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The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34 ＋ stem cells in the presence of fins-like tyrosine kinase 3 ligand and thrombopoietin

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Cellular & Molecular Immunology 2012年第6期9卷 446-454页

作者： AI Proietto D Mittag AW Roberts n sprigg L Wu Molecular Immunology Division The Walter and Eliza Hall Institute of Medical Research Parkville Vic. Australia Autoimmunity and Transplantation Division The Walter and Eliza Hall Institute of Medical Research Parkville Vic. Australia Transfusion Research Australian Red Cross Blood Services West Melbourne Vic. 3003 Australia Cancer and Haematology Division The Walter and Eliza Hall Institute of Medical Research Parkville Vic. Australia Tsinghua U niversity-Peking University Joint Center for Life Sciences Tsinghua University School of Medicine Beijing China

Dendritic cells （DCs） are immune cells specialized to capture, process and present antigen to T cells in order to initiate an appropriate adaptive immune response. The study of mouse DC has revealed a heterogeneous population of cells that differ in their development, surface phenotype and function. The study of human blood and spleen has shown the presence of two subsets of conventional DC including the CDlb/c＋ and CD141＋CLEC9A＋ conventional DC （cDC） and a plasmacytoid DC （pDC） that is CD304＋CD123＋. Studies on these subpopulations have revealed phenotypic and functional differences that are similar to those described in the mouse. In this study, the three DC subsets have been generated in vitrofrom human CD34＋ precursors in the presence of fins-like tyrosine kinase 3 ligand （FIt3L） and thrombopoietin （TPO）. The DC subsets so generated, including the CDlb/c＋ and CLEC9A＋ cDCs and CD123 ＋ pDCs, were largely similar to their blood and spleen counterparts with respect to surface phenotype, toll-like receptor and transcription factor expression, capacity to stimulate T cells, cytokine secretion and cross-presentation of antigens. This system may be utilized to study aspects of DC development and function not possible in vivo.

关键词： dendritic cells fms-like tyrosine kinase 3 ligand thrombopoietin

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西方各国急性缺血性卒中后死亡率和功能性预后的显著差异:来自亭扎肝素治疗急性缺血性卒中试验(TAIST)的资料

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 57-58页

作者： Gray L.J sprigg n Bath P.M.W 刘凯 Division of Stroke Medicine University of nottingham Queen’s Medical Centre South Block nottingham nG7 2UH United Kingdom Prof.

Background: The medical care of patients with acute stroke varies considerably between countries. This could lead to measurable differences in mortality and functional outcome. Objective: To compare case mix, clinical management, and functional outcome in stroke between 11 countries. Methods: All 1484 patients from 11 countries who were enrolled into the tinzaparin in acute ischaemic stroke trial (TAIST) were included in this substudy. Information collected prospectively on demographics, risk factors, clinical features, measures of service quality (for example, admission to a stroke unit), and outcome were assessed. Outcomes were adjusted for treatment assignment, case mix, and service relative to the British Isles. Results: Differences in case mix (mostly minor) and clinical service (many of prognostic relevance) were present between the countries. Significant differences in outcome were present between the countries. When assessed by geographical region, death or dependency were lower in north America (odds ratio (OR) adjusted for treatment group only = 0.52 (95% confidence interval, 0.39 to 0.71) and north west Europe (OR = 0.54 (0.37 to 0.78)) relative to the British Isles; similar reductions were found when adjustments were made for 11 case mix variables and five service quality measures. Similarly, case fatality rates were lower in north America (OR = 0.44 (0.30 to 0.66)) and Scandinavia (OR = 0.50 (0.33 to 0.74)) relative to the British Isles, whether crude or adjusted for case mix and service quality. Conclusions: Both functional outcome and case fatality vary considerably between countries, even when adjusted for prognostic case mix variables and measures of good stroke care. Differing health care systems and the management of patients with acute stroke may contribute to these findings.

