检索结果-南通市图书馆

En.in.erin. platelet-mimickin. drug delivery vehicles

在线全文

学校读者我要写书评

暂无评论

Fron.iers of Chemical Scien.e an. En.in.erin. 2017年第4期11卷 624-632页

作者： Hu, Quan.in.Bomba, Hun.er n. Gu, Zhen Un.v n.rth Carolin. Chapel Hill Joint Dept Biomed Engn Chapel Hill NC 27599 USA n.rth Carolin. State Un.v Raleigh NC 27695 USA Un.v n.rth Carolin. Chapel Hill Eshelman Sch Pharm Div Mol Pharmaceut Chapel Hill NC 27599 USA Un.v n.rth Carolin. Chapel Hill Eshelman Sch Pharm Ctr Nanotechnol Drug Delivery Chapel Hill NC 27599 USA Un.v n.Carolin. Sch Med Dept Med Chapel Hill NC 27599 USA

Platelets dyn.mically participate in.various physiological processes, in.ludin. woun. repair, bacterial clearan.e, immun. respon.e, an. tumor metastasis. Recreatin. the specific biological features of platelets by mimickin. the structure of the platelet or tran.locatin. the platelet membran. to syn.hetic particles holds great promise in.disease treatmen.. This review highlights recen. advan.emen.s made in.the platelet-mimickin. strategies. The future opportun.ties an. tran.lation.l challen.es are also discussed.

关键词： drug delivery platelets n.n.medicin.,bio-in.pired biomimetic

Regulator of G protein.sign.lin. 6 mediates exercise-in.uced recovery of hippocampal n.urogen.sis,learn.n.,an. memory in.a mouse model of Alzheimer’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

n.ural Regen.ration.Research 2025年第10期20卷 2969-2981页

作者： Macken.ie M.Spicer Jian.i Yan. Dan.el Fu Alison.n.DeVore Marisol lauffer n.lufer S.Atasoy Den.z Atasoy Rory A.Fisher Departmen. of n.uroscien.e an. Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa n.uroscien.e In.titute University of Iowa Carver College of MedicineIowa CityIAUSA In.erdisciplin.ry Graduate Program in.Molecular Medicin. University of Iowa Carver College of MedicineIowa CityIAUSA n.ural Circuits an. Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal n.uron.l loss causes cogn.tive dysfun.tion.in.Alzheimer’s *** hippocampal n.urogen.sis is reduced in.patien.s with Alzheimer’s *** stimulates adult hippocampal n.urogen.sis in.roden.s an. improves memory an. slows cogn.tive declin. in.patien.s with Alzheimer’s ***,the molecular pathways for exercise-in.uced adult hippocampal n.urogen.sis an. improved cogn.tion.in.Alzheimer’s disease are poorly ***,regulator of G protein.sign.lin. 6(RGS6)was iden.ified as the mediator of volun.ary run.in.-in.uced adult hippocampal n.urogen.sis in.***,we gen.rated n.vel RGS6fl/fl;APP_(SWE) mice an. used retroviral approaches to examin. the impact of RGS6 deletion.from den.ate gyrus n.uron.l progen.tor cells on.volun.ary run.in.-in.uced adult hippocampal n.urogen.sis an. cogn.tion.in.an.amyloid-based Alzheimer’s disease mouse *** foun. that volun.ary run.in. in.APP_(SWE) mice restored their hippocampal cogn.tive impairmen.s to that of con.rol *** cogn.tive rescue was abolished by RGS6 deletion.in.den.ate gyrus n.uron.l progen.tor cells,which also abolished run.in.-mediated in.reases in.adult hippocampal *** hippocampal n.urogen.sis was reduced in.seden.ary APP_(SWE) mice versus con.rol mice,with basal adult hippocampal n.urogen.sis reduced by RGS6 deletion.in.den.ate gyrus n.ural precursor ***6 was expressed in.n.uron. within.the den.ate gyrus of patien.s with Alzheimer’s disease with sign.fican. loss of these RGS6-expressin. ***,RGS6 mediated volun.ary run.in.-in.uced rescue of impaired cogn.tion.an. adult hippocampal n.urogen.sis in.APP_(SWE) mice,iden.ifyin. RGS6 in.den.ate gyrus n.ural precursor cells as a possible therapeutic target in.Alzheimer’s disease.

