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17β-雌二醇对人羊膜细胞β-防御素-4(HBD-4)表达调节的影响

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疾病监测与控制 2015年第6期9卷 380-380,379页

作者：包图雅白萨日娜李雅静耿世佳纳仁高娃内蒙古医科大学基础医学院内蒙古呼和浩特010059

目的探讨17β-雌二醇(E2)对人羊膜细胞内β-防御素-4(HBD-4)基因表达的影响。方法体外培养的人羊膜细胞内添加17β-雌二醇(2n M)培养4h、8h、12h、24h,同时各时间点设相应的对照组(Control组),通过real-time RT-PCR技术检测17β-雌二醇... 详细信息

目的探讨17β-雌二醇(E2)对人羊膜细胞内β-防御素-4(HBD-4)基因表达的影响。方法体外培养的人羊膜细胞内添加17β-雌二醇(2n M)培养4h、8h、12h、24h,同时各时间点设相应的对照组(Control组),通过real-time RT-PCR技术检测17β-雌二醇对人羊膜细胞内HBD-4 m RnA的表达变化的影响。结果 17β-雌二醇可上调人羊膜细胞中HBD-4 m RnA的表达(P<0.05)。结论 HBD-4在女性妊娠期羊膜细胞宿主免疫防御中起着重要的作用。

关键词： 17β-雌二醇羊膜细胞 HBD-4 调节

食管静脉曲张治疗:内镜下硬化和EUS引导下硬化治疗食管侧支静脉的随机对照研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 27-27页

作者： Andrade de Paulo G. Ardengh J. C. nakao F. S. Ferrari A.P. 陈瑜(译) 郑世成(校) Av. Dr. Altino Arantes 835/104 Sao Paulo SP 04042-034 Brazil 不详

Background: Endoscopic sclerotherapy (es) and band ligation are standard treatments for esophageal varices. Unfortunately, recurrence is common and seems to be related to esophageal collateral vessels, easily identified by EUS. Eradication of these vessels might lead to a more durable therapeutic effect. Objective: To compare es with EUS-guided sclerotherapy of collateral vessels (EUS-es). design: Randomized controlled trial. Setting: Endoscopy Unit, Division of Gastroenterology. Universidade Federal de S o Paulo, S o Paulo, Brazil. Patients and Interventions: Fifty cirrhotic patientswith esophageal varices were randomized into 2 groups: es (n = 25) and EUS-es (n = 25). EUS-es was targeted at collateral veins. Patients were followed-up for at least 6 months after eradication. Main Outcome Measurements: Efficacy in eradication, complications, and recurrence of varices. Results: Varices were eradicated in 48 patients who adhered to the study protocol. The mean (SD) number of sessions until eradication was 4.3 (1.5) for the es group and 4.1 (1.2) for the EUS-es group. In es group, 4 patients had mild bleeding. In EUS-es group, 4 patients had pain. The mean (SD) length of the follow-up period was 22.6 (6.9) months for the es group and 24.9 (8.1) months for the EUS-es group. Recurrence was seen in 4 patients after es and in 2 after EUS-es (P = .32). The presence of collateral vessels was associated with recurrence (P = .003). Conclusion: EUS-es is as safe and effective as es in variceal eradication. Recurrence tends to be less frequent and occurs later. Persistence of esophageal collateral vessels after sclerotherapy is a risk factor for recurrence.

关键词：食管静脉曲张随机对照研究食管侧支内镜下硬化硬化治疗 EUS 引导肝硬化患者随机对照试验随访时间

芋“3414”肥效试验与配方施肥推荐研究初报

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湖北农业科学 2017年第16期56卷 3034-3036页

作者：黄立强王必武吴惠生张德才喻霞刁英胡中立郑兴飞湖北省建始县土壤肥料工作站湖北建始445300 湖北省仙桃市土壤肥料工作站湖北仙桃433001 湖北省耕地质量与肥料工作总站武汉430070 武汉大学生命科学学院/莲藕研究中心武汉430072

