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An extract of Hypericum perforatum induces wound healing through inhibitions of Ca^(2+) mobilizations,mitochondrial oxidative stress and cell death in epithelial cells:Involvement of TRPM2 channels

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BIOCELL 2019年第4期43卷 271-283页

作者： FUAT USLUSOY mustafa NAZIROGLU Department of Plastic Reconstructive and Aesthetic Surgery Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Neuroscience Research Center Suleyman Demirel UniversityIspartaTurkey Drug Discovery Unit BSN HealthAnalysis and Innovation Ltd.Inc.TeknokentIspartaTurkey

The wound is induced by several mechanical and metabolic *** the etiology of the wound recovery,excessive oxidative stress,calcium ion(Ca^(2+))influx,and apoptosis have important ***^(2+)-permeable TRPM2 channel is activated by oxidative *** roles of Hypericum perforatum extract(HP)on the mechanical nerve injury-induced apoptosis and oxidative toxicity through regulation of TRPM2 in the experimental animals were recently *** potential protective roles in HP treatment were evaluated on the TRPM2-mediated cellular oxidative toxicity in the renal epithelium(MPK)*** cells were divided into three groups as control,wound,and wound+HP treatment(75μM for 72 h).Wound diameters were more importantly decreased in the wound+HP group than in the wound *** addition,the results of laser confocal microscopy analyses indicated protective roles of HP and TRPM2 antagonists(N-(p-Amylcinnamoyl)anthranilic acid and 2-aminoethyl diphenylborinate)against the wound-induced increase of Ca^(2+) influx and mitochondrial ROS *** wound-induced increase of early(annexin V-FITC)apoptosis and late(propidium iodide)apoptosis were also decreased in the cells by the HP *** conclusion,HP treatment acted protective effects against wound-mediated oxidative cell toxicity and apoptosis through TRPM2 *** effects may be attributed to their potent antioxidant effect.

关键词： Apoptosis Hypericum perforatum Oxidative stress TRPM2 channel Wound

A Model Predictive Control for Microgrids Considering Battery Aging

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 296-304页

作者： Ugur Can Yilmaz mustafa Erdem Sezgin Murat Gol Department of Electrical and Electronics Engineering Middle East Technical UniversityAnkaraTurkey

The increasing number of distributed energy resources(DERs),advancing communication and computation technologies,and reliability concerns of the customers have caused an intense interest in the concept of *** DERs are the biggest motivation of the microgrids due to their intermittent generation characteristics,they constitute a risk for system *** storage systems(BSSs)stand as one of the most effective solutions for this reliability ***,the inappropriate use of BSS creates other operational problems in power *** order to deal with these concerns explicitly in microgrids,an optimized microgrid central controller(MGCC)is the key factor,which controls the realtime operation of a *** work proposes a model predictive control(MPC)based MGCC that will provide optimal control of the microgrid,considering economic and operational *** proposed system will minimize the energy cost of the microgrid by utilizing mixed-integer linear programming(MILP)assuming the presence of DERs and BSS as well as the bi-directional grid ***,the aging effect of BSS will be considered in the proposed optimization problem which will provide an up-to-date system *** proposed method is evaluated using real load and photovoltaic(PV)generation data.

关键词： Microgrid optimization battery storage model predictive control mixed-integer linear programming

A system-wide approach to minimize the operational cost of bench production in open-cast mining operations

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International Journal of Coal Science & Technology 2019年第1期6卷 84-94页

作者： Burak Ozdemir mustafa Kumral Department of Mining and Materials Engineering McGill University 3450 University StreetMontrealQC H3A 0E8Canada

The production cycle of open-cast coal mines generally in eludes drilling, blasting, loading, hauling and coal preparation activities. Individual optimization of these activities does not mean that the whole system is optimized. This paper proposes a cost model considering all activities in mining cycle and system-wide approach to minimize the total mining cost of bench production. Since the fragmentation size and blast-hole diameter are linked to all activities of mining system, they are considered as decision variables in the problem form ul at io n. The operatio n costs are then minimized by using the evolutionary algorithm. Moreover, the impact of the change in the explosive price, and the hourly unit cost of equipment on total mining cost is quantified by sensitivity analysis. A case study is implemented to demonstrate the developed model.

