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An Endemic Plant of Ermenek Region （Turkey）, Muscari muscarmi： Economic Importance, and Is There a Useful Way Out Cultivation in Its Natural Habitats？

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Journal of Food Science and Engineering 2018年第4期8卷 189-190页

作者： Haydar Oztas Fulya Oztas mustafa onur aladag Ali Alas A.K. Education Faculty Necmettin Erbakan University Meram Konya 42000 Turkey Vocational High School Selcuk University Konya 42000 Turkey

Turkey is one of the most floristically rich countries in the world with endemic plants. Approximately one third of its flora is endemic. The Muscari muscarimi which belongs to the Liliaceae family is one of its most prominent endemic geophyte plants which originates in southwestern of Turkey where it is found in rocky places like Ermenek, Ba？yayla （Büyükkarap？nar village）, Sar？veliler. This species is the most sweetly scented member of the Liliaceae family, having something of the musk scent. Also, this plant locally is used in traditional medicine as antirheumatic, stomachic, diuretic and expectorant. In addition to this, it has also been used as food for humans and animals, ornamental plants in gardens. Morphologically, it has 3-6 linear-lanceolate, grayish-green leaves per plant and bulbs of 2-4 cm in diameter with thick fleshy perennial roots which delve down into the rocky ground of their natural habitats. The chemical is composed of polysaccharides, homoisoflavanons, glycosides etc. Main components of M. muscarimi were identified as （E）-β-ocimene （t-36%）, methyl salicylate （1-21%）, E-methyl isoeugenol （4-22%） and benzyl benzoate （7-56%）. The picking up of the plant bulbs from their natural habitats is prohibited, in accordance with international agreements for the protection of endangered geophytes. The overly habitat destruction in native growing area threatened the existence of the species categories. It is known that in vitro bulblet production in Muscari muscarimi is low. This is difficult for its cultivation in native Ermenek area districts. Recent works show that the culturing immature Musari muscarimi embryos on different growth media could be considered as a useful method for in vitro propagation. As a result, the geophytes, such as M. muscarimi, are eligible widely for perfume production and in the pharmaceutical industry as well as for ornamental flowers. Because of this plant economic importance, bulbs growing and cultivation in their natur

关键词： Muscari muscariml Ermenek endemic propagation.

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Effect of acetyl L-carnitine on human retinal pigment epithelium-19 cells in hypoxic conditions

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国际眼科杂志 2024年第10期24卷 1515-1521页

作者： Ali Dal onur Catak Murat Erdag Mehmet Canleblebici Ebru Onalan Ilay Buran Department of Ophthalmology Faculty of MedicineFirat UniversityElazig 23119Turkey Department of Ophthalmology Ata Sokmen Faculty of MedicineMustafa Kemal UniversityHatay 31100Turkey Department of Ophthalmology Kayseri State HospitalKayseri 38200Turkey Department of Medical Biology Faculty of MedicineFirat UniversityElazig 23100Turkey

AIM:To investigate the effect of acetyl-L-carnitine(ALCAR)on cell viability,morphological integrity,and vascular endothelial growth factor(VEGF)expression in human retinal pigment epithelium(ARPE-19)cells using a hypoxic ***:In the first set of experiments,the optimal CoCl_(2) dose was determined by exposing ARPE-19 cell cultures to different *** evaluate the effect of ALCAR on cell viability,five groups of ARPE-19 cell culture were established that included a control group,a sham group(200μM CoCl_(2)),and groups that received 1,10 and 100 mM doses of ALCAR combined with 200μM CoCl_(2),*** cell viability was measured by MTT *** morphological characteristics of cells were observed by an inverted phase contrast *** levels of VEGF and HIF-1α secretion by ARPE-19 cells were detected by enzyme linked immunosorbent assay(ELISA)***:ARPE-19 cells were exposed to different doses of CoCl_(2) in order to create a hypoxia ***,when exposed to a concentration of 200μM CoCl_(2),a notable decrease in viability to 83% was *** was found to increase the cell viability at 1 mM and 10 mM concentrations,while the highest concentration(100 mM)did not have an added *** cell viability was found to be significantly higher in the groups treated with a concentration of 1 mM and 10 mM ALCAR compared to the Sham group(P=0.041,P=0.019,respectively).The cell viability and morphology remained unaffected by the greatest dose of ALCAR(100 mM).The administration of 10 mM ALCAR demonstrated a statistically significant reduction in the levels of VEGF and HIF-1α compared with the Sham group(P=0.013,P=0.033,respectively).CONCLUSION:The findings from the current study indicate that ALCAR could represent a viable therapeutic option with the potential to open up novel treatment pathways for retinal diseases,particular relevance for age-related macular degeneration(AMD).However,to fully elucidate ALCAR’s application

