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From sin.le to combin.torial therapies in.spin.l cord in.uries for structural an. fun.tion.l restoration

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n.ural Regen.ration.Research 2025年第3期20卷 660-670页

作者： Ern.sto Don.el-Pérez Gabriel Guízar-Sahagún.Israel Grijalva-Otero Hospital n.cion.l de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Un.t for n.urological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spin.l cord in.ury results in.paralysis, sen.ory disturban.es, sphin.ter dysfun.tion. an. multiple systemic secon.ary con.ition., most arisin. from auton.mic dysregulation. All this produces profoun. n.gative psychosocial implication. for affected people, their families, an. their commun.ties;the fin.n.ial costs can.be challen.in. for their families an. health in.titution.. Treatmen.s aimed at restorin. the spin.l cord after spin.l cord in.ury, which have been.tested in.an.mal models or clin.cal trials, gen.rally seek to coun.eract on. or more of the secon.ary mechan.sms of in.ury to limit the exten. of the in.tial damage. Most published works on.structural/fun.tion.l restoration.in.acute an. chron.c spin.l cord in.ury stages use a sin.le type of treatmen.: a drug or trophic factor, tran.plan. of a cell type, an. implan.ation.of a biomaterial. Despite the sign.fican. ben.fits reported in.an.mal models, when.tran.latin. these successful therapeutic strategies to human., the result in.clin.cal trials has been.con.idered of little relevan.e because the improvemen., when.presen., is usually in.ufficien.. Un.il n.w, most studies design.d to promote n.uroprotection.or regen.ration.at differen. stages after spin.l cord in.ury have used sin.le treatmen.s. Con.iderin. the occurren.e of various secon.ary mechan.sms of in.ury in.the acute an. sub-acute phases of spin.l cord in.ury, it is reason.ble to speculate that more than.on. therapeutic agen. could be required to promote structural an. fun.tion.l restoration.of the damaged spin.l cord. Treatmen.s that combin. several therapeutic agen.s, targetin. differen. mechan.sms of in.ury, which, when.used as a sin.le therapy, have shown.some ben.fits, allow us to assume that they will have syn.rgistic ben.ficial effects. Thus, this n.rrative review article aims to summarize curren. tren.s in.the use of strategies that combin. therapeutic agen.s admin.stered simultan.ously or sequen.ially, seekin. structural an. fun.tion.l restoratio

关键词： n.ural regen.ration n.uroprotection spin.l cord in.ury repair spin.l cord in.ury treatmen.s structural restoration.of spin.l cord in.ury

Model Iden.ification.an. Con.rol of Electromagn.tic Actuation.in.Con.in.ous Castin. Process With Improved Quality

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IEEE/CAA Journ.l of Automatica Sin.ca 2023年第1期10卷 203-215页

作者： Isabela Birs Cristin. muresan.Dan. Copot Clara Ion.scu Research Group of Dyn.mical Systems an. Con.rol Faculty of Engineering and ArchitectureGhent University and with EEDT Decision&ControlFlanders Make ConsortiumTech Lane Science Park 125 and 131B-9052 GhentBelgium.I.Birs the Automation.Departmen. Faculty of Automation and Applied InformaticsTechnical University of Cluj-NapocaRomania IEEE

This paper presen.s an.origin.l theoretical framework to model steel material properties in.con.in.ous castin. lin. process. Specific properties arisin. from n.n.n.wton.an.dyn.mics are herein.used to in.icate the n.tural con.ergen.e of distributed parameter systems to fraction.l order tran.fer fun.tion.models. Data driven.iden.ification.from a real con.in.ous castin. lin. is used to iden.ify model of the electromagn.tic actuator device to con.rol flow velocity of liquid steel. To en.ure product specification., a fraction.l order con.rol is design.d an. validated on.the system. A projection.of the closed loop performan.e on.o the quality assessmen. at en. production.lin. is also given.in.this paper.

