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Burnout amongst radiologists:A bibliometric study from 1993 to 2020

World Journal of Psychiatry 2022年第2期12卷 368-378页

作者： Muhammad Fazal Hussain Qureshi Danish Mohammad Syed Mustafa Ali shah Mahira Lakhani muzna.shah Muhammad Hassan Ayub Sara Sadiq Medical College Ziauddin UniversityKarachi 75000SindhPakistan Department of Physiology CMH Institute of Medical SciencesBahawalpur 75000Pakistan

BACKGROUND Burnout amongst radiologists is common in many different institutions and is increasing day by *** battle burnout,we have to address the root causes already recognized in published ***,it is crucial to examine and discern important *** To provide evidence-based data and trends related to burnout in radiologists so that researchers can work on it further and develop preventive strategies to overcome this *** Bibliometric analysis conducted by two independent reviewers separately used Scopus Library for data extraction by using medical subject heading and International Classification of Diseases ***-nine articles were selected for analysis after an extensive *** Package for the Social Sciences version 20 was used for *** correlation coefficient,Kruskal Wallis test,and Mann-Whitney U test were *** The most productive period with regards to the number of publications was between 2017 and 2019.A total of 160 authors contributed to the topic burnout among radiologists,with an average of 3.26 authors per *** 41.68%of the authors were female,whilst 35%of them were first *** co-citation analysis by author involved 188 cited authors,13 of whom were cited at least 70 *** six out of forty-nine studies were funded by various government institutions and non-governmental *** Current analysis casts a spotlight on important trends being witnessed in regard to the mental health of radiologists,including lack of funding for mental health research,narrowing of female vs male citation gap,as well as authorship and citation trends.

关键词： Bibliometric Analysis Burnout Radiologist Stress Scientometrics

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Accidental Diagnosis of Infections among Blood Donors

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International Journal of Clinical Medicine 2019年第10期10卷 463-468页

作者： Sara Sadiq Mahira Lakhani Salman Baig Muhammad Fazal Hussain Qureshi muzna.shah Department of Physiology CMH Institute of Medical SciencesBahawalpurPakistan Student 3^(rd) Year MBBS Ziauddin UniversityKarachiPakistan Department of Otolaryngyology and Infection Control Bahria International HospitalKarachiPakistan

ntroduction: Due to widespread incidence and prevalence, human immunodeficiency virus (HIV), hepatitis B (HBV) and C (HCV), syphilis and malaria are the most common viral infections transmitted via blood transfusions. Yet there is insufficient information available about the exact prevalence of these infections among blood donors in Pakistan. The objectives of current study are to highlight the importance of blood screening among blood donors by finding the prevalence of high-risk transmissible diseases such as hepatitis B, hepatitis C, HIV, syphilis and malaria in the population of Nawabshah (Sindh) and to compare it with other provinces. Methods: A descriptive type of cross-sectional study was conducted on 37,845 blood donor volunteers at the blood bank of a tertiary care hospital, Peoples University of Medical and Health Sciences Hospital, in Nawabshah Sindh from 1st January 2018 to 31st December 2018. The data was taken from the well-maintained yearly record of the hospital blood bank. Analysis of all the data regarding blood donors was done using Statistical Program of Special Sciences (SPSS) version 20. Results: The most common age group was between 18 - 40 years. Donors were predominantly male (90%). HBV is the most prevalent disease amongst the blood donors of Peoples Medical College with a prevalence of 6.52% while HIV, HCV and malaria were 6.33%, 5.83% and 1.24% respectively whereas Syphilis is the least prevalent disease with a prevalence of 1.11%. Comparing with other provinces, the highest prevalence of hepatitis B was seen in Peoples Medical College, Nawabshah, Sindh whereas for hepatitis C it was the highest in Isra University Hospital, Hyderabad, Sindh. Moreover, Hayatabad Medical Complex in Peshawar was the least burdened with Hepatitis B (1.46%) and C (1.34%). Conclusion: Accidental diagnosis of blood-borne infections including Hepatitis B, C, HIV, Syphilis and malaria highlights importance of blood screening among the blood donors. There is a need

关键词： Blood Donors Infectious Diseases Hepatitis B Hepatitis C

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Frequency of Neurological Disorders and Related EEG Finding in a Tertiary Care Hospital of Karachi