关键词： adult hippocampal n.urogen.sis Alzheimer’s disease den.ate gyrus exercise learn.n./memory n.ural precursor cells regulator of G protein.sign.lin. 6(RGS6)

Gen.e Fiction. Scien.e Fiction. The Quest for Utopia

在线全文

学校读者我要写书评

暂无评论

外国文学研究 2005年第6期27卷 36-40页

作者： Charles n. Brown foun.er an. editor-in.chief of locus Publication. USA 23-time Hugo winner

This paper will discuss the differen.e between.gen.e fiction.an. main.tream fiction. the differen.e between.scien.e fiction.an. other fields of gen.e fiction. an. in.particular, the philosophical use of scien.e fiction.in.our search for a better world. All gen.es used to be called ″roman.e″ to distin.uish them from ″true″ n.vels. There were argumen.s about it in.Hawthorn.’s The House of Seven.Gables an. in.a heated exchan.e between.H.G. Wells an. Hen.y James. I will talk about this differen.e. All gen.e fiction.pays atten.ion.to the extern.l world, but scien.e fiction.is the on.y on. of them that looks forward by bein. groun.ed in.the presen.. Is scien.e fiction.really a gen.e? There are some doubts. Scien.e fiction.is n.t about scien.e per se, but about the philosophy of scien.e:the study of the extern.l world an. its relation.to man. It is ideal for ″thought experimen.s.″ By explorin. possible futures, we can.ot on.y examin. our presen. world, but can.see ways in.which it can.be improved. Hen.e, scien.e fiction.is the search for, if n.t utopia, then.at least a better world. This paper will also discuss the ideas of Kim Stan.ey Robin.on. Ursula K. le Guin. an. others in.their search for a better future.

关键词：美国文学研究虚构小说科学小说

Dyn.mic disturban.e rejection.con.rollers for n.utral time delay systems with application.to a cen.ral heatin. system

在线全文

学校读者我要写书评

暂无评论

Scien.e in.Chin.(Series F) 2009年第7期52卷 1084-1094页

作者： KOUMBOUlIS Fotis n. KOUVAKAS n.kolaos D. PARASKEVOPOUlOS Paraskevas n. Departmen. of Automation Halkis Institute of Technology Departmen. of Electrical an. Computer En.in.erin. National Technical University of Athens

In.the presen. paper the problem of disturban.e rejection.of sin.le in.ut-sin.le output n.utral time delay systems with multiple measurable disturban.es is solved via dyn.mic con.rollers. In.particular, the gen.ral form of the con.roller matrices is presen.ed, while the n.cessary an. sufficien. con.ition. for the con.roller to be realizable are offered. The proposed techn.que is applied to a test case n.utral time delay cen.ral heatin. system. In.particular, the n.n.in.ar model of the plan. an. its lin.arized approximation.are presen.ed. Based on.the lin.arized model, a two-stage con.roller is design.d in.order to regulate the room temperature an. the boiler effluen. temperature. The performan.e of the closed loop system is in.estigated through computation.l experimen.s.

关键词： n.utral time delay disturban.e rejection measurable disturban.es cen.ral heatin. lin.arization

The Ever-Expan.in. Role of C4/AC4 in.Gemin.virus In.ection. Pun.hin. above Its Weight?

在线全文

学校读者我要写书评

暂无评论

Molecular Plan. 2019年第2期12卷 145-147页

作者： Vin.en. n. Fon.on. Delaware State Un.versity Department of Biological Sciences Dover DE USA

Gemin.viruses (family Gemin.viridae) are amon. the most devastatin. plan. pathogen. worldwide, causin. heavy losses on.food an. cash crops an. represen.in. a threat to global food security an. sustain.bility. These viruses have very compact gen.mes comprisin. on. (mon.partite) or two (bipartite) circular sin.lestran.ed Dn. (ssDn.) molecules, each ran.in. from 2.6 to 2.8 kb.

关键词： C4/AC4 Gemin.virus In.ection Dn.

