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POM analysis and computational interactions of 8-hydroxydiospyrin inside active site of protein tyrosine phosphatase 1B

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BIOCELL 2021年第3期45卷 751-759页

作者： SAUD BAWAZER ASGHAR KHAN ABDUR RAUF TAIBI B EN HADDA YAHYA SAL-AWTHAN OMAR BAHATTAB UMER RASHID INAMULLAH KHAN muhammad A SIF NAWAZ MD SAHAB UDDIN OLATUNDE AHMED MOHAMMAD A LI SHARIATI Department of Pharmaceutical Chemistry Faculty of PharmacyUmm Al-Qura UniversityMakkah21955Saudi Arabia Department of Medicine Khyber Teaching Hospital Peshawar25000Pakistan Department of Chemistry University of SwabiSwabi23430Pakistan LCM Laboratory Mohammed First UniversityFaculty of SciencesOujda60000Morocco Biology Department Faculty of SciencesUniversity of TabukTabuk1144Saudi Arabia Department of Biology Faculty of ScienceIbb UniversityIbbYemen Department of Chemistry COMSATS University IslamabadAbbottabad CampusAbbottabad22060Pakistan Department of Pharmacy University of PeshawarPeshawar25120Pakistan Department of Biotechnology Shaheed Benazir Bhutto UniversitySheringal14400Pakistan Department of Pharmacy Southeast UniversityDhaka1213Bangladesh Pharmakon Neuroscience Research Network Dhaka1207Bangladesh Department of Biochemistry Abubakar Tafawa Balewa UniversityBauchi740272Nigeria Moscow State University of Technologies and Management(The First Cossack University) Moscow119991Russian Federation

Proteintyrosine phosphatase 1B(PTP1B)inhibitionis consideredas a potentialtherapeuticfor the treatmentof cancer,type2 diabetes,*** presentwork,weinvestigatedtheanti-diabeticpotentialof8-hydroxydiospyrin(8-HDN)from *** against the PTP1B *** showed significant inhibitory activity of PTP1B with an IC 50 value of 18.37±0.02μM.A detailed molecular docking study was carried out to analyze the binding orientation,binding energy,and mechanism of inhibition.A comparative investigation of 8-HDN in the catalytic,as well as the allosteric site of PTP1B,was *** energy data showed that compound 8-HDN is more selective for the allosteric site and hence avoids the problems associated with catalytic site *** inhibition mechanism of 8-HDN can be further investigated as an active lead compound against PTP1B by using in vitro and in vivo models.

关键词： Diospyros lotus Roots 8-Hydroxydiospyrin Molecular docking Protein tyrosine phosphatase 1B

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Mepiquat chloride priming confers the ability of cotton seed to tolerate salt by promoting ABA-operated GABA signaling control of the ascorbate–glutathione cycle

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Journal of Cotton Research 2023年第4期6卷 288-305页

作者： QI Qian WANG Ning RUAN Sijia muhammad Noor ZHANG Hengheng SHI Jianbin DONG Qiang XU Qinghua SONG Meizhen YAN Gentu ZHANG Xiling WANG Xiangru National Key Laboratory of Cotton Bio-Breeding and Integrated Utilization Institute of Cotton Research of Chinese Academy of Agricultural SciencesAnyang 455000HenanChina Institute of Western Agriculture the Chinese Academy of Agricultural sciencesChangji 831100XinjiangChina

