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Plant cell wall-mediated disease resistance:Current understanding and future perspectives

Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa Jorda Miguel Angel Torres Marina Martın-Dacal Diego Jose Berlanga Patricia Fernandez-Calvo Elena Gomez-Rubio Sonsoles Martın-Santamarıa Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigaciones Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen infection,wounding,or other stresses leads to the release of wall molecules,such as carbohydrates(glycans),that function as damage-associated molecular patterns(DAMPs).DAMPs are perceived by the extracellular ectodomains(ECDs)of pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released from the walls and extracellular layers of microorganisms interacting with plants are recognized as microbe-associated molecular patterns(MAMPs)by specific ECD-PRRs triggering PTI *** number of oligosaccharides DAMPs/MAMPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly focused on receptors of the LysM-PRR family,which are involved in the perception of various molecules,such as chitooligosaccharides from fungi and lipo-chitooligosaccharides(i.e.,nod/MYC factors from bacteria and mycorrhiza,respectively)that trigger differential physiological ***,additional families of plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and Malectin domains in their ECDs(LRR-MAL RKs),Catharanthus roseus RECEPTOR-LIKE KInASE 1-LIKE group(CrRLK1L)with Malectin-like domains in their ECDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

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Head neck:检测细针穿刺样品中的HPV16可用于诊断HPV阳性

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现代生物医学进展 2017年第8期17卷 I0004-I0004页

作者： Lars Sivars MD David Landin MD Linnea Haeggblom MSci nikolaos Tertipis phd nathalie Gr uuml n phd Cinzia Bersani phd Linda Marklund MD, phd Mehran Ghaderi phd Anders n auml sman MD, phd Torbj ouml rn Ramqvist phd Cecilia nordfors phd Eva Munck ndash Wikland MD, phd Edneia Tani MD, phd Tina Dalianis MD, phd Department of Oncology - Pathology Karolinska Institutet Stockholm Sweden Department of Oto-Rhino-Laryngology Head and Neck Surgery CLINTEC Karolinska Institutet Stockholm Sweden Department of Clinical Pathology Karolinska University Hospital Stockholm Sweden Department of Medical Biochemistry and Microbiology Microbiology - Immunology Uppsala University Uppsala Sweden

口咽鳞状细胞癌HPV16是指人乳头瘤病毒16型。HPV有多种类型，其中低危型HPV感染，主要引起生殖器疣（俗称菜花）。而高危型HPV感染则引起生殖器癌和子宫颈癌上皮细胞病变，此病毒为生殖器癌和子宫颈癌前细胞病毒的开端。

关键词： HPV16 人乳头瘤病毒16型鳞状细胞癌阳性诊断样品穿刺检测

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Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate n_(5) and n_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-Vázquez Cristina González-Barreira Paula Oreiro-Martínez Ana M.García-Deibe Jesús Sanmartín-Matalobos Matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of n_(5) and n_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid n_(5),n_(6)macrocycle Coordination chemistry Chirality Biological activity Molecule magnet

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The importance of post-COVID condition phenotypes characterization to decipher the mechanisms underlying this post-viral syndrome

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World Journal of Pediatrics 2024年第6期20卷 633-634页

作者： Jon Izquierdo-Pujol Sara Moron-Lopez IrsiCaixa and Institute for Health Science Research Germans Trias i Pujol(IGTP) Can Ruti CampusBadalonaSpain Biomedicine doctoral programme Faculty of BiologyUniversity of BarcelonaBarcelonaSpain CIBERInFEC MadridSpain

The coronavirus disease-19(COVID-19)outbreak,caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),was declared a global pandemic in March *** has affected over 700 million people worldwide and resulted in almost 7 million deaths,equating to a 1%mortality *** present,the majority of COVID-19 cases are either asymptomatic or mild,typically resolving within two ***,between 1%and 10%of COVID-19 survivors do not fully recover and experience a post-viral syndrome referred to as"long COVID","post-acute COVID-19 syndrome"(PASC),or"post-COVID condition"(PCC).This post-viral syndrome affects both adult and pediatric ***,most of the studies published to date evaluate the adult population,leaving a gap in our understanding of its impact on children and adolescents.