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Journal of Biosciences and Medicines 2019年第11期7卷 56-64页

作者： Danish Mohammad Syeda Saba Zaidi Bina Fawad Muhammad Fazal Hussain Qureshi Zain Jawed Abubaker Muhammad Zubair Shaikh muzna.shah Mahira Lakhani Sara Sadiq Ziauddin University Karachi Pakistan Department of Neurology Liaquat National Hospital Karachi Pakistan Department of Community Health Sciences Ziauddin University Karachi Pakistan Department of Physiology CMH Institute of Medical Sciences Bahawalpur Pakistan

Background: Electroencephalogram (EEG) is defined as a method of detecting brain waves signifying the electrical conductivity of the brain. Globally, EEG is used to further classify neuropsychiatric disorders. Objective: To evaluate the prevalence of abnormal EEGs and related neurological disorders and it’s correlation with age and gender. Methodology: A descriptive cross sectional study was conducted in Neurology department, Ziauddin hospital, Karachi, Pakistan from June 2018 to May 2019. A total of 440 individuals based on inclusion criteria were selected through Non-probability consecutive sampling. Informed consent was obtained from study participants. A self-designed structured questionnaire and EEG record were used for data collection. Data were entered and analyzed using SPSS v 20. Mean and standard deviation was calculated for numerical variable and frequency and percentages were calculated for categorical variable. Independent t-test and chi square was used to check association of abnormal EEG with age and gender. P value of ≤0.05 was considered statistically significant. Results: The mean age of study participants was 52.98 ± 22.68 years. There were 54.5% (n = 240) males. Approximately 45.2% (n = 199) participants had predisposing condition which can lead to abnormal EEG. EEG records of 39.8% (n = 175) of the patients was normal while 60.2% (n = 265) had abnormal records. Diffuse neuronal dysfunction consistent with encephalopathy was found in 45.2%. Mild neuronal dysfunction consistent with encephalopathy accounted for 33.5% of cases. Significant difference was found in Abnormal EEG among different age group (p = 0.01). Chi square shows an association between abnormal EEG and male gender (p = 0.025). Conclusion: EEG plays a vital role in the diagnosis of neuropsychiatric conditions in developing countries. EEGs can further help to determine the relationship of different neuropsychiatric conditions and can help in early diagnosis and better prognosis.

关键词： Neurological Disorders EEG Association

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COVID-19 vaccination and myocarditis: A review of current literature

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World Journal of Virology 2022年第4期11卷 170-175页

作者： Kartik Dhaduk Jagjit Khosla muzna Hussain Vrunda Mangaroliya Shaylika Chauhan Kumar Ashish Rahul Gupta Suman Pal Department of Internal Medicine Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18702United States Department of Cardiology University of OklahomaOklahomaOK 73019United States Department of Internal Medicine Carolina East Medical CenterNorth CarolinaNC 28560United States Department of Medicine Westchester Medical CenterValhallaNY 10595United States Department of Internal Medicine University of New MexicoNew MexicoNM 87106United States

Vaccination for coronavirus disease 2019(COVID-19)is a critical strategy in controlling the current pandemic of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).After widespread COVID-19 vaccine implementation,isolated case reports about myocarditis as a potential adverse reaction started *** of November 12,2021,Centers for Disease Control and Prevention(CDC)has reported 1793 cases of myocarditis or pericarditis among young people with age 12-29 years,most cases have been reported in the male adolescent age group after the second dose of mRNA COVID-19 *** is very important to monitor the safety standards and adverse reactions of vaccines to effectively implement the vaccination *** CDC and the United States Food and Drug Administration actively monitor vaccine-associated adverse reactions a well-known platform such as Vaccine Adverse Event Reporting *** continues to recommend COVID-19 vaccines and booster doses for eligible individuals(age limit according to the type of vaccine)after careful consideration from risk-benefit assessment and favorable outcomes from *** behind COVID-19 vaccine-induced myocarditis are not clear yet but several possibilities such as molecular mimicry between the spike protein of SARS-CoV-2 and self-antigens,immune response to mRNA,and activation of host immunological system,trigger of the pre-existing dysregulated immunological system have been documented in the ***,data suggests a good prognosis,especially in young *** this review article,we cover currently available data on COVID-19 vaccine-related myocarditis incidence,concerns,possible mechanisms of myocarditis,current treatment,and outcome trends,risk vs benefit assessment of COVID-19 vaccination in this current pandemic.

