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Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis

World Journal of Gastroenterology 2007年第6期13卷 837-844页

作者： Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz murat keskin murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak Uludag University Medical School Department of Internal Medicine Bursa Turkey Uludag University Medical School Department of Gastroenterology Bursa Turkey Uludag University Medical School Department of Biochemistry Bursa Turkey Uludag University Medical School Department of Statistics Bursa Turkey Uludag University Medical School Department of Pathology Bursa Turkey

AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology.

关键词： Steatosis Steatohepatitis Cytokeratin 18 M30-antigen M65-antigen

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Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients

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World Journal of Gastroenterology 2007年第45期13卷 6027-6030页

作者： Serkan Torun Enver Dolar Yusuf Yilmaz murat keskin murat Kiyici Melda Sinirtas Emre Sarandol Selim Gurel Selim Giray Nak Macit Gulten Uludag University Medical School Department of Internal Medicine Bursa 16059 Turkey Uludag University Medical School Department of Gastroenterology Bursa 16059 Turkey Uludag University Medical School Department of Microbiology and Infectious Diseases Bursa 16059 Turkey Uludag University Medical School Departmentof Biochemistry Bursa 16059 Turkey

AIM： To investigate the diagnostic efficacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis （SBP）. METHODS： A total of 63 consecutive patients with cirrhotic ascites （38 male, 25 female） tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic fluid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of ≥ 250/mm^3. RESULTS： Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specificity, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically significant effects on diagnostic accuracy. CONCLUSION： Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP.

关键词： Spontaneous bacterial peritonitis Urinaryreagent strip Leukocyte esterase Nitrite

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Dynamic magnetic behavior of the mixed spin (2, 5/2) Ising system with antiferromagnetic/antiferromagnetic interactions on a bilayer square lattice

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Chinese Physics B 2013年第12期22卷 160-167页

作者： Mehmet Ertas Mustafa keskin Department of Physics Erciyes University

Using the mean-field theory and Glauber-type stochastic dynamics, we study the dynamic magnetic properties of the mixed spin （2, 5/2） Ising system for the antiferromagnetic/antiferromagnetic （AFM/AFM） interactions on the bilayer square lattice under a time varying （sinusoidal） magnetic field. The time dependence of average magnetizations and the thermal variation of the dynamic magnetizations are examined to calculate the dynamic phase diagrams. The dynamic phase diagrams are presented in the reduced temperature and magnetic field amplitude plane and the effects of interlayer coupling interaction on the critical behavior of the system are investigated. We also investigate the influence of the frequency and find that the system displays richer dynamic critical behavior for higher values of frequency than that of the lower values of it. We perform a comparison with the ferromagnetic/ferromagnetic （FM/FM） and AFM/FM interactions in order to see the effects of AFM/AFM interaction and observe that the system displays richer and more interesting dynamic critical behaviors for the AFM/AFM interaction than those for the FM/FM and AFM/FM interactions.

关键词： dynamic magnetic behavior of a bilayer Ising system mixed spins glauber-type stochastic dynamics antiferromagnetic/antiferromagnetic interactions

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Relaxation theory of spin-3/2 Ising system near phase transition temperatures

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Chinese Physics B 2010年第8期19卷 257-269页

作者： Osman Canko Mustafa keskin Department of Physics Erciyes University

Dynamics of a spin-3/2 Ising system Hamiltonian with bilinear and biquadratic nearest-neighbour exchange interactions is studied by a simple method in which the statistical equilibrium theory is combined with the Onsager＇s theory of irreversible thermodynamics. First, the equilibrium behaviour of the model in the molecular-field approximation is given briefly in order to obtain the phase transition temperatures, i.e. the first- and second-order and the tricritical points. Then, the Onsager theory is applied to the model and the kinetic or rate equations are obtained. By solving these equations three relaxation times are calculated and their behaviours are examined for temperatures near the phase transition points. Moreover, the z dynamic critical exponent is calculated and compared with the z values obtained for different systems experimentally and theoretically, and they are found to be in good agrement.

关键词： spin-3/2 Ising system 0nsager theory

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Phase diagrams in mixed spin-3/2 and spin-2 Ising system with two alternative layers within the effective-field theory

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Chinese Physics B 2011年第6期20卷 112-124页

作者： Bayram Deviren Yasin Polat Mustafa keskin Department of Physics Nevsehir University Institute of Science Erciyes University Department of Physics Erciyes University

The phase diagrams in the mixed spin-3/2 and spin-2 Ising system with two alternative layers on a honeycomb lattice are investigated and discussed by the use of the effective-field theory with correlations. The interaction of the nearest-neighbour spins of each layer is taken to be positive （ferromagnetic interaction） and the interaction of the adjacent spins of the nearest-neighbour layers is considered to be either positive or negative （ferromagnetic or antiferromagnetic interaction）. The temperature dependence of the layer magnetizations of the system is examined to characterize the nature （continuous or discontinuous） of the phase transitions and obtain the phase transition temperatures. The system exhibits both second- and first-order phase transitions besides triple point （TP）, critical end point （E）, multicritical point （A）, isolated critical point （C） and reentrant behaviour depending on the interaction parameters. We have also studied the temperature dependence of the total magnetization to find the compensation points, as well as to determine the type of behaviour, and N-type behaviour in Neel classification nomenclature existing in the system. The phase diagrams are constructed in eight different planes and it is found that the system also presents the compensation phenomena depending on the sign of the bilinear exchange interactions.

