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Detection of microbial antigenic components of circulating immune complexes in HIV patients:Involvement in CD4^+ T lymphocyte count depletion

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 828-832页

作者： Ezeani Michael Chukwudi Onyenekwe CC Wachukwu CK Anyiam DCD Meludu sc Ukibe RN Ifeanyichukwu M Onochie A Anahalu I Okafor UU Department of Immunology Nnamdi Azikiwe University Nnewi CampusAnambra State Nigeria Department of Medical Laboratory science Nnamdi Azikiwe University Nnewi CampusAnambra State Nigeria Department of Medical Laboratory science Rivers State University of Science and TechnologyPort-HarcourtRiver State Nigeria Department of Histopathology Nnamdi Azikiwe University Nnewi CampusAnambra State Nigeria Department of Human Biochemistry Nnamdi Azikiwe University Nnewi CampusAnambra State Nigeria Department of Biochemistry Anambra State UniversityUli Anambra State Nigeria Department of Medical Laboratory science Microbiology UnitNnamdi Azikiwe University Teaching HospitalNnewiAnambra State Nigeria Department of Pharmacology Nnamdi Azikiwe University Nnewi CampusAnambra State Nigeria

Objective:To investigate the prevalence of microbial antigenic components of circulating immune complexes amongst grades of CD4 T lymphocyte counts in HIV sero positive and seronegative ***:Polyethelene glycol(PEG-600) and buffering methods of precipitation and dissociation of immune complexes was used to generate immune solution from sera of 100 HIV sero-positive and 100 HIV sero-negative *** were categorized into 3 grades based on CD4 count:> 500 cell/mm,200-499 cell/mm3 and <200 cell/*** immune solutions were assayed using membrane based immunoassay and antibody titration, along side its unprocessed serum for detection of various microbial antigens and or antibodies. CD4 T cell counts were estimated using Patec Cyflow SL-3 ***:Antigenic component of immune complexes of various infectious agents was detected in 99 and 70 HIV seropositive and HIV sero-negative participants,*** group A,there were 10 HIV positive participants,including 4(40.0%) had circulating immune complexes(CICs) due to Salmonella species only:1(10.0%) due to Salmonella-Plasmodium falciparum(***),SalmonellaP. falciparum-HCV and *** antigens,*** group B,45(45.4%) HIV seropositive participants with CICs had CD4 T lymphocyte count between 200-499 cells/mm^*** of these,20(44.4%) had CICs due to Salmonella species only:9(20%) due to Salmonella-P. *** group C,there were 44(44.4%) HIV sero-positive participants,including 3(6.8%) due to Salmonella species only:24(54.4%) due to ***:2(4.5%) due to P. falciparum ***:In HIV sero-positive participants,presence of heterogeneity of Salmonella *** antigens was highly incriminated in CD4 count depletion but not homogeneity of malaria parasites *** parasites antigens only were incriminated in CD4^+ count depletion amongst HIV sero-negative *** taking any decision on the management

关键词： HIV/AIDS Immune complexes Microbial antigens HIV positive participant CD4^+ lymphocyte count

First successful domestication of a white strain of Auricularia cornea from Thailand

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Studies in Fungi 2020年第1期5卷 420-434页

作者： Bandara AR Mortimer PE Vadthanarat S Xingrong P Karunarathna sc Hyde KD Kakumyan P Xu J CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Centre for Mountain Futures Kunming Institute of BotanyKunming 650201YunnanChina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand school of science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanChina

Intraspecies colour variations in cultivated edible mushrooms present novel and potentially valuable alternatives to the research and cultivation *** this study,we collected,identified,and domesticated a white strain of Auricularia cornea from *** brown strain of *** is one of the top two species of Auricularia cultivated and traded in *** both white and brown phenotypes of *** belong to a single species,we established their similarities or *** morphological characteristics and phylogenetic analysis of ITS rDNA sequence data were used to confirm the taxonomic placement of the white *** strain in the same clade with the brown *** analysis showed that fat,fiber,protein,and total soluble sugar contents of the white *** were significantly higher than the commercially used brown *** melanin content of the white strain of ***(less than 1.5 mg/100g)was not significantly different from that of the brown *** discovery may create new opportunities for the mushroom growing industry and for smallholder farmers in Asia.

