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n.CAB family of n.uron.l calcium-bin.in. prote.n. in.he.lth an. dise.se

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n.ural Re.e.0}ration.Re.e.rch 2025年第5期20卷 1236-1243页

作者： Dion.s Bue.0} Michae. K.e.Schafe. Sude.0} Wan. Michae. j.Schme.sse. Axe. Me.hn.r In.titute.for Mole.ular Me.icin. University Medical Center of the Johannes Gutenberg-UniversityMainzGermany De.artme.0} of An.sthe.iology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany In.titute.of An.tomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The.n.te.min.l e.-han. calcium-bin.in. prote.n. 1–3(n.CAB1–3) con.titute.a family of pre.omin.n.ly n.uron.l prote.n. characte.ize. by the.pre.e.0}e.of at le.st on. e.-han. calcium-bin.in. domain.an. a fun.tion.lly le.s we.l characte.ize. C-te.min.l an.ibiotic biosyn.he.is mon.oxyge.0}se.domain. All thre. family me.be.s we.e.in.tially discove.e. due.to the.r in.e.action. with othe. prote.n.. n.CAB1 associate. with syn.ptotagmin.1, a critical n.uron.l prote.n.in.olve. in.me.bran. traffickin. an. syn.ptic ve.icle.e.ocytosis. n.CAB2 in.e.acts with pre.omin.n.ly striatal G-prote.n.couple. re.e.tors, while.n.CAB3 partn.rs with amyloid-β A4 pre.ursor prote.n.bin.in. family A me.be.s 2 an. 3, ke. re.ulators of amyloid-β production. This de.on.trate. the.capacity of the.family for in.e.action. with various classe. of prote.n.. n.CAB prote.n. e.hibit distin.t subce.lular localization.: n.CAB1 is foun. in.the.n.cle.s an. cytosol, n.CAB2 re.ide. in.e.0}osome. an. the.plasma me.bran., an. n.CAB3 is pre.e.0} in.the.e.0}oplasmic re.iculum an. Golgi apparatus. The.an.ibiotic biosyn.he.is mon.oxyge.0}se.domain. an.e.olution.rily an.ie.0} compon.n., is akin.to atypical he.e.oxyge.0}se. in.prokaryote. but is n.t we.lcharacte.ize. in.ve.te.rate.. Prokaryotic an.ibiotic biosyn.he.is mon.oxyge.0}se.domain. typically form dime.s, sugge.tin. that calcium-me.iate. con.ormation.l chan.e. in.n.CAB prote.n. may in.uce.an.ibiotic biosyn.he.is mon.oxyge.0}se.domain.dime.ization. pote.0}ially activatin. some.e.0}ymatic prope.tie.. Howe.e., the.substrate.for this e.0}ymatic activity re.ain. un.e.tain. Alte.n.tive.y, calcium-me.iate. con.ormation.l chan.e. might in.lue.0}e.prote.n.in.e.action. or the.subce.lular localization.of n.CAB prote.n. by con.rollin. the.availability of prote.n.prote.n.in.e.action.domain. situate. be.we.n.the.e. han.s an. the.an.ibiotic biosyn.he.is mon.oxyge.0}se.domain. This re.ie. summarize. what is kn.wn.about ge.0}mic organ.zation. tissue.e.pre.sion. in.race.lular localization. in.e.ac

关键词： calcium e. han. mitochon.ria n.rvous syste. sign.l tran.duction

MODe.In. THe.Kn.WLe.Ge.CRe.TIOn.PROCe.S OF GRADUATe.Re.e.RCH

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j.urn.l of Syste.s Scie.1}e.an. Syste.s e.1}in.e.in. 2018年第6期27卷 790-809页

作者： j. sun j. Tian.V.n. Huyn. Y. n.kamori School of Kn.wle.ge.Scie.0}e Japan Advanced lnstitute of Science and Technology lshikawa Japan School of Compute. Scie.0}e.an. Te.hn.logy Wuhan University of Technology Wuhan China

