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High-throughput computational screening and in vitro evaluation identifies 5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione(C3),as a novel EGFR—HER2 dual inhibitor in gastric tumors

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Oncology Research 2024年第2期32卷 251-259页

作者： MESFER al SHAHRANI REEM GAHTANI MOHAMMAD ABOHASSAN MOHAMMAD alSHAHRANI YASSER alRAEY AYED DERA MOHAMMAD RAJEH asiri PRASANNA RAJAGOPalAN Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Khalid UniversityAbhaSaudi Arabia

Gastric cancers are caused primarily due to the activation and amplification of the EGFR or HER2 kinases resulting in cell proliferation,adhesion,angiogenesis,and *** therapies are ineffective due to the intra-tumoral heterogeneity and concomitant genetic ***,dual inhibition strategies are recommended to increase potency and reduce *** this study,we have conducted computational high-throughput screening of the ChemBridge library followed by in vitro assays and identified novel selective inhibitors that have a dual impediment of EGFR/HER2 kinase ***-based High-throughput Virtual Screening(D-HTVS)was used to screen the whole ChemBridge small molecular library against EGFR and *** atomistic molecular dynamic simulation was conducted to understand the dynamics and stability of the protein-ligand ***/HER2 kinase enzymes,KATOIII,and Snu-5 cells were used for in vitro *** atomistic Molecular Dynamics simulations followed by solvent-based Gibbs binding free energy calculation of top molecules,identified compound C3(5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione)to have a good affinity for both EGFR and *** predicted compound,C3,was promising with better binding energy,good binding pose,and optimum interactions with the EGFR and HER2 residues.C3 inhibited EGFR and HER2 kinases with IC50 values of 37.24 and 45.83 nM,*** GI50 values of C3 to inhibit KATOIII and Snu-5 cells were 84.76 and 48.26 nM,*** on these findings,we conclude that the identified compound C3 showed a conceivable dual inhibitory activity on EGFR/HER2 kinase,and therefore can be considered as a plausible lead-like molecule for treating gastric cancers with minimal side effects,though testing in higher models with pharmacokinetic approach is required.

关键词： Dual inhibitor Drug discovery EGFR/HER2 kinase Gastric cancer High-throughput screening

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Unusual Case of Radiation Induced Balanitis after Chemoradiation for Upper Rectal Adenocarcinoma

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Open Journal of Gastroenterology 2014年第2期4卷 69-72页

作者： Mutahir A. Tunio mushabbab al asiri Rashad Mohamed Akasha Stanciu Laura Gabriela Gillian Mary Boyle Medical Physics King Fahad Medical City Riyadh KSA Radiation Oncology Comprehensive Cancer Center King Fahad Medical City Riyadh KSA Radiation Therapy Unit king Fahad Medical City Riyadh KSA

Background: Penile toxicity after preoperative concurrent chemoradiation (CCRT) for rectal cancers is extremely rare and only two cases of phimosis and one case of recto-cavernosalfistula have been reported so far in literature. Preoperative CCRT for rectal cancer is given in prone position and with the support of belly board (BBD) to avoid small bowel toxicity. However, positional errors during rectal radiotherapy can lead to unexpected penile toxicity. Case Presentation: A 50-year-old Saudi male with diagnosed case of rectal adenocarcinoma stage cT3N1M0 was given preoperative CCRT 50.4 Gy in 28 fractions with three-dimensional conformal radiation therapy (3DCRT) in prone position using belly board with concurrent oral capecitabine 825 mg/2 twice a day. After the completion of CCRT, he complained of severe soreness, itching over glans penis and dysuria. Examination revealed grade 3 erythema, skin desquamation over glans penis (balanitis). Portal imaging of treatment revealed glans penis to lie within posterior radiation beam. A patient was assured and he recovered fully after local steroids and short course of antibiotics. Conclusion: Penile toxicity after CCRT for rectal cancer is extremely rare manifestation. Radiation oncologists and therapists must be aware of this rare side effect and must assure proper patient education and positioning during CCRT for rectal cancer.