关键词： Mine production cycle Rock fragmentation - Cost optimization Evolutionary algorithm Sensitivity analysis

Prediction of wear loss quantities of ferro-alloy coating using different machine learning algorithms

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Friction 2020年第1期8卷 107-114页

作者： Osman ALTAY Turan GURGENC mustafa ULAS Cihan OZEL Software Engineering Firat UniversityElazig 23119Turkey Automotive Engineering Firat UniversityElazig 23119Turkey Mechanical Engineering Firat UniversityElazig 23119Turkey

In this study,experimental wear losses under different loads and sliding distances of AISI 1020 steel surfaces coated with(wt.%)50FeCrC‐20FeW‐30FeB and 70FeCrC‐30FeB powder mixtures by plasma transfer arc welding were *** dataset comprised 99 different wear amount measurements obtained experimentally in the *** linear regression(LR),support vector machine(SVM),and Gaussian process regression(GPR)algorithms are used for predicting wear quantities.A success rate of 0.93 was obtained from the LR algorithm and 0.96 from the SVM and GPR algorithms.

关键词： surface coating plasma transfer arc(PTA)welding wear prediction machine learning algorithms

A new approach for prediction of the wear loss of PTA surface coatings using artificial neural network and basic,kernel-based,and weighted extreme learning machine

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Friction 2020年第6期8卷 1102-1116页

作者： mustafa ULAS Osman ALTAY Turan GURGENC Cihan OZEL Department of the Software Engineering Firat UniversityElazig 23119Turkey Department of the Automotive Engineering Firat UniversityElazig 23119Turkey Department of the Mechanical Engineering Firat UniversityElazig 23119Turkey

Wear tests are essential in the design of parts intended to work in environments that subject a part to high *** tests involve high cost and lengthy experiments,and require special test *** use of machine learning algorithms for wear loss quantity predictions is a potentially effective means to eliminate the disadvantages of experimental methods such as cost,labor,and *** this study,wear loss data of AISI 1020 steel coated by using a plasma transfer arc welding(PTAW)method with FeCrC,FeW,and FeB powders mixed in different ratios were obtained experimentally by some of the researchers in our *** mechanical properties of the coating layers were detected by microhardness measurements and dry sliding wear *** wear tests were performed at three different loads(19.62,39.24,and 58.86 N)over a sliding distance of 900 *** this study,models have been developed by using four different machine learning algorithms(an artificial neural network(ANN),extreme learning machine(ELM),kernel-based extreme learning machine(KELM),and weighted extreme learning machine(WELM))on the data set obtained from the wear test *** R2 value was calculated as 0.9729 in the model designed with WELM,which obtained the best performance among the models evaluated.

关键词： wear loss prediction surface coating plasma transferred arc welding artificial neural network extreme learning machine

Relationship between non-alcoholic fatty liver disease and coronary heart disease

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World Journal of Clinical Cases 2020年第20期8卷 4688-4699页

作者： Ugur Arslan mustafa Yenerçağ Department of Cardiology University of Health Sciences Samsun Training and Research HospitalSamsun 55400Turkey

Non-alcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver disease and considered a liver manifestation of metabolic *** is in close relationship with insulin resistance,obesity,diabetes mellitus,all of which increase risk of cardiovascular disease(CVD).Besides,many studies point out that NAFLD independently contributes to the development of atherosclerosis and *** the other hand,CVDs are the leading cause of death in NAFLD *** pathophysiological changes and molecular mechanisms play an important role in NAFLD for CVD *** is common in NAFLD,which also mainly contributes to the CVD formation and *** studies linking atherosclerotic CHD and NAFLD are present in the *** CHD,mainly detected by coronary computed tomography views,have been detected more common in NAFLD *** of NAFLD has been found to be more common in patients with severe CHD and in stable CHD,NAFLD has been found to be associated with more diffuse *** acute coronary syndromes,especially in acute myocardial infarction,patients with NAFLD have been found to have poor prognosis when compared with NAFLD free *** this review,our aim is to evaluate the relationship between NAFLD and CHD in detail and go over the pathophysiological mechanisms underlying this relationship.