关键词： colour variation Melanin Southeast Asia wood-ear mushrooms

Giant Asian honeybee or Bambara stings causing myocardial infarction,bowel gangrene and fatal anaphylaxis in Sri Lanka:a case series

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Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 586-588页

作者： Budagoda BDSS Kodikara KAS Kularatne WKS Mudiyanse RM Edussuriya DH Edirisinghe JP Karunaratne IP Weerakoon KGAD Medagedara sc Kularatne SAM Department of Medicine Faculty of MedicineUniversity of PeradeniyaSri Lanka 'Department of Forensic Medicine Faculty of MedicineUniversity of PeradeniyaSri Lanka Teaching Hospital PeradeniyaSri Lanka Department of Forensic Medicine Faculty of MedicineUniversity of PeradeniyaSri Lanka Department of Zoology Faculty of ScienceUniversity of PeradeniyaPeradeniyaSri Lanka

The sting of Giant Asian honeybee(Apis dorsata) or Bambara in Sinhala and Kanmge Kulavi in Tamil is a common environmental hazard in Sri Lanka known to cause immediate allergic reactions,which could be fatal in sensitized *** reported myocardial infarction, bowel gangrene and fatal anaphylaxis in a prospectively proven case series and the association of these uncommon complications with delayed removal of stingers from the patients’skin.

关键词： Giant Asian honeybee Bambara Myocardial infarction Bowel gangrene Fatal anaphylaxis Sri Lanka

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EPSON IP—100数码照片打印机

微型计算机 1999年第12期19卷 69-71页

作者： Labs.,sc

screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries

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Cellular & Molecular Immunology 2017年第3期14卷 308-318页

作者： Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick sc Leung school of Life sciences The Chinese University of Hong Kong Shatin N.T. Hong Kong SAR China Department of Pediatrics and Adolescent Medicine Queen Mary Hospital The University of Heng Kong Pokfulam Hong Kong SAR China Department of Biochemistry and Molecular Medicine University of California Davis CA 95616 USA Division of Rheumatology/Allergy School of Medicine University of California Davis CA 95616 USA

The one-bead-one-compound （OBOC） combinatorial peptide library is a powerful tool to identify ligand and receptor interactions. Here, we applied the OBOC library technology to identify mimotopes specific to the immunoglobulin E （IgE） epitopes of the major shellfish allergen tropomyosin. OBOC peptide libraries with 8-12 amino acid residues were screened with serum samples from patients with shellfish allergy for IgE mimotopes of tropomyosin. Twenty-five mimotopes were identified from the screening and their binding reactivity to tropomyosin-specific IgE was confirmed by peptide ELISA. These mimotopes could be divided into seven clusters based on sequence homology, and epitope mapping by EpiSearch of the clustered mimotopes was performed to characterize and confirm the validity of mimotopes. Five out of six of the predicted epitopes were found to overlap with previously identified epitopes of tropomyosin. To further confirm the mimicry potential of mimotopes, BALB/c mice were immunized with mimotopes conjugated to keyhole limpet hemocyanin and assayed for their capacity to induce tropomyosin-specific antibodies. BALB/c mice that received mimotope immunization were found to have an elevated level of tropomyosin-specific immunoglobulin G, but not mice that received an irrelevant mimotope. This study pioneers the successful application of the OBOC libraries using whole sera to screen and identify multiple shrimp allergen mimotopes and validates their mimicry potential using in vitro, in vivo, and in silico methods.