关键词： Coronavirus disease 2019 vaccine Myocarditis mRNA vaccine Severe acute respiratory syndrome coronavirus-2 Vaccine complications Risk assessment

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Estimation of HCV viral load and liver enzymes among different patients groups of District Gujrat, Pakistan

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Advances in Bioscience and Biotechnology 2013年第9期4卷 866-871页

作者： Asim Mushtaq Mujahid Azeem Tariq Umer Rashid Amber Afroz Nadia Zeeshan Abdul R. Asif muzna Zahur Department of Biochemistry and Molecular Biology University of Gujrat Gujrat Pakistan Department of Clinical Chemistry University Medical Centre Goettingen Germany Department of Pathology Hashmat Medical College Gujrat Pakistan

Hepatitis C has a 3% of the global disease burden that remains endemic in many regions of the world. According to a general statistical survey it has approximately 5.3% seroprevalence in Pakistan. HCV is a persistent and silent disease thus making the primary diagnosis complicated. Occasionally HCV positive population could not be diagnosed by routine HCV antibody testing therefore requires molecular diagnosis. This study is aimed to determine the prevalence of HCV and to estimate the HCV viral load by quantitative analysis among different patient groups of District Gujrat, Pakistan. A total of 597 samples were collected from clinically diagnosed liver patients that were categorized into three age groups: 1) up to 25 years;2) 26-50 years 3) above 50 years. All samples were subjected to real time PCR for determination and quantification of HCV RNA. Activity of liver aminotransferases was measured. The overall prevalence of HCV-RNA was 73.87%. Females had slightly higher HCV prevalence which is 74.06% while 73.45% in males. Highest prevalence of active HCV infection was found in age group 26-50. In addition, liver function tests showed that 28.12% HCV-positive patients do not have elevated ALT level whereas 32.65% did not show elevated AST levels. It may be assumed that there is not a significant relationship between increased viral load and liver amino transferases. The study concluded a significantly higher rate of HCV infection in young population. Moreover screening with antibody and liver function tests alone does not exclude the possibility of HCV infection.

关键词： Hepatitis C Viral Load Alanine Aminotransferase Aspartate Aminotransferase HCV RNA Gujrat

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Homeobox leucine zipper proteins and cotton improvement

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Advances in Bioscience and Biotechnology 2013年第10期4卷 15-20页

作者： muzna Zahur Muhammad Ahsan Asif Nadia Zeeshan Sajid Mehmood Muhammad Faheem Malik Abdul R. Asif Department of Biochemistry and Molecular Biology University of Gujrat Gujrat Pakistan Department of Clinical Chemistry University Medical Center Goettingen Goettingen Germany

Transcription factors play key roles in plant development and stress responses through their interaction with cis-elements and/or other transcription factors. Homeodomain associated leucine zipper proteins (HD-Zip) constitute a family of transcription factors that are characterized by the presence of a DNA-binding domain closely linked with leucine zipper motif functioning in dimer formation. This type of association is unique to plants and considered as an excellent candidate to activate developmental responses to altering environmental conditions. Cotton is the most important fiber plant with a lot of local and commercial uses in the world. HD-Zip proteins not only have key roles in different stages of vascular and inter-fascicular fiber differentiation of cotton but also are suggested to have an important role against abiotic stress that is one of the key factors limiting cotton productivity. Plants have developed various strategies to manage stress conditions through a combination of metabolic, physiological and morphological adaptations. These adaptive changes rely largely on alterations in gene expression. Therefore, transcriptional regulators play a crucial role in stress tolerance. Being a transcription factor HD-Zip might be a useful target for genetic engineering to generate multiple stress tolerance in susceptible plants. In the following chapter, we discussed how the HD-Zip proteins would play a useful role for cotton development both in fiber production and stress adaptation.

