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新的国际伏特和欧姆标准

宇航计测技术 1990年第5期 62-65+72页

作者： Barry n. taylor 徐殿一

本文评论新的国际上一致同意的以约瑟夫逊效应和量子霍尔效应为基确的伏特和欧姆基准,这两项基准于1990年1月1日在全世界开始生效。本文还评论各个国家标准实验室报道的以新标准进行校准所使用的方法。

关键词：量子霍尔效应 RK 现值实验室约瑟夫逊效应欧姆表电阻表

Effect of high dose in.raven.us ascorbic acid on.the level of in.lammation.in.patien.s with rheumatoid arthritis

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Modern.Research in.In.lammation 2012年第2期1卷 26-32页

作者： n. Mikirova A. Rogers J. Casciari P. taylor Riordan.Clin.c Wichita USA

Rheumatoid arthritis (RA) is a major in.lammatory join. disease that causes cartilage destruction. bon. erosion., an. join. destruction. Oxidative stress is elevated in.RA patien.s implyin. reactive oxygen.species (ROS) are possible mediators of tissue damage. ROS trigger a cascade of even.s through n.clear factors’ activation.(n.-kappa B), which up-regulates gen. expression.of pro-in.lammatory cytokin.s that mediate the immun. respon.es causin. in.lammation. As ascorbic acid can.reduce oxidative stress, decrease production.of pro-in.lammatory cytokin.s, an. suppress the activation.of n.-kappa B, we suggest that millimolar con.en.ration.of ascorbic acid may be useful in.RA treatmen.. In.our study we an.lyzed the effect of in.raven.us vitamin.C (IVC) treatmen. on.eleven.subjects with RA. Our data suggest that IVC therapy with dosages of 7.5 g - 50 g can.reduce in.lammation. The level of in.lammation.as measured by C-reactive protein.levels was decreased on.average by 44%. Based on.our pilot study, we hypothesize that IVC therapy can.be a useful strategy in.treatin. RA.

关键词： Rheumatoid Arthritis In.lammation C-Reactive Protein In.raven.us Vitamin C

Treatmen. an. preven.ion.of epilepsy in.on.hocerciasis-en.emic areas is urgen.ly n.eded

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In.ectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebun.ers Joseph n.lson.Siewe Fodjo Olivia Kamoen.Luis-Jorge Amaral Amber Haderman. Chiara Trevisan.Mark J.taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman.Maria-Gloria Basan.z Dan.Bhwan. Thomson.Lakwo Gasim Abd-Elfarag Sebastien.D.Pion Global Health In.titute University of AntwerpAntwerpBelgium Departmen. of n.urology Heilig Hart ZiekenhuisLierBelgium Departmen. of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicin. LiverpoolUK Departmen. of Computer Scien.e University of AntwerpAntwerpBelgium In.titute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German.Cen.er for In.ection.Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Human.ties an. Social Scien.es Nagasaki UniversityNagasakiJapan MRC Cen.re for Global In.ectious Disease An.lysis an. Lon.on.Cen.re for n.glected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK n.tion.l In.titute for Medical Research TangaTanzania Vector Con.rol Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Human.ty JubaSouth Sudan Fren.h n.tion.l Research In.titute for Sustain.ble Developmen. MontpellierFrance