关键词： acute mortality respiratory

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Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez Rubén Sambuelli Kazim A.Sheikh Pablo H.H.Lopez Laboratorio de neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química Biológica-Centro de Investigaciones en Química Biológica de Córdoba(CIQUIBIC)-Consejo nacional de Investigaciones Cientificas y Técnicas(COnICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhibitor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b monoclonal *** findings open the possibility of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-Barrésyndrome nerve repair ROCK Y-27632

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长期存活肿瘤患儿不良预后的医学评估

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美国医学会杂志（中文版） 2008年第3期27卷 137-147页

作者： Maud M. Geenen, MD Mathilde C. Cardous-Ubbink, MSc Leontien C. M. Kremer, MD, phd Cor van den Bos, MD, phd Helena J. H. van der Pal, MD Richard C. Heinen, MSc Monique. M. Jaspers, phd, MSc Caro C. E. Koning, MD, phd Foppe Oldenburger, MD nelia E. Langeveld, phd, Rn Augustinus A. M. Hart, MSc Piet J. M. Bakker, MD, phd Huib n. Caron, MD, phd Flora E. van Leeuwen, phd, MSc 张成海(译) 武爱文(译) 徐光炜(校) Late Effects Study Group and Outpatient Clinic/Polikliniek Late Effecten Kindertumoren(PLEK) Emma Children's Hospital/Academic Medical Center: Departments of Medical Oneology Department of Pediatric Oncology Academic Medical Center:and Departments of Radiotherapy netherlands Cancer Institute Amsterdamthe Netherlands Late Effects Study Group and Outpatient Clinic/Polikliniek Late Effecten Kindertumoren(PLEK) Department of Pediatric Oncology Epidemiology netherlands Cancer Institute Amsterdamthe Netherlands Late Effects Study Group and Outpatient Clinic/Polikliniek Late Effecten Kindertumoren(PLEK) Medical Informatics netherlands Cancer Institute Amsterdamthe Netherlands Late Effects Study Group and Outpatient Clinic/Polikliniek Late Effecten Kindertumoren(PLEK) Radiotherapy netherlands Cancer Institute Amsterdamthe Netherlands Radiotherapy netherlands Cancer Institute Amsterdamthe Netherlands

背景：癌症患儿存活改善与多种治疗相关并发症相伴。然而，绝大多数有关癌症儿童生存率的研究仅局限于单一的远期效应。目的：在一个有完整的长期随访资料的大型儿童癌症生存队列中对癌症长期存活的不良预后（临床或亚临床病症）的总负... 详细信息

背景：癌症患儿存活改善与多种治疗相关并发症相伴。然而，绝大多数有关癌症儿童生存率的研究仅局限于单一的远期效应。目的：在一个有完整的长期随访资料的大型儿童癌症生存队列中对癌症长期存活的不良预后（临床或亚临床病症）的总负荷进行评估。设计、地点及人群：于1362例已生存5年的儿童癌症患者中进行回顾性队列研究。患儿1966至1996年在荷兰一家医疗机构接受治疗。所有生存者均被邀请到晚期效应诊所进行不良事件医学评估。2004年1月以前发生的不良事件依据标准方式进行严重度分级。主要观测指标：随访结束时治疗别不良事件（依据严重性）的发生率以及各种治疗相关疾病高度或严重负荷（危险度92或危及生命或致残的不良事件≥1个）的相对危险度。结果：94．3％的生存者完成了随访（中位随访时间17年）。随访结束时中位年龄为24、4岁。大约75％的生存者有1个或更多不良事件，24．6％发生5个或以上不良事件。而且，40％的生存者至少有1个严重、危及生命或致残的不良事件。在接受单纯放疗的生存者中，55％的患者观察到高度或严重不良事件负荷。接受单纯化疗的生存者发生率为15％，而单纯手术治疗的存活者相应发生率则为25％（校正后相对危险分别为2．18[95％可信区间，1．62—2．95]和0．65[95％可信区间，0．46—0．90]）。不良事件高度或严重负荷最常见于骨肿瘤生存者（64％），较少见于白血病或Wilms瘤生存者（12％）。结论：在成年时，很大一部分儿童癌症生存者都存在高度或严重疾病负荷，尤其是在放疗后。这强调了对儿童癌症生存者根据危险分层进行终生医学监视的必要性。