关键词： epitope mimotope OBOC peptide library tropomyosin

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颈动脉体对化学信号的换能作用

生理学报 2007年第2期59卷 128-132页

作者： Prem KUMAR B.sc. D.Phil 伯明翰大学医学院生理学系

颈动脉体可以将低氧和血液中其它刺激信号(可能包括低血糖)转换成不同强度的传入神经放电,沿心肺和神经内分泌反射的传入途径进入中枢,形成反射环路。低氧可抑制颈动脉体Ⅰ型细胞中的多种K+通道,这种作用可能有种属差异; K+通道的抑制... 详细信息

颈动脉体可以将低氧和血液中其它刺激信号(可能包括低血糖)转换成不同强度的传入神经放电,沿心肺和神经内分泌反射的传入途径进入中枢,形成反射环路。低氧可抑制颈动脉体Ⅰ型细胞中的多种K+通道,这种作用可能有种属差异; K+通道的抑制使膜电位去极化,启动电压依赖性Ca2+内流,最后导致神经分泌和传入放电。离子通道埘低氧的反应可能是通过间接途径发生的,因此近期的工作集中在研究颈动脉体Ⅰ型细胞中在低氧感受中起关键作用的其它蛋白质。虽然有人认为来源于线粒体和／或NADPH的活性氧(reactive oxygen species,ROS)起一定作用,但是它们在颈动脉体中转导低氧信号的证据还不足。目前正在对另外两种假设进行检验。第一种假设是血红素加氧酶2(haemoxygenase 2,HO-2)通过信号分子CO控制特殊K+通道的活动,而CO的生成量与氧分压高低有关。第二种假设是认为细胞能量感受器腺苷酸活化蛋白激酶(AMP- activated protein kinase,AMPK)起作用;低氧时AMP／ATP比值升高,激活AMPK,从而抑制Ⅰ型细胞的K+通道,传入放电增加。颈动脉体的细胞上具有丰富的对氧敏感的K+通道,低氧感受这个重要的细胞活动可以通过多条途径进行,在总反应中每种蛋白质也可能起不同的作用,例如不同蛋白质对氧的亲合力不同等。关于颈动脉体感受低血糖的机制尚不清楚,但最近有证据提示,它并非由K+通道关闭引起的,因此感受低血糖的机制和感受低氧的机制是不同的。

关键词：颈动脉体化学受体低氧化学转换腺苷酸活化蛋白激酶葡萄糖

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对人类致病的耶尔森杆菌的Yops

地方病译丛 1994年第4期15卷 15-19页

作者： Stra.,sc 王芳

THE MAKING OF REGIONAL DIAGRAMS IN OMEI-SHAN

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地理学报 1940年 142-146页

作者： SHU-TANG LEE,M.sc National Central University National Central University Cantab Cantab

The author made a short visit to the Omei-shan during the summer 1940in the company of a group of his fourteen students in an excursion organgizedby the Geographical Department of the National Central University, Chun... 详细信息

关键词： In THE MAKING OF REGIONAL DIAGRAMS IN OMEI-SHAN than

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南亚Ⅰ型痢疾志贺氏菌引起的流行性菌痢

国外医学（流行病学．传染病学分册） 1989年第5期16卷 224-227页

作者： Pal sc 吕品红

志贺氏细菌性痢疾是南亚国家的地方性流行病。据报道,发病率为1～15%。流行的血清型是弗氏志贺氏菌群,偶而也分离到宋内氏志贺氏菌株及波氏志贺氏菌株,很少遇到毒力较强的Ⅰ型痢疾志贺氏菌。 1969～1970年起源于中美国家的细菌性痢疾大... 详细信息

志贺氏细菌性痢疾是南亚国家的地方性流行病。据报道,发病率为1～15%。流行的血清型是弗氏志贺氏菌群,偶而也分离到宋内氏志贺氏菌株及波氏志贺氏菌株,很少遇到毒力较强的Ⅰ型痢疾志贺氏菌。 1969～1970年起源于中美国家的细菌性痢疾大流行,是由于出现了高毒力和高传染性的Ⅰ型痢疾志贺氏菌株所造成。

关键词：细菌性痢疾志贺氏菌

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