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A Double-Sided View to Adult Vaccination:The Opinions and Attitudes of Patients and Health Workers

Health 2018年第12期10卷 1697-1713页

作者： Raziye Sule Gümüstakim Pinar Bilgili murat cevik Duygu Ayhan Baser Adem Doganer Selda Handan Karahan Saper Zuhal Kanevetci Ergül Ozcelebi Medical Faculty Sutcu Imam UniversityKahramanmarasTurkey Department of Family Medicine Medical SchoolHacettepe UniversityAnkaraTurkey

Objective: Although there are adult vaccination schemes in our country, there are serious deficiencies in the way that doctors direct the patients to this vaccination, but also patients have to make and demand these vaccinations. The aim of our study is to identify the shortcomings in this area and draw a roadmap for what arrangements should be made in terms of physicians and patients in order to increase adult immunization rates in primary care. Method: We conducted a two-phase, multicentered, descriptive clinical trial between October and December 2017. The first phase of the trial was carried out with patients from 3 Family Health Centers in Antalya, Istanbul and Osmaniye. Patients to be interviewed were selected voluntarily among Family Health Center’s applicants. The second phase of the trial was carried out with health workers, who were participated to trial from 26 different provinces of Turkey. In the process, a questionnaire of 19 questions was applied to primary health care workers by the internet. Results: 490 patients were included in the study. There was a significant difference between gender, age, education level and guideline follow-up and vaccination status of patients [p Conclusion: As a result of the studies including our study about adult vaccination, only 10% - 20% of the targeted groups in adults can be vaccinated. However, just like in childhood during adulthood, vaccinations protect individuals from diseases and provide economic benefits. Firstly, the knowledge level of physicians on adult immunization should be updated with in-service trainings, they should first be convinced to vaccinate because they are in risk group and then they should be recommended vaccination to patient to increase the vaccination rates.

关键词： Adult Vaccination Health Workers Patients

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Redox active polymer metal chelates for use in flexible symmetrical supercapacitors:Cobalt-containing poly(acrylic acid)polymer electrolytes

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Journal of Energy Chemistry 2021年第4期30卷 145-153页

作者： Emre cevik Ayhan Bozkurt Department of Genetics Research Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Department of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

The novel polymer metal chelate electrolytes(polychelates)were prepared by incorporation of cobalt sulfate(Co)into poly(acrylic acid)(PAA)host ***-solid state supercapacitor devices were fabricated using polychelates,PAA-Co X(X:3,5,7,and 10)where X represents the doping fraction(w/w)of Co in *** polymer metal electrolytes were showed excellent bending-stretching properties,thermal stability and electrochemical durability with an optimum ionic conductivity of 3.15×10^(-4) S cm^(-1).Hierarchically porous activated carbon and nano-sized conductive carbon were used to form carbon composite symmetrical device *** electric double-layer capacitor(EDLC)and redox reactions of Co-incorporated polychelates at the interfaces of porous activated carbon provided an optimum specific capacitance of 341.33 F g^(-1) with a device of PAA-Co7,which is at least 15 times enhancement compared to the device of pristine *** PAA-Co7 device also provided energy density of 21.25 Wh kg^(-1) at a power density of 117.69 W kg^(-1).A prolonged cyclic stability of the device exhibited superior capacitive performance after 10,000 charge-discharge cycles and the maintained 90%of its initial *** addition,the supercapacitor with a dimension of 1.5 cm×3 cm containing PAA-Co7 successfully operated the red-blue-green(RGB)LED light.

关键词： Supercapacitor Redox active supercapacitor Cobalt Poly(acrylic acid) Polymer electrolyte

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Reflection and Transmission of Regular Waves from/Through Single and Double Perforated Thin Walls

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China Ocean Engineering 2017年第4期31卷 466-475页

作者： Nadji CHIOUKH Esin cevik Yalcin YUKSEL Department of Civil Engineering University of Djillali Liabes Sidi Bel-Abbes 22000 Algeria Laboratory of Naval Aero-Hydrodynamics Department of Maritime Engineering USTO MB Oran 31000 Algeria Department of Civil Engineering Yildiz Technical University Istanbul Turkey