关键词： Cotton Stress Transcription Factor HD-Zip Proteins Homeobox Leucine Zipper

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Identification and optimization of a potent and highly selective D3 dopamine receptor agonist

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中国药理学与毒理学杂志 2017年第10期31卷 950-951页

作者： Amy E MORITZ R Benjamin FREE Warren WEINER muzna BACHANI Trevor DOYLE Noel SOUTHALL Marc FERRER Jonathan A JAVITCH Joseph STEINER Ara ABRAMYAN Lei SHI Jeffrey AUBé Kevin FRANKOWSKI David R SIBLEY Molecular Neuropharmacology Section National Institute of Neurological Disorders and StrokeNational Institutes of Health Bethesda MD 20814 University of North Carolina Chapel Hill NC27599 Neurotherapeutic Development Unit National Institute of Neurological Disorders and StrokeNational Institutes of Health Bethesda MD 20814 National Center for Advancing Translational Sciences Rockville MD 20892 Columbia University New York NY 10032 Computational Chemistry and Molecular Biophysics Unit Molecular Targets and Medications Discovery Branch National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224

OBJECTIVE Dopamine receptors(DRs) are involved in the development and treatment of many neuropsychiatric *** available dopaminergic drugs modulate both DRD2 and DRD3,leading to side effects and uncertainty as to the roles each DR subtype plays *** lab employed high throughput screening paradigms to discover highly selective modulators for the *** The NIH Molecular Libraries Program 400,000 + small molecule library was screened using the Discove Rx Path Hunter?β-arrestin assay for compounds that activate the DRD3 without effects on the *** and counter-screens assessed selectivity and mechanisms of *** identified 62 potential agonists,and chose the most promising to perform a structure-activity relationship(SAR) study to increase potency while maintaining *** lead compound identified through this process,ML417,was also characterized using bioluminescence resonance energy transfer(BRET)-based β-arrestin recruitment and G-protein activation assays as well as p-ERK *** neuroprotective properties of this compound were assessed using a SHSY5 Y neuronal cell *** ML417 displays potent,DRD3-selective agonist activity in multiple functional *** and functional GPCR screens(>165 receptors) show ML417 has limited cross-reactivity with other ***417 also displays superior(compared to the reference compound pramipexole),dose-dependent protection against a decrease in neurite length induced by 10 μmol·L^(-1) of the neurotoxin,6-hydroxydopamine,in the SHSY5 Y cell *** We have discovered and characterized ML417,a potent and highly selective DRD3 *** compound will be useful as a research tool,and may prove useful as a therapeutic drug lead.

关键词： Dopamine receptor high throughput screening subtype selectivity neuroprotection

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High levels of Zinc-α-2-Glycoprotein among Omani AIDS patients on combined antiretroviral therapy

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Asian Pacific Journal of Tropical Biomedicine 2014年第8期4卷 610-613页

作者： Sidgi Syed Anwer Hasson Mohammed Saeed Al-Balushi muzna Hamed Al Yahmadi Juma Zaid Al-Busaidi Elias Antony Said Mohammed Shafeeq Othman Talal Abdullah Sallam Mohammed Ahmad Idris Ali Abdullah Al-Jabri Department of Microbiology and Immunology College of Medicine and Health SciencesSultan Qaboos UniversityPOBox 35MuscatOman Department of Community Health Faculty of Applied Medical SciencesAl-Baha UniversitySaudi Arabia

Objective:To investigate the levels of zinc-α-2-glycoprotein(ZAG) among Omani AIDS patients receiving combined antiretroviral therapy(cART).Methods:A total of 80 Omani AIDS patients(45 males and 33 females),average age of 36 *** were receiving cART at the Saltan Qaboos University Hospital(SQUH).Muscat,Oman,were tested for the levels of *** addition,SO healthy blood donors(46 males and 34 females),average age of 26 years,attending the SOUH Blood Bank,were tested in parallel as a control *** of the ZAG levels was performed using a competitive enzyme—linked immunosorbent assay and in accordance with the manufacturer's ***:The ZAG levels were found to he significantly higher among AIDS patients compared to the healthy individuals(P=0.033).A total of 56(70%) of the AIDS patients were found to have higher levels of ZAG and 16(20%) AIDS patients were found to have high ZAG levels,which are significantly(P>0.031) associated with weight ***:ZAG levels are high among Omani AIDS patients on cART and this necessitales the measurement of ZAG on routine basis,as it is associated with weight loss.

关键词： Zinc-α-2-glycoprotein AIDS Patients Combined antiretroviral therapy Levels Oman

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