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World Journal of Virology 2025年第1期14卷 51-62页

作者： Pratiksha Moliya Anmol singh Navdeep singh Vikash kumar Aalam Sohal Department of Transplant Hepatology University of Nebraska Medical CenterOmahaNE 69198United States Department of Medicine Tristar Centennial Medical CenterNashvilleTN 37203United States Department of Medicine Government Medical CollegeAmritsar 143001PunjabIndia Department of Gastroenterology and Hepatology Creighton University School of MedicinePhoenixAZ 85012United States

Human immunodeficiency virus(HIV)modifies CD4-positive cells,resulting in immunodeficiency and a wide range of gastrointestinal(GI)*** burden of HIV-related GI illnesses has significantly evolved with the widespread use of antiretroviral therapy(ART).While ART has effectively reduced the occurrence of opportunistic infections,it has led to an increase in therapy-related GI *** esophageal conditions in HIV patients include gastroesophageal reflux disease,idiopathic esophageal ulcers,herpes simplex virus,cytomegalovirus(CMV),and candidal ***’s sarcoma,a hallmark of acquired immunodeficiency syndrome,may affect the entire GI *** and peptic ulcer disease are also frequently seen in patients with ***,often linked to both opportunistic infections and ART,requires careful *** diarrhea,often a sign of colitis caused by bacterial infections such as Shigella or Clostridium difficile,is *** bowel lymphoma,although rare,is increasing in *** disorders,including proctitis,fissures,and anal squamous cell carcinoma,are particularly relevant in homosexual men,underlining the importance of timely *** review comprehensively explores the epidemiology,pathogenesis,and treatment considerations for the various GI disorders associated with HIV,highlighting the importance of accurate diagnosis and effective treatment to improve outcomes for HIV-infected patients.

关键词： Human immunodeficiency virus Opportunistic infections Antiretroviral treatment Gastrointestinal

Derated Mode of Power Generation in PV System Using Modified Perturb and Observe MPPT Algorithm

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 1183-1192页

作者： Vinit kumar mukesh singh Thapar Institute of Engineering and Technology PatialaPunjabIndia

In a grid-integrated photovoltaic system(GIPVS),there exist issues such as surplus active power and inadequate performance of maximum power point tracking(MPPT).A surplus active power causes the overvoltage problem at the point of common coupling in low-or medium-voltage grid during the peak hours of power ***,the inadequate performance of the MPPT algorithm results in power loss due to high settling time during the sudden change of ***,to solve the surplus power problem,the curtailment of active power is suggested with improved MPPT algorithm under variable irradiance *** this paper,a derated power generation mode(DPGM)control strategy is presented for the curtailment of active ***,a drift-free(named as modified)perturb and observe(P&O)technique is also proposed to improve the performance of the MPPT ***,the DPGM control scheme with the intermediate boost converter shaves the surplus active power during the peak hours of power ***,the modified MPPT algorithm deals with the fluctuation of irradiance during non-peak ***,the proposed control scheme delivers in a more efficient system during the peak hours of power *** addition,it reduces the power loss and settling time during the change of irradiance for non-peak *** on the proposed control scheme,a 30 kW system has been simulated in MATLAB/Simulink using Simpower tools under different environmental conditions.

关键词： Derated power generation mode(DPGM) gridintegrated photovoltaic system intermediate boost converter modified perturb and observe voltage source inverter

Telemedicine and public health–pearls and pitfalls

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World Journal of Methodology 2025年第2期15卷 177-179页

作者： Ranjeet kumar Sinha Sony Sinha Prateek Nishant Arvind kumar Morya Arshi singh Department of Community Medicine Patna Medical CollegePatna 800004BiharIndia Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia Department of Ophthalmology ESIC Medical CollegePatna 801103BiharIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology Guru Nanak Eye CenterNew Delhi 110001India

We hereby comment on the interesting systematic review by Grewal et al where they have provided an overall picture of the current status of available tele-health programs in the United States with emphasis on the Amazon *** analysis is an appreciable effort in discovering the features available and features lacking in these tele-health *** concept of tele-health originated to curtail the need for physical attendance of patients at health clinics,and has been beneficial during the coronavirus disease 2019 *** implore that the pearls and pitfalls of these programs have to be understood by policymakers prior to forming a consensus regarding the availability,accessibility and affordability of these programs as methods of healthcare *** proliferation of tele-health programs in their current form may pose threats to patient and provider safety and medicolegal ***,patients and providers must work together to improve them to meet their expectations and enable them to provide the best care for the ailing public.