Background Ensuring that seeds germinate and emerge normally is a prerequisite for cotton production,*** areas with salinized *** with mepiquat chloride(MC)can promote seed germination and root growth under salt stress,but its mechanism has not been fully *** this study,physiological and biochemical experiments revealed that MC-priming promotes the tolerance of cotton seeds to salt stress by increasing the ability of antioxidant enzymes related to the ascorbate-glutathione(AsA-GSH)cycle to scavenge reactive oxygen species(ROS).Results Results revealed that treatment with inhibitors of abscisic acid(ABA)and γ-aminobutyric acid(GABA)biosynthesis reduced the positive effects of ***,MC-priming increased the contents of ABA and GABA under salt stress by stimulating the expression levels of GhNCED2 and GhGAD4 and the activity of calmodulin-binding(CML)glutamate decarboxylase(GAD).Further analysis showed that an inhibitor of ABA synthesis reduced the positive impacts of MC-priming on the content of GABA under salt stress,but the content of ABA was not affected by the GABA synthesis ***,a multi-omics analysis revealed that MC-priming increased the abundance and phosphorylation levels of the proteins related to ABA signaling,CML,and Ca^(2+)channels/transporters in the MC-primed treatments,which resulted in increased oscillations in Ca^(2+)in the MC-primed cotton seeds under salt *** In summary,these results demonstrate that MC-mediated ABA signaling operates upstream of the GABA synthesis generated by GAD by activating the oscillations of Ca^(2+)and then enhancing activity of the AsA-GSH cycle,which ensures that cotton seeds are tolerant to salt stress.

关键词： Seed priming Salinity stress ABA signaling γ-aminobutyric acid ROS scavenging Mepiquat chloride

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The coastal medicinal plant Vitex rotundifolia: a mini-review on its bioactive compounds and pharmacological activity

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Traditional Medicine Research 2021年第2期6卷 1-10页

作者： Nurul Husna Azizul Wan Amir Nizam Wan Ahmad Nurul Laili Rosli muhammad Aniq Hamzah Mohd Azmi Choo En Liang Noor Wini Mazlan Suvik Assaw Biomedicine Program School of Health SciencesUniversiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia Faculty of Science and Marine Environment Universiti Malaysia TerengganuKuala Nerus 21030TerengganuMalaysia

Humans have long used natural remedies like plants and herbs to treat ***,research has been ongoing to find alternative pharmaceutical drugs based on traditionally used plants,as natural products show fewer side effects compared to synthetic *** plants have long been targeted in drug development due to their bioactive compounds like alkaloids,flavonoids,and *** is not only the case for terrestrial plants,but marine environments also provide a larger diversity of flora and fauna with medicinal bioactive *** rotundifolia,also known as Beach Vitex,is a coastal plant that has been traditionally used to treat a variety of diseases including premenstrual syndrome,headaches,migraines,colds,and eye *** have been many review papers on ***,emphasizing its taxonomy,distribution,and biological *** current mini-review not only summarizes the pharmacology and bioactivity of ***,but it also provides new information on the main bioactive compounds of *** such as flavonoids,phenolic acid,and terpenes and their current pharmacological activity in vitro and in vivo *** information can be useful for developing new pharmaceutical and nutraceutical agents to treat and manage disease.

关键词： Vitex rotundifolia Fructus viticis Marine plants Anti-inflammation Anti-nociception Antioxidant

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Impact of Joule heating and multiple slips on a Maxwell nanofluid flow past a slendering surface

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Communications in Theoretical Physics 2022年第1期74卷 1-15页

作者： Hijaz Ahmadand Shafiq Ahmad muhammad Naveed Khan Sohail Nadeem Aysha Rehman Hijaz Ahmad Rifaqat AN Department of Mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan Department of Mathematics University of GujratGujrat50700 Pakistan Section of Mathematics International Telematic University UninettunoCorso Vittorio Emanuele II3900186 RomaItaly Department of Mathematics College of Science and ArtsMuhayilKing Khalid University 9004AbhaSaudi Arabia

This manuscript presents a study of three-dimensional magnetohydrodynamic Maxwell nanofluid flow across a slendering stretched surface with Joule *** impact of binary chemical reactions,heat generation,thermal radiation,and thermophoretic effect is also taken into *** multiple slip boundary conditions are utilized at the boundary of the *** appropriate similarity variable is used to transfer the flow modeled equations into ODEs,which are numerically solved by the utilization of the MATLAB bvp4c *** involved parameter's impact on the concentration,velocity,and temperature distribution are scrutinized with *** transport rates(mass,heat)are also investigated using the same variables,with the results reported in tabulated *** is seen that the fluid relaxation,magnetic,and wall thickness characteristics diminish the velocities of ***,the velocity,concentration,and temperature slip parameters reduce the velocities of fluid,temperature,and concentration *** results are compared to existing studies and shown to be in dependable agreement.