关键词： Fatty liver Hepatosteatosis Coronary heart disease Atherosclerosis Cardiovascular Artery

Incorporating the Istanbul-Ankara high-speed railway into the Belt and Road Initiative:Negotiation,institutional alignment and regional development

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Journal of Geographical Sciences 2021年第5期31卷 747-762页

作者： Seth SCHINDLER mustafa Kemal BAYIRBAG GAO Boyang Global Development Institute University of ManchesterM139PL ManchesterUnited Kingdom Department of Political Science and Public Administration Middle East Technical UniversityAnkara 06800Turkey School of Management Science and Engineering Central University of Finance and EconomicsBeijing 100081China

This article contributes to a small but growing body of multi-sited and multi-scalar research on the Belt and Road *** focus on relations at the national,regional and international scales,and present original research from China and Turkey,to show how the Istanbul-Ankara high-speed railway has served as a testing ground for China's Belt and Road Initiative(BRI).Its construction was initially funded by the European Investment Bank,but it is now part of the backbone of the Turkish Government's Middle Corridor plan which enhances west-east connectivity and integration with the Caucasus and Central *** show that in contrast to multinational corporations from the OECD that seek to remain footloose,Chinese state-owned enterprises(SOEs)seek to adapt to,apprehend and ultimately shape local *** the case of Turkey this proved difficult given its institutional alignment with the European ***,while the railway project was completed successfully by a consortium led by a Chinese SOE,Turkey's dynamic and complex regulatory environment discourages Chinese SOEs in the infrastructure *** conclude that the Turkish and Chinese governments are currently pursuing complementary territorial visions yet their cooperation is project-based and pragmatic.

关键词： Belt and Road Initiative infrastructure high speed rail regional development Turkey China

Acarbose is again on the stage

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World Journal of Diabetes 2022年第1期13卷 1-4页

作者： mustafa Altay Department of Endocrinology and Metabolism University of Health Sciences TurkeyKeçiören Health Administration and Research CenterKeçiören 06290AnkaraTurkey

Acarbose is an agent that has been used to treat type 2 diabetes for about 30 years;it prevents postprandial hyperglycemia by inhibiting carbohydrate digestion in the small *** incretin-based treatments have been preferred over the last 10 to 15 years,the use of acarbose is not as common in treating type 2 diabetes as *** studies have shown that acarbose also produces a weight-loss effect by increasing glucagon-like peptide 1(GLP-1).The positive effect of acarbose on GLP-1,and increasing evidence that it provides cardiovascular protection,suggests that acarbose may again be considered among the first-choice antidiabetic agents,as it was in the 1990s.

关键词： Acarbose Cardiovascular protection Glucagon-like peptide 1 Obesity Waist-to-height ratio

A Study on Monotone Self-Dual Boolean Functions

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Acta Mathematicae Applicatae Sinica 2017年第1期33卷 43-52页

作者： mustafa ALTUN Marc D.RIEDEL Electronics and Communication Engineering Istanbul Technical University Electrical and Computer Engineering University of Minnesota

This paper shows that monotone self-dual Boolean functions in irredundant disjuntive normal form （IDNF） do not have more variables than disjuncts. Monotone self-dual Boolean functions in IDNF with the same number of variables and disjuncts are examined. An algorithm is proposed to test whether a monotone Boolean function in IDNF with n variables and n disjuncts is self-dual. The runtime of the algorithm is O（n3）.

关键词： duality problem monotone Boolean functions self-dual Boolean functions