关键词： acetyl-L-carnitine(ALCAR) human retinal pigment epithelium(ARPE-19) vascular endothelial growth factor(VEGF) hypoxia-inducible factor 1(HIF-1α)

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An experimental and numerical study of chemically enhanced water alternating gas injection

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Petroleum Science 2015年第3期12卷 470-482页

作者： Saeed Majidaie mustafa onur Isa M.Tan Leap Energy-Subsurface Consulting Services Department of Petroleum and Natural Gas Engineering Istanbul Technical University Applied Science Department Universiti Teknologi Petronas

In this work, an experimental study combined with numerical simulation was conducted to investigate the potential of chemically enhanced water alternating gas （CWAG） injection as a new enhanced oil recovery method. The unique feature of this new method is that it uses alkaline, surfactant, and polymer additives as a chemical slug which is injected during the water alternating gas （WAG） process to reduce the interfacial tension （IFT） and simultaneously improve the mobility ratio. In essence, the proposed CWAG process involves a combination of chemical flooding and immiscible carbon dioxide （CO2） injection and helps in IFT reduction, water blocking reduction, mobility control, oil swelling, and oil viscosity reduction due to CO2 dissolution. Its performance was compared with the conventional immiscible water alter- nating gas （I-WAG） flooding. Oil recovery utilizing CWAG was better by 26 % of the remaining oil in place after waterflooding compared to the recovery using WAG conducted under similar conditions. The coreflood data （cumulative oil and water production） were history mat- ched via a commercial simulator by adjusting the relative permeability curves and assigning the values of the rock and fluid properties such as porosity, permeability, and the experimentally determined IFT data. History matching ofthe coreflood model helped us optimize the experiments and was useful in determining the importance of the parameters influencing sweep efficiency in the CWAG process. The effectiveness of the CWAG process in pro- viding enhancement of displacement efficiency is evident in the oil recovery and pressure response observed in the coreflood. The results of sensitivity analysis on CWAG slug patterns show that the alkaline-surfactant-polymer injection is more beneficial after CO2 slug injection due to oil swelling and viscosity reduction. The CO2 slug size analysis shows that there is an optimum CO2 slug size, around 25 % pore volume which leads to a maximum oil recover

关键词： Enhanced water alternating gas (CWAG) Enhanced oil recovery Interfacial tension Mobilitycontrol ~ Water blocking

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Effect of endogenous hypergastrinemia on gallbladder volume and ejection fraction in patients with autoimmune gastritis

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 527-531页

作者： mustafa Yakut onur Keskin Irfan Soykan Division of Gastroenterology Ibni Sina HospitalAnkara University Faculty of Medicine