关键词：医学评估肿瘤患儿长期存活不良预后单纯手术治疗癌症生存者相对危险度不良事件

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运用标准均数差的汇总分析中的数据提取错误

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美国医学会杂志（中文版） 2008年第1期27卷 38-45页

作者： Peter C. GФtzsche, MD, DrMedSci AsbjФn Hrbbjartsson, MD, phd Katja Maric, MSc Britta Tendal, MSc 彭斌(译) 李舜伟(校) nordic Cochrane Centre Rigshospitalet Copenhagen Denmark. 不详

背景：对使用不同标准或等级量表记录性质相似结果的试验进行汇总分析（metaanalysis）时，需要通过复杂的数据处理及数据转换将其统一为一致的衡量尺度，即标准均数差（standardized mean difference，SMD）。目前尚不清楚运用这种汇... 详细信息

背景：对使用不同标准或等级量表记录性质相似结果的试验进行汇总分析（metaanalysis）时，需要通过复杂的数据处理及数据转换将其统一为一致的衡量尺度，即标准均数差（standardized mean difference，SMD）。目前尚不清楚运用这种汇总分析的可靠性。目的：研究汇总分析中的标准均数差（SMDs）是否准确。资料来源：对2004年发表的、以SMD来报告结果的汇总分析进行系统审查，无语种限制。从每个汇总分析中随机选取2项试验研究。我们力图用Hedges校正g值，通过独立计算SMD重复原汇总分析结果。数据提取：我们的主要观察指标是在选择的2项试验中至少1项结果（总估计值或町信区间）与原作者相差0．1以上的汇总分析所占的比例。由于很多常用治疗方法的效果与安慰剂相比均在0．1与0．5之间，因此我们选择0．1作为切分点。结果：在纳入研究的27个汇总分析中，有10个（37％）不能在0．1切分值内于2项试验中至少一项重复其试验结果。有4个汇总分析其估计差异≥0．6。常见的问题是患者数、平均值、标准差及效果符号存在错误。总体上看，有17个汇总分析（63％）在检查的2项试验中至少有1项出现错误。对于差异至少为0．1的汇总分析，我们检查了所有试验的数据，并用作者的方法进行了我们自己的汇总分析。结果发现，在10个汇总分析中有7个是错误的（70％）；1个汇总分析随后被撤回，2个显著性差异消失或出现。结论：根据SMDs进行汇总分析发生错误的比率很高，表明尽管统计过程看似简单，但资料提取特别容易出现误差，以致产生阴性甚或相反的结果。这不但给相关研究者以启示，也提示所有的读者，包括杂志审稿者和决策者，在接触这些汇总分析时应保持警惕。

关键词：汇总分析数据提取标准差均数试验研究 SMDs 数据转换数据处理

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以心肺适应能力及肥胖为老年人死亡率的预测指标

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美国医学会杂志（中文版） 2008年第2期27卷 128-128页

作者： Xuemei Sui, MD Micheal J. La Monte, phd James n. l,aditka, phd 顾佳(译)

背景：尽管机体的运动量及有氧代谢能力会随着年龄的增长而降低，而肥胖的患病率则会随着年龄的增长而增加，但是目前尚未在老年人群中深入研究心肺适应能力、肥胖、死亡率三者之间的关系。目的：明确老年人心肺适应能力、肥胖、死亡率... 详细信息

背景：尽管机体的运动量及有氧代谢能力会随着年龄的增长而降低，而肥胖的患病率则会随着年龄的增长而增加，但是目前尚未在老年人群中深入研究心肺适应能力、肥胖、死亡率三者之间的关系。目的：明确老年人心肺适应能力、肥胖、死亡率三者之间的关系。

