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Effects of 8-Hydroxyisocapnolactone-2-3-diol and friedelin on mast cell degranulation

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1043-1046页

作者： muhammad Novrizal Abdi sahid Agung Endro Nugroho Ratna Asmah Susidarti Kazutaka Maeyama Department of Pharmacology Graduate School of MedicineEhime UniversityEhime791-0295Japan Department of Pharmaceutical Chemistry Faculty of PharmacyUniversitas Gadjah MadaYogyakarta55281Indonesia Department of Pharmacology Faculty of PharmacyUniversitas Gadjah MadaYogyakarta55281Indonesia

ObjectiveTo investigate the effects of friedelin (terpenoid) and 8-hydroxyisocapnolactone-2-3-diol (coumarin) with concentration 10 μM, 30 μM, and 100 μM on inhibiting mast cells (MCs) *** investigation was performed in vitro by administering each compound into rat peritoneal MCs and rat basophilic leukemia-2H3 cells followed by activation with 50 μg/mL of compound 48/80 or 1 μM of ionomycin. The concentration of histamine released from each group was measured by a high-performance liquid chromatography-fluorometry system with post-column derivatization using ***8-Hydroxyisocapnolactone-2-3-diol inhibited degranulation of compound 48/80 activated-rat peritoneal MCs with the histamine release percentages of 74.57%, 72.21% and 51.79% when the 10 μM, 30 μM and 100 μM concentrations were used, respectively. Where as about 81% histamine was released by the control group. Degranulation inhibition ability was also observed in ionomycin-activated rat basophilic leukemia-2H3 cells. In contrast, friedelin failed to inhibit degranulation in either cell type. The inhibition of 8-hydroxyisocapnolactone-2-3-diol was not related to the depletion of histamine synthesis as implied by the total histamine *** results exhibit the promising of 8-hydroxyisocapnolactone-2-3-diol is a potential parent structure for developing a MCs stabilizer.

关键词： 8-Hydroxyisocapnolactone-2-3-diol Friedelin Mast cell Degranulation Histamine

Nipah Virus Unveiled: A Review Article

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Advances in Bioscience and Biotechnology 2024年第3期15卷 161-173页

作者： Munama Magdum Md. Abir Tazim Chowdhury Mahmuda Khandaker Razdip Datta Md. Naheed Rayhan Md. Siffat Uddin Md. Junayed Imam Bhuiyan Md. Ahaduzzaman Md. Abdullah Al-Mahammud Kabir Mohammad Zishan Uddin Md. Estiak Ullah sahid Subrata Saha Department of Community Medicine Shaheed Monsur Ali Medical College Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Bangladesh Department of Microbiology Shaheed Monsur Ali Medical College Dhaka Bangladesh Department of Anesthesia Dhaka Dental College & Hospital Dhaka Bangladesh Department of Cardiothoracic Anesthesia Evercare Hospital Dhaka Bangladesh Department of Medicine Times Multicare Hospital Ltd. Dhaka Bangladesh Barking Havering and Redbridge University Hospitals NHS Trust Romford UK

Nipah virus (NiV) is a highly infectious zoonotic pathogen that poses a significant threat to human and animal health. First identified in Malaysia in 1998, NiV has since caused several outbreaks in Southeast Asia, with sporadic cases reported in Bangladesh and India. The virus is primarily transmitted to humans through direct contact with infected animals, primarily fruit bats, or through the consumption of contaminated fruits and their juices. NiV infection presents a wide spectrum of clinical features, ranging from mild respiratory illness to severe encephalitis, with a high case fatality rate. The incubation period typically ranges from 4 to 14 days, during which patients develop fever, headache, myalgia, and respiratory symptoms such as cough and sore throat. As the disease progresses, neurological signs become prominent, including altered consciousness, seizures, and focal deficits. Severe cases may exhibit acute respiratory distress syndrome and multi organ failure. Laboratory findings often include lymphocytopenia, thrombocytopenia, and elevated liver enzymes. Diagnosis of NiV infection requires specialized laboratory testing, including reverse transcription-polymerase chain reaction (RT-PCR) and serological assays. Currently, no specific antiviral treatment exists for NiV infection, and management primarily focuses on supportive care. Prevention and control strategies encompass public health interventions, surveillance, and raising awareness among healthcare providers and the general population. The emergence and re-emergence of NiV highlight the urgent need for continued research, improved diagnostic capabilities, and the development of effective vaccines and therapeutics to mitigate the impact of this deadly virus.

