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Effects of the hydro-ethanolic extract of Marrubium vulgare in female rats

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 154-158页

作者： Rim Aouni Mossadok Ben Attia Mohamed Habib Jaafoura Amina Bibi-Derbel mustapha Haouari Faculty of Sciences of Bizerte Department of life Sciences7021 JarzounaUniversity of Carthage INNTA SURVEN Research Laboratory(Monitoring and nutritional epidemiology in Tunisia) Laboratoire Biomonitoring of the Environment Faculty of Sciences of Bizerte.7021 JarzounaUniversity of Carthage Orthopedic InstituteMohamed Kassab Laboratory of Cyto-Morphology and Anatomy Pathologic National Institute of Nutrition and Food technology Clinical laboratory of biochemistry Ecole Superior of Science and Technology of Health of Tunis University of Tunis El Manar

Objective:To evaluate the effects of ethanol–water(80:20) extract of Marrubium vulgare(***) on the hematological parameters,macroscopic and histological aspects of the uterus and fetus in non-pregnant and pregnant ***:Female rats were divided into 4 equal groups(n = 9),group N(normal rats) and group G(pregnant rats) considered as control groups,group NE(normal rats treated with the ethanol–water(80:20,v/v) extract of ***) and group GE(pregnant rats treated with the extract).The ethanol–water(80:20) plant extract was administered in a single daily dose 1 g/kg at the morning,during 19 *** the 19 day of the experiment,animals were sacrificed,the uterus and fetuses were removed for the morphological and histological studies and the blood was collected in EDTA tubes for the measurement of hematological parameters with the use of an automate ‘HORIBA ABX Micros 60 Hematology Analyzer'.Results:Our results showed,in group NE and GE,a significant decrease on hematological parameters:red blood cells(NE:18.6%;GE:38.4%),hematocrit(NE:13.8%;GE:20.4%),hemoglobin(NE:12.1%;GE:8.3%) and mean corpuscular volume(NE:6.4%;GE:2%) with P more less a ***,the extract of *** caused a significant decrease on the mean implantations of fetuses(82.5%,P<0.001) and their size(47.2%,P< 0.01).As for the macroscopic and histological appearance of uterus,our data showed no change in normal treated *** contrast,the treated pregnant rats showed a severe histological change characterized by the existence of location of stopped ***,it was also found in the uterus of these rat lyses placental and embryo ***:All these results support the hypothesis of an abortifacient effect of ***.

关键词： Vegetal extract Abortificiant effect Hematological parameters Fetuses Uterus Histology

Human liver stem/progenitor cells decrease serum bilirubin in hyperbilirubinemic Gunn rat

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World Journal of Gastroenterology 2014年第30期20卷 10553-10563页

作者： Cédric Maerckx Tatiana Tondreau Silvia Berardis Jos van Pelt mustapha Najimi Etienne Sokal Laboratory of Pediatric Hepatology and Cell Therapy Université Catholique de Louvain - Institut de Recherche Clinique et Expérimentale1200 BrusselsBelgium Katholieke Universiteit Leuven Hepatologie3000 LeuvenBelgium

AIM: To test the ability of adult-derived human liver stem/progenitor cells (ADHLSC) from large scale cultures to conjugate bilirubin in vitro and in bilirubin conjugation deficient rat.

关键词： Liver stem/progenitor cells Gunn rat Hepatocyte in vitro and in situ differentiation Uridine diphosphate-glucuronosyltransferase 1A1

Geometric Inversion of Two-Dimensional Stokes Flows – Application to the Flow between Parallel Planes

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Engineering（科研） 2010年第10期2卷 780-787页

作者： mustapha Hellou 不详

Geometric inversion is applied to two-dimensional Stokes flow in view to find new Stokes flow solutions. The principle of this method and the relations between the reference and inverse fluid velocity fields are presented. They are followed by applications to the flow between two parallel plates induced by a rotating or a translating cylinder. Thus hydrodynamic characteristics of flow around circular bodies obtained by inversion of the plates are thus deduced. Typically fluid flow patterns around two circular cylinders in contact placed in the centre of a rotating or a translating circular cylinder are illustrated.