开展"3414"肥效试验,研究了不同肥料配比对芋(Colocasia esculenta)及芋荷梗产量的影响,建立了氮、钾肥施肥量与产量的回归方程,探索了获得芋及芋荷梗的最佳施肥量。结果表明,合理施肥可有效提高芋及芋荷梗的产量,且对芋荷梗的增产效果... 详细信息

开展"3414"肥效试验,研究了不同肥料配比对芋(Colocasia esculenta)及芋荷梗产量的影响,建立了氮、钾肥施肥量与产量的回归方程,探索了获得芋及芋荷梗的最佳施肥量。结果表明,合理施肥可有效提高芋及芋荷梗的产量,且对芋荷梗的增产效果更加明显,过量施用钾肥会造成芋及芋荷梗产量明显降低,若以芋荷梗为主要采收目标时,可适当增加氮、钾肥的施用量。在该试验土壤条件下,推荐施肥量为氮肥225.0~337.5 kg/hm^2,钾肥171.0~235.5 kg/hm^2。

关键词：芋(Colocasia esculenta) “3414”肥效试验回归方程推荐

大豆转录因子GmnAC8的克隆及耐旱性功能分析

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中国油料作物学报 2017年第1期39卷 1-12页

作者：方义生刘宝红陈水莲陈海峰张婵娟袁松丽郝青南杨中路张晓娟单志慧邱德珍陈李淼周新安中国农业科学院油料作物研究所农业部油料作物生物学与遗传育种重点实验室湖北武汉430062

大豆转录因子GmnAC8在耐旱材料和敏感材料中明显差异表达,该基因CDS序列全长1 092bp,编码363个氨基酸残基。通过软件预测,蛋白质相对分子质量为41.82k D,等电点为8.51,其n-端含有42aa组成的nAC保守结构域,C-端高度变异。进化树分析表明... 详细信息

大豆转录因子GmnAC8在耐旱材料和敏感材料中明显差异表达,该基因CDS序列全长1 092bp,编码363个氨基酸残基。通过软件预测,蛋白质相对分子质量为41.82k D,等电点为8.51,其n-端含有42aa组成的nAC保守结构域,C-端高度变异。进化树分析表明,该蛋白与菜豆、红豆、绿豆同源关系最近。在洋葱表皮细胞中的亚细胞定位分析表明GmnAC8蛋白定位于细胞核。转录水平表达分析表明,GmnAC8基因在转基因株系叶中的表达量要明显高于根中的表达量;GmnAC8基因受0.1mmol/L IAA和ABA诱导表达量显著上升,受GA和sa抑制。GmnAC8基因在拟南芥中超量表达可以使拟南芥叶片更绿,耐旱能力增强。抗旱生理指标检测表明,在干旱处理10d后,转基因拟南芥叶中蛋白质含量、脯氨酸含量、POD活性均高于野生型拟南芥,丙二醛含量明显低于野生型拟南芥,仅为42%。本研究结果为进一步研究GmnAC8在植物耐旱反应中的分子机理奠定基础。

关键词：大豆干旱胁迫 GmnAC8基因功能分析

nFKB1启动子多态性与乳糜泻基因易感性无关

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 60-60页

作者： Rueda B. núez C. López-nevot M.. J.Martn 成虹 Instituto de Parasitologa Y Biomedicina López neyra CSICParque Tecnológico Campus de la SaludAvd.del Conocimiento s/n.ES-18100 ArmillaGranadaSpainDr.

Objective. The nuclear factor(nF)-κB is one of the pivotal regulators of autoimmunity and inflammation, which has been shown to be activated in the inflamed mucosa of patients with celiac disease(CD). Recently, in the nFKB1 gene promoter region, a common insertion/deletion(-94ins/ delATTG) polymorphism located between two putative key promoter regulatory elements was described. The aim of this study was to investigate the contribution of the -94ins/ delATTG nFKB1 gene promoter functional variant to CD genetic predisposition. Material and methods. A case-control cohort comprising 478 patients with CD and 711 healthy controls as well as a panel of 196 celiac families was genotyped for the 94ins/delATTG nFKB1 polymorphism, using a polymerase chain reaction (PCR) method combined with fluorescence technology. Results. We found no statistically significant differences between CD patients and controls when the -94ins/delATTG genotype and allele distributions were compared. Accordingly, the familial analysis did not reach statistically significant deviation in the transmission of -94ins/delATTG alleles to the affected offspring. Conclusions. from these results, it could be suggested that the -94ins/delATTG nFKB1 polymorphism does not play a major role in CD susceptibility.