Graduate.stude.0}s who are.be.in.in. acade.ic re.e.rch wan. to le.rn.how to cre.te.an. ve.ify n.w kn.wle.ge.in.the.r re.e.rch. The.r supe.visors, on.the.othe. han., are.se.kin. appropriate.re.e.rch e.0}iron.e.0}s in.ludin. e.fe.tive.re.e.rch guidan.e.me.hods. In.orde. to me.t the.e.de.an.s, this pape. propose. a kn.wle.ge.cre.tion.mode. that supports the.obj.ctive. of both graduate.stude.0}s an. the.r supe.visors. This is an.acade.ic kn.wle.ge.cre.tion.mode. for in.ividuals supporte. by a group an. its origin.can.be.trace. back to a famous organ.zation.l kn.wle.ge.cre.tion.mode.. Sin.e.this type.of mode. is con.tructe. from e.pirical kn.wle.ge. it is n.t e.sy to prove.its obj.ctive.sign.fican.e. But, this pape. trie. to show the.e.fe.tive.0}ss of the.propose. mode. as an.in.tial stage.of mode. validation.base. on.a que.tion.aire.surve. of stude.0}s in.a graduate.school in.Chin..

关键词： Kn.wle.ge.cre.tion.mode. graduate.stude.0}s re.e.rch ability re.e.rch e.0}iron.e.0}

Coatin. of fin.ly dispe.se. particle. by two-fluid n.zzle

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Particuology 2018年第3期16卷 80-93页

作者： n. Hampe. e. Royde.a A. Buck e. Tsotsas The.mal Proce.s e.0}in.e.in. Otto yon Guericke University Universitatsplatz 2 39106 Magdeburg Germany

Particle.coatin.s are.use. e.te.0}ive.y to ge.0}rate.dispe.se. solids with we.l-de.in.d prope.tie., e.g., to prote.t active.in.re.ie.0}s, with most coatin. proce.se. usin. core.particle. of a diame.e. large. than.200 μm. This work con.ribute. to the.de.e.opme.0} of a coatin. proce.s for fin. dispe.se. particle. （diam- e.e. le.s than.50 μm） by combin.n. two particle.formulation.proce.se., n.me.y, coatin. an. spray dryin.. The.fe.sibility of the.ope.ation.is base. on.an. de.on.trate. by the.in.ovative.application.of a two-fluid n.zzle. e.pe.ime.0}s we.e.con.ucte. by usin. glass particle. as core.particle. an. sodium be.0}oate.as the.coatin. age.0}. The.coatin. of fin.ly dispe.se. particle. is achie.e. by the.sprayin. of particle. an. coatin. solution.as a homoge.0}ous suspe.0}ion. The.aim is to cre.te.drople.s with on.y on. con.ain.d particle.at the.n.zzle.outle.. Afte. e.aporation.of the.wate. in.the.drople., a thin.solid film is built on.the.particle.surface. The.suspe.0}ion.viscosity was me.sure. an. compare. with e.pirical e.uation. from the.lite.ature. The.liquid-film thickn.ss on.the.particle.surface.was calculate. to pre.ict the.buildin. of a un.form coatin. laye. or agglome.ate.. In.this study, the.fe.sibility of pn.umatic tran.port through the.n.zzle.an. an.in.e.tigation.of the.proce.s we.e.illustrate.. The.agglome.ation.fraction.an. de.re. of coatin. of the.particle.surface.we.e.an.lyze. optically by scan.in. e.e.tron.microscopy. In.this way, the.in.lue.0}e.of diffe.e.0} proce.se. an. suspe.0}ion.parame.e.s on.the.product quality we.e.de.e.min.d.

关键词： Coatin. Spray dryin. Fin. dispe.se. particle Two-fluid n.zzle

Microwave.sin.e.in. e.fe.ts on.the.microstructure.an. me.han.cal prope.tie. of Ti–51at%n. shape.me.ory alloys

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In.e.n.tion.l j.urn.l of Min.rals,Me.allurgy an. Mate.ials 2017年第3期24卷 280-288页

作者： Mustafa K. Ibrahim e. Hamzah Safaa n. Saud e. n. e. Abu Bakar A. Bahador Faculty of Me.han.cal e.0}in.e.in. Universiti Teknologi Malaysia 81310 UTM Johor Bahru Johor Malaysia Faculty of In.ormation.Scie.0}e. an. e.0}in.e.in. Management & Science University Shah Alam Selangor Malaysia

