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Efficacy and safety of rebamipide/nizatidine in patients with erosive gastritis: A randomized, multicenter, phase 4 study

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World Journal of Gastroenterology 2024年第48期30卷 5152-5161页

作者： Donghoon Kang myung-Gyu Choi Ki-Nam Shim Hye-Kyung Jung Seung-joo Nam Jung Ho Park Sang Gyun Kim Nam-Hoon Kim Su Jin Hong Tae joo Jeon Jae Il Chung Hang Lak Lee Ju Yup Lee Tae oh Kim Chang Min Lee Sun Moon Kim Jeong-Hwan Kim Jang Eon Kim Jeong Seop Moon Ho Dong Kim Wan-Sik Lee Hong Jun Park Department of Internal Medicine Seoul St.Mary’s HospitalThe Catholic University of KoreaSeoul 06591South Korea Department of Internal Medicine Ewha Womans University Seoul HospitalGastroenterology and Hepatology CenterSeoul 07985South Korea Department of Internal Medicine Ewha Womans University Mokdong HospitalSeoul 07985South Korea Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289South Korea Department of Medicine Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181South Korea Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul 03080South Korea Department of Internal Medicine Ilsan Paik HospitalInje University College of MedicineGoyang 10380South Korea Department of Internal Medicine Digestive Disease CenterSoonchunhyang University Bucheon HospitalBucheon 31538South Korea Department of Internal Medicine Inje University College of MedicineSanggye Paik HospitalSeoul 01757South Korea Department of Gastroenterology Sahmyook Medical CenterSeoul 02500South Korea Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Internal Medicine Inje University Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea Department of Internal Medicine Gyeongsang National University School of MedicineGyeongsang National University HospitalJinju 52727South Korea Department of Internal Medicine Konyang University HospitalDaejeon 35365South Korea Gastroenterology Center Konkuk University Medical CenterSeoul 05030South Korea Department of Gastroenterology Seoul Medical CenterSeoul 02053South Korea Department of Gastroenterology Inje University Busan Paik HospitalBusan 47392South Korea Department of Gastroenterology St.Carollo HospitalSooncheon 57931South Korea Division of Gastroenterology Department of Internal

BACKGROUND For the treatment of gastritis,rebamipide,a mucoprotective agent,and nizatidine,a gastric acid suppressant,are commonly employed *** To compare the efficacy of Mucotra®SR(rebamipide 150 mg)and Axid®(nizatidine 150 mg)combination therapy with the sole administration of Axid®in managing erosive *** A total of 260 patients diagnosed with endoscopically confirmed erosive gastritis were enrolled in this open-label,multicenter,randomized,phase 4 clinical trial,allocating them into two groups:Rebamipide/nizatidine combination twice daily vs nizatidine twice daily for 2 *** full-analysis set analysis encompassed 239 patients(rebamipide/nizatidine,n=121;nizatidine,n=118),while the per-protocol analysis included 218 patients(n=110 vs 108).Post-treatment assessments comprised primary(erosion improvement rate)and secondary(erosion and edema cure rates,erythema improvement rates,hemorrhage,and gastrointestinal symptoms)***,drug-related adverse effects were *** Primary efficacy assessment showed a statistically significant improvement rate in mucosal erosions in the combination group compared to the control group in the full-analysis set(rebamipide/nizatidine 62.0%,nizatidine 49.2%,P=0.046),with a similar trend noted in the per-protocol analysis(62.7%vs 50.0%,P=0.058).Both groups were effective in curing erosion and edema and improvement of bleeding,erythema,and gastrointestinal symptoms,whereas no inter-group differences were *** confined to the participants with gastritis symptoms,improvement of erosion was more optimal in the combination group(63.0%vs 49.5%,P=0.046).No adverse events related to the drugs were *** Rebamipide/nizatidine combination is effective in treatment of erosive gastritis.

关键词： Gastritis Erosive gastritis Combination therapy Rebamipide Nizatidine

Endoscopic resection of gastric and esophageal cancer

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Gastroenterology Report 2015年第4期3卷 330-338,I0002页

作者： Bryan Balmadrid joo Ha Hwang Division of Gastroenterology University of WashingtonSeattleWAUSA

Endoscopic submucosal dissection(ESD)and endoscopic mucosal resection(EMR)techniques have reduced the need for surgery in early esophageal and gastric cancers and thus has lessened morbidity and mortality in these *** is a relatively new technique in western countries and requires rigorous training to reproduce the proficiency of Asian countries,such as Korea and Japan,which have very high complete(en bloc)resection rates and low complication *** plays a valuable role in early esophageal *** has shown better en bloc resection rates but it is easier to master and maintain proficiency in EMR;it also requires less procedural *** early esophageal adenocarcinoma arising from Barrett’s,ESD and EMR techniques are usually combined with other ablative modalities,the most common being radiofrequency ablation because it has the largest dataset to prove its *** EMR techniques have been used with some success in early gastric cancers but ESD is currently preferred for most of these *** has the added advantage of resecting into the submucosa and thus allowing for endoscopic resection of more aggressive(deeper)early gastric cancer.

