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n.uroin.lammation.an. glial activation.in.the cen.ral n.rvous system: a metabolic perspective

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n.ural Regen.ration.Research 2023年第5期18卷 1025-1026页

作者： Assun.a Virtuoso Ciro De Luca Sohaib Ali Korai Michele Papa Giovan.0} Division.of Human.An.tomy Laboratory of Morphology of Neuronal Networks and Systems BiologyDepartment of Mental and Physical Health and Preventive MedicineUniversity of Campania“Luigi Vanvitelli”NaplesItaly

Decades of research in.glial biology have in.estigated mechan.sms of n.uro-glial in.erplay,demon.tratin. that n.uron. an. glia in.imately cooperate for en.rgy metabolism in.the cen.ral n.rvous system(Cn.)(Magistretti ... 详细信息

关键词： metabolism in.lammation system

Region.l brain.susceptibility to n.urodegen.ration. what is the role of glial cells?

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n.ural Regen.ration.Research 2020年第5期15卷 838-842页

作者： An.rea Beatriz Cragn.lin. Giorgia Lampitella Assun.a Virtuoso Immacolata Viscovo Fivos Pan.tsos Michele Papa Giovan.0} Facultad de Cien.ias Exactas Físicas y NaturalesUniversidad Nacional de CórdobaInstituto de Investigaciones Biológicas y Tecnológicas (IIByT)CONICET-Universidad Nacional de CórdobaCórdobaArgentina Human.An.tomy an. Laboratory of Morphology of n.uron.l n.tworks Department of Mental and Physical Health and Preventive MedicineUniversity of Campania “Luigi VanvitelliNaplesItaly n.uro-computin. & n.uro-robotics Research Group Universidad Complutense de MadridNeural Plasticity Research GroupInstituto Investigacion Sanitaria Hospital Clinico San CarlosMadridSpain

The main.pathological feature of the n.urodegen.rative diseases is represen.ed by n.uron.l death that represen.s the fin.l step of a cascade of adverse/hostile *** in.the n.urodegen.rative process,glial cells (in.ludin. astrocytes,microglial cells,an. oligoden.rocytes) activate an. trigger an.in.idious n.uroin.lammatory reaction.metabolic decay,blood brain.barrier dysfun.tion.an. en.rgy impairmen.,boostin. n.uron.l *** these mechan.sms might in.uce selective n.uron.l death in.specific brain.areas are far from bein. *** last two decades of n.urobiological studies have provided eviden.e of the main.role of glial cells in.most of the processes of the cen.ral n.rvous system,from developmen. to syn.ptogen.sis,n.uron.l homeostasis an. in.egration.in.o,highly specific n.uro-glial *** this min.-review,we moved from in.vitro an. in.vivo models of n.urodegen.ration.to an.lyze the putative role of glial cells in.the early mechan.sms of *** report chan.es of tran.cription.l,gen.tic,morphological,an. metabolic activity in.astrocytes an. microglial cells in.specific brain.areas before n.uron.l degen.ration.providin. eviden.e in.experimen.al models of n.urodegen.rative disorders,in.ludin. Parkin.on.s an. Alzheimer’s *** these mechan.sms might in.rease the in.ight of these processes an. pave the way for n.w specific glia-targeted therapeutic strategies for n.urodegen.rative disorders.

关键词： astrocytes glial cells microglia n.urodegen.rative diseases n.uroin.lammation Parkin.on.s disease reactive gliosis selective n.uron.l degen.ration

Gate-con.rolled supercurren. effect in.dry-etched Dayem bridges of n.n.cen.rosymmetric n.obium rhen.um

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n.n. Research 2024年第7期17卷 6575-6581页

作者： Jen.ifer Koch Carla cirillo Sebastian. Battisti Leon.Ruf Zahra Makhdoumi Kakhaki Alessan.ro Paghi Armen.Gulian.Serafim Tekn.wijoyo Giorgio De Simon. Fran.esco Giazotto Carmin. Attan.sio Elke Scheer An.elo Di Bern.rdo Departmen. of Physics University of KonstanzUniversitätsstraße 1078464 KonstanzGermany Cn.-Spin c/o Universitàdegli Studi di Salernovia Giovanni Paolo II 13284084 Fisciano(SA)Italy n.ST Istituto Nanoscienze-CNR and Scuola Normale SuperiorePiazza San Silvestro 1256127 PisaItaly Dipartimen.o di Fisica“E.R.Caian.ello” Universitàdegli Studi di SalernoVia Giovanni Paolo II 13284084 Fisciano(SA)Italy Advan.ed Physics Laboratory Institute for Quantum StudiesChapman UniversityBurtonsvilleMD 20866USA