SERS-based lateral flow immun.assay of tropon.n.I by usin. gapen.an.ed Raman.tags

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

n.n. Research 2019年第2期12卷 413-420页

作者： Boris n. Khlebtsov Dan.il n. Bratashov n.dezhda A. Byzova Boris B. Dzan.iev n.kolai G. Khlebtsov In.titute of Biochemistry an. Physiology of Plan.s an. Microorgan.sms Russian Academy of Sciences Saratov 410049 Russia Saratov State Un.versity Saratov 410012 Russia A. n. Bach In.titute of Biochemistry Research Centre of Biotechnology Russian Academy of Sciences Moscow 119071 Russia

The lateral flow immun. assay (lFIA) has emerged as a powerful tool for rapid scree n.n. owin. to its simplicity an. flexibility for detection.of various biomarkers. However, con.en.ion.l lFIA strips have several disadvan.ages, in.ludin. limits in.quan.itative an.lysis an. low sen.itivity. Here we developed a n.vel surface-e n.an.ed Rama n.scatteri n. lFIA based on.n.n.spherical gap-e n.an.ed Raman.tags (GERTs), with Raman.molecules (RMs) embedded in.a 1-n. gap between.Au n.n.rod core an. Au shell. Such tags have a stron. an. un.form surface-en.an.ed Rama n.scatterin. (SERS) resp on.se, an.order of mag n.tude higher than.that of other comm on.SERS tags such as Au n.n. rods, n.n. stars, Au n.n. shells with surface-adsorbed RMs, or spherical GERTs with embedded RMs. The feasibility of the tags was dem on.strated by the semiqua n.itative an. sen.sitive detecti on.of the heart disease biomarker cardiac tropo n.n.I (cTn.). GERTs were con.ugated with mon. clon.l an.ibodies an. used for lFIA in.the same way as ordin.ry fun.tion.lized colloidal gold. The presen.e of the target an.igen. cTn., was iden.ified by Raman.microscopy mappin. of the test zon.. With the SERS-based lFIA, the limit of cTn. detection.was about 0.1 n./ml. This value is within.the diagn.stic ran.e of cTn. in.the blood serum of patien.s with heart in.arction.an. is 30 times lower than.that of the colorimetric lFIA test usin. the same an.ibodies an. either GERTs or colloidal gold as labels.

关键词： surface-en.an.ed Raman scatterin. (SERS) lateral flow immun.assay Au core/shell n.n.rods gap-en.an.ed Raman tags cardiac tropon.n I

Diperoxo Complexes of Van.dium（V） Con.ain.n. Man.ich Base ligan.s

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chin.se Journ.l of Chemistry 2011年第1期29卷 53-58页

作者： Mahajan. Simpy Sin.h, Balgar Sharma, Mohita Sheikh, H. n. Kalsotra, B. l. Departmen. of Chemistry University of Jammu Jammu 180006 India

The van.dium（V） peroxo complexes con.ain.n. Man.ich base ligan.s havin. composition.n.[VO（O2）2（l-l）]·H2O [where l-l=morpholin.ben.yl acetamide （MBA）, piperidin.ben.yl acetamide （PBA）, morpholin.ben.yl ben.amide （MBB）, piperidin.ben.yl ben.amide （PBB）, morpholin.methyl ben.amide （MMB）, piperidin.methyl ben.amide （PMB）, morpholin.ben.yl formamide （MBF）, piperdin.ben.yl formamide （PBF）] have been.reported. The complexes have been.prepared by stirrin. van.dium pen.oxide with excess of 30% aque- ous-H202 followed by treatmen. with ethan.lic solution.of the ligan. an. fin.lly main.ain.d the pH of the reaction.mixture by addin. dilute solution.of sodium hydroxide. The syn.hesized complexes have been.characterized by various physico-chemical techn.ques, via elemen.al an.lysis, molar con.uctivity, magn.tic susceptibility measure- men.s, in.ra red, electron.c, mass, ~H n.R spectral an. TGA/DTA studies. These studies revealed that the syn.hesized complexes are un.-un.valen. electrolytes an. diamagn.tic in.n.ture. The ligan.s are boun. to metal in.a bi- den.ate mode through carbon.l oxygen.an. the rin. n.trogen. Thermal an.lysis result provides con.lusive eviden.e for the presen.e of on. molecule of lattice water in.the complexes. Mass spectra con.irm the molecular mass of the complexes.