In this paper, reflection and transmission coefficients of regular waves from/through perforated thin walls are investigated. Small scale laboratory tests have been performed in a wave flume firstly with single perforated thin Plexiglas plates of various porosities. The plate is placed perpendicular to the flume with the height from the flume bottom to the position above water surface. With this thin wall in the flume wave overtopping is prohibited and incident waves are able to transmit. The porosities of the walls are achieved by perforating the plates with circular holes. Model settings with double perforated walls parallel to each other forming so called chamber system, have been also examined. Several parameters have been used for correlating the laboratory tests’ results. Experimental data are also compared with results from the numerical model by applying the multi-domain boundary element method （MDBEM） with linear wave theory. Wave energy dissipation due to the perforations of the thin wall has been represented by a simple yet effective porosity parameter in the model. The numerical model with the MDBEM has been further validated against the previously published data.

关键词： wave-structure interaction perforated thin walls boundary element experimental tests wave reflection wave transmission

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Microfluidic methods used in exosome isolation

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BIOCELL 2023年第5期47卷 959-964页

作者： ADEM OZCELIK OZGE cevik Department of Mechanical Engineering Aydın Adnan Menderes UniversityAydın09010Turkiye Department of Biochemistry School of MedicineAydın Adnan Menderes UniversityAydın09010Turkiye

Exosomes are important biomarkers for clinical *** is critical to isolate secreted exosomes from bodily fluids such as blood,saliva,breast milk,and urine for liquid biopsy *** field of microfluidics provides numerous benefits for biosample processing,diagnostics,and *** microfluidics-based methods have been employed for the isolation and purification of exosomes in the last ten *** microfluidic methods can be grouped into two categories based on passive and active isolation *** the first group,inertial and hydrodynamic forces are employed to separate exosomes based on their size *** the second group,external forcefields are integrated into microfluidic platforms to actively isolate exosomes from other *** this paper,the application of microfluidic methods in exosome isolation is discussed,and future perspectives on this field are highlighted.

关键词： Exosome Microfluidic exosome isolation Microfluidics Exosome separation

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Bio-fabrication of liver cancer stem cells and testing of gemcitabine

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 497-505页

作者： Evrim cevik Omer Erdogan Ozge cevik Department of Machinery and Metal Technologies Aydin Adnan Menderes UniversityKocarli Vocational High SchoolAydin 09970Turkey Department of Medicinal Biochemistry Aydin Adnan Menderes UniversitySchool of MedicineAydin 09010Turkey

Aim:Cancer stem cells are cell populations that are essential in drug resistance and cancer *** liver cancer cells exhibit the characteristics of cancer stem cells,and it is crucial to study the activities and interactions of drugs in these ***7 is a human liver cancer cell with stem cell biomarkers and is used with induced pluripotent stem cells to form various cancer organoids through encapsulation *** to their ease of use without animal testing,bio-fabrication studies of cell-encapsulated models have gained importance in the pharmaceutical industry in recent *** study aimed to biofabricate Huh7 human liver cancer stem cells by alginate encapsulation and test gemcitabine’s ***:Huh7 cells were encapsulated with alginate(0.8%w/v)and fibronectin,and their viability was evaluated with 3.2μM gemcitabine on days 1,3,6,9,and ***,gene expressions of stem cell markers CD90 and AFP were evaluated in encapsulated Huh7 cells by *** addition,IL-6 secretion in the cell medium was measured by ELISA for the tumor ***:Encapsulation of Huh7 cells was found to maintain their viability and stem cell properties for up to 12 *** addition,alginate-encapsulated Huh7 cells were bio-fabricated to demonstrate long-term gemcitabine *** the effect of the gemcitabine was evaluated in alginate-encapsulated Huh7 cells,CD90 and AFP mRNA levels were significantly reduced in the cells and IL-6 secretion was decreased in the tumor ***:This study demonstrated that bio-fabrication of alginate-encapsulated Huh7 cells is a novel approach for long-term drug testing in liver cancer ***-fabricated alginate-encapsulated cancer stem cells may be a cheaper and faster method for the testing of many drugs.