关键词： Inversion Transformation Geometric Inversion Stokes Flow Viscous Eddies Flow around a Cylinder Microflow

Investigation of the Characteristics of the 2008 Wenchuan and 2013 Lushan Earthquakes and Their Relationship

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地质学报 2013年第S1期 6-7页

作者： LIN Jian Shinji TODA Ross S.STEIN mustapha MEGHRAOUI Woods Hole Oceanographic Institution Tohoku University U.S.Geological Survey EOST-Institut de Physique du Globe de Strasbourg

This presentation illustrates the characteristics of the 2008 Wenchuan and 2013 Lushan earthquakes, investigates their stress interaction, and discusses the implications on regional seismicity rate changes. In 2008, we calculated that the 12 May 2008 Mw=7.9 Wenchuan earthquake has increased Coulomb failure stress on adjacent major fault systems, including the ends of the 2008 Longmen Shan rupture,

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Hamiltonian Polynomial Eigenvalue Problems

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Journal of Applied Mathematics and Physics 2020年第4期8卷 609-619页

作者： mustapha Bassour Faculté des Sciences Juridiques Economiques et Sociales Ait Melloul Morocco LISTI Laboratory ENSA Ibn Zohr University Agadir Morocco

We present in this paper a new method for solving polynomial eigenvalue problem. We give methods that decompose a skew-Hamiltonian matrix using Cholesky like-decomposition. We transform first the polynomial eigenvalue problem to an equivalent skew-Hamiltonian/Hamiltonian pencil. This process is known as linearization. Decomposition of the skew-Hamiltonian matrix is the fundamental step to convert a structured polynomial eigenvalue problem into a standard Hamiltonian eigenproblem. Numerical examples are given.

关键词： Hamiltonian Matrix Polynomial Eigenvalue Problem Skew-Hamiltonian/Hamiltonian Pencil Cholesky Like-Decomposition

Profiling neuroprotective potential of trehalose in animal models of neurodegenerative diseases:a systematic review

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Neural Regeneration Research 2023年第6期18卷 1179-1185页

作者： Kah Hui Yap Shahrul Azmin Suzana Makpol Hanafi Ahmad Damanhuri Muzaimi mustapha Jemaima Che Hamzah Norlinah Mohamed Ibrahim Department of Medicine UKM Medical CentreKuala LumpurMalaysia Department of Biochemistry UKM Medical CentreKuala LumpurMalaysia Department of Neurosciences School of Medical SciencesUniversiti Sains MalaysiaKelantanMalaysia Department of Ophthalmology UKM Medical CentreKuala LumpurMalaysia

Trehalose,a unique nonreducing crystalline disaccharide,is a potential disease-modifying treatment for neurodegenerative diseases associated with protein misfolding and aggregation due to aging,intrinsic mutations,or autophagy *** systematic review summarizes the effects of trehalose on its underlying mechanisms in animal models of selected neurodegenerative disorders(tau pathology,synucleinopathy,polyglutamine tract,and motor neuron diseases).All animal studies on neurodegenerative diseases treated with trehalose published in Medline(accessed via EBSCOhost)and Scopus were *** the 2259 studies screened,29 met the eligibility *** to the SYstematic Review Center for Laboratory Animal Experiment(SYRCLE)risk of bias tool,we reported 22 out of 29 studies with a high risk of *** present findings support the purported role of trehalose in autophagic flux and protein *** review identified several other lesser-known pathways,including modifying amyloid precursor protein processing,inhibition of reactive gliosis,the integrity of the blood-brain barrier,activation of growth factors,upregulation of the downstream antioxidant signaling pathway,and protection against mitochondrial *** absence of adverse events and improvements in the outcome parameters were observed in some studies,which supports the transition to human clinical *** is possible to conclude that trehalose exerts its neuroprotective effects through both direct and indirect ***,heterogeneous methodologies and outcome measures across the studies rendered it impossible to derive a definitive *** studies on trehalose would need to clarify three important questions:1)bioavailability with oral administration,2)optimal time window to confer neuroprotective benefits,and 3)optimal dosage to confer neuroprotection.