BACKGROUND: Gastrin has a cholecystokinetic action on gallbladder motility, and cholecystokinin and gastrin act directly on the smooth muscle of the gallbladder. The aim of this study was to investigate the effect of endogenous hypergastrinemia on gallbladder motility in patients with autoimmune gastritis. METHODS: Forty-one patients (29 females, 12 males; mean age, 46 years) with autoimmune gastritis and 29 healthy subjects (17 females, 12 males; mean age, 44.8 years) were enrolled in the study. Fasting and postprandial gallbladder volumes were measured ultrasonographically with the ellipsoid technique and the ejection fraction of the gallbladder was calculated from fasting and postprandial volumes. All subjects were investigated after 12 hours of fasting and 30 minutes after a standard test meal. RESULTS: The gallbladder ejection fraction (%) of the patients with autoimmune gastritis was lower than that of the control group (46.06±18.28% vs 55.03±14.67%, P=0.032). There was no difference between patients with autoimmune gastritis and the control group in terms of the mean fasting gallbladder volume (30.38±12.85 vs 29.27±9.91 cm 3 , P=0.189) and the mean postprandial gallbladder volume (15.67±8.32 vs 13.44±7.69 cm 3 , P=0.258). Logistic regression analysis of baseline parameters revealed that 'abdominal bloating' was a risk factor for the low gallbladder ejection fraction in autoimmune gastritis patients (P=0.045, F=4.40). In addition, logistic regression analysis of baseline parameters revealed that smoking (n=5, P=0.025, F=5.44) is a predictor of low gallbladder ejection fraction in patients with autoimmune ***: Patients with endogenous hypergastrinemia have a low gallbladder ejection fraction compared with healthy controls. This study shows that at least part of upper gastrointestinal symptoms observed in this patient population may be due to altered gallbladder motility.

关键词： gallbladder motility autoimmune gastritis hypergastrinemia

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The Effects of Aging Time on the Structural and Electrochemical Properties of Composite Coatings on CP-Ti Substrate

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Journal of Bionic Engineering 2017年第3期14卷 532-539页

作者： onur Comakli mustafa Yazici Tuba Yetim Ali Fatih Yetim Ayhan Celik Department of Mechanical Engineering Faculty of Engineering Ataturk University 25240 Erzurum Turkey High Technology Research Centre Erzurum Technical University 25070 Erzurum Turkey Faculty of Engineering and Architecture Department of Chemical Engineering Erzurum Technical University 25070 Erzurum Turkey Faculty of Engineering and Architecture Department of Mechanical Engineering Erzurum Technical University 25070 Erzurum Turkey

TiO2-SiO2 composite films were produced on commercially pure titanium （CP-Ti） substrate by a sol-gel method to in- vestigate the behavior of sol aging time and its potential effects on the structural and electrochemical properties of composite coatings. Anatase-TiO2 and quartz-SiO2 peaks were observed on all composite coated samples according to XRD results. It was observed that the average grain size increased with sol aging time. Also, the average smallest grain size was seen at composite coatings prepared from unaged sol according to the width of the peaks. Electrochemical behavior of coated samples was mainly investigated by potentiodynamic polarization and Electrochemical Impedance Spectroscopy （EIS） in Simulated Body Fluid （SBF） solution. In corrosion tests, the composite coatings showed better anti-corrosion behavior than that of uncoated samples. In addition, the corrosion properties of the composite films were considerably affected by sol aging time. Corrosion resistance of coatings decreased with increasing aging time and the best result was obtained from composite coatings prepared from unaged sol.

关键词： bioinspired TiO2-SiO2 coatings CP-Ti substrate electrochemical properties sol-gel

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(E)-1-[4-(2-hydroxy-5-methoxybenzylideneamino)-phenyl]ethanone and (E)-1-[4-(2-hydroxy-4-methoxybenzylideneamino) phenyl]ethanone:X-ray and DFT-calculated structures

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Chinese Journal of Structural Chemistry 2011年第1期30卷 111-119页

作者： SAHN onur BYKGNGR Orhan ALBAYRAK igdem ODABASOGLU mustafa Department of Physics Faculty of Arts and SciencesOndokuz Mayls University Department of Science Education Sinop University Chemistry Programme Pamukkale University 20159 Denizli

The isomeric structures of（E）-1-[4-（2-hydroxy-5-methoxybenzylideneamino）-phenyl] ethanone（I） and（E）-1-[4-（2-hydroxy-4-methoxybenzylideneamino） phenyl]ethanone（Ⅱ） ,both C16H15NO3,have been determined using X-ray diffraction techniques and characterized by IR,and their molecular structures have also been optimized at the B3LYP/6-31G（d,p） level using density functional theory（DFT） . The energetic behaviors of the title compounds in solvent media have been examined using B3LYP method with the 6-31G（d,p） basis set by applying the polarizable continuum model（PCM） . The total energies of the title compounds decrease with the increasing polarity of the solvent. In addition,DFT calculations of the title compounds＇ molecular electrostatic potentials（MEP） were performed at the B3LYP/6-31G（d,p） level of theory. X-ray study shows that the title compounds both have strong intramolecular O-H…N hydrogen bonds. The molecules of Ⅰ are linked into a one-dimensional framework structure by C-H…π interactions,while in Ⅱ,intermolecular π···π interactions result in the formation of infinite chains running along the [010].