关键词： Maxwell nanofluid slendering stretching surface Joule heating thermal radiation thermophoretic effect

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压水堆导向筒内流场及控制棒流致振动分析

压水堆导向筒内流场及控制棒流致振动分析

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作者：阿里（muhammad Ali）华北电力大学(北京)

学位级别：硕士

本文主要研究了压水堆内控制棒的流致振动特性并分析了导向筒周围及内部的流场,通过分析得到不同流量工况下控制棒的流致振动特性。研究中搭建控制棒流致振动的实验装置,并将CFD的数值模拟结果和实验进行对比。实验装置中包含四根控制... 详细信息

本文主要研究了压水堆内控制棒的流致振动特性并分析了导向筒周围及内部的流场,通过分析得到不同流量工况下控制棒的流致振动特性。研究中搭建控制棒流致振动的实验装置,并将CFD的数值模拟结果和实验进行对比。实验装置中包含四根控制棒模拟件和三层导向板,控制棒模拟件通过螺纹连接在星型支撑结构上。实验装置设置底部和侧面两个进水口,一个高于侧面进水口的出水口。实验中采用激光位移传感器进行控制棒的振动测量,传感器直接与采集后处理系统相连接。改变流场的工况,获得在不同进口流量下的控制棒振动位移、流场速度分布、流场压力分布和控制棒表面的压力分布等实验数据。实验的结果与数值计算的结果相一致。实验中使用DASP等软件进行噪声去除等后处理,使用TECPLOT进行流场的测量数据与模拟结果对比。

关键词：流致振动(FIV) 数值模拟计算分析压水堆控制棒模型分析

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Alarming Presentation of a Seemingly Common Condition in a Patient with Renal Impairment

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Open Journal of Nephrology 2013年第4期3卷 181-183页

作者： Mohammad Budruddin muhammad Yasir Khalil Issa Al Salmi Ramaiah Shilpa Nephrology Department Royal Hospital Muscat Oman Nephrology Department Tawam Hospital Al Ain UAE

We received a 23-year-old male, working in the Army for 18 months, with advanced renal impairment, haemoptysis and hyperkalemia. An impression of the pulmonary renal syndrome was made and he was managed aggressively with haemodialysis, plasma exchange and pulsing with methyl prednisolone. His condition improved, but the renal functions did not. The vasculitic workup including Extractable Nuclear Antigen (ENA) and Anti-Neutrophil Cytoplasmic Antibody (ANCA) which were sent on admission came out to be negative. As he apparently responded to the initial management protocol, he was subjected to renal biopsy which did not reveal any vasculitis but was consistent for end-stage renal disease. Subsequently he was subjected to lung biopsy which also was not supportive for vasculitis. However, we concluded that the initial pointers for Wegener’s granulomatosis were misleading. The haemoptysis entirely subsided as the congestion improved. He was maintained on Haemodialysis three times per week schedule and discharged to the peripheral health care facility.

关键词： Haemoptysis Renal Impairment Pulmonary Renal Syndrome Haemodialysis ENA ANCA Vasculitis Pulmonary Oedema

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基于GIS的巴基斯坦北部文化遗址时空分布特征及保护对策

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中国科学院大学学报（中英文） 2021年第4期38卷 467-477页

作者：姜纯骆磊 Shahina Tariq muhammad Ali 姚娅王心源中国科学院空天信息创新研究院中国科学院数字地球重点实验室北京100094 中国科学院大学北京100049 联合国教科文组织国际自然与文化遗产空间技术中心北京100094 COMSATS信息技术学院伊斯兰堡45550

巴基斯坦北部地区是历史上犍陀罗文化的中心区域,拥有大量的印度教、佛教和伊斯兰教文化遗址。借助考古文献资料、数字高程模型以及野外实地调查与验证数据,运用GIS空间分析方法,对巴基斯坦北部地区印度教、佛教和伊斯兰教文化遗址的时... 详细信息

