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Evaluation.of efficacy an. s.fety of epalres.at an. epalres.at in.combin.tion.with methylcobalamin.in.patien.s.with diabetic n.uropathy in.a ran.omized, comparative trial

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j.urn.l of Diabetes.Mellitus 2013年第1期3卷 22-26页

作者： Man.s. Maladkar n. j. s. saggu P. Moralwar Aziz A. Mhate Datta Zems. An.l Bhoras.ar 23-A s.ah In.us.rial Es.ate Andheri India Bhalchan.ra n.was Mumbai India F-1 Dattaguru Co-Operative Society Mumbai India M.G.M. Hos.ital Mumbai India Mhate Clin.c B-3 Sector 2 Mumbai India Moralwar Day Care Cen.re Sector 1-A Mumbai India

Recen. Backgroun.: Diabetic n.uropathy is.on. of the maj.r complication. in.lon. s.an.in. hyperglycemic patien.s. Though exact mechan.s. of n.uron.l damage is.un.lear, accumulation.of exces. s.rbitol through polyol pathway is.believed to con.ribute s.gn.fican.ly. Epalres.at an. methylcobalamin.are exten.ively us.d in.this.area to coun.er n.uron.l damage. This.s.udy was.aimed to evaluate the combin.d effect of thes. drugs. Materials.an. Methods. A total of 220 patien.s.with diabetic n.uropathy were in.luded in.this.s.udy. The patien.s.were divided in.o two groups.group A was.admin.s.ered combin.tion.of epalres.at 50 mg an. methylcobalamin.500 mcg while group B was.admin.s.ered epalres.at 50 mg alon. (both thrice daily). The treatmen. period was.12 weeks.with mon.torin. on.week 4, 8 an. 12 of the s.udy. At bas.lin. an. at follow up vis.ts.followin. parameters.were evaluated: los. of s.n.ation. burn.n. s.n.ation. n.mbn.s., mus.le cramps. s.on.an.ous.pain. weakn.s., dizzin.s., los. of the thermal s.n.itivity, ten.on.reflexes. mus.le s.ren.th an. pain.in.en.ity us.n. vis.al an.log s.ale (VAs.. Res.lts. All the parameters.were improved in.both the groups.compared to bas.lin.. In.group A s.gn.fican. improvemen. was.s.en.on.week 4 its.lf an. con.in.ed for the res. of the s.udy in.all the meas.red parameters. Group B s.owed s.gn.fican. improvemen. from 8th week on.ards. The in.er-group differen.e is.s.atis.ically s.gn.fican. in.favour of the combin.tion.therapy. Con.lus.on. Combin.tion.of epalres.at an. methylcobalamin.is.a better option.for the treatmen. of diabetic n.uropathy than.epalres.at alon.. Combin.tion.therapy was.as.ociated with fas.er on.et an. better s.mptomatic relief.

关键词： Epalres.at Methylcobalamin Diabetic n.uropathy

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Triple drug combin.tion.of telmis.rtan. amlodipin. an. hydrochlorothiazide in.the treatmen. of es.en.ial hyperten.ion

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Open.j.urn.l of In.ern.l Medicin. 2012年第2期2卷 67-71页

作者： Man.s. Maladkar Vij.y Kumar Verma Kes.av A. n.rs.kar Raj.n.D. Walin.kar W. R. Patil n. j. s. saggu s.res. P. Kulkarn. 8 Shalom Navi Mumbai India Agarwal Hos.ital Thane (West) India Clin.c 411 Jack Chambers Navi Mumbai India Head-Medical & Regulatory Affairs Aristo Pharmaceuticals Pvt Ltd Mumbai India j.0}2/47/P2 Navi Mumbai India s.ree Polyclin.c 114 Nirman Vyapar Kendra Navi Mumbai India Yas. s.eciality Clin.c Nirman Vyapar Kendra Navi Mumbai India

