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Characterization of Microstructural and Morphological Properties in As-deposited Ta/NiFe/IrMn/CoFe/Ta Multilayer System

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Journal of Materials Science & Technology 2014年第4期30卷 359-364页

作者： Ramis mustafa ksoglu Umut Sarac mustafa yildirm Hakan inar Department of Materials Sciences and Engineering University of Anadolu Department of Elementary Education University of Bartin

Surface morphology and its relationship with microstructure in Ta/NiFe/IrMn/CoFe/Ta multilayer system deposited by pulsed DC magnetron sputtering have been investigated in dependence of Ta buffer and NiFe seed layer thicknesses using atomic force microscopy. The structural parameters such as grain size, dislocation density, texture and strain were calculated. For each surface, a self-affinity behavior with mean fractal dimensions in the range of 2.03-2.18 was found. Additionally, it was also observed that the surface of all samples has locally smooth textured surface structure in the short range. The texture aspect parameter and texture direction index have been obtained for isotropy/anisotropy surface texture. A significant relationship between the surface texture and the strength of the 〈111〉 texture in IrMn layer has been found. The analysis indicated that the surface roughness is strongly affected by the thicknesses of the NiFe seed and Ta buffer layers.

关键词： Pulsed DC magnetron sputtering Surface roughness Strain and texture

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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

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Frontiers of Medicine 2015年第3期9卷 368-373页

作者： Naci Topaloglu Adem Kucuk Sule yildirm mustafa Tekin Havva Erdem mustafa Deniz Canakkale Onsekiz Mart University Medical Faculty Department of Pediatrics Canakkale Turkey Diizce Atatiirk State Hospital Department of Pediatric Surgery Diizce Turkey Diizce University Medical Faculty Department of Pathology Diizce Turkey Canakkale Onsekiz Mart University Medical Faculty Department of Physiology Canakkale Turkey

Glucagon-like peptide-2 （GLP-2） has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion （I/R） injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups （n = 8）. The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion （HIR, vehicle saline-treated） group; and the third group was the GLP-2 pretreated I/R （GLP2-IR） group. Each rat in the third group was intraperitoneally administered 5 ~tg GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the fiver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline- treated HIR group （P 〈 0.001）, whereas GLP-2 pretreatment significantly decreased their levels （P 〈 0.01）. Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.

关键词： ischemia/reperfusion liver glucagon-like peptide-2 alanine aminotransferase

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