关键词： endoscopic submucosal dissection endoscopic mucosal resection endoscopic ablation early gastric cancer early esophageal cancer

Effect of hafnium and molybdenum addition on inclusion characteristics in Co-based dual-phase high-entropy alloys

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1639-1650页

作者： Yong Wang Wei Wang joo Hyun Park Wangzhong Mu Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education&Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081China Department of Materials Science and Engineering KTH Royal Institute of TechnologySE-10044StockholmSweden Department of Chemical Engineering Northeast Electric Power UniversityJilin 132012China Department of Materials Science and Chemical Engineering Hanyang UniversityAnsan 15588Korea Engineering Materials Division of Materials ScienceDepartment of Engineering Science and MathematicsLuleå University of Technology97187 LuleåSweden

Specific grades of high-entropy alloys(HEAs)can provide opportunities for optimizing properties toward high-temperature *** this work,the Co-based HEA with a chemical composition of Co_(47.5)Cr_(30)Fe_(7.5)Mn_(7.5)Ni_(7.5)(at%)was *** refractory metallic elements hafnium(Hf)and molybdenum(Mo)were added in small amounts(1.5at%)because of their well-known positive effects on high-temperature *** characteristics were comprehensively explored by using a two-dimensional cross-sectional method and extracted by using a three-dimensional electrolytic extraction *** results revealed that the addition of Hf can reduce Al_(2)O_(3)inclusions and lead to the formation of more stable Hf-rich inclusions as the main *** addition cannot influence the inclusion type but could influence the inclusion characteristics by affecting the physical parameters of the HEA *** calculated coagulation coefficient and collision rate of Al_(2)O_(3)inclusions were higher than those of HfO_(2)inclusions,but the inclusion amount played a larger role in the agglomeration behavior of HfO_(2)and Al_(2)O_(3)*** impurity level and active elements in HEAs were the crucial factors affecting inclusion formation.

关键词： high-entropy alloy non-metallic inclusion agglomeration thermodynamics alloying

A survey of inverse reinforcement learning techniques

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International Journal of Intelligent Computing and Cybernetics 2012年第3期5卷 293-311页

作者： Shao Zhifei Er Meng joo School of Electrical and Electronics Engineering Nanyang Technological UniversitySingapore

Purpose-This purpose of this paper is to provide an overview of the theoretical background and applications of inverse reinforcement learning(IRL).Design/methodology/approach-Reinforcement learning(RL)techniques provide a powerful solution for sequential decision making problems under *** uses an agent equipped with a reward function to find a policy through interactions with a dynamic ***,one major assumption of existing RL algorithms is that reward function,the most succinct representation of the designer’s intention,needs to be provided *** practice,the reward function can be very hard to specify and exhaustive to tune for large and complex problems,and this inspires the development of IRL,an extension of RL,which directly tackles this problem by learning the reward function through expert *** this paper,the original IRL algorithms and its close variants,as well as their recent advances are reviewed and ***-This paper can serve as an introduction guide of fundamental theory and developments,as well as the applications of ***/value-This paper surveys the theories and applications of IRL,which is the latest development of RL and has not been done so far.

关键词： Inverse reinforcement learning Reward function Reinforcement learning Artificial intelligence Learning methods

Role of GABA plasticity in stroke recovery

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Neural Regeneration Research 2014年第23期9卷 2026-2028页

作者： Nam-Jong Paik Eun joo Yang Department of Rehabilitation Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital

Stroke is a leading cause of long-term disability. Most stroke patients regain their function partially or fully during the first 3-6 months depending on location and size of the lesion. During this functional recovery phase, cortical reorganization or plasticity occurs, and physiological responsiveness or neuronal excitability is altered in the ipsilesional and contralesional areas. However, how to drive successful plastic changes or successful stroke recovery are not fully elucidated yet.

关键词： GABA Role of GABA plasticity in stroke recovery

The Literary Imagination of the White Pagoda and Dynastic Change in Early Ming Hangzhou

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2015年第1期9卷 54-74页

作者： Fumiko joo East Asian Studies Program Krieger School of Arts & Sciences Johns Hopkins University Baltimore MD 21218 USA

This article examines the literary imaginations of the White Pagoda and demonstrates a shift in its representation from a metaphor for the Song court＇s fate to a fantastic site for the subjugation of unworldly beings. In the late thirteenth century, the Yuan-appointed Tibetan Buddhist monk Yang Lianzhenjia exhumed the imperial mausoleums of the defeated Southern Song, built the White Pagoda on the site of the old Southern Song palace in Hangzhou, and interred the exhumed bones under it. Enthusiastic Song loyalists thus considered the White Pagoda to be a symbol of a humiliating past in which the Mongol Yuan dynasty occupied the south. Meanwhile, Qu You, an early-Ming writer from Hangzhou, began to imagine that the White Pagoda served to pacify the innocent, lonely dead who died during the Song-Yuan social disturbance. Investigating the discourse of the early Ming literati in regard to the pagoda site and the supernatural in early Ming Hangzhou leads to the conclusion that the literary imagination of the White Pagoda would have also contributed to the development of the White Snake Legend, where a white serpent spirit was subdued under Thunder Peak Pagoda in Hangzhou.