关键词：急性缺血性卒中 TAIST 肝素治疗功能性预后死亡率

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“枯木逢春”的机遇与挑战:代谢储备状态下颈动脉闭塞的处理策略

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中国卒中杂志 2018年第4期13卷 397-399页

作者：刘德志 MADDULA M sprigg n BATH P M 上海市第一人民医院神经内科不详中国卒中学会

颈动脉闭塞病变如何处理,一直以来是一个让神经内科医生感觉很棘手的问题。来自新西兰的Mohana Maddula在本综述中提出,基于血管形态学及血流动力学评估后治疗策略的制定或许能给此类患者带来更多获益。结合笔者近期遇到的一例左侧颈内... 详细信息

颈动脉闭塞病变如何处理,一直以来是一个让神经内科医生感觉很棘手的问题。来自新西兰的Mohana Maddula在本综述中提出,基于血管形态学及血流动力学评估后治疗策略的制定或许能给此类患者带来更多获益。结合笔者近期遇到的一例左侧颈内动脉次全闭塞患者,解读本综述。患者男性,65岁,因＂头晕伴记忆力下降半年＂入院。既往糖尿病史15年,高血压史10年。

关键词：颈动脉闭塞状态储备代谢血流动力学血管形态学记忆力下降闭塞病变

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育龄期妊娠和非妊娠女性的初次脑卒中发生率比较:以英国人口为基础的队列研究

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中华高血压杂志 2017年第5期25卷 467-467页

作者：刘莉叶鹏 Ban L sprigg n Abdul Sultan A nelson-Piercy C Bath PM Ludvigsson JF Stephansson O Tata LJ

与相似年龄的非妊娠女性相比，妊娠女性的脑卒中风险可能增加，但这种风险的严重程度和影响时机尚不清楚。该研究调查了育龄女性初次发生脑卒中事件的风险，并比较了在妊娠期间与产后早期与平时的风险差异。

关键词：非妊娠女性脑卒中队列研究初次发生率育龄期人口英国

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Measures of intracranial compartments in acute intracerebral haemorrhage:data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial(RIGHT-2)

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Stroke & Vascular neurology 2023年第2期8卷 151-160页

作者： Kailash Krishnan Zhe Kang Law Lisa J Woodhouse Rob A Dineen nikola sprigg Joanna M Wardlaw Philip M Bath Stroke Department of Acute MedicineNottingham University Hospitals NHS TrustNottinghamUK Stroke Trials Unit University of NottinghamNottinghamUK Department of Medicine National University of Malaysia Faculty of MedicineKuala LumpurMalaysia Radiological Sciences Research Group University of NottinghamNottinghamUK national Institute of Health Research nottingham Biomedical Research Centre University of NottinghamNottinghamUK Centre for Clinical Brain Sciences UK Dementia Research InstituteChancellor's BuildingUniversity of EdinburghEdinburghUK

Background and purpose Intracerebral haemorrhage volume(ICHV)is prognostically important but does not account for intracranial volume(ICV)and cerebral parenchymal volume(CPV).We assessed measures of intracranial compartments in acute ICH using computerised tomography scans and whether ICHV/ICV and ICHV/CPV predict functional *** also assessed if cistern effacement,midline shift,old infarcts,leukoaraiosis and brain atrophy were associated with *** Data from 133 participants from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial trial were *** included ICHV(using ABC/2)and ICV(XYZ/2)(by independent observers);ICHV,ICV and CPV(semiautomated segmentation,SAS);atrophy(intercaudate distance,ICD,Sylvian fissure ratio,SFR);midline shift;leukoaraiosis and cistern effacement(visual assessment).The effects of these measures on death at day 4 and poor functional outcome at day 90(modified Rankin scale,mRS of>3)was *** ICV was significantly different between XYZ and SAS:mean(SD)of 1357(219)vs 1420(196),mean difference(MD)62 mL(pno significant difference in ICHV between ABC/2 and *** was very good agreement for ICV measured by SAS,CPV,ICD,SFR,leukoaraiosis and cistern score(all interclass correlations,n=10:interobserver 0.72-0.99,intraobserver 0.73-1.00).ICHV/ICV and ICHV/CPV were significantly associated with mRS at day 90,death at day 4 and acute neurological deterioration(all pnd cistern effacement at baseline were associated with poor functional outcome but old infarcts,leukoaraiosis and brain atrophy were *** Intracranial compartment measures and visual estimates are *** adjusted for ICH and CPV could be useful to prognosticate in acute *** presence of midline shift and cistern effacement may predict outcome but the mechanisms need validation in larger studies.

关键词： measures Tri nitrate

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius niroshan Siriwardena Joanna M Wardlaw nikola sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service nHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of neuroscience Newcastle UniversityNewcastle upon TyneUK Department of neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and nIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTn,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTn in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTn did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTn may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTn in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KnOWn On THIS TOPIC⇒Transdermal glyceryl trinitrate(GTn)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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