关键词： Telemedicine Remote Access Availability Accessibility Affordability Ethics Privacy Medicolegal liability

Effect of random movement and cooperative hunting in the prey-predator system:A dynamical approach

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International Journal of Biomathematics 2024年第3期17卷 211-240页

作者： Shivam Teekam singh mukesh kumar Department of Mathematics Graphic Era Deemed to be University 566/6 Bell RoadSociety AreaClenent Town DehradunUttarakhand 248002India Department of Computer Science and Engineering Graphic Era Deemed to be University 566/6 Bell RoadSociety AreaClement Town DehradunUttarakhand 248002India

Self-diffusion prerequisite is obtained as the spreading approach of biological *** hunting is a common behavior in predator populations that promotes predation and the coexistence of the prey-predator *** the other side,the Allee effect among prey may cause the system to become *** this paper,a difusive prey predator system with cooperative hunting and the weak Allee effect in prey populations is *** linear stability and Hopf-bifurcation analysis had been used to examine the system's *** the spatial stability of the system,the conditions for Turing instability have been *** multiple-scale analysis has been used to derive the amplitude equations of the *** stability analysis of these amplitude equations leads to the formation of Turing ***,numerical simulations are used to analyze spatial patterns forming in 1-D and *** studies indicate that the model can generate a complex pattern structure and that self-diffusion has a drastic impacton species distribution.

关键词： Prey predator system hunting cooperation Allee effect Hopf-bifurcation diffusive instability amplitudeequation

Trigonometric tension B-spline collocation approximations for time fractional Burgers’equation

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Journal of Ocean Engineering and Science 2024年第5期9卷 508-516页

作者： Brajesh kumar singh mukesh Gupta School of Physical and Decision Sciences Department of MathematicsBabasaheb Bhimrao Ambedkar University Lucknow 226025(UP)INDIA

This manuscript’s aim is to form and examine the numerical simulation of Caputo-time fractional nonlinear Burgers’equation via collocation approach with trigonometric tension B-splines as base ***,L 1 discretization formula is utilized for the time fractional derivative and after linearizing the nonlinear term,the trigonometric tension B-spline interpolants are utilized to get a system of simultaneous linear equations that are solved via Gauss elimination ***,numerical approximation at the desired time level is *** is demonstrated via von-Neumann approach that proposed scheme produces stable *** results of six different test examples having their analytical solutions are compared with the results in the literature to validate the accuracy and efficiency of the scheme.

关键词： Fractional Burgers’equation Trigonometric tension B-spline Collocation scheme Gauss elimination method

Comparative efficacy of hyperbaric bupivacaine vs hyperbaric ropivacaine in spinal anesthesia for cesarean section:A metaanalysis

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World Journal of Methodology 2025年第2期15卷 154-165页

作者： Rishi Anand Deb Sanjay Nag Roushan Patel Prashant Sharma Vamsi Krishna Uppalapati Umesh kumar singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JhārkhandIndia

BACKGROUND Intrathecal bupivacaine is the traditional anesthetic drug used in spinal anesthesia for caesarean sections(CSs),but ropivacaine has emerged as a potential *** meta-analysis compares the efficacy and safety of intrathecal hyper-baric bupivacaine vs hyperbaric ropivacaine for cesarean *** To systematically evaluate and compare the efficacy and safety of intrathecal hyperbaric bupivacaine and hyperbaric ropivacaine for spinal anesthesia in *** A thorough search of electronic databases was carried out to find pertinent randomized controlled trials(RCTs)comparing intrathecal hyperbaric ropi-vacaine and hyperbaric bupivacaine during ***,Cochrane database,Google Scholar,and Scopus were searched,and papers from January 2000 to January 2024 were deemed eligible and filtered using predetermined inclusion and exclusion *** were assessed for methodological quality,and data were extracted for time to adequate anesthesia(sensory and motor blockade),duration of sensory and motor block,hemodynamic changes and side effect *** standardized mean difference with 95%CI was used for continuous *** variables were assessed using the Mantel-Haenszel test and the random effect model to compute the odds *** Total 8 RCTs were selected from a pool of 119 search results for *** meta-analysis evaluated pooled effect sizes and assessed heterogeneity among the *** primary objective was to compare key outcomes to identify any significant variances in efficacy and safety profiles between two local *** analysis revealed that the difference in the onset of sensory blockade between the two local anesthetics was statistically insignificant(P=0.1586).However,the onset of motor blockade appeared to be faster with bupivacaine(P=0.03589).Additionally,the regression of sensory and motor blockade occurred earlier in the ropivacaine ***,the duration of the first analgesic