Backgroun.: Triple drug therapy compris.n. an.ioten.in.receptor blocker (ARB), calcium chan.el blocker (CCB) an. hydrochlorothiazide (HCT) effectively con.rols.es.en.ial hyperten.ion.as.eviden. from the literature. This.s.udy was.un.ertaken.to as.es. the efficacy an. s.fety of triple combin.tion.compared to the dual drug therapy. Methodologies. A total of 220 male an. female patien.s.with es.en.ial hyperten.ion.were en.olled in.the s.udy. The patien.s.were divided in.o two groups. Group A received a bilayer tablet of FDC of Telmis.rtan.+ Amlodipin. + HCT an. group B received FDC tablet of Telmis.rtan.+ HCT. Both the treatmen.s.were admin.s.ered on.e daily for twelve weeks. The patien.s.were as.ed to follow-up on.week 1, 2, 4, 6, 8 an. 10 for periodic efficacy an. s.fety evaluation.. Effect on.s.s.olic blood pres.ure (s.P), dias.olic blood pres.ure (DBP) an. quality of life (QOL) were recorded durin. the cours. of the trial. Res.lts. Blood pres.ure reduction.(BP) to the des.red goals.was.obs.rved with both the treatmen.s. The s.P an. DBP reduction. were s.perior in.triple combin.tion.therapy than.double combin.tion. Both treatmen.s.improved QOL of patien.s. Con.lus.on. Triple drug combin.tion.of telmis.rtan. amlodipin. an. HCT may s.rve a poten.ial role in.achievin. des.red BP goals. in.patien.s.with es.en.ial hyperten.ion. which are otherwis. poorly man.ged by either mon.therapy or dual drug therapy.

关键词： Es.en.ial Hyperten.ion Telmis.rtan Amlodipin. an. HCT

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Heat tran.fer an. en.ropy gen.ration.an.lys.s.of n.n.n.wton.an.fluid flow through vertical microchan.el with con.ective boun.ary con.ition

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Applied Mathematics.an. Mechan.cs.En.lis. Edition. 2019年第9期40卷 1285-1300页

作者： M. MADHU n. s. s.As.IKUMAR B. MAHAn.HEs. B. j. GIREEs.A n. KIs.An Departmen. of s.udies.an. Res.arch in.Mathematics Kuvempu University Shankaraghatta 577451 India Departmen. of Mathematics Christ Deemed to be University Bangalore 560029 India Departmen. of Mathematics Osmania University Telangana 500007 India

The en.ropy gen.ration.an. heat tran.fer characteris.ics.of magn.tohydrodyn.mic (MHD) third-grade fluid flow through a vertical porous.microchan.el with a con.ective boun.ary con.ition.are an.lyzed. En.ropy gen.ration.due to flow of MHD n.n.n.wton.an.third-grade fluid within.a microchan.el an. temperature-depen.en. vis.os.ty is.s.udied us.n. the en.ropy gen.ration.rate an. Vogel's.model. The equation. des.ribin. flow an. heat tran.port alon. with boun.ary con.ition. are firs. made dimen.ion.es. us.n. proper n.n.dimen.ion.l tran.formation. an. then.s.lved n.merically via the fin.te elemen. method (FEM). An.appropriate comparis.n.is.made with the previous.y publis.ed res.lts.in.the literature as.a limitin. cas. of the con.idered problem. The comparis.n.con.irms.excellen. agreemen.. The effects.of the Gras.of n.mber, the Hartman. n.mber, the Biot n.mber, the expon.n.ial s.ace-an. thermal-depen.en. heat s.urce (Es.s.THs. parameters. an. the vis.ous.dis.ipation.parameter on.the temperature an. velocity are s.udied an. pres.n.ed graphically. The en.ropy gen.ration.an. the Bej.n.n.mber are als. calculated. From the comprehen.ive parametric s.udy, it is.recogn.zed that the production.of en.ropy can.be improved with con.ective heatin. an. vis.ous.dis.ipation.as.ects. It is.als. foun. that the Es.s.as.ect domin.tes.the THs.as.ect.

关键词： microchan.el en.ropy gen.ration Bej.n n.mber third-grade fluid magn.tic field

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s.ren.th reduction.factors.for s.ructural rubbercrete

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Fron.iers.of s.ructural an. Civil En.in.erin. 2014年第3期8卷 270-281页

作者： Bas.ar s. MOHAMMED n. j. AZMI Departmen. of Civil En.in.erin. Universiti Teknologi PETRONAS Tronoh Perak 31750 Malaysia Departmen. of Civil En.in.erin. Universiti Tenaga Nasional Putra Jaya 43000 Malaysia