关键词：乳糜泻 nFKB1 启动子多态性调控元件计学家系分析自身免疫队列研究关键因子

55例非交通性和交通性脑积水患者的B波客观分析

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 28-28页

作者： Stephensen H. Andersson n. Eklund A. M. Tisell 李一明 Hydrocephalus Research Unit Sahlgrenska University HosPital Gteborg University 413 45 Gteborg Sweden Dr.

Background: B waves, slow and rhythmic oscillations in intracranial pressure (ICP), are claimed to be one of the best predictors of outcome after surgery for normal pressure hydrocephalus (nPH). Object: To determine the relation between the percentage of B waves and outcome in patients with hydrocephalus, and also t he diurnal variation of B waves. Methods: ICP and patient behaviour were recorde d overnight (17 to 26 hours) in 29 patients with non- communicating hydrocephal us and 26 with nPH. The B wave activity, measured with an amplitude threshold of 0.5, 0.75, 1.0, 1.5, 2.0, 3.0, and 5.0 mm Hg, was estimated as the percentage o f total monitoring time (% B waves) using a computer algorithm, and correlated with postoperative outcome, defined as changes in 12 standardised symptoms and signs. Results: There was no linear correlation between improvement after surger y in the 55 patients and total % B waves, but a correlation was found between improvement and % B waves during sleep (r=0.39, p=0.04). The percentage of B w aves was the same during sleep and wakefulness, and patients with nPH had the sa me proportion of B waves as the non- communicating patients. Conclusions: B wav es are commonly observed in patients with both communicating and non- communica ting hydrocephalus, but are only weakly related to the degree of postsurgical im provement.

关键词：交通性脑积水客观分析正常颅压脑积水最佳预测睡眠状态振荡波昼夜变化计算法线性相关弱相关

局限性脉络膜血管瘤光动力治疗后持续性脉络膜肥厚

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 40-40页

作者： Hussain n. Das T. Mohan Ram L. S. Sumasri K. 王大江(译) 不详 Smt. Kanuri sa Itkamma Retina-Vitreous Services L. V. Prasad Eye Institute L. V. Prasad Marg Banjara Hills Hyderabad 500 034 India

A 19-year-old man presented with blurred vision in the right eye,which was diagnosed as a circumscribed choroidal hemangioma. The choroidal thickening on B-scan ultrasonography persisted after receiving repeat photody... 详细信息

关键词：局限性脉络膜血管瘤光动力疗法持续性治疗后肥厚男性患者视物模糊维替泊芬肿瘤消退 B超检查

Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat sajeewa S.n.Maharachchikumbura Walter Rossi Marco Leonardi Hyang Burm Lee Hye Yeon Mun Jos Houbraken Thuong T.T.nguyen Sun Jeong Jeon Jens Christian frisvad Dhanushka n.Wanasinghe Robert Lucking Andre Aptroot Marcela E.S.Caceres samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak nimali Ide Silva Kasun M.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene Mayrada Silva Soares Helio Longoni Plautz Jr Helen Maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina Mariade Souza-Motta Oliane Maria Correia Magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.Manawasinghe Wei Dong Sheng-nan Zhang Dan-Feng Bao Milan C.samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang Monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-Mei Tian Armin Mesic sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada norphanphoun napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage Ming Zeng Thilini Chethana deping Wei Martina Reblova Jacques Fournier Jana nekvindova Renan do nascimento Barbosa Jose Ewerton Felintodos santos neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo Erio Camporesi Timur S.Bulgakov saisamorn Lumyong E.B.Gareth Jones Putarak Chomnunti Eleni Gentekaki frank Bungartz Xiang-Yu Zeng sally fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul M Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly department of Botany Goa UniversityGoaIndia no.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches Museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of Microbial