Backgroun. There is in.reasin. epidemiological eviden.e supportin. the association.between.on.hocerciasis an. seizures, rein.orcin. the con.ept of on.hocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an.update on.the n.w kn.wledge about OAE an. to propose recommen.ation. to the World Health Organ.zation.how to address this public health *** text Durin. the 2n. In.ern.tion.l Workshop on.OAE held on.19-21 September, 2023, in.An.werp, Belgium, participan.s recogn.sed OAE as a substan.ial yet n.glected public health problem, particularly in.areas of sub-Saharan.Africa where on.hocerciasis remain. hyperen.emic. Eviden.e from prospective population.based studies suggest that stren.then.n. on.hocerciasis elimin.tion.efforts leads to a sign.fican. reduction.of OAE in.iden.e. There is a n.ed to validate an.OAE case defin.tion.to estimate the burden.of disease an. iden.ify on.hocerciasis-en.emic areas requirin. in.en.ification.of on.hocerciasis elimin.tion.programmes an. in.egration.of epilepsy care. It is expected that raisin. awaren.ss about OAE will boost the population.uptake of ivermectin. The implemen.ation.of a commun.ty-based epilepsy treatmen. programme offerin. free an.i-seizure medication. (ASMs) has shown.high effectiven.ss in.reducin. the frequen.y of seizures an. improvin. the overall quality of life of people with *** To reduce OAE burden. en.an.ed collaboration.between.on.hocerciasis an. men.al health programmes at commun.ty, n.tion.l, an. in.ern.tion.l levels is required. Urgen. efforts are n.eded to en.ure the un.n.errupted provision.of free ASMs in.on.hocerciasis-en.emic areas. Furthermore, OAE should be in.luded in.the quan.ification.of the on.hocerciasis disease burden.

关键词： On.hocerciasis Morbidity Burden.of disease Preven.ion Ivermectin Epilepsy n.ddin. syn.rome Treatmen. Children Policy

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Total organ.c halogen.TOX) in.human.urin.: A halogen.specific method for human.exposure studies

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Journ.l of En.iron.en.al Scien.es 2017年第8期29卷 285-295页

作者： Susan. Y.Kimura Weiwei Zhen. taylor n.Hipp Joshua M.Allen.Susan.D.Richardson Departmen. of Chemistry an. Biochemistry University of South Carolina Key Laboratory of Public Health Safety Ministry of Education Department of Environmental Health School of Public Health Fudan University

Disin.ection.by-products（DBPs） are a complex mixture of compoun.s un.n.en.ion.lly formed as a result of disin.ection.processes used to treat drin.in. water. Effects of lon.-term exposure to DBPs are mostly un.n.wn.an. were the subject of recen. epidemiological studies. However,most bioan.lytical methods focus on.a select few DBPs. In.this study, a n.w comprehen.ive bioan.lytical method has been.developed that can.quan.ify mixtures of organ.c halogen.ted compoun.s, in.ludin. DBPs, in.human.urin. as total organ.c chlorin.（TOCl）, total organ.c bromin.（TOBr）, an. total organ.c iodin.（TOI）. The optimized method con.ists of urin. dilution. adsorption.to activated carbon. pyrolysis of activated carbon. absorption.of gases in.an.aqueous solution. an. halide an.lysis with ion.chromatography an. in.uctively coupled plasma-mass spectrometry. Spike recoveries for TOCl, TOBr, an. TOI measuremen.s ran.ed between.78% an. 99%. Average TOCl, TOBr, an. TOI con.en.ration. in.five urin. samples from volun.eers who con.umed tap water were 1850, 82, an. 21.0 μg/L as X^-, *** who con.umed sprin. water（con.rol） had TOCl, TOBr, an. TOI average con.en.ration. in.urin. of 1090, 88, an. 10.3 μg/L as X^-, respectively. TOCl an. TOI in.the urin. samples from tap water con.umers were higher than.the con.rol. However, TOBr was slightly lower in.tap water urin. samples compared to min.ral water urin. samples, in.icatin. other sources of en.iron.en.al exposure other than.drin.in. water. A larger sample population.that con.umes tap water from differen. cities an. min.ral water is n.eded to determin. TOCl, TOBr, an. TOI exposure from drin.in. water.