巴基斯坦北部地区是历史上犍陀罗文化的中心区域,拥有大量的印度教、佛教和伊斯兰教文化遗址。借助考古文献资料、数字高程模型以及野外实地调查与验证数据,运用GIS空间分析方法,对巴基斯坦北部地区印度教、佛教和伊斯兰教文化遗址的时空分布特征、保存现状进行研究,并提出相应保护对策。结果表明:巴基斯坦北部地区先后经历了印度教文化、佛教文化、伊斯兰教文化的传入、兴衰等演变过程。核密度估计显示3种文化遗址分布范围、聚集程度有所不同,但都以伊斯兰堡周边区域聚集程度最高。基于高分辨率的DEM分析表明,90%以上的文化遗址距离河流小于800 m,反映其位置选择对于河流的依赖与需求。从分布的高程看,3种文化遗址大多数在800 m以下、坡度范围在0°~10°之间,主要沿河道和交通要道分布。统计数据表明:伊斯兰教遗址数目最多,佛教遗址次之,印度教遗址最少,反映遗址保存的数量随时间而变化。由于自然因素和人类活动,一些文化遗址如古佩拉、维吉等保存状况较差,亟待加大保护力度。针对遗址目前的保存状况与面临的风险,提出对应的保护措施。

关键词：巴基斯坦文化遗址空间分析时空分布保存状况

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Reasons of Vaccine Hesitancy among Pakistanis with Available COVID-19 Vaccine: The Next Challenge in the Fight against COVID-19

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Natural Science 2021年第6期13卷 211-217页

作者： Wajiha Rizwan muhammad Nasir Rana Mulazim Hussain Bukhari Asma Mushtaq Masood Sadiq The Children Hospital/Institute of Child Health Lahore Pakistan Azad Jammu Kashmir Medical College Muzaffarabad Pakistan

The government of Pakistan started vaccination campaign for the frontline healthcare pro-viders, as they are more likely to be exposed to COVID-19 patients. In the next step, it ex-tended the free vaccination campaign to include people above 60 and 50 years of age re-spectively. The drive is now open to all citizens >18 years of age. There is a significant re-luctance to get vaccinated even though the government has provided it free of cost. The project uses self-reporting method to assess reasons of vaccine hesitancy among Pakistanis and possible solutions to overcome this problem. Concern for serious side effects was the most common issue 154 (48.42%) reported among all groups of people, including the healthcare workers. The major sources of COVID-19 related information were television 117 (36.8%) and healthcare professionals 105 (33%). The participants reported that they can be convinced to get vaccinated if more published data related to vaccine efficacy and safety is available 118 (37.1%), they observe no side effect among vaccine recipients 90 (28.3%) or higher government officials get the same vaccine 39 (12.3%). Vigorous analysis and publication of data generated is paramount to increase the percentage of people being vaccinated. The healthcare professionals should share evidence-based knowledge related to vaccine efficacy and safety through television and social media to increase acceptance rates and hence, decrease mortality and morbidity from COVID-19 in Pakistan.

关键词： COVID-19 Vaccine Hesitancy Vaccine Side Effects Vaccine and Propaganda Herd Immunity

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Evidence-based consensus on the diagnosis, prevention and management of hepatitis C virus disease

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World Journal of Hepatology 2015年第3期7卷 616-627页

作者： Mahrukh Akbar Shaheen muhammad Idrees Division of Molecular Virology National Centre of Excellence in Molecular Biology University of the Punjab

Hepatitis C virus(HCV) is a potent human pathogen and is one of the main causes of chronic hepatitis round the world. The present review describes the evidencebased consensus on the diagnosis, prevention and management of HCV disease. Various techniques, for the detection of anti-HCV immunoglobulin G immunoassays, detection of HCV RNA by identifying virus-specific molecules nucleic acid testings, recognition of core antigen for diagnosis of HCV, quantitative antigenassay, have been used to detect HCV RNA and core antigen. Advanced technologies such as nanoparticlebased diagnostic assays, loop-mediated isothermal amplification and aptamers and Ortho trak-C assay have also come to the front that provides best detection results with greater ease and specificity for detection of HCV. It is of immense importance to prevent this infection especially among the sexual partners, injecting drug users, mother-to-infant transmission of HCV, household contact, healthcare workers and people who get tattoos and piercing on their skin. Management of this infection is intended to eradicate it out of the body of patients. Management includes examining the treatment(efficacy and protection), assessment of hepatic condition before commencing therapy, controlling the parameters upon which dual and triple therapies work, monitoring the body after treatment and adjusting the co-factors. Examining the treatment in some special groups of people(HIV/HCV co-infected, hemodialysis patients, renal transplanted patients).