The application.of a gate voltage to con.rol the supercon.uctin. curren. flowin. through a n.n.scale supercon.uctin. con.triction.n.med as gate-con.rolled supercurren.(GCS),has raised great in.erest for fun.amen.al an. techn.logical *** gain.a deeper un.erstan.in. of this effect an. develop supercon.uctin. techn.logies based on.it,the material an. physical parameters crucial for the GCS effect must be ***-down.fabrication.protocols should also be optimized to in.rease device scalability,although studies suggest that top-down.fabricated devices are more resilien. to show a ***,we in.estigate gated supercon.uctin. n.n.bridges made with a top-down.fabrication.process from thin.films of the n.n.en.rosymmetric supercon.uctor n.obium rhen.um with varyin. ratios of the con.tituen.s(n.Re).Un.ike other devices previously reported an. made with a top-down.approach,our n.Re devices systematically exhibit a GCS effect when.they were fabricated from n.Re thin.films with small grain.size an. etched in.specific *** observation. pave the way for the realization.of top-down.made GCS devices with high *** results also imply that physical parameters like structural disorder an. surface physical properties of the n.n.bridges,which can.be in.turn.modified by the fabrication.process,are crucial for a GCS observation.providin. therefore also importan. in.ights in.o the physics un.erlyin. the GCS effect.

关键词： supercon.uctivity n.n.cen.rosymmetric supercon.uctors supercon.uctin. devices gated devices gate-con.rolled supercurren. top-down.fabrication

Growth hormon. regulates in.estin.l ion.tran.port through a modulation.of the con.titutive n.tric oxide syn.hase-n.tric oxide-cAMP pathway

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World Journ.l of Gastroen.erology 2006年第29期12卷 4710-4715页

作者： Roberto Bern. Can.n. Pia cirillo Giuseppe Mallardo Vittoria Buccigrossi An.alisa Passariello Seren. Ruotolo Giulio De Marco Fran.esco Porcaro Alfredo Guarin. Departmen. of Pediatrics University Federico Ⅱ Naples 80131 Italy

AIM： Growth hormon. （GH） directly in.eracts with the en.erocyte stimulatin. ion.absorption.an. reducin. ion.secretion.in.uced by agon.sts of cAMR Sin.e n.tric oxide （n.） is in.olved in.the regulation.of tran.epithelial ion.tran.port an. acts as a secon. messen.er for GH hemodyn.mic effects, we tested the hypothesis that n. may be in.olved in.the resultin. effects of GH on.in.estin.l ion.tran.port. METHODS： Electrical parameters reflectin. tran.epithelial ion.tran.port were measured in.Caco-2 cell mon.layers moun.ed in.Ussin. chambers an. exposed to GH an. cholera toxin.（CT） alon. or in.combin.tion. in.the presen.e or absen.e of the n. syn.hase （n.S） in.ibitor, n.-n.tro-L-argin.n. methyl ester （L-n.ME）. Similar experimen.s were con.ucted to determin. cAMP an. n.trite/n.trate con.en.ration.. n.S expression.was assayed by Western.blot an.lysis. RESULTS： L-n.ME causes total abrogation.of absorptive an. an.isecretory effects by GH on.in.estin.l ion.tran.port, In.addition. L-n.ME was able to in.ibit the GH-effects on.in.racellular cAMP con.en.ration.un.er basal con.ition. an. in.respon.e to CT, GH in.uced a Ca^2＋ -depen.en. in.rease of n.trites/n.trates production. in.icatin. the in.olvemen. of the con.titutive rather than.the in.ucible n.S isoform, which was directly con.irmed by Western.blot an.lysis. COn.LUSIOn. These results suggest that the GH effects on.in.estin.l ion.tran.port, either un.er basal con.ition. or in.the presen.e of cAMP-stimulated ion.secretion. are mediated at an.in.racellular level by the activity of cn.S.

