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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Pollution of water resources due to industrialization in arid zone of Rajasthan, India

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Journal of Environmental Sciences 2001年第2期13卷 218-223页

作者： khan M A Central Arid Zone Research Institute 印度 342003

In arid zone of Rajasthan, India, nearly 21,900 hm2 area along Bandi River has been affected by industrial effluent discharge into the river bed. Analysis of groundwater samples collected from these sites revealed that area at the vicinity of the river is most affected. The effluent water in the river is the main source of contamination of ground water. Concentration of sodium and chloride has been higher with proportional increase in TDS and EC value in the area within zone A (river water), zone B (0-100 m), zone C (101-250 m), zone D (251-500 m) and zone E (501-1000 m). There is decreasing trend in ion concentration from zone A to zone E and F, reflecting reduced effect of effluents. The pollution of water resources has resulted in the degradation of other natural resources such as land, soil and vegetation. Nearly 4463 hm2 (20.38%) area has been very severely affected. EC value at places exceeds 20 dS/m. Soil and land have become hard, compact and saline. Cropping intensity has declined. In the area (3633 hm2) affected severely, the EC value of water varies from 10-20 dS/m. Irrigation with such water has created problem of salinity, sodicity in soils. Herbal biomass declined considerably. Double cropping has almost stopped. Almost 8494 hm2 area is affected moderately. EC of ground water varies from 5 to 10 dS/m. Fragile surface crust, declining trend of phosphorous and potassium in the soil, poor density of natural vegetation are significant manifestations. Apart from this, 5305 hm2 area is slightly affected.

关键词： India Pollution of water resources due to industrialization in arid zone of Rajasthan

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Accumulation of Pb,Cu,and Zn in native plants growing on contaminated sites and their potential accumulation capacity in Heqing,Yunnan

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Journal of Environmental Sciences 2008年第12期20卷 1469-1474页

作者： Sardar khan Department of Soil Environmental Sciences Research Center for Eco-Environmental Sciences Department of Environmental Sciences University of Peshawar25120 Peshawar

Phytoremediation is one of the cost-effective and environmental friendly technologies used to remove contaminants from contaminated soils,which has been intensively studied during the last ***,few economical and effective remediation methods are available for the remediation of Pb contaminated *** study was conducted to assess the potential of 19 plants growing on contaminated sites in Pb mine *** and associated soil samples were collected and analyzed for total metal concentrati...

关键词： accumulation of Pb Cu and Zn cultivated crops accumulator lead mine remediation

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LDH-based nanomaterials for photocatalytic applications:A comprehensive review on the role of bi/trivalent cations, anions,morphology, defect engineering, memory effect, and heterojunction formation

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Journal of Energy Chemistry 2023年第9期84卷 242-276页

作者： Azmat Ali khan Muhammad Tahir Nazish khan Baluchistan University of Information Technology Engineering and Management Sciences(BUITEMS)P.O.Box 87100QuettaPakistan Chemical and Petroleum Engineering Department UAE UniversityP.O.Box 15551Al AinUnited Arab Emirates The University of Agriculture Swat P.O.Box 19040Pakistan

Using sunlight to drive chemical reactions via photocatalysis is paramount for a sustainable *** several photocatalysts,employing layered double hydrides(LDH) for photocatalytic application is most straightforward and desirable owing to their distinctive two-dimensional(2D) lamellar structure and optical *** article reviews the advancements in bimetallic/trimetallic LDHs and various strategies to achieve high efficiency toward an outstanding performing ***,the tuning of LDH components that control the electro nic and structural properties is *** tu ning obtained through the adoption,combination,and incorporation of different cations and anions is also *** progress of modification methods,such as the adoption of different morphologies,delamination,and defect engineering towards enhanced photocatalytic activities,is discussed in the *** band engineering,structural characteristics,and redox tuning are further deliberated to maximize solar energy harvesting for different photocatalytic ***,the progress obtained in forming hierarchical heterostructures through hybridization with other semiconductors or conducting materials is systematically disclosed to get maximum photocatalytic ***,the structural changes during the in-situ synthesis of LDH and the stability of LDH-based photocatalysts are *** review also summarizes the improvements in LDH properties obtained through modification tactics and discusses the prospects for future energy and environmental applications.