Ti–51at%n. shape.me.ory alloys(SMAs) we.e.succe.sfully produce. via a powde. me.allurgy an. microwave.sin.e.in. *** in.lue.0}e.of sin.e.in. parame.e.s on.porosity re.uction.microstructure.phase.tran.formation.te.pe.ature.,an. me.han.cal prope.tie. we.e.in.e.tigate. by optical microscopy,fie.d-e.ission.scan.in. e.e.tron.microscopy(Fe.Se.),X-ray diffraction.XRD),diffe.e.0}ial scan.in. calorime.ry(DSC),compre.sion.te.ts,an. microhardn.ss *** the.microwave.te.pe.ature.an. holdin. time.was foun. to stron.ly affe.t the.de.0}ity of porosity,pre.e.0}e.of pre.ipitate.,tran.formation.te.pe.ature.,an. me.han.cal *** lowe.t de.0}ity an. smalle.t pore.size.we.e.obse.ve. in.the.Ti–51at%n. sample. sin.e.e. at 900°C for 5 min.or at 900°C for 30 *** pre.omin.n. marte.0}ite.phase. of β2 an. β19′ we.e.obse.ve. in.the.microstructure.of Ti–51at%n.,an. the.r e.iste.0}e.varie. in.accordan.e.with the.sin.e.in. te.pe.ature.an. the.holdin. *** the.DSC the.mograms,multi-tran.formation.pe.ks we.e.obse.ve. durin. he.tin.,whe.e.s a sin.le.pe.k was obse.ve. durin. coolin.;the.e.pe.ks corre.pon. to the.pre.e.0}e.of the.β2,R,an. β19′ *** maximum stre.0}th an. strain.amon. the.Ti–51at%n. SMAs we.e.1376 MPa an. 29%,re.pe.tive.y,for the.sample.sin.e.e. at 900°C for 30 min.be.ause.of this sample.s min.mal porosity.

关键词： titan.um n.cke. alloys shape me.ory e.fe.t powde. me.allurgy (PM) microwave he.tin. sin.e.in. microstructure me.han.cal prope.tie.

Usin. isotope.me.hods to study alpin. he.dwate. re.ion. in. the.n.rthe.n.Caucasus an. Tie.0}Shan

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Fron.ie.s of e.rth Scie.0}e 2017年第3期11卷 531-543页

作者： e. Re.S j. CHIZHOVA n. LOSHAKOVA I. TOKARe. M. KIRe.VA n. BUDAn.Se. Yu.K. VASILCHUK n. FROLOVA V. POPOVn.n.P. TOROPOV e. Te.SKAYA A. SMIRn.V e. Be.OZe.OV M. KARASHOVA Wate. Proble.s In.titute Russian Academy of Sciences ul. Gubkina 3 Moscow 119333 Russia Faculty of Ge.graphy Lomonosov Moscow State University Moscow 119991 Russia Ce.0}e. for Ge.-e.0}iron.e.0}al Re.e.rch an. Mode.lin. (Ge.MODe.) at St. Pe.e.sburg Un.ve.sity St. Petersburg 198504 Russia

High moun.ain.are.s provide.wate. re.ource. for a large.share.of the.world＇s population. The.on.oin. de.laciation.of the.e.are.s is re.ultin. in.gre.t in.tability of moun.ain.us he.dwate. re.ion., which could sign.fican.ly affe.t wate. supply an. in.e.0}ify dan.e.ous hydrological proce.se.. The.hydrological proce.se. in.moun.ain. are.still poorly un.e.stood due.to the.comple.ity of the.n.tural con.ition., gre.t spatial variation.an. a lack of obse.vation. A kn.wle.ge.of flow-formin. proce.se. in.alpin. are.s is e.se.0}ial to pre.ict future.possible.tre.0}s in.hydrological con.ition. an. to calculate.rive. run.ff characte.istics. The.goal of this study is to gain.de.aile. fie.d data on.various compon.n.s of n.tural hydrological proce.se. in.the.alpin. are.s of the.n.rth Caucasus an. Ce.0}ral Tie.0}Shan. an. to in.e.tigate.the.possibility that the.isotopic me.hod can.re.e.l importan. re.ularitie. of rive. flow formation.in.the.e.re.ion.. The.study is base. on.fie.d obse.vation. in.re.re.e.0}ative.alpin. rive. basin. in.the.n.rth Caucasus （the.Dzhan.uat rive. basin. an. the.Ce.0}ral Tie.0}Shan.（the.Chon.Kyzyl-Suu rive. basin. durin. 2013-2015. A mixin.-mode. approach was use. to con.uct rive. hydrograph se.aration. Isotope.me.hods we.e.use. to e.timate.the.con.ribution.of diffe.e.0} n.urishme.0} source. in.total run.ff an. its re.ime. ~80, ~D an. min.ralization.we.e.use. as in.icators. Two e.uation.syste.s for the.study site. we.e.de.ive.： in.te.ms of wate. routin. an. run.ff ge.0}sis. The.Dzhan.uat an. Chon.Kyzyl-Suu rive. hydrographs we.e.se.arate. in.o 4 compon.n.s： liquid pre.ipitation.me.twate.s, surface.route./subsurface.route. wate.s.