关键词：心肺适应能力老年人群死亡率肥胖预测指标有氧代谢能力运动量患病率

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Expression changes of mi RnA-regulated genes associated with the formation of the leafy head in cabbage

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Horticultural Plant Journal 2024年第4期10卷 1007-1019页

作者： Jorge Aleman-Baez Jose Fernando Acevedo-Zamora Johan Bucher Chengcheng Cai Roeland E.Voorrips Guusje Bonnema Plant Breeding Wageningen University and ResearchWageningenThe Netherlands

The vegetative development of cabbage(Brassica oleracea ***)passes through seedling,rosette,folding and heading *** that form the rosette are large and mostly *** the following developmental stages,the plants produce leaves that curve inward to produce the leafy *** microRnAs and their target genes have been described participating in leaf development and leaf *** aim of this study is to investigate the role of miRnA-regulated genes in the transition from the rosette to the heading *** compared the mi RnA and gene abundances between emerging rosette and heading *** remove transcripts(miRnAs and genes)whose regulation was most likely associated with plant age rather than the change from rosette to heading stage,we utilized a non-heading collard green(*** ***)morphotype as *** resulted in 33 DEMs and 1998 DEGs with likely roles in the transition from rosette to heading stage in *** these 1998 DEGs,we found enriched GO terms related to DnA-binding transcription factor activity,transcription regulator activity,iron ion binding,and *** predicted the target genes of these 33 DEMs and focused on the subset that was differentially expressed(1998DEGs)between rosette and heading stage leaves to construct mi RnA-target gene interaction *** main finding is a role for miR396b-5p targeting two Arabidopsis thaliana orthologues of GROWTH REGULATInG FACTORs 3(GRF3)and 4(GRF4)in pointed cabbage head formation.

关键词： Brassica oleracea var.capitata RnA sequencing miRnA-target gene network leafy head formation

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ALTERATIOn In EnTEROCYTE GEnE EXPRESSIOn MAY EXPLAIn STRUCTURAL AnD FUnCTIOnAL CHAnGES FOLLOWInG GLUTAMInE SUPPLEMEnTED PAREnTERAL nUTRITIOn

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Chinese Medical Sciences Journal 1999年第2期14卷 112-116页

作者： JiangZhuming,MD LiuYuewu,MD,phd MaYongxian,MD BaiManxi,MD,phd QiangBoqing,phd RobertSmith,MD DepartmentofSurgery PekingUnionMedicalCollegeHospitalBeijing100730 MolecularBiologyLaboratoryofChineseAcademyofMedicalSciences Beijing100730 JoslinDiabeticCenter DepartmentofSurgeryMassachusettsGeneralHospitalandBrighamandWomen＇sHospitalHarvardMedicalSchool

ＩＮＴＲＯＤＵＣＴＩＯＮＡｌｔｅｒａｔｉｏｎｓｉｎｉｎｔｅｓｔｉｎａｌｓｔｒｕｃｔｕｒｅａｎｄｆｕｎｃｔｉｏｎｏｃｕｒｆｏｌｏｗｉｎｇｍａｊｏｒｏｐｅｒａｔｉｏｎ，ｒａｄｉｏｔｈｅｒａｐｙａｎｄｌｏｎｇｔｅｒｍｐａｒ... 详细信息

ＩＮＴＲＯＤＵＣＴＩＯＮＡｌｔｅｒａｔｉｏｎｓｉｎｉｎｔｅｓｔｉｎａｌｓｔｒｕｃｔｕｒｅａｎｄｆｕｎｃｔｉｏｎｏｃｕｒｆｏｌｏｗｉｎｇｍａｊｏｒｏｐｅｒａｔｉｏｎ，ｒａｄｉｏｔｈｅｒａｐｙａｎｄｌｏｎｇｔｅｒｍｐａｒｅｎｔｅｒａｌｎｕｔｒｉｔｉｏｎ（...

关键词：肠上皮细胞基因表达谷氨酸盐补充肠外营养肠功能

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