关键词： Adsorbable organ.c halogen.AOX) Total organ.c halogen.TOX) Disin.ection.by-products(DBPs) Total organ.c chlorin.(TOCl) Total organ.c bromin.(TOBr) Total organ.c iodin.(TOI) Urin. Drin.in. water

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Corn.al en.othelial cell den.ity an. morphology in.low an. moderate myopic Chin.se eyes

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In.ern.tion.l Journ.l of Ophthalmology(En.lish edition. 2013年第4期6卷 467-470页

作者： Saman.h Delshad jane Mei Chun n.tion.l In.titute of Ophthalmic Scien.es School of OptometryLot 2Lorong Utara BPetaling Jaya 46200Darul EhsanSelangorMalaysia

AIM:To describe an. compare the corn.al en.othelial cell den.ity an. morphology in.youn.,low an. moderate myopic Chin.se adults in.Malaysian.Chin.se population.·METHODS:n.n.con.act specular microscopy(Topcon.SP3000P,Tokyo,Japan. was performed in.low(n.=78;21.22±1.51 years) an. moderate(n.=78;21.82±1.40 years)myopic *** mean.of three con.ecutive measuremen.s of en.othelial cell den.ity(MCD),coefficien. of variation.CV) in.the cell size,an. hexagon.l appearan.e of the cell were obtain.d.·RESULTS:In.low myopic eyes the MCD was 3 063.0±176.2/mm2,the mean.CV was 33.4 ±4.0% an. the mean.hexagon.l appearan.e of the cell was 57.9 ±2.7%.In.moderate myopic eyes the MCD was 2961.6 ±159.0/mm2,the mean.CV was 33.9 ±3.6% an. mean.hexagon.l appearan.e of the cell was 56.2 ±4.7%.There were statistically sign.fican. differen.es in.MCD(P n. hexagon.l appearan.e of the cell(P n.low an. moderate myopic eyes.·COn.LUSIOn.The corn.al en.othelial cell layer in.more myopic eyes ten.s to have less MCD an. cell hexagon.lity compared to lower myopic ***,there is n. sign.fican. differen.e in.CV between.low an. moderate myopic eyes.

关键词： corn.a myopic eyes specular microscopy en.othelial cell den.ity morphology

Urin.ry n.clear magn.tic reson.n.e spectroscopy of a Ban.ladeshi cohort with hepatitis-B hepatocellular carcin.ma: A biomarker corroboration.study

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World Journ.l of Gastroen.erology 2016年第16期22卷 4191-4200页

作者： I jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun.Al-Mahtab Sheikh M Akbar Salimur Rahman.An.on.o Riva Roger Williams Simon.D taylor-Robin.on In.titute of Hepatology London Foundation for Liver Research Departmen. of Chemistry University College London Division.of Digestive Diseases Department of Surgery and Cancer Imperial College London Departmen. of Hepatology Bangabandhu Sheikh Mujib Medical University Departmen. of Medical Scien.es Toshiba General Hospital

AIM: To establish if a distin.t urin.ry metabolic profile could be iden.ified in.Ban.ladeshi hepatitis-B hepatocellular carcin.ma (HCC) patien.s compared to cirrhosis patien.s an. ***: Urin. samples from 42 Ban.ladeshi patien.s with HCC (39 patien.s with hepatitis-B HCC), 47 with cirrhosis on.a backgroun. of hepatitis B, 46 with chron.c hepatitis B, an. seven.ethn.cally-matched healthy con.rols were an.lyzed usin. n.clear magn.tic reson.n.e (n.R) spectroscopy. A full dietary an. medication.history was recorded for each subject. The urin.ry n.R data were an.lyzed usin. prin.ipal compon.n. an.lysis (PCA) an. orthogon.l partial least squared discrimin.n. an.lysis (OPLS-DA) techn.ques. Differen.es in.relative sign.l levels of the most discrimin.tory metabolites iden.ified by PCA an. OPLS-DA were compared between.subject groups usin. an.in.epen.en. samples Kruskal-Wallis on.-way an.lysis of varian.e (An.VA) test with all pairwise multiple comparison.. Within.the patien. subgroups, the Man.-Whitn.y U test was used to compare metabolite levels depen.in. on.hepatitis B e-an.igen.(HBeAg) status an. treatmen. with an.i-viral therapy. A Ben.amin.-Hochberg adjustmen. was applied to acquire the level of sign.fican.e for multiple testin., with a declared level of statistical sign.fican.e of P n.fican. differen.es in.age (P n. body mass in.ex (P n.cal subgroups. Serum alan.n. amin.tran.ferase (ALT) was sign.fican.ly higher in.the HCC group compared to con.rols (P n.was gen.rally markedly elevated in.HCC compared to con.rols; an. serum creatin.n. levels were sign.fican.ly reduced in.the HCC group compared to the cirrhosis group (P = 0.004). A three-factor PCA scores plot showed clusterin. of the urin.ry n.R spectra from the four subgroups. Metabolites that con.ributed to the discrimin.tion.between.the subgr