关键词： Nipah Virus Zoonotic Pathogen Outbreaks Surveillance

A review on non-isolated low-power DC-DC converter topologies with high output gain for solar photovoltaic system applications

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Clean Energy 2022年第4期6卷 557-572页

作者： Tole Sutikno Hendril Satrian Purnama Nuryono Satya Widodo Sanjeevikumar Padmanaban Mohd Rodhi sahid Department of Electrical Engineering Industrial Technology FacultyUniversitas Ahmad Dahlan55191 YogyakartaIndonesia Embedded System and Power Electronics Research Group 55191 YogyakartaIndonesia CTiF Global Capsule Department of Business Development and TechnologyAarhus UniversityHerning 7400Denmark School of Electrical Engineering Faculty of EngineeringUniversiti Teknologi MalaysiaJohorMalaysia

The major challenges of the high-gain DC-DC boost converters are high-voltage stress on the switch,extreme duty ratio operation,diode reverse-recovery and converter efficiency *** are many topologies of high-gain converters that have been widely developed to overcome those problems,especially for solar photovoltaic(PV)power-system *** this paper,20 high-gain and low-power DC-DC converter topologies are selected from many topologies of available ***,seven prospective topologies with conversion ratios of>15 are thoroughly reviewed and *** selected topologies are:(i)voltage-multiplier cell,(ii)voltage doubler,(iii)coupled inductor,(iv)converter with a coupled inductor and switch capacitor,(v)converter with a switched inductor and switched capacitor,(vi)cascading techniques and(vii)voltage-lift *** topology has its advantages and disadvantages.A comparison of the seven topologies is provided in terms of the number of components,hardware complexity,maximum converter efficiency and voltage stress on the *** are presented in ***,in the future,it will be easier for researchers and policymakers to choose the right converter topologies and build them into solar PV systems based on their needs.

关键词： distributed energy and smart grid energy and environment energy system and policy solar

Phylogeography and morphometric variation in the Cinnamon Hummingbird complex:Amazilia rutila(Aves:Trochilidae)

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Avian Research 2021年第4期12卷 509-525页

作者： Melisa Vázquez-López Nandadevi Córtes-Rodríguez sahid M.Robles-Bello Alfredo Bueno-Hernández Luz E.Zamudio-Beltrán Kristen Ruegg Blanca E.Hernández-Baños Museo de Zoología Facultad de CienciasUniversidad Nacional Autónoma de MéxicoApartado Postal04510 Mexico CityMexico Department of Biology Ithaca CollegeIthacaNY 14850USA Museo de Zoología Facultad de Estudios Superiores ZaragozaUniversidad Nacional Autónoma de MéxicoMexico CityMexico Department of Biology Colorado State UniversityFort CollinsCO 80523USA

Background:The Mesoamerican dominion is a biogeographic area of great interest due to its complex topography and distinctive climatic *** area has a large diversity of habitats,including tropical deciduous forests,which house a large number of endemic ***,we assess phylogeographic pattern,genetic and morphometric variation in the Cinnamon Hummingbird complex Amazilia rutila,which prefers habitats in this *** resident species is distributed along the Pacific coast from Sinaloa—including the Tres Marías Islands in Mexico to Costa Rica,and from the coastal plain of the Yucatán Peninsula of Mexico south to ***:We obtained genetic data from 85 samples of ***,using 4 different molecular markers(mtDNA:ND2,COI;nDNA:ODC,MUSK)on which we performed analyses of population structure(median-joining network,STRU CTU RE,FST,AMOVA),Bayesian and Maximum Likelihood phylogenetic analyses,and divergence time *** order to evaluate the historic suitability of environmental conditions,we constructed projection models using past scenarios(Pleistocene periods),and conducted Bayesian Skyline Plots(BSP)to visualize changes in population sizes over *** analyze morphometric variation,we took measurements of 5 morphological traits from 210 study *** tested for differences between sexes,differences among geographic groups(defined based on genetic results),and used PCA to examine the variation in multivariate ***:Using mtDNA,we recovered four main geographic groups:the Pacific coast,the Tres Marías Islands,the Chiapas region,and the Yucatán Peninsula together with Central *** same groups were recovered by the phylogenetic results based on the multilocus *** based on BSP results showed constant population size over time throughout the *** complex and within each geographic *** niche model projec-tions onto past scenarios revealed no drastic changes in suitable conditions,but revealed some

关键词： Amazilia rutila Genetic structure Genetic variation Phylogeography Tres Marías Islands Trochilidae Tropical deciduous forest

Nipah Virus Unveiled: A Review Article

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Diagnostic Dilemma with a Case of Primary Bronchopulmonary Actinomycosis Causing Unilateral Destroyed Lung: A Case Report and Literature Review

Advances in Bioscience and Biotechnology（生命科学与技术进展） 2024年第3期 161页

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Open Journal of Thoracic Surgery 2022年第1期12卷 1-10页

作者： Md. Abir Tazim Chowdhury Sohail Ahmed Md. Zulfiqur Haider S. M. A. Zulker Nine Md. Kamrul Hasan Md. Estiak Ullah sahid Musfaqus Shalehin Md. Abdullah Al-Mahammud Kabir Niaz Ahmed Munama Magdum Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Bangladesh Department of Cardiothoracic Anesthesia Evercare Hospital Dhaka Bangladesh Department of Community Medicine Shaheed Monsur Ali Medical College Dhaka Bangladesh