关键词： Rectal Cancer Preoperative Chemoradiation Penile Toxicity Balanitis Rare Side Effect

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Risk of Radiation Induced Carotid Artery Stenosis in Supraclavicular Lymph Node Irradiation in Breast Cancer Patients

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Journal of Cancer Therapy 2014年第3期5卷 238-245页

作者： Reham Abdulmoniem Yasser Bayoumi mushabbab al asiri Reem Zatar Abdullah al Amro Majed Mosely Mohamed Hamada Eyad al Saeed Abdulrahman al Hadab Mutahir A. Tunio King Saud University Riyadh KSA Medical Physics Department Comprehensive Cancer Center King Fahad Medical City Riyadh KSA Radiation Oncology Department Comprehensive Cancer Center King Fahad Medical City Riyadh KSA Radiation Oncology Department National Cancer Institute Cairo University Giza Egypt

Background: The risk of carotid vessel stenosis is high after radiotherapy (RT) to neck;however, carotid vessels are unavoidable during supraclavicular (SC-RT) in adjuvant treatment of breast cancer (BC). However, carotid vessels RT dose is less well-understood. We aimed to determine the carotid vessels doses received by different techniques for SC-RT. Materials and Methods: Thirty consecutive BC patients were planned to receive SC-RT and breast after breast conserving surgery (BCS) after taking 5 mm image slices on computed tomography (CT) simulation. Organs at risk (OAR) including carotid vessels, lungs, spinal cord alongwith clinical target volume (CTV) for primary tumor and lymph nodes were delineated. Comparative analysis was done between two treatment plans;three-field conformal radiation therapy (3F-CRT) and four field conformal RT (4F-CRT) for CTV and carotid vessels doses. Results: The 4F-CRT was found better than 3F-3DCRT regarding coverage and homogeneity of the CTV volume. The 98% of the CTV was covered by 84% dose in 3F-CRT and 95% in 4F-CRT (p 0.001). The carotid vessels maximum dose in the in 3F-CRT was 54.5 ± 1.3 Gy compared to 51.6 ± 1.3 Gy in 4F-CRT (p 0.014), however the mean dose did not differ significantly (p value 0.8). The ipsilateral lung dose did not differ between the two techniques (p Value 0.9). Conclusion: The 4F-CRT plan was found better than 3F-CRT in CTV coverage with minimal dose to the carotid vessel and without significant higher dose to the ipsilateral lung.

关键词： Breast Cancer Supraclavicular Radiotherapy Carotid Vessel Dose

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Contrast Normalization Strategies in Brain Tumor Imaging:From Preprocessing to Classification

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1539-1562页

作者： Samar M.alqhtani Toufique A.Soomro Faisal Bin Ubaid Ahmed ali Muhammad Irfan Abdullah A.asiri Department of Information Systems College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Electronic Engineering The University of LarkanoLarkanaSindh75660Pakistan Computer Science Department Sukkur IBA UniversitySukkurSindh65200Pakistan Eletrical Engineering Department Sukkur IBA UniversitySukkurSindh65200Pakistan Electrical Engineering Department College of EngineeringNajran UniversityNajran61441Saudi Arabia Radiological Sciences Department College of Applied Medical SciencesNajran UniversityNajran61441Saudi Arabia

Cancer-related to the nervous system and brain tumors is a leading cause of mortality in various *** resonance imaging(MRI)and computed tomography(CT)are utilized to capture brain *** plays a crucial role in the diagnosis of brain tumors and the examination of other brain ***,manual assessment of MRI images by radiologists or experts is performed to identify brain tumors and abnormalities in the early stages for timely ***,early diagnosis of brain tumors is intricate,necessitating the use of computerized *** research introduces an innovative approach for the automated segmentation of brain tumors and a framework for classifying different regions of brain *** proposed methods consist of a pipeline with several stages:preprocessing of brain images with noise removal based on Wiener Filtering,enhancing the brain using Principal Component Analysis(PCA)to obtain well-enhanced images,and then segmenting the region of interest using the Fuzzy C-Means(FCM)clustering technique in the third *** final step involves classification using the Support Vector Machine(SVM)*** classifier is applied to various types of brain tumors,such as meningioma and pituitary tumors,utilizing the Contrast-Enhanced Magnetic Resonance Imaging(CE-MRI)*** proposed method demonstrates significantly improved contrast and validates the effectiveness of the classification framework,achieving an average sensitivity of 0.974,specificity of 0.976,accuracy of 0.979,and a Dice Score(DSC)of ***,this method exhibits a shorter processing time of 0.44 s compared to existing *** performance of this method emphasizes its significance when compared to state-of-the-art methods in terms of sensitivity,specificity,accuracy,and *** enhance the method further in the future,it is feasible to standardize the approach by incorporating a set of classifiers to increase the robustness of the brain classi