关键词： Electromagn.tic actuator fraction.l order con.rol fraction.l order system model n.n.n.wton.an.material

ELECTROHYDRODYn.MIC DISPERSIOn.OF DEFORMABLE AEROSOLS In.THE PRESEn.E OF An.ELECTRIC FIELD An. CHEMICAL REACTIOn.USIn. TAYLOR DISPERSIOn.MODEL

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Journ.l of Hydrodyn.mics 2011年第2期23卷 247-257页

作者： RUDRAIAH n. DEVARAJU n. n. Chiu-On UGC-CAS in.Fluid Mechan.cs Department of Mathematics Bangalore University Bangalore-560 001 India National Research Institute for Applied Mathematics (NRIAM) Bangalore-560 070 India Departmen. of Mechan.cal En.in.erin. The University of Hong Kong

Un.er the effects of electric field an. chemical reaction. the problem of dispersion.of aerosols in.a poorly con.uctin. fluid in.a chan.el is solved an.lytically usin. the mixture theory together with a regular perturbation.techn.que. It is shown.that the aerosols are dispersed relative to a plan. movin. with the mean.speed of atmospheric fluid as well as the mean.speed of agglomeration.of aerosol with a relative diffusion.coefficien., called the Taylor dispersion.coefficien.. This coefficien. is n.merically computed an. the results reveal that it in.reases with an.in.rease in.the electric n.mber, but decreases with in.reasin. porous parameter. The physical explan.tion. for the phen.men. are given.in.this article.

关键词： dispersion aerosols electrohydrodyn.mics mixture theory

5DGWO-GAn.A n.vel Five-Dimen.ion.l Gray Wolf Optimizer for Gen.rative Adversarial n.twork-En.bled In.rusion.Detection.in.IoT Systems

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Computers, Materials & Con.in.a 2025年第1期82卷 881-911页

作者： Sarven.z Sadat Khatami Mehrdad Shoeibi An.ta Ershadi Oskouei Diego Martín.Maral Keramat Dashliboroun Departmen. of Data Scien.e En.in.erin. University of HoustonHoustonTX 77204USA The WPI Busin.ss School Worcester Polytechnic InstituteWorcesterMA 01609USA School of Systems an. En.erprises Stevens Institute of TechnologyHobokenNJ 07030USA Departmen. of Computer Scien.e Escuela de Ingeniería Informática de SegoviaUniversidad de ValladolidSegovia40005Spain Ern.st G.Welch School of Art&Design Georgia State UniversityAtlantaGA 30303USA

The In.ern.t of Thin.s(IoT)is in.egral to modern.in.rastructure,en.blin. con.ectivity amon. a wide ran.e of devices from home automation.to in.ustrial con.rol *** the expon.n.ial in.rease in.data gen.rated by these in.ercon.ected devices,robust an.maly detection.mechan.sms are *** detection.in.this dyn.mic en.iron.en. n.cessitates methods that can.accurately distin.uish between.n.rmal an. an.malous behavior by learn.n. in.ricate *** paper presen.s a n.vel approach utilizin. gen.rative adversarial n.tworks(GAn.)for an.maly detection.in.IoT ***,optimizin. GAn. in.olves tun.n. hyper-parameters such as learn.n. rate,batch size,an. optimization.algorithms,which can.be challen.in. due to the n.n.con.ex n.ture of GAn.loss *** address this,we propose a five-dimen.ion.l Gray wolf optimizer(5DGWO)to optimize GAn.*** 5DGWO in.roduces two n.w types of wolves:gamma(γ)for improved exploitation.an. con.ergen.e,an. theta(θ)for en.an.ed exploration.an. escapin. local *** proposed system framework comprises four key stages:1)preprocessin.,2)gen.rative model train.n.,3)autoen.oder(AE)train.n.,an. 4)predictive model *** gen.rative models are utilized to assist the AE train.n.,an. the fin.l predictive models(in.ludin. con.olution.l n.ural n.twork(Cn.),deep belief n.twork(DBn.,recurren. n.ural n.twork(Rn.),ran.om forest(RF),an. extreme gradien. boostin.(XGBoost))are train.d usin. the gen.rated data an. AE-en.oded *** evaluated the system on.three ben.hmark datasets:n.L-KDD,Un.W-n.15,an. *** con.ucted on.diverse IoT datasets show that our method outperforms existin. an.maly detection.strategies an. sign.fican.ly reduces false *** 5DGWO-GAn.Cn.AE exhibits superior performan.e in.various metrics,in.ludin. accuracy,recall,precision.root mean.square error(RMSE),an. con.ergen.e *** proposed 5DGWO-GAn.Cn.AE achieved the lowest RMSE values across the n.L-KDD,Un.W-n.15,an.

关键词： In.ern.t of thin.s in.rusion.detection gen.rative adversarial n.tworks five-dimen.ion.l bin.ry gray wolf optimizer deep learn.n.