This article is the tenth series of the Fungal Diversity notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,Micarea squamulosa,Muriphaeosphaeria angustifoliae,neoacladium indicum,neodidymelliopsis sambuci,neosetophoma miscanthi,***,nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy

湖南省细菌耐药监测网2012—2021年胸、腹腔积液细菌耐药性监测报告

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中国感染控制杂志 2023年第12期22卷 1438-1451页

作者：唐咏雪王思雨谢小兵陈丽华付陈超李晨李艳明刘君任南石国民邬靖敏杨怀德袁红霞郑铭黄勋吴安华宁兴旺文细毛湖南中医药大学第一附属医院医学检验与病理中心湖南长沙410007 中南大学湘雅三医院检验科湖南长沙410013 中南大学湘雅医院医院感染控制中心湖南长沙410008 湖南省细菌耐药监测网办公室湖南长沙410008 浏阳市中医医院检验科湖南浏阳410300 中南大学湘雅医院检验科湖南长沙410008 湘潭市中心医院检验科湖南湘潭411100 湖南省医院感染管理质量控制中心湖南长沙410008 长沙市中心医院检验科湖南长沙410004 长沙市第一医院检验科湖南长沙410005 张家界市人民医院检验科湖南张家界427000 郴州市第一人民医院检验医学中心湖南郴州423000 国家老年疾病临床医学研究中心(湘雅医院) 湖南长沙410008

目的了解湖南省胸、腹腔积液分离细菌的分布及耐药性变迁,为临床正确诊断及合理用药提供参考。方法收集湖南省细菌耐药监测网2012—2021年各成员单位上报数据,细菌耐药监测方法参照全国细菌耐药监测网(CARSS)技术方案执行,应用WHOnET 5.... 详细信息

目的了解湖南省胸、腹腔积液分离细菌的分布及耐药性变迁,为临床正确诊断及合理用药提供参考。方法收集湖南省细菌耐药监测网2012—2021年各成员单位上报数据,细菌耐药监测方法参照全国细菌耐药监测网(CARSS)技术方案执行,应用WHOnET 5.6软件对胸、腹腔积液分离细菌及药敏结果数据进行分析。结果2012—2021年湖南省细菌耐药监测网成员单位胸、腹腔积液标本共分离细菌28934株,其中胸腔积液分离菌株5752株、腹腔积液分离23182株。胸腔积液分离率居前5位的细菌依次为大肠埃希菌(907株,15.8%)、金黄色葡萄球菌(535株,9.3%)、肺炎克雷伯菌(369株,6.4%)、表皮葡萄球菌(452,7.9%)、溶血葡萄球菌(285株,5.0%)。胸腔积液耐甲氧西林金黄色葡萄球菌(MRsa)的检出率为24.3%~39.2%,耐甲氧西林凝固酶阴性葡萄球菌(MRCnS)的检出率为58.8%~77.1%。腹腔积液分离率居前5位的细菌依次为大肠埃希菌(8264株,35.6%)、肺炎克雷伯菌(2074株,9.0%)、屎肠球菌(1458株,6.3%)、表皮葡萄球菌(1383株,6.0%)、铜绿假单胞菌(1152株,5.0%)。腹腔积液MRsa的检出率为22.1%~52.4%,且检出率呈下降趋势(P=0.004),MRCnS的检出率为60.4%~79.4%。腹腔积液中肠杆菌目细菌对头孢唑林、头孢呋辛、头孢曲松、头孢吡肟的耐药率均呈现下降趋势(均P<0.05)。胸、腹腔积液中未发现对万古霉素、利奈唑胺和替考拉宁耐药的葡萄球菌,屎肠球菌对多数测试药物的耐药率高于粪肠球菌。肠杆菌目细菌对亚胺培南和美罗培南耐药率≤8.5%;非发酵革兰阴性杆菌对亚胺培南、美罗培南的耐药率≤43.3%。结论2012—2021年湖南省细菌耐药监测网胸、腹腔积液数据结构较完整,不同年份分离病原菌组成及药物敏感性不尽相同。

关键词：细菌抗菌药物耐药性胸腔积液腹腔积液湖南省细菌耐药监测网药物敏感性试验监测