关键词： Brain tumor magnetic resonance imaging principal component analysis fuzzy c-clustering support vector machine

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Assessment of Breast Cancer Prevention Practices among Women Attending Primary Health Care in Abha City, Aseer Region, Saudi Arabia

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International Journal of Clinical Medicine 2024年第2期15卷 31-54页

作者： Sabah Mohammed asiri Sultan Yahia alfifii Tagreed Khairan al-Rashidi Sager Misfer alqahtani Faiz Abdulrahman alshafa Fayez Mari alamri Amal Mohammed asiri Fatima Mohammed ali almagadi Thuraya Mohammed asiri Department of Therapeutic Assistance Management General Directorate of Health Affairs Asser Region Abha Saudi Arabia Department of Health Affairs General Directorate of Health Affairs Asser Region Abha Saudi Arabia Department of Kidney King Khaled Hospital Hail Saudi Arabia Department of Nursing Sarat Abida Hospital Aseer Saudi Arabia Department of Radiation Oncology King Faisal Medical City Abha Saudi Arabia Department of Health Affairs KSA MOH Department of Kidney Dialysis Centers General Directorate of Health Affairs Aseer Region Abha Saudi Arabia Department of Operation Ahad Rafidah Hospital General Directorate of Health Affairs in Asseer Region Abha Saudi Arabia South Qunfudah General Hospital Jizan Saudi Arabia Armed Forces Southern Region Hospital Aseer Saudi Arabia

Cancer is a leading cause of death worldwide, with breast cancer being the most common (2.26 million new cases and 685,000 deaths). In Saudi Arabia, breast cancer ranked the first among females in 2014, accounting for 15.9% of all cancers reported among Saudi nationals and 28.7% of all cancers reported among females of all ages. Early detection of breast cancer could decrease the risks, have a better prognosis, and have better outcomes/more successful treatments. Prevalence of breast cancer reached more than 25% of all diagnosed cancer in the kingdom among women. Aim: This study aims to assess the knowledge and performance of women attending primary care centers about breast self-examination and mammogram screening for prevention and early detection of breast cancer in Abha city primary healthcare centers, Kingdom of Saudi Arabia. Research Method: cross sectional design was conducted by using questionnaire, which was distributed to primary care center nurses. The collected data was statistically analyzed using the Statistical Package for Social Sciences, version 25. Results: The study found that participants had poor awareness and knowledge about breast self-examination, risk factors for breast cancer, and trends and practices in early diagnosis of breast cancer. Conclusion and Recommendations: It recommends increasing awareness campaigns and providing educational programs to improve knowledge and practices.

关键词： Assessment Breast Cancer Prevention Practices Women Attending Health Care Centers Abha City

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Unilateral Choanal Atresia in Adults: A Case Series

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第3期13卷 187-193页

作者： Sultan Kadasah Abdulaziz al Qahtani Ghalib al-Sayed Abdullah al Helali Saud aldhabaan Abdullah Musleh ali Asiry Mohammed asiri Shahd Dlboh Adnan al-Malki Abdulsalam alqhtani Mohammed al-khulban Sahar al-Otaibi Department of Surgery College of Medicine University of Bisha Bisha Saudi Arabia Department of Otolaryngology Head and Neck Surgery Armed Forces Southern Region Hospital Khamis Mushait Saudi Arabia Department of Otolaryngology Head and Neck Surgery Abha Children&#8217s Hospital Abha Saudi Arabia Department of Surgery College of Medicine King Khalid University Abha Saudi Arabia Department of Otolaryngology Head and Neck Surgery Aseer Central Hospital Abha Saudi Arabia College of Medicine King Khalid University Abha Saudi Arabia