关键词： mixed spin-3/2 and spin-2 Ising system effective-field theory compensation phenomena phase diagrams

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Influences of Crystal-Field and Interlayer Coupling Interactions on Dynamic Phase Diagrams of a Mixed-Spin(3/2,2)Bilayer System

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Communications in Theoretical Physics 2018年第6期69卷 741-748页

作者： Mustafa keskin Yusuf Kocak Physics Department Erciyes University38039 KayseriTurkey

Influences of crystal-fields （DA and DB ） and interlayer coupling interactions （J3） on dynamic magnetic critical behaviors of a mixed-spin （3//2, 2） bilayer system under an oscillating magnetic field are investigated by the Glauber-type stochastic dynamics based on the mean-field theory. For this purpose, dynamic phase diagrams are constructed in the reduced temperature and magnetic field amplitude plane for the ferromagnetic/ferromagnetic （FM/FM）, antiferromagnetic/ferromagnetic （AFM/FM） and AFM/AFM interactions in detail. We observe that the influences of DA, DB and Ja interactions parameters on the behavior of the dynamic phase diagrams are very much.

关键词： mixed-spin (3/2 2) bilayer system dynamic phase diagrams, Glauber-type stochastic dynamics mean-field theory

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Fibonacci and Lucas Congruences and Their Applications

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Acta Mathematica Sinica,English Series 2011年第4期27卷 725-736页

作者： Refik keskin DEMiRTURK BITIM Department of Mathematics Faculty of Science and Arts Sakarya University 54187 Sakarya Turkey

In this paper we obtain some new identities containing Fibonacci and Lucas numbers. These identities allow us to give some congruences concerning Fibonacci and Lucas numbers such as L2mn＋k ≡（-1）（m＋1）nLk（modLm）, F2mn＋k ≡（-1）（m＋1）nFk （modLm）, L2mn＋k ≡ （-1）mn Lk（mod Fm） and F2mn＋k≡ （-1）mn Fk （mod Fm）. By the achieved identities, divisibility properties of Fibonacci and Lueas numbers are given. Then it is proved that there is no Lucas number Ln such that Ln = L2ktLmx2 for m 〉 1 and k≥1. Moreover it is proved that Ln = LmLr is impossible if m and r are positive integers greater than 1. Also, a conjecture concerning with the subject is given.

关键词： Fibonacci numbers Lucas numbers congruences

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On Baer-Kaplansky Classes of Modules

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Algebra Colloquium 2017年第4期24卷 603-610页

作者： Derya keskin Tutuncu Rachid Tribak Department of Mathematics Hacettepe University 06800 Beytepe Ankara Turkey Centre Regional des Metiers de L'Education et de la Formation (CRMEF)-Tanger Avenue My Abdelaziz Souani B.P. 3117 Thngier Morocco

We are interested in studying when the class of local modules is Baer- Kaplansky. We provide an example showing that even over a commutative semisimple ring R, we can find two non-isomorphic simple R-modules S1 and S2 such that the rings EndR（S1） and EndR（S2） are isomorphic. We show that over any ring R, the class of semisimple R-modules is Baer Kaplansky if and only if so is the class of simple R-modules.

关键词： Baer Kaplansky class of modules local modules semisimple rings

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Kinetic Ising model in a time-dependent oscillating external magnetic field:effective-field theory

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Chinese Physics B 2010年第5期19卷 187-194页

作者： Bayram Deviren Osman Canko Mustafa keskin Institute of Science Erciyes University38039 KayseriTurkey Department of Physics Nevsehir University50300 NevsehirTurkey Department of Physics Erciyes University38039 KayseriTurkey

Recently, Shiet al. [2008 Phys. Left. A 372 5922] have studied the dynamical response of the kinetic Ising model in the presence of a sinusoidal oscillating field and presented the dynamic phase diagrams by using an effective-field theory （EFT） and a mean-field theory （MFT）. The MFT results are in conflict with those of the earlier work of Tome and de Oliveira, [1990 Phys. Rev. A 41 4251]. We calculate the dynamic phase diagrams and find that our results are similar to those of the earlier work of Tome and de Oliveira; hence the dynamic phase diagrams calculated by Shiet al. are incomplete within both theories, except the low values of frequencies for the MFT calculation. We also investigate the influence of external field frequency （w） and static external field amplitude （h0） for both MFT and EFT calculations. We find that the behaviour of the system strongly depends on the values of w and h0.

关键词： kinetic Ising model effective-field theory mean-field theory

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(D_(4))-Objects in Abelian Categories

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Algebra Colloquium 2022年第2期29卷 231-240页

作者： Berke Kalebogaz Derya keskin Tutuncu Department of Mathematics Hacettepe University 06800 BeytepeAnkaraTurkey

Let A be an abelian category and M∈*** M is called a(D_(4))-object if,whenever A and B are subobjects of M with M=A⊕B and f:A→B is an epimorphism,Ker f is a direct summand of *** this paper we give several equivalent conditions of(D_(4))-objects in an abelian *** other results,we prove that any object M in an abelian category A is(D_(4))if and only if for every subobject K of M such that K is the intersection K_(1)∩K_(2)of perspective direct summands K_(1)and K_(2)of M with M=K_(1)+K_(2),every morphismφ:M→M/K can be lifted to an endomorphismθ:M→M in End _(A)(M).

关键词： (D_(4))-object abelian category

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