关键词： LDH Properties Potential photocatalyst Photocatalytic application Photocatalytic properties Improvement strategies

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Heat Transfer of Casson Fluid over a Vertical Plate with Arbitrary Shear Stress and Exponential Heating

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Computers, Materials & Continua 2022年第4期71卷 1025-1034页

作者： Dolat khan Gohar Ali Arshad khan Ilyas khan Department of Mathematics City University of Science and Information TechnologyPeshawar25000Pakistan Institute of Computer Sciences and Information Technology The University of AgriculturePeshawarPakistan Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh City72915Vietnam

The basic objective of this work is to study the heat transfer of Casson fluid of non-Newtonian *** fluid is considered over a vertical plate such that the plate exhibits arbitrary wall shear stress at the *** transfers due to exponential plate heating and natural convection are due to buoyancy ***(MHD)analysis in the occurrence of a uniform magnetic field is also *** medium over the plate is porous and hence Darcy’s law is *** governing equations are established for the velocity and temperature fields by the usual Boussinesq *** problem is first written in dimensionless form using some useful non-dimensional quantities and then *** exact analysis is performed and hence solutions via integral transform are *** analysis of various pertinent parameters on temperature distribution and velocity field are reported *** is found that pours medium permeability parameter retards the fluid motion whereas,velocity decreases with increasing magnetic *** and temperature decrease with increasing Prandtl number whereas the Grashof number enhances the fluid ***,it is concluded from this study that the results obtained here are more general and in a limiting sense several other solutions can be *** Newtonian fluid results can be easily established by taking the Casson parameter infinitely large i.e.,whenβ→∞.

关键词： Heat transfer casson fluid shear stress natural convection

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Quantum Stackelberg Duopoly in a Noninertial Frame

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Chinese Physics Letters 2011年第7期28卷 5-8页

作者： Salman khan M.Khalid khan Department of Physics Quaid-i-Azam UniversityIslamabad 45320Pakistan

We study the influence of the Unruh effect on quantum Stackelberg *** is shown that the acceleration of a noninertial frame strongly affects the payoffs of the *** validation of the subgame perfect Nash equilibrium is limited to a particular range of acceleration of the noninertial *** benefit of the initial state entanglement in the quantum form of the duopoly in the inertial frame is adversely affected by the *** duopoly can become a follower advantage only in a small region of the acceleration.

关键词： acceleration Stackelberg Quantum

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Non-Maximal Tripartite Entanglement Degradation of Dirac and Scalar Fields in Non-Inertial Frames

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Communications in Theoretical Physics 2014年第3期61卷 281-288页

作者： Salman khan Niaz Ali khan M.K.khan Department of Physics COMSATS Institute of Information Technology Chak Shahzad Department of Physics Quaid-i-Azam University

The π-tangle is used to study the behavior of entanglement of a nonmaximal tripartite state of both Dirac and scMar fields in accelerated frame. For Dirac fields, the degree of degradation with acceleration of both one-tangle of accelerated observer and π-tangle, for the same initial entanglement, is different by just interchanging the values of probability amplitudes. A fraction of both one-tangles and the π-tangle always survives for any choice of acceleration and the degree of initial entanglement. For scalar field, the one-tangle of accelerated observer depends on the choice of values of probability amplitudes and it vanishes in the range of infinite acceleration, whereas for 1r-tangle this is not always true. The dependence of π-tangle on probability amplitudes varies with acceleration. In the lower range of acceleration, its behavior changes by switching between the values of probability amplitudes and for larger values of acceleration this dependence on probability amplitudes vanishes. Interestingly, unlike bipartite entanglement, the degradation of π-tangle against acceleration in the case of sca/ar fields is slower than for Dirac fields.