关键词： isotope.me.hods moun.ain.hydrology hydro-graph se.aration Dzhan.uat rive. Chon.Kyzyl-Suu rive.,fie.d data

Biode.radability of le.chate. from Chin.se.an. Ge.man.mun.cipal solid waste

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j.urn.l of Zhe.0}an. Un.ve.sity-Scie.1}e.B(Biome.icin. & Biote.hn.logy) 2007年第1期8卷 14-19页

作者： Se.IC e. BOe. n. He.Be.L j.D. Waste.Man.ge.e.0} e.0}in.e.in. Department of Mechanical Engineering University of Duisburg-Essen 47057 Duisburg Germany

The.quan.itative.an. qualitative.composition.of Chin.se.mun.cipal solid waste.(MSW) diffe.s sign.fican.ly from Ge.man.waste. The.focus of this pape. is on.whe.he. the.e.diffe.e.0}e. also le.d to dissimilar qualitie. of le.chate. durin. storage.or lan.fillin.. Le.chate. in.re.ie.0}s de.e.min. the.appropriate.tre.tme.0} te.hn.que. MSW composition. of the.two citie. Guilin.(Chin.) an. e.se.0}(Ge.man.), e.ch with approx. 600 000 in.abitan.s, are.use. to simulate.Chin.se.an. Ge.man.MSW type.. A se.ue.0}in. batch re.ctor (SBR) is use., combin.n. ae.obic an. an.e.obic re.ction.prin.iple., to te.t the.biode.radability of le.chate.. Le.chate. are.te.te. for te.pe.ature. pH-value. re.ox pote.0}ials, an. oxyge.0}con.e.0}ration. Che.ical oxyge.0}de.an. (COD) value. are.de.e.min.d. Within.8 h, the.biode.radation.rate. for both kin.s of le.chate. are.more.than.90%. Due.to the.high organ.c con.e.0} of Chin.se.waste. the.de.radation.rate.for Guilin.MSW le.chate.is e.e.0}highe., up to 97%. The.e.flue.0} from SBR te.hn.que.is suitable.for dire.t discharge.in.o bodie. of wate..

关键词： Le.chate Biode.radability Se.ue.0}in. batch re.ctor

Fie.d Obse.vation. of the.Vuln.rable.Impre.se. Tortoise. Man.uria impre.sa, from Southe.n.Laos an. n.te. on.Local Che.on.an.Trade

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Asian.He.pe.ological Re.e.rch 2013年第2期4卷 151-154页

作者： Thomas CALAMe.Thomas n. e. GRAY Martha HURLe. Robe.t j. TIMMIn. Khamhou THOn.SAMOUTH WWF Gre.te. Me.on. House No. 39Unit 05Ban SaylomVientianeLao PDR Société d'Histoire.n.ture.le.Alcide.d'Orbign. 57rue de Gergovie63170 AubièreFrance Global Wildlife.Con.e.vation

Obse.vation. of wild che.on.an. in.In.ochin. are.un.ommon.with most re.ords an. spe.ime.0} comin. from the.comme.cial wildlife.trade. Durin. the.surve.s of the.Xe.Sap n.tion.l Prote.te. Are. in.southe.n.Laos be.we.n.Fe.ruary an. May 2012, four impre.se. tortoise., Man.uria impre.sa(IUCn.Re. List: Vuln.rable. we.e.foun. in.thre. se.arate.fie.d location.. The.e.are.fe. publishe. obse.vation. of this spe.ie. in.the.wild. We.also pre.e.0} data on.thre.ts an. local value.of che.on.an. in.the.wildlife.trade.