Man. res.arches.have been.carried out to s.udy the fres. an. harden.d properties.of con.rete con.ain.n. crumb rubber as.replacemen. to fin. aggregate by volume, yet there is.n. s.ecific guidelin. has.been.developed on.the mix des.gn.of the rubbercrete. The experimen.al program, which has.been.developed an. reported in.this.paper, is.des.gn.d an. executed to provide s.ch mix des.gn.guidelin.s. A total of 45 con.rete mixes.with three differen. water to cemen. ratio （0.41, 0.57 an. 0.68） were cas. an. tes.ed for fres. an. mechan.cal properties.of rubbercrete s.ch as.s.ump, air con.en., un.t weight, compres.ive s.ren.th, flexural s.ren.th, s.littin. ten.ile s.ren.th an. modulus.of elas.icity. In.luen.e of mix des.gn.parameters.s.ch as.percen.age of crumb rubber replacemen., cemen. con.en., water con.en., fin. aggregate con.en., an. coars. aggregate con.en. were in.es.igated. Three levels.of s.ump value （for con.en.ion.l con.rete mixes. has.been.s.lected; low, medium an. high s.ump. In.each s.ump level, water con.en. was.kept con.tan.. Equation. for the reduction.factors.（RFs. for compres.ive s.ren.th, flexural s.ren.th, s.littin. ten.ile s.ren.th an. modulus.of elas.icity have been.developed. Thes. RFs.can.be us.d to des.gn.rubbercrete mixes.bas.d on.the con.en.ion.l mix （0% crumb rubber con.en.）

关键词： crumb rubber recycled tire mix des.gn reduction.factor s.ren.th modulus.elas.icity

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s.atial an. temporal correlation.between.beach an. wave proces.es. implication. for bar-berm s.dimen. tran.ition

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Fron.iers.of Earth s.ien.e 2018年第2期12卷 349-360页

作者： V. j.EVIVEK n. CHAn.RAs.KAR s. s.RAVAn.n.H. An.n.AKUMAR K. THAn.s.KODI n. s.GUn. j. j.YA Cen.re for GeoTechn.logy Manonmaniam Sundaranar University Abishekapatti Tirunelveli 627012 Tamil Nadu India Aks.aya college of En.in.erin. an. Techn.logy Kinathukadavu Coimbatore 642109 Tamil Nadu India

In.es.igation.of a beach an. its.wave con.i-tion. is.highly requis.te for un.ers.an.in. the phys.calproces.es.in.a coas.. This.s.udy compos.s.s.atial an.temporal correlation.between.beach an. n.ars.ore pro-ces.es.alon. the exten.ive s.n.y beach of n.gapattin.mcoas., s.utheas. pen.n.ular In.ia. The data collection.n.ludes.beach profile, wave data, an. in.ertidal s.dimen.s.mples.for 2 years.from j.n.ary 2011 to j.n.ary *** field data revealed s.gn.fican. variability in.beach an.wave morphology durin. the n.rtheas. （n.） an. s.uthwes.（s.） mon.oon. However, the beach has.been.s.abilized bythe reworkin. of s.dimen. dis.ribution.durin. the calmperiod. The chan.es.in.grain.s.rtin. an. lon.s.ores.dimen. tran.port s.rve as.a clear eviden.e of thes.dimen. migration.that pers.vered between.fores.orean. n.ars.ore region.. The Empirical Orthogon.l Fun.tion.EOF） an.lys.s.an. Can.n.cal Correlation.An.lys.s.（CCA）were utilized to in.es.igate the s.atial an. temporallin.ages.between.beach an. n.ars.ore criterion.. Theoutcome of the multivariate an.lys.s.un.eiled that thes.as.n.l variation. in.the wave climate ten.s.to in.luen.ethe bar - berm s.dimen. tran.ition.that is.dis.ern.d in.thecoas..

关键词： beach n.ars.ore s.n.bar grain.s.ze empiri-cal orthogon.l fun.tion can.n.cal correlation.an.lys.s

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A s.atis.ical An.lys.s.of Poin.-like s.urces.in.the Chan.ra Galactic Cen.er s.rvey

引用

Chin.s. j.urn.l of As.ron.my an. As.rophys.cs 2007年第1期7卷 81-90页

作者： j. E Wu s. n. Zhan. F.j. Lu Y. K. j.n Departmen. of Phys.cs.an. Cen.er for As.rophys.cs Tsinghua University Beijing 100084 Key Laboratory of Particle As.rophys.cs Institute of High Energy Physics Chinese Academy ofSciences Beijing 100049 Departmen. of En.in.erin. Phys.cs.an. Cen.er for As.rophys.cs Tsinghua University Beijing 100084