关键词： Urin.ry metabolic profilin. Hepatocellular carcin.ma n.clear magn.tic reson.n.e spectroscopy Hepatitis B Ban.ladesh

Thermodyn.mics of the Secon. Dissociation.Con.tan.s (pK<sub>2</sub>) of Piperazin.-n.n.-bis-2-hydroxypropan.sulfon.c Acid (POPSO Sesquisodium Salt) an. Associated Thermodyn.mic Fun.tion. from (278.15 to 328.15) K

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Journ.l of Biophysical Chemistry 2014年第4期5卷 143-151页

作者： Rabin.ra n. Roy Lakshmi n. Roy Katherin. E. Hun.ley taylor R. Wehmeyer Lucas S. Tebbe Hoffman.Departmen. of Chemistry Drury University Springfield MO USA

The secon. acidic dissociation.con.tan.s of proton.ted piperazin.-n.n.-bis-2-hydroxypropan.-sulfon.c acid (POPSO sesquisodium salt) have been.determin.d at 12 differen. temperatures from (278.15 to 328.15) K in.ludin. 310.15 K. Electromotive-force measuremen. techn.que was used employin. hydrogen.silver chloride cells without liquid jun.tion. The results of pK2 are given.by the equation. pK2 = -1041.77/T + 51.0459 - 6.97646ln.. The un.ertain.y of the fit is ±0.0008. At 289.15 K, pK2 = 7.8029;whereas, at 310.15 K (body temperature), pK2 = 7.6862. Thus, the buffer solution. of POPSO an. its sodium salt are useful for pH con.rol in.the physiological pH region.of (7.0 to 8.5). The chan.es of Gibbs free en.rgy (G°), en.halpy (H°), en.ropy (S°) an. heat capacity Cp° were computed from the temperature derivative of the pK2 for the dissociation.of the zwitterion.c acid POPSO±-3 = POPSO-4 + H+ in.the stan.ard state. At 298.15 K, these results are compared with those of similar compon.n.s, which are the derivatives of the paren. compoun.s TAURIn., PIPERAZIn. an. MORPHOLIn..

关键词： pH Buffer Compoun. Liquid Jun.tion Thermodyn.mic Fun.tion. Activity Coefficien.s Electromotive-Force pK2

Residen. in.olvemen. in.the prostatic urethral lift:implemen.in. in.ovative techn.logy in.an.academic settin.

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Asian.Journ.l of An.rology 2021年第6期23卷 616-620页

作者： Ridwan.Alam Matthew J Rabin.witz taylor P Kohn.Van.ssa n.Peña James L Liu Yasin.Bhan.i Amin.S Herati Departmen. of Urology The James Buchanan Brady Urological InstituteJohns Hopkins University School of MedicineBaltimoreMD 21287USA

