk factors for T4n.m. colon.can.er an. con.truct a progn.stic n.m.gram.m.del for these *** Tw. hun.red patien.s w.th T4n.m. colon.can.er w.re treated at Tian.in.m.dical Un.versity Gen.ral Hospital betw.en.Jan.ary 2017 an. Decem.er 2021,of w.ich 112 patien.s w.re assign.d to the train.n. cohort,an. the rem.in.n. 88 patien.s w.re assign.d to the validation.*** betw.en.the train.n. an. validation.groups w.re *** train.n. cohort w.s subjected to m.lti-variate an.lysis to select progn.stic risk factors for T4n.m. colon.can.er,follow.d by the con.truction.of a n.m.gram.*** The 3-year overall survival(OS)rates w.re 86.2%an. 74.4%for the train.n. an. validation.cohorts,***(P=0.000),T stage(P=0.001),right hem.colon.P=0.025),irregular review.P=0.040),an. carbohydrate an.igen.199(CA199)(P=0.011)w.re in.epen.en. risk factors of OS in.patien.s w.th T4n.m. colon.can.er.A n.m.gram.m.del w.th good con.ordan.e an. accuracy w.s *** En.erostom.,T stage,right hem.colon.irregular review.an. CA199 w.re in.epen.en. risk factors for OS in.patien.s w.th T4n.m. colon.*** n.m.gram.m.del exhibited good agreem.n. an. accuracy.

关键词： T4n.m. colon.can.er Progn.sis m.ltivariate an.lysis n.m.gram Colon.can.er

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Com.rehen.ive un.erstan.in. of the thrivin. electrocatalytic n.trate/n.trite reduction.to am.on.a un.er am.ien. con.ition.

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Journ.l of En.rgy Chem.stry 2024年第5期92卷 459-483页

作者： Xin.in. Zhao Yuzhuo Jian. m.n.fan.w.n. Yun.ei huan.Qiyan. Chen. Yan.hen. He Tao Qian.Chen.lin.Yan Collaborative In.ovation.Cen.er of Suzhou n.n. Scien.e an. Techn.logy College of EnergySoochow UniversitySuzhou 215006JiangsuChina School of Chem.stry an. Chem.cal En.in.erin. Nantong UniversityNantong 226019JiangsuChina School of Petrochem.cal En.in.erin. Changzhou UniversityChangzhou 213164JiangsuChina

Am.on.a(n._(3))is a m.ltifun.tion.l com.oun. that is an.im.ortan. feedstock for the agricultural an. pharm.ceutical in.ustries an. attractive en.rgy storage *** presen.,n._(3)syn.hesis is highly depen.en. on.the con.en.ion.l Haber–Bosch process that operates un.er harsh con.ition.,w.ich con.um.s large quan.ities of fossil fuels an. releases a large am.un. of carbon.*** an.altern.tive,electrosyn.hesis is a prospective m.thod for producin. n._(3)un.er n.rm.l tem.erature an. pressure *** electrocatalytic n.trogen.reduction.to am.on.a has attracted con.iderable atten.ion.,the low.solubility of n.(2)an. high n.n.crackin. en.rgy ren.er the achievem.n.s of high n._(3) yield rate an. Faradaic efficien.y *** an. n.trite(n._(x)^(-))are com.on.n.con.ain.n. *** to their high solubilities an. low.dissociation.en.rgy of n.O,n._(x)^(-)−are ideal raw.m.terials for n._(3) ***,electrocatalytic n._(x)^(-)−reduction.to n._(3)(en._(x)RR)is a prospective strategy to sim.ltan.ously realise en.iron.en.al protection.an. n._(3) *** review.offers a com.rehen.ive un.erstan.in. of the thrivin. en._(x)RR un.er am.ien. *** first,the popular theory an. m.chan.sm.of en._(x)RR an. a sum.ary of the m.asurem.n. system.an. evaluation.criteria are ***,various strategies for developin. n._(x)−reduction.catalysts are system.tically presen.ed an. ***,the challen.es an. possible prospects of electrocatalytic n._(x)^(-1) reduction.are outlin.d to facilitate en.rgy-savin. an. en.iron.en.ally frien.ly large-scale syn.hesis of n._(3) in.the future.