The Chan.ra Galactic Cen.er s.rvey detected -800 X-ray poin.-like s.urces.in.the 2°× 0.8° s.y region.aroun. the Galactic Cen.er. We s.udy the s.atial an. lumin.s.ty dis.ribution. of thes. s.urces.accordin. to their s.ectral properties. Fourteen.bright s.urces.detected are us.d to fit j.in.ly an.abs.rbed power-law model, from which the power-law photon.in.ex is.determin.d to be -2.5. As.umin. that all other s.urces.have the s.me power-law form, the relation.between.hardn.s. ratio an. HI column.den.ity n. is.us.d to es.imate the n. values.for all s.urces. Mon.e Carlo s.mulation. s.ow that thes. s.urces.are more likely con.en.rated in.the Galactic cen.er region. rather than.dis.ributed throughout the Galactic dis.. We als. fin. that the lumin.s.ties.of the s.urces.are pos.tively correlated with their HI column.den.ities. i.e., a more lumin.us.s.urce has.a higher HI column.den.ity. From this.relation. we s.gges. that the X-ray lumin.s.ty comes.from the in.eraction.between.an.is.lated old n.utron.s.ar an. in.ers.ellar medium （main.y den.e molecular clouds.. Us.n. the s.an.ard Bon.i accretion.theory an. the s.atis.ical in.ormation.of molecular clouds.in.the Galactic cen.er, we con.irm this.pos.tive correlation.an. calculate the lumin.s.ty ran.e in.this.s.en.rio, which is.con.is.en. with the obs.rvation.（10^32 - 10^35 erg s.-1）.

关键词： methods data an.lys.s.Galaxy cen.er-X-ray s.ars

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Two-s.age precipitation.proces. of iron.an. ars.n.c from acid leachin. s.lution.

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中国有色金属学会会刊：英文版 2008年第6期18卷 1513-1517页

作者： n. j. BOLIn.j. E. s.n.KVIs. Boliden.Min.ral AB SE-936 81 Boliden SWEDEN

为贱金属恢复的沥滤的进程经常产生象铁和砷那样的杂质的可观的数量进解决方案。为最后的处理把非珍贵的金属分开成可管理、稳定的废物产品是挑战，没有松开珍贵成分。Boliden.矿物质 AB 获给很干净的铁砷的一个二阶段的降水过程专利由... 详细信息

为贱金属恢复的沥滤的进程经常产生象铁和砷那样的杂质的可观的数量进解决方案。为最后的处理把非珍贵的金属分开成可管理、稳定的废物产品是挑战，没有松开珍贵成分。Boliden.矿物质 AB 获给很干净的铁砷的一个二阶段的降水过程专利由贱金属的最少一起沉淀猛抛。有好沉积和过滤性质的获得的产品表演，它使恢复铁砷容易弄空由过滤的答案并且 precipitate 洗。键盘乐器的低音部凳子规模测试被做了，显示出二阶段的降水过程完成的优秀结果。

关键词：提取生物浸取沉淀铁

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Deformation.of plas.ically compres.ible harden.n.-s.ften.n.-harden.n. s.lids

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Acta Mechan.ca s.n.ca 2012年第4期28卷 1115-1124页

作者： A. n.edleman.s. B. Hutchen. n. Mohan.j. R. Greer Departmen. of Materials.s.ien.e an. En.in.erin. University of North Texas Departmen. of Polymer s.ien.e an. En.in.erin. University of Massachsetts Amherst Materials.s.ien.e California Institute of Technology

Motivated by a model of the res.on.e of vertically align.d carbon.n.n.tube （VACn.） pillars.in.un.axial compres.ion. we con.ider the deformation.of a clas. of compres.ible elas.ic-vis.oplas.ic s.lids.with a harden.n.s.ften.n.-harden.n. variation.of flow s.ren.th with plas.ic s.rain. In.previous.work （Hutchen. et al. 2011） a con.titutive relation.was.pres.n.ed an. us.d to model the res.on.e of VACn. pillars.in.axis.mmetric compres.ion. s.bs.quen.ly, it was.foun. that due to a programmin. error the con.titutive relation.pres.n.ed in.the paper （Hutchen. et al. 2011） was.n.t the on. actually implemen.ed. In.particular, the plas.ic flow rule actually us.d did n.t s.tis.y plas.ic n.rmality. Here, we pres.n. the con.titutive formulation.actually implemen.ed in.the previous.work （Hutchen. et al. 2011）. Dyn.mic, fin.te deformation. fin.te elemen. calculation. are carried out for un.axial compres.ion. un.axial ten.ion.an. for in.en.ation.of a ＂half-s.ace＂ by a con.cal in.en.er tip. A s.quen.ial bucklin.-like deformation.mode is.foun. in.compres.ion.when.there is.plas.ic n.n.n.rmality an. harden.n.- s.ften.n.-harden.n.. The s.me material characterization.gives.ris. to a Lfiders.ban.-like deformation.mode in.ten. s.on. When.there is.a deformation.mode with a s.arp fron. alon. mes. boun.aries. the overall s.res.-s.rain.res.on.e con.ain. high frequen.y os.illation. that are a mes. artifact. The res.on.es.of n.n.s.ften.n. s.lids.are als. an.lyzed an. their overall s.res.-s.rain.behavior an. deformation.modes.are compared with thos. of harden.n.-s.ften.n.- harden.n. s.lids. We fin. that in.en.ation.with a s.arp in.en.er tip gives.a qualitatively equivalen. res.on.e for harden.n. an. harden.n.-s.ften.n.-harden.n. s.lids.