Adoption.of the prostatic urethral lift(PUL)as a treatmen. for ben.gn.prostatic hyperplasia highlights the importan.e of train.n. residen.s with n.vel techn.logy without compromisin. patien. *** study examin.s the effect of residen. in.olvemen. durin. PUL on.patien. an. procedural *** chart review was con.ucted on.all con.ecutive PUL cases performed by a sin.le academic urologist between.October 2017 an. n.vember *** in.post-graduate year(PGY)1–3 are con.idered jun.or residen.s,while those in.PGY 4–6 are sen.or *** In.ern.tion.l Prostate Symptom Score(IPSS)an. quality of life(QOL)scores were used to measure *** an. mixed-effects lin.ar regression.models were used to compare *** were 110 patien.s with a median.age of 66.4 *** were in.olved in.73 cases(66.4%),an. sen.or residen.s were in.olved in.31 of those *** in.olvemen. was n.t associated with adverse perioperative outcomes with respect to the n.mber of implan.s fired,the percen.age of implan.s successfully placed,or the postoperative catheterization.*** adjustmen. for con.oun.in. factors,jun.or residen.s were associated with sign.fican.ly lon.er case len.th compared to the atten.in. alon.(+12.6 min.P=0.003)but sen.or residen.s were n.t(+2.4 min.P=0.59).IPSS an. QOL scores were n.t sign.fican.ly affected by residen. in.olvemen.(P=0.12 an. P=0.21,respectively).The presen.e of surgeon.-in.train.n.,particularly those in.the early stages,prolon.s PUL case len.th but does n.t appear to have an.adverse impact on.patien. outcomes.

关键词： in.ern.hip an. residen.y operative time prostatic hyperplasia prostheses an. implan.s quality of life

Effect of An.rosten.dion. on.Adipogen.sis in.Murin. C3H10T1/2 Mesen.hymal Cells

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Open.Journ.l of En.ocrin. an. Metabolic Diseases 2015年第2期5卷 9-18页

作者： Pan.uran.an.Ramaraj Jorge n. Artaza In.ran. Sin.a-Hikim Wayn. E. taylor Departmen. of Biochemistry Kirksville College of Osteopathic Medicine A.T. Still University of Health Sciences Kirksville MO USA Division.of En.ocrin.logy Charles R. Drew University of Medicine and Science Los Angeles CA USA Departmen. of Health an. Life Scien.es Charles R. Drew University of Medicine and Science Los Angeles CA USA

Clin.cal trials of weak an.rogen.an.rosten.dion. (AD) admin.stered at a high con.en.ration. showed an.in.rease in.muscle mass in.men.like stron. an.rogen. testosteron. (T) an. dihydrotestosteron. (DHT), but did n.t show an. in.ibitory effect on.fat mass un.ike stron. an.rogen.. This observation.prompted us to check the in.vitro effect of AD on.adipogen.sis usin. mouse mesen.hymal multipoten. cells (C3H10T1/2), which can.differen.iate in.o both myoblasts an. adipocytes. Results in.icated that AD in.ibited adipogen.sis at 10 n., 100 n. an. 1 μM con.en.ration., but n.t at 10 μM con.en.ration. AD did n.t in.ibit adipogen.sis at 10 μM con.en.ration.an. also did n.t in.ibitmyogen.sis at 10 μM con.en.ration. Addition.of bicalutamide, an.an.rogen.receptor (AR) an.agon.st decreased myogen.sis an. in.reased adipogen.sis, in.icatin. that the effect of AD was mediated through AR. An.ther weak an.rogen.dehydroepian.rosteron. (DHEA) also showed the same pattern.of adipogen.sis in.10T1/2 cells. AD also showed a similar pattern.of adipogen.sis in.3T3-L1 preadipocyte cells. Thus, the in.vitro results of AD on.adipogen.sis correlated with the in.vivo results of AD on.fat-mass from clin.cal trials an. suggested a possible differen.e in.biological action.between.weak an.rogen. (AD, DHEA) an. stron. an.rogen. (T, DHT) on.adipogen.sis. Sin.e the biological action.of AD was mediated through AR, this physiological differen.e on.dipogen.sis could be due to the n.ture (partial agon.st/an.agon.st) of AD bin.in. to AR.

关键词： An.rosten.dion. Adipogen.sis Myogen.sis An.rogen Receptor Bicalutamide