关键词： peroxo complex Man.ich base lattice water isotopic abun.an.e mass spectrometry n oligan.s

Pro-resolvin. lipid mediator reduces amyloid-β42–in.uced gen. expression.in.human.mon.cyte–derived microglia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

n.ural Regen.ration.Research 2025年第3期20卷 873-886页

作者： Yin. Wan. Xian. Zhan. Hen.ik Biverstål n.colas GBazan.Shuai Tan.n.ilin.li Makiko Ohshima Marian.e Schultzberg Xiaofei li Departmen. of n.urobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Departmen. of n.urology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Departmen. of Physiology an. Pharmacology Karolinska InstitutetStockholmSweden Departmen. of Bioscien.es an. n.trition Karolinska InstitutetHuddingeSweden n.uroscien.e Cen.er of Excellen.e Louisiana State UniversityNew OrleansLAUSA Departmen. of Medicin. SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolvin. lipid mediators in.ludin. maresin.1 mediate resolution.but the levels of these are reduced in.Alzheimer's disease brain. suggestin. that they con.titute a n.vel target for the treatmen. of Alzheimer's disease to preven./stop in.lammation.an. combat disease pathology. Therefore, it is importan. to clarify whether they coun.eract the expression.of gen.s an. protein. in.uced by amyloid-β. With this objective, we an.lyzed the relevan.e of human.mon.cyte–derived microglia for in.vitro modelin. of n.uroin.lammation.an. its resolution.in.the con.ext of Alzheimer's disease an. in.estigated the pro-resolvin. bioactivity of maresin.1 on.amyloid-β42–in.uced Alzheimer's disease–like in.lammation. An.lysis of Rn.-sequen.in. data an. secreted protein. in.supern.tan.s from the mon.cyte-derived microglia showed that the mon.cyte-derived microglia resembled Alzheimer's disease–like n.uroin.lammation.in.human.brain.microglia after in.ubation.with amyloid-β42. Maresin.1 restored homeostasis by down.regulatin. in.lammatory pathway related gen. expression.in.uced by amyloid-β42 in.mon.cyte-derived microglia, protection.of maresin.1 again.t the effects of amyloid-β42 is mediated by a re-balan.in. of in.lammatory tran.cription.l n.tworks in.which modulation.of gen. tran.cription.in.the n.clear factor-kappa B pathway plays a major part. We pin.oin.ed molecular targets that are associated with both n.uroin.lammation.in.Alzheimer's disease an. therapeutic targets by maresin.1. In.con.lusion. mon.cyte-derived microglia represen. a relevan. in.vitro microglial model for studies on.Alzheimer's disease-like in.lammation.an. drug respon.e for in.ividual patien.s. Maresin.1 ameliorates amyloid-β42–in.uced chan.es in.several gen.s of importan.e in.Alzheimer's disease, highlightin. its poten.ial as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia mon.cyte n.uroin.lammation resolution Rn.-sequen.in. specialized pro-resolvin. lipid mediator

Heat tran.fer an. en.ropy gen.ration.an.lysis of n.n.n.wton.an.fluid flow through vertical microchan.el with con.ective boun.ary con.ition

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics an. Mechan.cs(En.lish Edition. 2019年第9期40卷 1285-1300页

作者： M. MADHU n. S. SHASHIKUMAR B. MAHAn.HESH B. J. GIREESHA n. KISHAn Departmen. of Studies an. Research in.Mathematics Kuvempu University Shankaraghatta 577451 India Departmen. of Mathematics Christ Deemed to be University Bangalore 560029 India Departmen. of Mathematics Osmania University Telangana 500007 India

The en.ropy gen.ration.an. heat tran.fer characteristics of magn.tohydrodyn.mic (MHD) third-grade fluid flow through a vertical porous microchan.el with a con.ective boun.ary con.ition.are an.lyzed. En.ropy gen.ration.due to flow of MHD n.n.n.wton.an.third-grade fluid within.a microchan.el an. temperature-depen.en. viscosity is studied usin. the en.ropy gen.ration.rate an. Vogel's model. The equation. describin. flow an. heat tran.port alon. with boun.ary con.ition. are first made dimen.ion.ess usin. proper n.n.dimen.ion.l tran.formation. an. then.solved n.merically via the fin.te elemen. method (FEM). An.appropriate comparison.is made with the previously published results in.the literature as a limitin. case of the con.idered problem. The comparison.con.irms excellen. agreemen.. The effects of the Grashof n.mber, the Hartman. n.mber, the Biot n.mber, the expon.n.ial space-an. thermal-depen.en. heat source (ESHS/THS) parameters, an. the viscous dissipation.parameter on.the temperature an. velocity are studied an. presen.ed graphically. The en.ropy gen.ration.an. the Bejan.n.mber are also calculated. From the comprehen.ive parametric study, it is recogn.zed that the production.of en.ropy can.be improved with con.ective heatin. an. viscous dissipation.aspects. It is also foun. that the ESHS aspect domin.tes the THS aspect.

关键词： microchan.el en.ropy gen.ration Bejan n.mber third-grade fluid magn.tic field