关键词： Bio-fabrication cancer stem cells gemcitabine liver cancer alginate beads

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Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

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World Journal of Gastroenterology 2015年第1期21卷 311-317页

作者： Dilek cevik Gokhan Yildiz Mehmet Ozturk BilG en Genetics and Biotechnology Center Department of Molecular Biology and GeneticsBilkent UniversityAnkara 06800Turkey Centre de Recherche Inserm-Université Joseph Fourrier U823 La Tronche 38706France Advanced Biomedical Research Center Dokuz Eylul UniversityIzmir 35340Turke

AIM: To determine the mutation status of human telomerase reverse transcriptase gene(TERT) promoter region in hepatocellular carcinoma(HCC) from different geographical ***: We analyzed the genomic DNA sequences of 59 HCC samples comprising 15 cell lines and 44 primary tumors,collected from patients living in Asia,Europe and *** amplified a 474 bp DNA fragment of the promoter region of TERT gene including the 1295228 and 1295250 sequence of chromosome 5 by using *** were then sequenced by Sanger technique and the sequence data were analyzed with by using DNADynamo software in comparison with wild type TERT gene sequence as a ***: The TERT mutations were found highly frequent in *** of the fifteen tested cell lines displayed C228 T mutation,and one had C250 T mutation with a mutation frequency up to 60%.All of the mutations were heterozygous and mutually *** out of forty-four tumors displayed C228 T mutation,and additional five tumors had C250 T mutation providing evidence for mutation frequency of 34% in primary *** the geographic origins of HCC tumors tested,TERT promoter mutation frequencies were higher in African(53%),when compared to non-African(24%) tumors(P = 0.056).There was also a weak inverse correlation between TERT promoter mutations and murine double minute 2 single nucleotide polymorphism 309 TG polymorphism(P = 0.058).Mutation frequency was nearly two times higher in established HCC celllines(60%) compared to the primary tumors(34%).CONCLUSION: TERT promoter is one of most frequent mutational targets in liver cancer,and hepatocellular carcinogenesis is highly associated with the loss of telomere-dependent cellular senescence control.

关键词： Hepatocellular carcinoma Liver cancer Telomerase r

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Development of an Amperometric Hydrogen Peroxide Biosensor based on the Immobilization of Horseradish Peroxidase onto Nickel Ferrite Nanoparticle-Chitosan Composite

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Nano-Micro Letters 2011年第2期3卷 91-98页

作者： Furkan Yalcner Emre cevik Mehmet Senel Abdulhadi Baykal Department of Chemistry Faculty of Arts and SciencesFatih University

Nickel ferrite(NiFe_2O_4) nanoparticles have been dispersed in chitosan solution in order to fab ricate nanocomposite *** peroxidase(HRP) has been immobilized onto this chitosan NiFe_2O_4 nanocomposite film via physical *** size of the NiFe_2O_4 nanoparticles has been estimated us ing X ray diffraction pattern and scanning electron microscopy(SEM) to be 40±9 *** chitosan NiFe_2O_4 nanocomposite film and HRP/chitosan NiFe_2O_4 bioelectrode have been characterized using SEM *** HRP/chitosan NiFe_2O_4 nanocomposite bioelectrode has a response time of 4 s,linearity as 0.3 to 12 m M of H2O2,sensitivity as 22 n A/m *** effects of p H and the temperature of the immobilized HRP electrode have also been studied.

关键词： Biosensor NiFe_2O_4 Horseradish peroxidase Nanoparticle Chitosan

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Colorectal cancer: The epigenetic role of microbiome

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World Journal of Clinical Cases 2019年第22期7卷 3683-3697页

作者： Hussein Sabit Emre cevik Huseyin Tombuloglu Department of Genetics Institute for Medical Research and Consultations Imam Abdulrahman Bin Faisal University

Colorectal cancer(CRC)is the third most common cancer in men(746000 cases per year)and the second most common cancer in women globally(614000 cases per year).The incidence rate of CRC in developed countries(737000 cases per year)is higher than that in less developed countries(624000 cases per year).CRC can arise from genetic causes such as chromosomal instability and microsatellite *** etiologic factors underlie CRC including age,diet,and *** microbiota represent a proven cause of the disease,where they play pivotal roles in modulating and reshaping the host *** active microbial metabolites have been found to drive carcinogenesis,invasion,and metastasis via modifying both the methylation landscape along with histone structure in intestinal *** microbiota,in response to diet,can exert both beneficial and harmful functions in humans,according to the intestinal balance of number and types of these *** the intestinal microbial community is diverse among individuals,these microbes cumulatively produce 100-fold more proteins than the human genome itself,which calls for further studies to elaborate on the complicated interaction between these microorganisms and intestinal ***,understanding the exact role that gut microbiota play in inducing CRC will help attain reliable strategies to precisely diagnose and treat this fatal disease.