Choanal atresia (CA) is a rare occlusion of the posterior choanae. Unilateral cases have been reported more than bilaterally, and it’s more often right-sided in those patients. According to the literature, mixed bony-membranous atresia is the most common type. There is a high incidence of craniofacial and visceral anomalies associated with congenital choanal atresia. Therefore, investigation for associated congenital anomalies is an important step before the surgery. We report 2 cases of incidental finding of unilateral choanal atresia in a 21- and 17-year-old with nasal discharge being the only complaint in the former and nasal obstruction with headache in the latter. The patients were then scheduled for day-surgery as a case of choanal atresia for transnasal, endoscopic repair and posterior septectomy. The patients were discharged home on the same day with the absence of restenosis or other complications.

关键词： Choanal Atresia Nasal Obstruction Congenital Anomaly

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Short Text Mining for Classifying Educational Objectives and Outcomes

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Computer Systems Science & Engineering 2022年第4期41卷 35-50页

作者： Yousef asiri College of Computer Science and Information Systems Najran UniversityNajran61441Saudi Arabia

Most of the international accreditation bodies in engineering education(e.g.,ABET)and outcome-based educational systems have based their assess-ments on learning outcomes and program educational ***,map-ping program educational objectives(PEOs)to student outcomes(SOs)is a challenging and time-consuming task,especially for a new program which is applying for ABET-EAC(American Board for Engineering and Technology the American Board for Engineering and Technology—Engineering Accreditation Commission)*** addition,ABET needs to automatically ensure that the mapping(classiﬁcation)is reasonable and *** classiﬁcation also plays a vital role in the assessment of students’*** the PEOs are expressed as short text,they do not contain enough semantic meaning and information,and consequently they suffer from high sparseness,multidimensionality and the curse of *** this work,a novel associative short text classiﬁcation tech-nique is proposed to map PEOs to *** datasets are extracted from 152 self-study reports(SSRs)that were produced in operational settings in an engineering program accredited by *** datasets are processed and transformed into a representational form appropriate for association rule *** extracted rules are utilized as delegate classiﬁers to map PEOs to *** proposed asso-ciative classiﬁcation of the mapping of PEOs to SOs has shown promising results,which can simplify the classiﬁcation of short text and avoid many problems caused by enriching short text based on external resources that are not related or relevant to the dataset.

关键词： ABET accreditation association rule mining educational data mining engineering education program educational objectives student outcomes associative classiﬁcation

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A Novel Internet of Medical Thing Cryptosystem Based on Jigsaw Transformation and Ikeda Chaotic Map

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Computer Systems Science & Engineering 2023年第9期46卷 3017-3036页

作者： Sultan almakdi Mohammed Salshehri Yousef asiri Mimonah al Qathrady Anas Ibrar Jawad Ahmad Department of Computer Science Najran UniversityNajran61441Saudi Arabia Department of Information Systems Najran UniversityNajran61441Saudi Arabia Department of Electrical Engineering Wah Engineering CollegeUniversity of WahWah Cantt47040Pakistan School of Computing Edinburgh Napier UniversityEdinburghEH105DTUK

Image encryption has attracted much interest as a robust security solution for preventing unauthorized access to critical image *** picture encryption is a crucial step in many cloud-based and healthcare *** this study,a strong cryptosystem based on a 2D chaotic map and Jigsaw transformation is presented for the encryption of medical photos in private Internet of Medical Things(IoMT)and cloud storage.A disorganized three-dimensional map is the foundation of the proposed *** dispersion of pixel values and the permutation of their places in this map are accomplished using a nonlinear encoding *** suggested cryptosystem enhances the security of the delivered medical images by performing many *** validate the efficiency of the recommended cryptosystem,various medical image kinds are used,each with its unique *** measures are used to evaluate the proposed cryptosystem,which all support its robust *** simulation results confirm the supplied cryptosystem’s ***,it provides strong robustness and suggested protection standards for cloud service applications,healthcare,and *** is seen that the proposed 3D chaotic cryptosystem obtains an average entropy of 7.9998,which is near its most excellent value of 8,and a typical NPCR value of 99.62%,which is also near its extreme value of 99.60%.Moreover,the recommended cryptosystem outperforms conventional security systems across the test assessment criteria.