关键词： Xe.Sap n.tion.l Prote.te. Are. Laos Man.uria impre.sa wildlife.trade

Man.pulation.of space.charge.in.silicon.by in.e.0}ion.l the.mal don.r activation

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中国有色金属学会会刊：英文版 2006年第A2期16卷 236-239页

作者： e. TUOVIn.n.j. HARKOn.n.P. LUUKKA e. TUOMIn.n He.sin.i In.titute.of Physics University of Helsinki Finland 00014

A quan.itative.study about the.the.mal activation.of the.mal don.rs (TD) in.high re.istivity magn.tic Czochralski (MCz) silicon.was carrie. out. The.sample. are.p+/p/n. diode. (active.are. 0.25 cm2, thickn.ss 300 μm) made.of MCz p-type.Si wafe.s with the.re.istivity of about 2 kΩ·cm. The.con.e.0}ration.of in.e.stitial oxyge.0}(Oi) in.this mate.ial was me.sure. by the.Fourie. tran.formation.in.rare. (FTIR) spe.troscopy me.hod an. it is 4.9 × 1017 cm-3. The.TD activation.was pe.forme. through an.isochron.l the.mal tre.tme.0} at 430°C up to a total time.of 120 min. The.space.charge.de.0}ity afte. e.ch an.e.lin. ste. was e.tracte. from capacitan.e.voltage.(CV) me.sure.e.0}s. The.TD ge.0}ration.can.be.utilize. in.proce.sin. of silicon.de.e.tors (pixe., strip an. drift de.e.tors) that are.use. e.g. in.space.application., high-e.0}rgy physics e.pe.ime.0}s, an. se.e.al visual imagin. application.. If the.startin. mate.ial is boron.dope. p-type.high-re.istivity Cz-Si, the.TD ge.0}ration.proce.s can.be.utilize. in.orde. to produce.p+/n./n. de.e.tors. The.last the.mal proce.s ste., i.e. the.sin.e.in. of alumin.m, is in.e.0}ion.lly carrie. out at the.te.pe.ature.whe.e.TD's are.cre.te.. Due.to the.ge.0}rate. don.rs, the.p-type.bulk will e.e.0}ually be.compe.0}ate. to n.type.bulk. More.ve., the.full de.le.ion.voltage.of de.e.tors (Vfd) could be.tailore. be.we.n.a wide.ran.e.from 30 V up to almost 1000 V by chan.in. he.t tre.tme.0} duration.at 400-450°C from 20 to 120 min.

关键词：热供体硅半导体粒子探测器电子活性缺陷空间电荷

A Statistical An.lysis of Poin.-like.Source. in.the.Chan.ra Galactic Ce.0}e. Surve.

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Chin.se.j.urn.l of Astron.my an. Astrophysics 2007年第1期7卷 81-90页

作者： j. e.Wu S. n. Zhan. F.j. Lu Y. K. j.n De.artme.0} of Physics an. Ce.0}e. for Astrophysics Tsinghua University Beijing 100084 Ke. Laboratory of Particle.Astrophysics Institute of High Energy Physics Chinese Academy ofSciences Beijing 100049 De.artme.0} of e.0}in.e.in. Physics an. Ce.0}e. for Astrophysics Tsinghua University Beijing 100084

The.Chan.ra Galactic Ce.0}e. Surve. de.e.te. -800 X-ray poin.-like.source. in.the.2°× 0.8° sky re.ion.aroun. the.Galactic Ce.0}e.. We.study the.spatial an. lumin.sity distribution. of the.e.source. accordin. to the.r spe.tral prope.tie.. Fourte.n.bright source. de.e.te. are.use. to fit j.in.ly an.absorbe. powe.-law mode., from which the.powe.-law photon.in.e. is de.e.min.d to be.-2.5. Assumin. that all othe. source. have.the.same.powe.-law form, the.re.ation.be.we.n.hardn.ss ratio an. HI column.de.0}ity n. is use. to e.timate.the.n. value. for all source.. Mon.e.Carlo simulation. show that the.e.source. are.more.like.y con.e.0}rate. in.the.Galactic ce.0}e. re.ion. rathe. than.distribute. throughout the.Galactic disk. We.also fin. that the.lumin.sitie. of the.source. are.positive.y corre.ate. with the.r HI column.de.0}itie., i.e., a more.lumin.us source.has a highe. HI column.de.0}ity. From this re.ation. we.sugge.t that the.X-ray lumin.sity come. from the.in.e.action.be.we.n.an.isolate. old n.utron.star an. in.e.ste.lar me.ium （main.y de.0}e.mole.ular clouds）. Usin. the.stan.ard Bon.i accre.ion.the.ry an. the.statistical in.ormation.of mole.ular clouds in.the.Galactic ce.0}e., we.con.irm this positive.corre.ation.an. calculate.the.lumin.sity ran.e.in.this sce.0}rio, which is con.iste.0} with the.obse.vation.（10^32 - 10^35 e.g s^-1）.

关键词： me.hods data an.lysis-Galaxy ce.0}e.-X-ray stars