关键词： Colorectal Cancer Colorectal cancer Epigenetics Gut Microbiota

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Raloxifene-loaded and aptamer-bonded exosomes induce autophagic and apoptotic death in HeLa cells by enhancing the lysosomotropic effect

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BIOCELL 2023年第5期47卷 1051-1063页

作者： OMER ERDOGAN GULEN MELIKE DEMIRBOLAT OZGE cevik Department of Medical Biochemistry School of MedicineAydin Adnan Menderes UniversityAydin09010Turkey Department of Pharmaceutical Technology Faculty of PharmacyAcibadem Mehmet Ali Aydinlar UniversityIstanbul34758Turkey

Background:Raloxifene,a selective estrogen receptor modulator,is also known to be a lysosomotropic *** bioavailability of raloxifene is around 2%due to extensive hepatic *** are nanosized vesicles that are naturally released from ***:In this study,exosomes released from HeLa cervical cancer cells were loaded with raloxifene to increase its bioavailability,and an aptamer was attached to the exosome membrane for targeting only HeLa *** of exosomes isolated from HeLa cells was performed by transmission electron microscopy,zeta sizer,and western *** addition,the cytotoxic,apoptotic,autophagic,and lysosomotropic effects of the prepared Exo-Apt-Ral formulation on HeLa cervical cancer cells were ***:According to zeta analysis,the sizes of the empty exosome and Exo-Apt-Ral formulation were measured as 66±12 and 120±21 nm,*** was a rise in the lysosomal permeability of HeLa cells after the Exo-Apt-Ral *** addition,both apoptotic and autophagic death mechanisms were triggered in HeLa cells after the Exo-Apt-Ral ***:This study showed that raloxifene functionalized by loading into aptamer-bound exosomes can be a new targeted drug carrier system for cervical cancer.

关键词： Aptamer Autophagy Cervical cancer Exosomes Raloxifene

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Advancing Deepfake Detection Using Xception Architecture:A Robust Approach for Safeguarding against Fabricated News on Social Media

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Computers, Materials & Continua 2024年第12期81卷 4285-4305页

作者： Dunya Ahmed Alkurdi Mesut cevik Abdurrahim Akgundogdu College of Information Engineering Al-Nahrain UniversityBaghdad10011Iraq Department of Electrical and Computer Engineering Altinbas UniversityIstanbul34000Turkey Electrical and Electronics Engineering Department Istanbul University-CerrahpasaIstanbul34320Turkey

Deepfake has emerged as an obstinate challenge in a world dominated by ***,the authors introduce a new deepfake detection method based on Xception *** model is tested exhaustively with millions of frames and diverse video clips;accuracy levels as high as 99.65%are *** are the main reasons for such high efficacy:superior feature extraction capabilities and stable training mechanisms,such as early stopping,characterizing the Xception *** methodology applied is also more advanced when it comes to data preprocessing steps,making use of state-of-the-art techniques applied to ensure constant *** an ever-rising threat from fake media,this piece of research puts great emphasis on stringent memory testing to keep at bay the spread of manipulated *** also justifies better explanation methods to justify the reasoning done by the model for those decisions that build more trust and *** ensemble models being more accurate have been studied and examined for establishing a possibility of combining various detection frameworks that could together produce superior ***,the study underlines the need for real-time detection tools that can be effective on different social media sites and digital ***,protecting privacy,and public awareness in the fight against the proliferation of deepfakes are important *** significantly contributing to the advancements made in the technology that has actually advanced detection,it strengthens the safety and integrity of the cyber world with a robust defense against ever-evolving deepfake threats in ***,the findings generally go a long way to prove themselves as the crucial step forward to ensuring information authenticity and the trustworthiness of society in this digital world.

关键词： Deepfake Detection Xception architecture data processing image processing intelligent information systems social media security

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