关键词： Jigsaw transformation cryptosystem image encryption medical images Ikeda map chaotic system

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Spontaneous Monochorionic Triamniotic Triplet Pregnancy: A Case Report

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Open Journal of Obstetrics and Gynecology 2023年第6期13卷 1075-1080页

作者： al Hussain al Hazmi Ola Tayeb Afrah al Mutairi Mufareh asiri Maternity Hospital King Saud Medical City Riyadh KSA

Background: Monochorionic triamniotic (MCTA) triplet pregnancy is a rare entity associated with a high risk of complications. In most previously reported cases, the pregnancy was conceived with the use of assisted reproductive technologies, and these cases were associated with complications. Case Presentation: We report a 28-year-old woman with a spontaneously conceived MCTA triplet pregnancy diagnosed at the gestational age of 26 weeks. all fetuses had normal amniotic fluid and umbilical artery Doppler findings were normal. The estimated weight of fetuses was 848 g, 891 g, and 1 kg, respectively. The patient was managed conservatively with a plan to monitor fetal growth every two weeks and a Doppler study twice weekly. On the 8th day of admission, the patient developed labor pains. Per vaginal examination revealed 1 - 2 cm cervical dilatation. Cesarean section was performed, and three girls were delivered with a single placenta (birth weight: 820, 925, and 960 g, respectively). Conclusion: Monochorionic triplet pregnancy is associated with a higher risk of fetal morbidity and mortality. Therefore, awareness of its complications can facilitate better management of such cases.

关键词： Monochorionic Triamniotic Triplet Pregnancy Case Report

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Malicious URL Classification Using Artificial Fish Swarm Optimization and Deep Learning

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Computers, Materials & Continua 2023年第1期74卷 607-621页

作者： Anwer Mustafa Hilal Aisha Hassan Abdalla Hashim Heba G.Mohamed Mohamed K.Nour Mashael M.asiri ali M.al-Sharafi Mahmoud Othman Abdelwahed Motwakel Department of Electrical and Computer Engineering International Islamic University Malaysia 53100 Kuala LumpurMalaysia Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia Department of Electrical Engineering College of EngineeringPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Sciences College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of Computer Science College of Science&Art at MahayilKing Khalid UniversitySaudi Arabia Department of Computer Science College of Computers and Information TechnologyUniversity of BishaSaudi Arabia Department of Computer Science Faculty of Computers and Information TechnologyFuture University in EgyptNew Cairo11835Egypt

Cybersecurity-related solutions have become familiar since it ensures security and privacy against cyberattacks in this digital *** Uniform Resource Locators(URLs)can be embedded in email or Twitter and used to lure vulnerable internet users to implement malicious data in their *** may result in compromised security of the systems,scams,and other such *** attacks hijack huge quantities of the available data,incurring heavy financial *** the same time,Machine Learning(ML)and Deep Learning(DL)models paved the way for designing models that can detect malicious URLs accurately and classify *** this motivation,the current article develops an Artificial Fish Swarm algorithm(AFSA)with Deep Learning Enabled Malicious URL Detection and Classification(AFSADL-MURLC)*** presented AFSADL-MURLC model intends to differentiate the malicious URLs from genuine *** attain this,AFSADL-MURLC model initially carries out data preprocessing and makes use of glove-based word embedding *** addition,the created vector model is then passed onto Gated Recurrent Unit(GRU)classification to recognize the malicious ***,AFSA is applied to the proposed model to enhance the efficiency of GRU *** proposed AFSADL-MURLC technique was experimentally validated using benchmark dataset sourced from Kaggle *** simulation results confirmed the supremacy of the proposed AFSADL-MURLC model over recent approaches under distinct measures.

关键词： Malicious URL cybersecurity deep learning machine learning metaheuristics gated recurrent unit

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