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Journal of Natural Gas Chemistry 2009年第2期18卷 187-190页

作者： Syed Tajammul Hussain muhammad Mazhar muhammad arif nadeem National Centre for Physics Quaid-i-Azam UniversityIslamabad 43520 Pakistan Department of Chemistry Quaid-i-Azam UniversityIslamabad 43520 Pakistan

In Fischer-Tropsch synthesis reaction, methane formation is one of the side reactions which must be suppressed in order to get better catalytic selectivity for light olefins. In the present study, we have modified cobalt based Fischer-Tropsch catalyst and developed a process to minimize methane production, consequently to produce maximum yield of light olefins. Manganese-cobalt oxide supported on H-5A zeolite catalyst was synthesized using modified H-5A zeolite, to increase its surface acid sites. Increased acidity of zeolite plays a major part in the suppression of methane formation during the Fischer-Tropsch reaction. The modified zeolite results in the electronic modification of catalyst surface by creating new active catalytic sites. The results are compared with other supported catalysts along with unmodified zeolite. Appreciable reduction in methane formation is achieved on modified zeolite supported catalyst in comparison with unsupported catalyst.

关键词： methane formation Fisher-Tropsch synthesis manganese cobalt suppression

Asymptomatic dengue infection in adults of major cities of Pakistan

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Asian Pacific Journal of Tropical Medicine 2017年第10期10卷 1002-1006页

作者： Ibrar Rafique muhammad arif nadeem Saqib muhammad arif Munir Huma Qureshi Ijaz-ul-Haq Taseer Rizwan Iqbal Waqaruddin Ahmed Tasleem Akhtar Rizwanullah Pakistan Health Research Council Head OfficeIslamabadPakistan Pakistan Health Research Council Research CentreNishtar Medical CollegeMultanPakistan Pakistan Health Research Council Research CentreKing Edward Medical UniversityLahorePakistan Pakistan Health Research Council Research CentreJinnah Postgraduate Medical CentreKarachiPakistan Pakistan Health Research Council Research CentreKhyber Medical CollegePeshawarPakistan

Objective: To determine the asymptomatic dengue infection in adults of Pakistani ***: This study was conducted in five major cities(Islamabad, Karachi, Lahore,Multan, and Peshawar) of Pakistan.A total of 5 230 adults aged 18 years and above without a history of dengue fever at any point in their life were enrolled from participating *** who were confirmed for dengue previously were *** the total, 62.6%(n = 3 276) were male with an average age of 34.6 *** were briefed about the objectives of the study, and written consent was obtained to perform dengue Ig G test using enzyme linked immunosorbent *** brief information related to age, gender and area was also taken on ***: Overall 32.3%(n = 1 691) was having asymptomatic dengue infection which was 67.5%(n = 756) in Karachi followed by 39.1%(n = 391) in Islamabad, 29.9%(n =316) in Lahore and 21%(n = 228) in Peshawar and none from *** males were affected with asymptomatic dengue infection than *** asymptomatic dengue infection was significantly higher in different cities; however, there was no significant difference with respect to age ***: The asymptomatic dengue infection is higher in cities ***,Islamabad and Lahore which are at risk of developing secondary dengue *** is a need of awareness among the public about secondary dengue infection.

关键词： Dengue Exposure Secondary dengue infection Asymptomatic

Comprehensive genetic screening reveals wide spectrum of genetic variants in monogenic forms of diabetes among Pakistani population

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World Journal of Diabetes 2021年第11期12卷 1957-1966页

作者： Ibrar Rafique Asif Mir Shajee Siddiqui muhammad arif nadeem Saqib Asher Fawwad Luc Marchand muhammad Adnan muhammad Naeem Abdul Basit Constantin Polychronakos Department of Biological Sciences International Islamic UniversityIslamabad 44000Pakistan Departments of Pediatrics and Human Genetics McGill University Health Centre Research InstituteMontreal H4A 3J1Canada Research Development and Coordination Pakistan Health Research CouncilIslamabad 44000Pakistan Department of Medicine Pakistan Institute of Medical SciencesIslamabad 44000PakistanPakistan Department of Medical Laboratory Technology National Skills UniversityIslamabad44000Pakistan Department of Biochemistry Baqai Institute of Diabetology and EndocrinologyBaqai Medical UniversityKarachi 74600SindhPakistan PHRC Research Centre FJMUPakistan Health Research CouncilLahore 54000Pakistan Department of Biotechnology Quaid-I-Azam UniversityIslamabad 44000Pakistan Department of Medicine Baqai Institute of Diabetology and EndocrinologyBaqai Medical UniversityKarachi 74600SindhPakistan