关键词： crystal structure Schiff base DFT molecular electrostatic potential

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A 99-year old patient with takotsubo cardiomyopathy recovering from cardiogenic shock

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Journal of Geriatric Cardiology 2019年第7期16卷 578-579页

作者： mustafa Yenercag Ugur Arslan Güney Erdogan onur Osman Seker Osman Can Yontar Department of Cardiology University of Health Sciences Samsun Training and Research Hospital

Takotsubo syndrome(TTS)is a rare clinical entity commonly seen in post-menopausal women after an emotional or sometimes physical stress.[1,2]This syndrome is thought to be caused by increased circulation catecholamine levels secondary to an adrenergic stimulus resulting in transient coronary spasm and microvascular dysfunction.[3]TTS is characterized by acute and reversible left ventricular dysfunction with the typical ECG and clinical findings of an acute coronary syndrome but no significant coronary stenosis.[4]Typically,in TTS,antero-apical ballooning is observed in ventriculography,and segmentary wall motion abnormalities are observed in magnetic resonance imaging and *** heart failure,left ventricular outflow tract obstruction,mitral regurgitation and cardiogenic shock may complicate this syndrome.[5]Herein,we present a case who is the oldest one in the literature with TTS and cardiogenic shock.

关键词： Apical ballooning Levosimendan Takotsubo cardiomyopathy

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The Effects of Temperature and Humidity around the Beehives on the Distribution of Nosema ceranae, and also Geographical and Seasonal Activity of the Infection in the Eastern Black Sea Region of Turkey.

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Journal of Environmental Science and Engineering(B) 2016年第11期5卷 513-522页

作者： onur Tosun mustafa Yaman Giresun University Alucra Turan Bulutcu Vocational School Giresun 28700 Turkey Karadeniz Technical University Department of Biology Trabzon 61080 Turkey

20 localities were randomly selected in Eastern Black Sea Region of Turkey and samples were collected from around the beehives from April to September. Total of 4,640 dead adult worker bees were examined during the study. Total infection rate in worker bees was 21.23%. Nosema ceranae was identified in all localities with molecular techniques. Temperature and humidity values were measured from around the beehives during field studies. The infection rate ofN. ceranae increased proportionally with increasing temperature and humidity factors. Humidity was more effective than temperature on the infection rate ofN. ceranae. The seasonal activity ofN. ceranae was studied. The highest infection rates were observed in June and July. N. ceranae infection rate was higher in localities that were in low-altitude than in localities that were in high-altitude.

关键词： Temperature humidity geographical distribution Nosema ceranae Apis mellifera Turkey.

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Investigation of Methylation Profiles of TP53, Caspase 9, Caspase 8, Caspase 3 Genes Treated with DNA Methyl Transferase Inhibitor (DNMTi) Zebularine (ZEB) and Caffeic Acid Phenethyl Ester (CAPE) on MCF-7 and MDA-MB-231 Breast Cancer Cell Lines

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Journal of Cancer Therapy 2019年第1期10卷 69-85页

作者： onur Eroglu Esin Guvenir Celik Hacer Kaya Merve Celen mustafa Karabicici Elif Karacoban Department of Molecular Biology and Genetics Faculty of Science and Letters Bilecik Seyh Edebali University Bilecik Turkey Biotechnology Research and Application Center Bilecik Seyh Edebali University Bilecik Turkey Vocational School of Medical Services Program of Medical Laboratory Techniques Bilecik Seyh Edebali University Bilecik Turkey Izmir Biomedicine and Genome Center Dokuz Eylul University Izmir Turkey