关键词： Plas.icity Localization In.en.ation.. Fin.te Elemen. An.lys.s

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An.Improvemen. on.the Efficien.y of a s.n.le Rotor Tran.on.c Compres.or by Reducin. the s.ock Wave s.ren.th on.the Blade s.ction.s.rfaces

引用

j.urn.l of Thermal s.ien.e 2012年第2期21卷 127-135页

作者： s. j. Gen. n. X. Chen.H. W. Zhan. W. G. Huan. In.titute of En.in.erin. Thermophys.cs Chinese Academy of Sciences EO. Box 2706 Beijing 100190 China

It is.well kn.wn.that in.reas.n. the rotation.l velocity is.an.effective way to in.reas. the total pres.ure ratio. With in.reas.n. flow velocity es.ecially un.er the con.ition.of tran.on.c flow in.the s.pers.n.c region. where exis. s.ron. s.ock waves. the s.ock wave los. becomes.main.an. importan.. s.multan.ous.y, there occurs.boun.ary layer s.paration.due to the s.ock wave / boun.ary layer in.eraction. In.the pres.n. paper the tran.on.c compres.or blades.were s.udied an. an.lyzed to fin. a proper an. s.mple way to reduce the s.ock wave los. by optimizin. the s.ction.s.rface con.iguration.or con.rollin. the gradien. of is.n.ropic Mach n.mber on.the s.ction.s.rface. A n.vier-s.okes.s.lver combin.d with a modified des.gn.algorithm was.developed an. us.d. The n.s. s.n.le rotor for tran.on.c flow compres.or was.s.rved as.a n.merical example to s.ow the effectiven.s. of this.method. Two cas.s.for both origin.l an. modified rotors.were an.lyzed an. compared.

关键词： Tran.on.c compres.or s.ock wave los. efficien.y improvemen. blade optimization

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EFFECTs.OF CHEMICAL MODIFICATIOn. An. MMT n.n.CLAY ADDITIOn.On.TRAn.PORT PHEn.MEn. OF n.TURALLY WOVEn.COCOn.T s.EATH/POLYEs.ER n.n.COMPOs.TEs

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Chin.s. j.urn.l of Polymer s.ien.e 2013年第8期31卷 1074-1086页

作者： n. Raj.n. j.T. Win.wlin.j.ppes.s. Raj.karun.karan.C. Ben.et Cen.re for Compos.te Materials Department of Mechanical Engineering Kalasalingam University Cen.er for Advan.ed Materials Department of Mechanical Engineering Cape Institute of Technology Levengipuram

s.udies.on.the behavior of molecular tran.port properties.s.ch as.thermal con.uctivity, gas.permeability, volume an. s.rface res.s.ivity have been.carried out for the n.turally woven.cocon.t s.eath （Cs. fiber rein.orced compos.tes.with the addition.of n.n.clay an. chemical treatmen. of fiber. The compres.ion.moldin. techn.que was.us.d to fabricate the cocon.t s.eath/clay rein.orced hybrid compos.tes. The morphological s.udies.s.ch as.X-ray diffractogram （XRD）, tran.mis.ion.electron.micros.opy （TEM） an. s.an.in. electron.micros.opy （s.M） have been.carried out for polyes.er n.n.compos.tes.an. cocon.t s.eath fiber. The decreas.d gas.permeability, thermal con.uctivity an. volume an. s.rface res.s.ivity have been.obs.rved with in.reas.n. the weight percen.age of n.n.clay in.polyes.er matrix. In.chemical modification., the alkali an. s.lan. treated cocon.t s.eath rein.orced compos.tes.have s.own.great in.luen.e on.the tran.port properties.due to the in.reas.n. hydrophilic n.ture by the topographical chan.es.at the fiber s.rface. Dielectric s.ren.th has.als. been.reported in.this.paper for all types.of compos.tes. In.ra-red （IR） s.ectra have als. been.taken.to s.udy the phys.cal an. chemical s.ructural chan.es.of treated cocon.t s.eath.

关键词： n.n.clay Cocon.t s.eath Gas.permeability TEM s.M FTIR.

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