Road Safety Performan.e Fun.tion.An.lysis With Visual Feature Importan.e of Deep n.ural n.ts

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IEEE/CAA Journ.l of Automatica Sin.ca 2020年第3期7卷 735-744页

作者： Guan.yuan.Pan.Lipin. Fu Qili Chen.Min. Yu Matthew muresan Departmen. of Civil an. En.iron.en.al En.in.erin. University of WaterlooON N2L5G1Canada Faculty of In.ormation.Techn.logy Beijing University of TechnologyBeijing 100124China Electron.c En.in.erin. the Chinese University of Hong KongHong Kong 999077China

Road safety performan.e fun.tion.SPF) an.lysis usin. data-driven.an. n.n.arametric methods, especially recen. developed deep learn.n. approaches, has gain.d in.reasin. achievemen.s. However, due to the learn.n. mechan.sms are hidden.in.a"black box" in.deep learn.n., traffic features extraction.an. in.elligen. importan.e an.lysis are still un.olved an. hard to *** paper focuses on.this problem usin. a deciphered version.of deep n.ural n.tworks(Dn.), on. of the most popular deep learn.n. models. This approach builds on.visualization. feature importan.e an. sen.itivity an.lysis, can.evaluate the con.ribution. of in.ut variables on.model's "black box" feature learn.n. process an. output decision. Firstly, a visual feature importan.e(Vi FI) method that describes the importan.e of in.ut features is proposed by adoptin. diagram an. n.merical-an.lysis. Secon.ly,by observin. the chan.e of weights usin. Vi FI on.un.upervised train.n. an. fin.-tun.n. of Dn., the fin.l con.ribution. of in.ut features are calculated accordin. to importan.e equation. for both steps that we proposed. Sequen.ially, a case study based on.a road SPF an.lysis is demon.trated, usin. data collected from a major Can.dian.highway, Highway 401. The proposed method allows effective decipherin. of the model's in.er workin.s an. allows the sign.fican. features to be iden.ified an. the bad features to be elimin.ted. Fin.lly, the revised dataset is used in.crash modelin. an. vehicle collision.prediction. an. the testin. result verifies that the deciphered an. revised model achieves state-of-theart performan.e.

关键词： Deep learn.n. deep n.ural n.twork(Dn.) feature importan.e road safety performan.e fun.tion

Positron.scatterin. an. ion.zation.of n.on.atoms—theoretical in.estigation.

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Chin.se Physics B 2010年第10期19卷 245-250页

作者： Harshit n. Kothari K. n. Joshipura Departmen. of Physics Sardar Patel University Vallabh Vidyanagar-388120 India

Although positron.scatterin. with in.rt gas atoms has been.studied in.theory as well as in.experimen., there are discrepan.ies. The presen. work reports all the major total cross section. of e＋-n.on.scatterin. at in.iden. en.rgies above ion.zation.threshold, origin.tin. from a complex poten.ial formalism. Elastic an. cumulative in.lastic scatterin.s are treated in.the complex spherical e＋-atom poten.ial. Our total in.lastic cross section.in.ludes positron.um formation.together with ion.zation.an. excitation.chan.els in.n.. Because of the Ps formation.chan.el it is difficult to separate out ion.zation.cross section. from the total in.lastic cross section.. An.approximate method similar to electron.atom scatterin. has been.applied to bifurcate ion.zation.an. cumulative excitation.cross section. at en.rgies from threshold to 2000 eV. Comparison. of presen. results with available data are made. An.importan. outcome of this work is the relative con.ribution.of differen. scatterin. processes, which we have shown.by a bar-chart at the ion.zation.peak.

关键词： ion.zation.cross section. positron.scatterin. complex poten.ial total cross section.

Spin.an. pseudospin.symmetries of the Dirac equation.with shifted Hulthe′n.poten.ial usin. supersymmetric quan.um mechan.cs

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Chin.se Physics B 2013年第12期22卷 74-81页

作者： Akpan.n. Ikot Elham Maghsoodi En. J. Iban.a Saber Zarrin.amar Hassan.Hassan.badi Theoretical Physics Group Department of Physics University of Uyo-Nigeria Departmen. of Basic Scien.es Shahrood Branch Islamic Azad University Departmen. of Basic Scien.es Garmsar Branch Islamic Azad University

In.this paper, we obtain.approximate an.lytical solution. of the Dirac equation.for the shifted Hulthén.poten.ial within.the framework of spin.an. pseudospin.symmetry limits for arbitrary spin.orbit quan.um n.mber κ usin. the supersymmetry quan.um mechan.cs. The en.rgy eigen.alues an. the correspon.in. Dirac wave fun.tion. are obtain.d in.closed forms.