关键词： amyotrophic lateral sclerosis autophagy neurodegenerative disease neuroinflammation polyglutamine tract protein refolding spinocerebellar ataxia synucleinopathy tau pathology trehalose

Finite element analysis and structural design of pretensioned inverted T-beams with web openings

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Frontiers of Structural and Civil Engineering 2009年第2期3卷 148-157页

作者： Hock Tian CHENG Bashar S.MOHAMMED Kamal Nasharuddin mustapha Faculty of Civil and Environmental Engineering Universiti Malaysia PahangMalaysia Department of Civil Engineering College of EngineeringUniversiti Tenaga NasionalMalaysia

This paper presents the results of a research project aimed at providing standard circular web openings to the popular precast pretensioned inverted *** size and placement and required materials strengths were *** this paper the nonlinear analysis and design of simply supported pretensioned inverted T-beam with circular web openings are *** design parameters are varied:opening location and number of *** results from nonlinear finite element analysis were substantiated by test results from five pretensioned inverted T-beams with web opening and one solid *** agreement is shown between the theoretical and the experimental *** test results obtained from this investigation show that the performance of the specimens with web openings is almost identical to that of the specimen without web openings.A simple design method for pretensioned inverted T-beam with circular web openings is proposed.

关键词： prestressed concrete inverted-T beam web opening

Synergistic Effect of Halloyosite Nanotube and Nanocellulose on Thermal and Mechanical Properties of Poly(Ethylmethacrylate-co-Acrylonitrile)Bionanocomposites

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Journal of Renewable Materials 2020年第3期8卷 301-317页

作者： Karima Ben Hamou Amal Kadimi Remo Merijs Meri Sergei Gaidukov Hamid Kaddami mustapha Raihane Mouhamed Lahcini Fouad Erchiqui Laboratory of Organometallic and Macromolecular Chemistry-Composites Materials Faculty of Sciences and Technology of MarrakechCadi Ayyad UniversityGuélizAv.A.El KhattabiMarrakechBP 618Morocco Engineering School University of Québec in Abitibi-Témiscamingue445 Boulevard de l'UniversitéRouyn-NorandaJ9X 5E4QuébecCanada Institute of Polymer Materials Riga Technical UniversityKaļķu iela 1Centra rajonsRīgaLV-1658Latvia

This work reports a comprehensive study on poly(Ethylmethacrylateco-Acrylonitrile)Poly(EMA-AN)nanocomposites reinforced with a hybrid mixture of nanoreiforcements based on nanocrystals of cellulose(NCC)(1 or 5%wt)and halloysite nanotubes(HNTs)(1 or 5%wt).The morphology,thermal and mechanical properties of these nanocomposites were *** dispersion of the nanofillers has been shown by scanning electron microscopy.A significant increase of the rubbery modulus and glass transition temperature were obtained upon filler addition,due to the reduction of mobility of the matrix macromolecular *** the other hand,compared with the neat Poly(EMAAN),the storage modulus of the nanocomposites increased by a factor 38 when adding 5 wt%NCC and by 17 for the same concentration of *** properties of ternary nanocomposites were furthers increased resulting from a synergistic effect of these two nanofillers.

关键词： Poly(Ethylmethacrylate-co-Acrylonitrile) nanocrystals cellulose halloysite nanotubes nanocomposites hybrid mechanical properties

A Finite Difference Method for Space Fractional Differential Equations with Variable Diffusivity Coefficient

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Communications on Applied Mathematics and Computation 2020年第4期2卷 671-688页

作者： K.A.mustapha K.M.Furati O.M.Knio O.P.Le Maître Department of Mathematics and Statistics King Fahd University of Petroleum and MineralsDhahran 31261Kingdom of Saudi Arabia Computer ElectricalMathermatical Sciences and Engineering DivisionKing Abdullah University of Science and TechnologyThuwal 23955Kingdom of Saudi Arabia CNRS LIMSIUniversitéParis-SaclayCampus Universitaire-BP 13391403 OrsayFrance

Anomalous diffusion is a phenomenon that cannot be modeled accurately by second-order diffusion equations,but is better described by fractional diffusion *** nonlocal nature of the fractional diffusion operators makes substantially more difficult the mathemati-cal analysis of these models and the establishment of suitable numerical *** paper proposes and analyzes the first finite difference method for solving variable-coefficient one-dimensional(steady state)fractional differential equations(DEs)with two-sided fractional derivatives(FDs).The proposed scheme combines first-order forward and backward Euler methods for approximating the left-sided FD when the right-sided FD is approximated by two consecutive applications of the first-order backward Euler *** scheme reduces to the standard second-order central difference in the absence of *** existence and uniqueness of the numerical solution are proved,and truncation errors of order h are demonstrated(h denotes the maximum space step size).The numerical tests illustrate the global 0(h)accu-racy,except for nonsmooth cases which,as expected,have deteriorated convergence rates.

关键词： Two-sided fractional derivatives Variable coefcients Finite diferences