关键词： Ropivacaine Bupivacaine Anesthesia Spinal Cesarean section Meta-analysis

Kelvin-Helmholtz instability with mass transfer through porous media: Effect of irrotational viscous pressure

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Journal of Hydrodynamics 2014年第4期26卷 624-636页

作者： AWASTHI mukesh kumar Department of Mathematics University of Petroleum and Energy Studies

This paper studies the effect of the irrotational viscous pressure on Kelvin-Helmholtz instability of the plane interface of two viscous and incompressible fluids in a fully saturated porous media with mass and heat transfers across the interface. In the earlier work, the instability of the plane interface of two viscous and streaming miscible fluids through porous media was studied by assuming that the motion and the pressure are irrotational and the viscosity enters the normal stress balance. This theory is called the viscous potential flow theory. Here, we use another irrotational theory in which the discontinuities in the irrotational tangential velocity and shear stress are eliminated in the global energy balance by considering viscous contributions of the irrotational pressure. The Darcy-Brinkman model is used in the investigation and the stability criterion is formulated in terms of a critical value of the relative velocity. It is observed that the heat and mass transfer has a destabilizing effect on the stability of the system while the irrotational shearing stresses stabilize the system.

关键词： Kelvin-Helmholtz stability porous medium irrotational viscous pressure heat and mass transfer

Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry

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Journal of Pharmaceutical Analysis 2016年第6期6卷 363-373页

作者： Sunil kumar Awantika singh Vikas Bajpai mukesh Srivastava Bhim Pratap singh Brijesh kumar Sophisticated Analytical Instrument Facility CSIR-Central Drug Research Institute Lucknow 226031 Uttar Pradesh India Academy of Scientific and Innovative Research (AcSIR) New Delhi 110025 India Biometry and Statistics Division CSIR-Central Drug Research Institute Lucknow 226031 Uttar Pradesh India Department of Biotechnology Mizoram University Tanharil 796004 Aizawl Mizoram India

Rauwolfia species(Apocynaceae) are medicinal plants well known worldwide due to its potent bioactive monoterpene indole alkaloids(MIAs) such as reserpine,ajmalicine,ajmaline,serpentine and ***,ajmalicine and ajmaline are powerful antihypertensive,tranquilizing agents used in *** is an aphrodisiac used in dietary *** there is no report on the comparative and comprehensive phytochemical investigation of the roots of Rauwolfia species,we have developed an efficient and reliable liquid chromatography-tandem mass spectrometry(LC–MS/MS) method for ethanolic root extract of Rauwolfia species to elucidate the fragmentation pathways for dereplication of bioactive MIAs using highperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC–ESI–QTOF–MS/MS) in positive ion *** identified and established diagnostic fragment ions and fragmentation pathways using reserpine,ajmalicine,ajmaline,serpentine and *** MS/MS spectra of reserpine,ajmalicine,and ajmaline showed C-ring-cleavage whereas E-ring cleavage was observed in serpentine via Retro Diels Alder(RDA).A total of 47 bioactive MIAs were identified and characterized on the basis of their molecular formula,exact mass measurements and MS/MS ***,ajmalicine,ajmaline,serpentine and yohimbine were unambiguously identified by comparison with their authentic standards and other 42 MIAs were tentatively identified and characterized from the roots of Rauwolfia hookeri,Rauwolfia micrantha,Rauwolfia serpentina,Rauwolfia verticillata,Rauwolfia tetraphylla and Rauwolfia *** of LC–MS followed by principal component analysis(PCA) has been successfully used to discriminate among six Rauwolfia species.

关键词： Rauwolfia species Monoterpene indole alkaloids (MIAs) HPLC–ESI–QTOF–MS/MS Principal component analysis (PCA)

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Communications in Theoretical Physics 2014年第1期61卷 121-126页

作者： mukesh kumar Raj kumar Department of Mathematics Motilal Nehru National Institute of Technology Allahabad

In the present work, the new exact solutions of the Boiti-Leon-Pempinelli system have been found. The system has extensive physical background. The exact solutions of the Boiti-Leon-Pempinelli system are investigated using similarity transformation method via Lie group theory. Lie symmetry generators are used for constructing similarity variables for the given system of partial differential equations, which lead to the new system of partial differentiaJ equations with one variable less at each step and eventually to a system of ordinary differential equations （ODEs）. Finally, these ODEs are solved exactly. The exact solutions are obtained under some parametric restrictions. The elastic behavior of the soliton solutions is shown graphically by taking some appropriate choices of the arbitrary functions involved in the solutions.

关键词： Boiti-Leon-Pempinelli system similarity transformation method Lie group theory soliton solutions