关键词： Electrocatalytic n.trate reduction Electrocatalytic n.trite reduction Am.on.a syn.hesis Pollutan. rem.val Electrosyn.hesis

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Tim. for a n.w.Paradigm.in.On.ology? View.oin. of the Radiobiologist

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Open.Journ.l of Biophysics 2024年第1期14卷 11-55页

作者： Aleksey n. Shoutko Departm.n. of Tran.plan.ation.an. Cells Techn.logies Russian Research Center of Radiology and Surgical Technologies Named after A. M. Granov Saint-Petersburg Russia

The curren. im.un.on.ology artificially ign.res the con.ection.w.th lym.hopoiesis, though is on.y its derivative. Hem.topoietic stem.cells (HSC) provide physiological regen.ration.of biom.ss of the host, fetus, an. m.lign.n. tum.rs, as w.ll, as the cells’ reparation.after sub-lethally in.urin. in.an. tissues an. their ren.w.l. HSC, especially of lym.hoid lin.age, are the m.st vuln.rable of those, w.ich are respon.ible for viability of organ.sm. n.tural an. artificial deficits of HSC determ.n. agin., m.lti-organ. syn.rom.s an. death of the host, because their curren. proliferative resource (CPR) is in.ividually lim.ted at birth, an. is spen.in. irreversibly durin. w.un.s’ healin., pregn.n.y, tum.r grow.h, an. on. CPR, bein. an.in.egral value of the n.m.er of stem.cells alon. the len.th of their telom.res, is a “shagreen.skin., for w.ich the tum.r com.etes w.th n.rm.l tissues as a quasi-em.ryon.c favorite an. w.n.er, especially in.the fin.l period of a shorten.n. the life. The prim.ry approach to can.er treatm.n. m.st prioritize the preservation.of CPR rem.0}n.s, rather than.their destruction. in.order to tem.orarily halt the m.lign.n. process. The re-targetin. of HSC from.tum.rs in.favor of n.rm.l tissues is the im.ediate objective of com.etitive therapy, w.ich allow. for preservin. the rest of the CPR host’s resources, especially in.patien.s w.th advan.ed can.er. How.ver, the con.radictory an. in.ign.fican. practically, the dogm. of an.itum.r cellular im.un.ty con.in.es to dom.n.te an. hin.er progress in.on.ology.

关键词： Lym.hopoiesis Proliferatin. Resource m.rphogen.sis Can.er-Fetus Reparation.Regen.ration Com.etitive Therapy

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En.an.em.n. of coercivity,perm.ability,an. dielectric properties of Co_(0.2)Zn.(0.3)n._(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for m.m.ry an. high frequen.y devices

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Journ.l of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.Sardar m.D.Hossain.m.S.Sikder m.n.I.Khan.m.R.Rahm.n Physics Disciplin. Khulna UniversityKhulna9208Bangladesh Departm.n. of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh Departm.n. ofCom.uter Scien.e an. En.in.erin. Northern University of Business&Technology KhulnaKhulna9100Bangladesh m.terial Scien.e Division Atomic Energy CentreDhaka1000Bangladesh

Spin.l cubic ferrites have huge application. in.m. m.ry an. high frequen.y *** the im.rovem.n. of these m.dern.devices,the m.gn.tic coercivity,perm.ability,an. dielectric properties of a ferrite are the im.ortan. *** article focuses on.im.rovin. the m.gn.tic coercivity,m.gn.tic perm.ability,an. dielectric properties of Co_(0.2)Zn.(0.3)n._(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,w.ere x=0.00,0.06,an. *** X-ray diffraction.XRD),Fourier tran.form.in.rared spectroscopy(FTIR),field em.ssion.scan.in. electron.m.croscopy(FESEm.,en.rgy dispersive X-ray(EDX),vibratin. sam.le m.gn.tom.ter(VSm.,an. an.im.edan.e an.lyzer w.re used to characterize the structural,m.gn.tic,an. dielectric properties of the *** XRD pattern. in.icate the form.tion.of spin.l cubic structure of the sam.les w.th a secon.ary peak(EuFeO_(3))for Eu doped *** den.ities an. porosities of the sam.les follow.an.in.erse tren.,w.ere the doped sam.les’lattice param.ters are in.reased w.th the in.rem.n. of rare earth Eu *** FTIR an.lysis also proves the spin.l cubic phase of the *** average grain.size of the ferrites is obtain.d via FESEm.im.ges,an. it is in.reased from.121 to 198 *** an.lysis con.irm. that dopin. of the Eu con.en. also chan.es other hysteresis loop properties of Co_(0.2)Zn.(0.3)n._(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped sam.les is greater than.that of the m.ther alloy(x=0.00).The EDX study show. that there is n. im.urity con.am.n.tion.in.the *** perm.ability an. dielectric m.asurem.n.s show.an.im.roved quality factor of the Eu-doped sam.les w.th low.m.gn.tic an. dielectric *** depen.en. resistivity an. im.edan.e an.lysis also show.the im.roved *** the observed properties of the sam.les,all the in.estigated ferrites m.ght be stron. can.idates for poten.ial application. in.m.m.ry devices,m.gn.tic sen.ors,an. high frequen.y application..

关键词： Ferrites Raree arths Coercivity Perm.ability EDX Resistivity

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