关键词： Hepatitis C virus Enzyme immunoassay Nucleic acid testing Loop-mediated isothermal amplification Sustained viral response Telaprevir Boceprevir Liver transplant

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巴基斯坦北部小喜马拉雅区Abbottabad组Sirban段寒武纪小壳化石的首次发现及其地层学意义

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地层学杂志 2023年第3期47卷 339-352页

作者： Shehryar Ahmed 潘兵 Malik muhammad Saud Sajid Khan 李国祥 muhammad Qasim 罗翠孙晓娟朱茂炎中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室江苏南京210008 中国科学院生物演化与环境卓越创新中心江苏南京210008 中国科学院大学地球与行星科学院北京100049 伊斯兰堡COMSATS大学(阿伯塔巴德校区)地球科学系巴基斯坦阿伯塔巴德市22060

小壳化石是寒武系纽芬兰统年代地层划分和全球对比的主要生物地层学依据。长期以来,喜马拉雅西侧的巴基斯坦北部寒武纪早期小壳化石的发现较为零星,导致该地区埃迪卡拉纪与寒武纪过渡期地层序列的划分缺乏统一认识,相关地层时代归属十... 详细信息

小壳化石是寒武系纽芬兰统年代地层划分和全球对比的主要生物地层学依据。长期以来,喜马拉雅西侧的巴基斯坦北部寒武纪早期小壳化石的发现较为零星,导致该地区埃迪卡拉纪与寒武纪过渡期地层序列的划分缺乏统一认识,相关地层时代归属十分不清晰。在第二次青藏科考任务的支持下,作者对巴基斯坦北部隶属于小喜马拉雅区的Hazara盆地东部前寒武纪与寒武纪过渡期地层Hazara组、Kakul组、Abbottabad组和Hazira组开展详细研究,首次在Kalu-di-Bandi剖面Abbottabad组Sirban段顶部硅磷质白云岩中发现了寒武纪纽芬兰世幸运期小壳化石组合。该小壳化石组合属种相对丰富,含有Anabarites trisulcatus、Protohertzina anabarica、Conotheca subcurvata、Hexangulaconularia formosa、Olivooides multisulcatus、Maikhanella pristinis、Lopochites latazonalis、Siphogonuchites sp.及Spirellus columnaris等分子。上述属种组合面貌常见于华南、印度北部、克什米尔、伊朗、蒙古国及西伯利亚的寒武纪纽芬兰世幸运期地层中,其中***和***是这一化石组合带中的标准分子。因此,本文以***和***的共同出现为标志,将Sirban段顶部的小壳化石组合命名为Anabarites trisulcatusProtohertzina anabarica组合带,时代上归属为寒武纪纽芬兰世幸运期。该化石组合的发现表明,该地区存在寒武纪幸运期地层记录,寒武系底界应位于Abbottabad组Sirban段内某个层位(不过确切的界线位置仍需将来进一步的生物地层学和化学地层学工作进行校对),同时也修正了前人将该地区寒武系底界置于Hazira组与Abbottabad组界线处或Abbottabad组与Kakul组界线处的观点。对比研究发现,Sirban段中的化石组合分子与华南***组合带面貌非常相似,且共有一些特征属种,支持寒武纪纽芬兰世印度次大陆北部的喜马拉雅区与华南之间的生物群存在较强联系、古地理位置很可能较为靠近的观点。

关键词：小壳化石生物地层 Abbottabad组纽芬兰统巴基斯坦小喜马拉雅区

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