关键词： Bei Qiong fall of the Song dynasty Hangzhou history SouthernSong imperial mausoleums Qu You White Pagoda White Snake Legend YangLianzhenjia

Formation Mechanism of MgO·Al_(2)O_(3) Spinel Inclusions in Stainless Steelmaking Processes

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Journal of Iron and Steel Research International 2011年第S2期18卷 320-330页

作者： PARK joo Hyun TODOROKI Hidekazu School of Materials Science and Engineering University of UlsanUlsan 680-749Korea Technical Research Center Nippon Yakin Kogyo Co.Ltd.KawasakishiKanagawa 210-8558Japan

The latest publications regarding the development of technology to control inclusion compositions focusing on MgO?Al2O3 spinel inclusions were summarized in this review article. The problems caused by spinel inclusions, which affect practice as well as products were shown. The formation mechanism of MgO?Al2O3 spinel inclusions is secondly explained thermodynamically from the view points of chemistries of molten steels and slag compositions. Furthermore, crystallization behaviour of spinel was introduced. Countermeasures conducted in practices and laboratories were shown along with some problems still left that should be solved in the future.

关键词： inclusion MgO?Al2O3 spinel thermodynamics crystallization stability deoxidation slag basicity

Spontaneous resolution of systemic sarcoidosis in a patient with chronic hepatitis C without interferon therapy

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World Journal of Gastroenterology 2006年第1期12卷 150-153页

作者： Tae-Hun Kim Jong-Eun joo Departments of Internal Medicine and Medical Research Institute Ewha Womans University College of MedicineSeoulSouth Korea Department of Pathology Eulji University School of MedicineSeoulSouth Korea

A 39-year-old male patient complaining of bilateral hand joint arthralgia was evaluated and found to have chronic hepatitis C and systemic sarcoidosis involving lung, skin, liver, and spleen. Hepatic and cutaneous sarcoidoses were confirmed by the presence of numerous noncaseating granulomas on histological examination. Pulmonary and splenic involvements were diagnosed by imaging studies. Fifteen months later, the sarcoidotic lesions in lung, liver, and spleen were resolved by radiological studies and a liver biopsy showed no granuloma but moderate to severe inflammatory activity, systemic sarcoidosis is a rare comorbidity of chronic hepatitis C which may spontaneously resolve.

关键词： Sarcoidosis Hepatitis C Spontaneous resolution

Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model

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World Journal of Gastroenterology 2017年第25期23卷 4559-4568页

作者： Seung Kak Shin Jae Hee Cho Eui joo Kim Eun-Kyung Kim Dong Kyun Park Kwang An Kwon Jun-Won Chung Kyoung oh Kim Yoon Jae Kim Division of Gastroenterology and Hepatology Department of Internal Medicine Gachon University Gil Medical Center

To evaluate the anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium (DSS)-induced colitis model. METHODSAn acute colitis mouse model was induced by oral administration of 5% DSS in the drinking water for 7 d. In the treated group, rosuvastatin (0.3 mg/kg per day) was administered orally before and after DSS administration for 21 d. On day 21, mice were sacrificed and the colons were removed for macroscopic examination, histology, and Western blot analysis. In the in vitro study, IEC-6 cells were stimulated with 50 ng/mL tumor necrosis factor (TNF)-α and then treated with or without rosuvastatin (2 μmol/L). The levels of reactive oxygen species (ROS), inflammatory mediators, and apoptotic markers were measured. RESULTSIn DSS-induced colitis mice, rosuvastatin treatment significantly reduced the disease activity index and histological damage score compared to untreated mice (P < 0.05). Rosuvastatin also attenuated the DSS-induced increase of 8-hydroxy-2’-deoxyguanosine and NADPH oxidase-1 expression in colon tissue. Multiplex ELISA analysis revealed that rosuvastatin treatment reduced the DSS-induced increase of serum IL-2, IL-4, IL-5, IL-6, IL-12 and IL-17, and G-CSF levels. The increased levels of cleaved caspase-3, caspase-7, and poly (ADP-ribose) polymerase in the DSS group were attenuated by rosuvastatin treatment. In vitro, rosuvastatin significantly reduced the production of ROS, inflammatory mediators and apoptotic markers in TNF-α-treated IEC-6 cells (P < 0.05). CONCLUSIONRosuvastatin had the antioxidant, anti-inflammatory and anti-apoptotic effects in DSS-induced colitis model. Therefore, it might be a candidate anti-inflammatory drug in patients with inflammatory bowel disease.

关键词： Oxidative stress Inflammatory bowel disease Rosuvastatin Apoptosis