Purpose: MCF-7 (ER+, WTP53) and MDA-MB-231 (ER Met, Mutant P53) Caffeic Acid Phenethyl Ester (CAPE) and DNA Methyl Transferase Inhibitor (DNMTi) in breast cancer cell lines of Zebularine (ZEB) single and combined application of TP53, caspase-9, caspase 8 and caspase-3 genes as a result of the use of single and combined drug methylation profiles are aimed to be evaluated by specific PCR method. Material-Metods: In the MCF-7 and MDA-MB-231 breast cancer cell lines, MTT test and survival analysis were performed as a result of single and combined application of CAPE and Zebularine and Methylation Specific PCR was performed to examine the methylation of caspase-3, caspase-8, caspase-9 and TP53 genes. Results: According to the results of 24-hour drug administration, the IC50 for the MCF-7 cell line was determined as 200 μM, for CAPE 40 μM and for the combined values of 50 μM ZEB + 5 μM CAPE. The effects of caspase-3, caspase-8, caspase-9 and TP53 genes on the methylation level of ZEB, CAPE and ZEB + CAPE drug combination were determined by using bisulfite modified DNAs in MCF-7 and MDA-MB-231 cell lines. Discussion: In the MCF-7 cell line, the 120 μM ZEB viability rate was 51%, and the viability of 80 μM ZEB MDA-MB-231 breast cancer cells decreased by 59.7%. After 20 μM CAPE, viability in MCF-7 cells decreased by 31% in 120 μM CAPE and MDA-MB-231 cells decreased by 41%. The viability with 40 μM CAPE decreased by 19% in MDA-MB-231 cells. It was found that 20 μM CAPE concentration was associated with TP53 methylation in MCF-7 cell lines. The 80 μM ZEB concentration was found to be closely related to the unmethylated status of the TP53 gene. These results obtained with 50 μM ZEB + 5 μM CAPE application were found to be related to the methylated-unmetylated status of the TP53 gene in half (50%). For the caspase-9 gene of MDA-MB-231 cells, 80 μM ZEB concentration was found to be associated with unmetylated status. The effective use of drugs with low concentrations of the drug

关键词： MCF-7 MDA-MB-231 Zebularine CAPE Breast Cancer Methylation

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Higher Energy Does Not Mean Better Outcome Following Endovenous Laser Ablation of Great Saphenous Vein

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World Journal of Cardiovascular Surgery 2014年第11期4卷 200-205页

作者： Celalettin Karatepe mustafa Aldemir Bayer Cinar Akif Onalan Halim Issever onur S.Goksel Cardiovascular Surgery Department Medical FacultyMustafa Kemal UniversityAntakyaTurkey Cardiovascular Surgery Department School of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Cardiovascular Surgery Department Medical Park HospitalIstanbulTurkey Cardiovascular Surgery Department Istanbul Medical FacultyIstanbul UniversityIstanbulTurkey Biostatistics and Public Health Department Istanbul Medical FacultyIstanbul UniversityIstanbulTurkey

Background: Endovenous laser ablation is a relatively newer alternative to treat great saphenous vein insufficiency. We evaluated the efficiency and safety of treatment endovenous laser procedures on the different saphenous vein diameters with different energy levels. Methods: Data regarding endovenous laser ablation of symptomatic chronic great saphenous venous insufficiency in 209 patients were prospectively recorded. Patients were grouped into two main groups based on their diameters as 5 to 7 millimeters (Group A) or more than 7 millimeters (Group B). Patients in each group was randomized into two groups as >90 J/cm (A1 and B1) or 80-90 J/cm (A2 and B2). Postoperative outcome and complications were recorded during follow-ups at 1st week;1st, 3rd and 6th months to examine the venous reflux and recanalization. Results: Perioperative complaints as pain, cramps and ankle swelling were more commonly observed in A1 group. Fatigue was more common in A2 and B2 groups. No major complications as deep vein thrombosis or skin burns were observed. Conclusions: Endovenous laser ablation is a safe and effective procedure with a high satisfaction rate shortening hospitalization durations and early ambulant activity. Pain, ankle swelling and fatigue are the most common minor complaints in the early postoperative period.

关键词： Endovenous Laser Ablation Great Saphenous Vein Varices

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