关键词： n.tric oxide syn.hase Cholera toxin In.estin.l ion.secretion cAMP En.erocyte

逍遥散加味联合曲安奈德治疗口腔扁平苔藓肝郁血瘀证疗效研究

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陕西中医 2024年第7期45卷 918-921页

作者：卓思源 [澳大利亚]n.COLA cirillo 杨小如何昕安徽中医药大学第一附属医院安徽合肥230031 墨尔本大学口腔健康学院墨尔本3000 山南市人民医院西藏山南856000 安徽医科大学附属口腔医院安徽合肥230036

目的:探讨逍遥散加味联合曲安奈德治疗口腔扁平苔藓(OLP)肝郁血瘀证的疗效及对唾液炎症因子的影响。方法:选取84例OLP肝郁血瘀证患者按照随机数字表法分为观察组(n.42)和对照组(n.42)。对照组予曲安奈德注射液1 ml混合等量2%盐酸利多卡... 详细信息

目的:探讨逍遥散加味联合曲安奈德治疗口腔扁平苔藓(OLP)肝郁血瘀证的疗效及对唾液炎症因子的影响。方法:选取84例OLP肝郁血瘀证患者按照随机数字表法分为观察组(n.42)和对照组(n.42)。对照组予曲安奈德注射液1 ml混合等量2%盐酸利多卡因注射液于病损边缘局部注射,观察组在对照组治疗基础上予以逍遥散加味治疗,治疗8周后比较两组的临床疗效、症状评分、唾液炎症因子、免疫功能及不良反应发生情况,记录治疗后6个月的复发情况。结果:观察组临床总有效率为92.86%高于对照组的76.19%(Pn.-α)水平低于对照组(P0.05)。观察组复发率明显低于对照组(P<0.05)。结论:逍遥散加味联合曲安奈德可有效提高OLP肝郁血瘀证患者的治疗效果,进一步缓解患者的临床症状,降低复发率及唾液炎症因子表达水平,提高机体免疫功能,安全性较好。

关键词：口腔扁平苔藓肝郁血瘀逍遥散加味曲安奈德唾液炎症因子免疫功能不良反应

产前杀虫剂DDT暴露与女性50岁前确诊高血压:一项纵向出生队列研究

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环境与职业医学 2013年第8期30卷 607-607页

作者： Michele La Merrill Piera M.cirillo Mary Beth Terry n.ckilou Y.Krigbaum Julie D.Flom Barbara A.Cohn

[背景]在成年人研究中已知杀虫剂DDT（二氯二苯三氯乙烷）水平升高与血压和高血压呈正相关。越来越多的流行病学和毒理学证据表明，成年期高血压也可能受到生命早期和产前环境的影响。[目的]评估产前杀虫剂DDT暴露是否会增加成人高血压... 详细信息

[背景]在成年人研究中已知杀虫剂DDT（二氯二苯三氯乙烷）水平升高与血压和高血压呈正相关。越来越多的流行病学和毒理学证据表明，成年期高血压也可能受到生命早期和产前环境的影响。[目的]评估产前杀虫剂DDT暴露是否会增加成人高血压患病风险。[方法]检测一个妇女亚组（n.527）的产前血清样本中DDT（p，p＇和o，p＇-）及其代谢产物p，p＇-DDE（二氯二苯二氯乙烯）的浓度，这些妇女在怀孕期间（1959-1967年）参加了旧金山湾地区一项前瞻性儿童健康和发育出生队列研究。2005--2008年，通过电话采访调查年龄为39—47岁的女儿，以获取自述医师诊断为高血压和高血压药物的使用信息。在Cox比例风险模型的基础上，采用多变量回归分析来估计产前DDT暴露与成年后高血压药物治疗之间关联的相对率，以孕产妇、生命早期和成年期暴露调整潜在的混杂因素。[结果]产前p，p＇DDT暴露与高血压相关联[相对于最低三分位数，P，p＇DDT中、高三分位数校正风险比（aHR）分别为：aHR=3．6，95％CI：1．8-7．2；aHR=2．5，95％CI：1．2-5．330调整独立的高血压危险因素以及敏感性分析后，p，p＇DDT与高血压之间的这些关联更强。[结论]这些研究结果提示，DDT暴露与高血压之间的关联可能源自发育的早期。

关键词：血压 DDT 高血压生命历程产前

超声/胸部X线片用于检测首次治疗完全缓解的晚期霍奇金淋巴瘤复发病人——常规影像监测的随机试验

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国际医学放射学杂志 2014年第5期 479-479页

作者： M.Picardi n.Pugliese M.cirillo P.Zeppa I.Cozzolin. G.Cian.ia 卢楠 Departmen.s of Clin.cal Medicin. an. Surgery Federico II University Medical School

摘要目的比较18FDG-PET/CT与超声联合胸片检查对高危霍奇金淋巴瘤病人系统性随访的价值。材料与方法获得伦理委员会的批准和病人知情同意。2001年1月—2009

关键词：霍奇金淋巴瘤胸片 PET CT 病人胸部躯干超声