Among chronic pulmonary infections, pulmonary actinomycosis is a rare one, caused by a gram-positive microaerophilic bacterium called Actinomyces. Aside from cervicofacial or abdominopelvic actinomycosis, pulmonary involvement is rare, and sometimes this type of infection results in a misdiagnosis of pulmonary tuberculosis or carcinoma. Clinical presentation of pulmonary actinomycosis could be acute or subacute, with lobar involvement. However, the disease is most commonly diagnosed at the chronic phase, with patients presenting mild fever, weight loss, and occasional hemoptysis. Here, we described the case of a 30-year-old male patient, presented with a history of respiratory complaints for more than three years and was diagnosed clinically and radiologically as a case of a destroyed left lung. Later on, post-operative tissue diagnosis was confirmed—pulmonary actinomycosis.

关键词： Pulmonary Actinomycosis Destroyed Lung Diagnostic Dilemma

Serum bicarbonate may independently predict acute kidney injury in critically ill patients:An observational study

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World Journal of Critical Care Medicine 2015年第1期4卷 71-76页

作者： Anuksha Gujadhur Ravindranath Tiruvoipati Elizabeth Cole Saada Malouf Erum sahid Ansari Kim Wong Department of Renal Medicine Frankston HospitalFrankston VIC 3199Australia School of Public Health Faculty of MedicineNursing and Health SciencesMonash University Department of Intensive Care Medicine Frankston HospitalFrankston VIC 3199Australia

AIM: To explore whether serum bicarbonate at admission to intensive care unit(ICU) predicted development of acute kidney injury(AKI).METHODS:We studied all patients admitted to our ICU over a 2 year period(February 2010 to 2012).The ICU has a case mix of medical and surgical patients excluding cardiac surgical,trauma and neurosurgical *** analysed 2035 consecutive patients admitted to ICU during the study *** were collected by two investigators independently and in duplicate using a standardised spread sheet to ensure *** data were checked for accuracy where *** was defined using the Kidney Disease Improving Global Outcomes *** were divided into two groups;patients who developed AKI or those who did not,in order to compare the baseline characteristics,and laboratory and physiologic data of the two *** analysis was used to identify if serum bicarbonate on admission predicted the development of ***:Of 2036 patients 152(7.5%)were excluded due to missing *** developed in 43.1%of the *** AKI group,compared to the nonAKI group,was sicker based on their lower systolic,diastolic and mean arterial pressures and a higher acutephysiology and chronic health evaluation(APACHE)Ⅲand SAPSⅡ***,patients who developed AKI had more co-morbidities and a higher proportion of patients who developed AKI required mechanical *** multi-regression analysis of independent variables showed that serum bicarbonate on admission(OR=0.821;95%CI:0.796-0.846;P<0.0001),APACHEⅢ(OR=1.011;95%CI:1.007-1.015;P<0.0001),age(OR=1.016;95%CI:1.008-1.024;P<0.0001)and presence of sepsis at ICU admission(OR=2.819;95%CI:2.122-23.744;P=0.004)were each significant independent predictors of *** area under the ROC curve was 0.8(95%CI:0.78-0.83),thereby demonstrating that the predictive model has relatively good discriminating power for predicting ***:Serum bicarbonate on admission may indepen

关键词： Acute kidney injury Bicarbonate Mortality Sepsis

The Impulsivity and Drinking Motives as Predictor of the Alcohol Consumption in College Students

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Psychology Research 2014年第1期4卷 40-47页

作者： Diana Betancourt Ocampo sahid Rafael Garcia Campos Jazmin Garcia Zarate Laura Alejandra Corona Guevara Alejandro Gonzalez-Gonzfilez Universidad Anahuac Mexico Norte Huixquilucan Mexico Universidad Nacional Autonoma de Moxico Mexico City Mexico

The main objective of this research is to determine the effect of the impulsivity as well as the causes of drinking alcohol in college. We selected a non-probabilistic sample of 36 students of a private college, 47.1% were male and 52.9 female, with an age range of 17-27 years and a mean of 20.66 years. To measure the alcohol consumption, we used an adapted version of the Drinking Motives Questionnaire, which consists of three dimensions: coping reasons, social reasons and conformity reasons. Impulsivity was evaluated with the adapted versions of the Plutchik scale consisting of 15 items in Likert scale with four response options ranging from never to always. These results showed that 93.6% of the participants reported the consumption of alcohol sometime in their lives. As for the effect of the causes for drinking and the impulsivity of the consumption in college students, the results showed that the three dimensions to drink explained 39% of the variance in the alcohol consumption among young people, however, impulsivity did not enter as a predictor variable.

关键词：食用酒精消费预测大学生饮酒民办高校消费量原因非概率