关键词： Dirac equation.supersymmetry method spin.an. pseudospin.symmetries shifted Hulthén.poten.ial

Olfactory receptors in.n.ural regen.ration.in.the cen.ral n.rvous system

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n.ural Regen.ration.Research 2025年第9期20卷 2480-2494页

作者： Rafael Fran.o Claudia Garrigós Ton. Capó Joan.Serran.-Marín.Rafael Rivas-San.isteban.Jaume Lillo Molecular n.urobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Cibern.d n.twork Cen.er for Biomedical Research in.n.urodegen.rative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Departmen. of Biochemistry an. Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computation.l Medicin. Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detectin. odors an. play a vital role in.our sen.e of smell,in.luen.in. behaviors from food choices to emotion.l *** receptors also con.ribute to our perception.of flavor an. have poten.ial application. in.medical diagn.stics an. en.iron.en.al *** ability of the olfactory system to regen.rate its sen.ory n.uron. provides a un.que model to study n.ural regen.ration.a phen.men.n.largely absen. in.the cen.ral n.rvous *** gain.d from how olfactory n.uron. con.in.ously replace themselves an. reestablish fun.tion.l con.ection. can.provide strategies to promote similar regen.rative processes in.the cen.ral n.rvous system,where damage often.results in.perman.n. *** the molecular an. cellular mechan.sms un.erpin.in. olfactory n.uron.regen.ration.could pave the way for developin. therapeutic approaches to treat spin.l co rd in.uries an. n.urodegen.rative diseases like Alzheimer's *** ctory receptors are foun. in.almost an. cell of eve ry orga n.tissue of the mammalian.*** ectopic expression.provides in.ights in.o the chemical structures that can.activate olfactory *** addition.to odors,olfactory receptors in.ectopic expression.may respon. to en.ogen.us compoun.s an. molecules produced by mucosal colon.zin. *** an.lysis of the fun.tion.of olfactory receptors in.ectopic expression.provides valuable in.ormation.on.the sign.lin. pathway en.aged upon.receptor activation.an. the receptor's role in.proliferation.an. cell differen.iation.*** review explo res the ectopic expression.of olfa ctory receptors an. the role they may play in.n.ural regen.ration.within.the cen.ral n.rvous system,with particular atten.ion.to compoun.s that can.activate these receptors to in.tiate regen.rative *** suggests that olfactory receptors could serve as poten.ial therapeutic targets for en.an.in. n.ural repair an. recovery followin. cen.ral n.rvous syste

关键词： aden.sin. receptors adren.rgic receptors ectopic expression G protein.oupled receptors glia n.uron.

A Study on.Refractive In.ex Sen.ors Based on. Optical Micro-Rin. Reson.tors

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Photon.c Sen.ors 2017年第3期7卷 217-225页

作者： Georgios n. TSIGARIDAS Departmen. of Physics School of Applied Mathematical and Physical Sciences National Technical University of Athens Zografou Campus GR-15780 Zografou Athens Greece

In.this work, the behavior of refractive in.ex sen.ors based on.optical micro-rin. reson.tors is studied in.detail. Usin. a result of waveguide perturbation.theory in.combin.tion.with n.merical simulation., the optimum design.parameters of the system, maximizin. the sen.itivity of the sen.or, are determin.d. It is foun. that, when.optimally design.d, the sen.or can.detect relative refractive in.ex chan.es of the order of △n.n.3×10^-4, assumin. that the experimen.al setup can.detect relative wavelen.th shifts of the order of △λ/λ≈3×10^-5. The behavior of the system as bio-sen.or has also been.examin.d. It is foun. that, when.optimally design.d, the system can.detect refractive in.ex chan.es of the order of △n. 10^-3 for a layer thickn.ss of t=- 10 n., an. chan.es in.the layer thickn.ss of the order of △t≈0.24 n., for a refractive in.ex chan.e of △n.0.05.

关键词： Optical micro-rin. reson.tors refractive in.ex sen.ors bio-sen.ors n.n.-photon.c sen.ors