关键词： tripartite entanglement noninertial frame

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Health risks associated with heavy metals in the drinking water of Swat,northern Pakistan

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Journal of Environmental Sciences 2013年第10期25卷 2003-2013页

作者： Kifayatullah khan Yonglong Lu Hizbullah khan Shahida Zakir Ihsanullah Sardar khan Akbar Ali khan Luo Wei Tieyu Wang Department of Environmental Sciences University of Peshawar State Key Laboratory of Urban and Regional Ecology Research Centre for Eco-environmental Sciences Chinese Academy of Sciences Nuclear Institute for Food and Agriculture

The concentrations of heavy metals such as Cd, Cr, Cu, Mn, Ni, Pb and Zn were investigated in drinking water sources （surface and groundwater） collected from Swat valley, Khyber Pakhtunkhwa, Pakistan. The potential health risks of heavy metals to the local population and their possible source apportionment were also studied. Heavy metal concentrations were analysed using atomic absorption spectrometer and compared with permissible limits set by Pakistan Environmental Protection Agency and World Health Organization. The concentrations of Cd, Cr, Ni and Pb were higher than their respective permissible limits, while Cu, Mn and Zn concentrations were observed within their respective limits. Health risk indicators such as chronic daily intake （CDI） and health risk index （HRI） were calculated for adults and children separately. CDIs and HRIs of heavy metals were found in the order of Cr 〉 Mn 〉 Ni 〉 Zn 〉 Cd 〉 Cu 〉 Pb and Cd 〉 Ni 〉 Mn 〉 Cr 〉 Cu 〉 Pb 〉 Zn, respectively. HRIs of selected heavy metals in the drinking water were less than 1, indicating no health risk to the local people. Multivariate and univariate statistical analyses showed that geologic and anthropogenic activities were the possible sources of water contamination with heavy metals in the study area.

关键词： daily intake drinking water health risk heavy metals multivariate analysis

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Systematic Geometric Error Modeling for Workspace Volumetric Calibration of a 5-axis Turbine Blade Grinding Machine

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Chinese Journal of Aeronautics 2010年第5期23卷 604-615页

作者： Abdul Wahid khan School of Mechanical Engineering and Automation Beijing University of Aeronautics and Astronautics

A systematic geometric model has been presented for calibration of a newly designed 5-axis turbine blade grinding machine. This machine is designed to serve a specific purpose to attain high accuracy and high efficiency grinding of turbine blades by eliminating the hand grinding process. Although its topology is RPPPR （P： prismatic; R： rotary）, its design is quite distinct from the competitive machine tools. As error quantification is the only way to investigate, maintain and improve its accuracy, calibra- tion is recommended for its performance assessment and acceptance testing. Systematic geometric error modeling technique is implemented and 52 position dependent and position independent errors are identified while considering the machine as five rigid bodies by eliminating the set-up errors of workpiece and cutting tool. 39 of them are found to have influential errors and are accommodated for finding the resultant effect between the cutting tool and the workpiece in workspace volume. Rigid body kinematics techniques and homogenous transformation matrices are used for error synthesis.

关键词： 5-axis machine tools calibration modeling geometric errors kinematics homogenous transformation matrices

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MODELING DAM-BREAK FLOOD OVER NATURAL RIVERS USING DISCONTINUOUS GALERKIN METHOD

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Journal of Hydrodynamics 2012年第4期24卷 467-478页

作者： khan Abdul A. Glenn Department of Civil Engineering Clemson University

A well-balanced numerical model is presented for two-dimensional, depth-averaged, shallow water flows based on the Discontinuous Galerkin （DG） method. The model is applied to simulate dam-break flood in natural rivers with wet/dry bed and complex topography. To eliminate numerical imbalance, the pressure force and bed slope terms are combined in the shallow water flow equations. For partially wet/dry elements, a treatment of the source term that preserves the well-balanced property is presented. A treatment for modeling flow over initially dry bed is presented. Numerical results show that the time step used is related to the dry bed criterion. The intercell numerical flux in the DG method is computed by the Harten-Lax-van Contact （HLLC） approximate Riemann solver. A two-dimensional slope limiting procedure is employed to prevent spurious oscillation. The robustness and accuracy of the model are demonstrated through several test cases, including dam-break flow in a channel with three bumps, laboratory dam-break tests over a triangular bump and an L-shape bend, dam-break flood in the Paute River, and the Malpasset dam-break case. Numerical results show that the model is robust and accurate to simulate dam-break flood over natural rivers with complex geometry and wet/dry beds.

关键词： Discontinuous Galerkin (DG) method shallow water flows dam-break flood well-balanced scheme

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