BACKGROUND Monogenic forms of diabetes(MFD)are single gene *** diagnosis is challenging,and symptoms overlap with type 1 and type 2 *** To identify the genetic variants responsible for MFD in the Pakistani population and their *** A total of 184 patients suspected of having MFD were *** inclusion criterion was diabetes with onset below 25 years of *** demographic and clinical information were taken from the *** maturity-onset diabetes of the young(MODY)probability score was calculated,and glutamate decarboxylase ELISA was *** negative patients and features resembling MODY were selected(n=28)for exome sequencing to identify the pathogenic *** A total of eight missense novel or very low-frequency variants were identified in 7 *** variants were found in genes for MODY,***1A(c.169C>A,***57Met),KLF11(c.401G>C,***134Ala),and HNF1B(c.1058C>T,***353Leu).Five variants were found in genes other than the 14 known MODY genes,***6(c.919G>A,***307Lys),WFS1(c.478G>A,***160Lys)and WFS1(c.517G>A,***173Lys),RFX6(c.1212T>A,***404Gln)and ZBTB20(c.1049G>A,***350His).CONCLUSION The study showed wide spectrum of genetic variants potentially causing MFD in the Pakistani *** MODY genes prevalent in European population(GCK,HNF1A,and HNF4a)were not found to be common in our *** of novel variants will further help to understand the role of different genes causing the pathogenicity in MODY patient and their proper management and diagnosis.

关键词： MODY Diabetes Genetics Monogenic diabetes Monogenic forms of diabetes

Developing Transparent IDS for VANETs Using LIME and SHAP:An Empirical Study

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Computers, Materials & Continua 2023年第12期77卷 3185-3208页

作者： Fayaz Hassan Jianguo Yu Zafi Sherhan Syed arif Hussain Magsi nadeem Ahmed Beijing Key Laboratory of Work Safety Intelligent Monitoring School of Electronic EngineeringBeijing University of Post and TelecommunicationBeijing100876China Department of Telecommunication Engineering Mehran University of Engineering and TechnologyJamshoro76062Pakistan State Key Laboratory of Networking and Switching Technology Beijing University of Post and TelecommunicationBeijing100876China School of Electronic Science Beijing University of Post and TelecommunicationBeijing100876China

Vehicular Ad-hoc Networks(VANETs)are mobile ad-hoc networks that use vehicles as nodes to create a wireless *** VANETs offer many advantages over traditional transportation networks,ensuring security in VANETs remains a significant challenge due to the potential for malicious *** study addresses the critical issue of security in VANETs by introducing an intelligent Intrusion Detection System(IDS)that merges Machine Learning(ML)–based attack detection with Explainable AI(XAI)*** study ML pipeline involves utilizing correlation-based feature selection followed by a Random Forest(RF)classifier that achieves a classification accuracy of 100%for the binary classification task of identifying normal and malicious *** innovative aspect of this study is the incorporation of XAI methodologies,specifically the Local Interpretable Model-agnostic Explanations(LIME)and SHapley Additive exPlanations(SHAP).In addition,this research also considered key features identified by mutual information-based feature selection for the task at *** major findings from this study reveal that the XAI-based intrusion detection methods offer distinct insights into feature *** features identified by mutual information,LIME,and SHAP predominantly relate to Transmission Control Protocol(TCP),Hypertext Transfer Protocol(HTTP),Domain Name System(DNS),and Message Queuing Telemetry Transport(MQTT)protocols,highlighting their significance in distinguishing normal and malicious network *** XAI approach equips cybersecurity experts with a robust means of identifying and understanding VANET malicious activities,forming a foundation for more effective security countermeasures.

关键词： Intrusion detection system machine learning security vehicular networks

Gene-gene,gene-environment,gene-nutrient interactions and single nucleotide polymorphisms of inflammatory cytokines

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World Journal of Diabetes 2015年第4期6卷 642-647页

作者： Amina nadeem Sadaf Mumtaz Abdul Khaliq Naveed muhammad Aslam arif Siddiqui Ghulam Mustafa Lodhi Tausif Ahmad Department of Physiology Army Medical CollegeNational University of Sciences and TechnologyIslamabad College of Medicine DammamUniversity of Dammam Department of Biochemistry Islamic International Medical CollegeRifah University Department of Physiology University of Health SciencesLahore Department of Physiology Islamic International Medical CollegeRifah University Department of Physiology AL-Nafees Medical CollegeIsra University Dean-Faculty of Pharmacy Margalla College of PharmacyMargalla Institute of Health Sciences

Inflammation plays a significant role in the etiology of type 2 diabetes mellitus(T2DM).The rise in the pro-inflammatory cytokines is the essential step in glucotoxicity and lipotoxicity induced mitochondrial injury,oxidative stress and beta cell apoptosis in T2 *** the recognized markers are interleukin(IL)-6,IL-1,IL-10,IL-18,tissue necrosis factor-alpha(TNF-α),C-reactive protein,resistin,adiponectin,tissue plasminogen activator,fibrinogen and *** mellitus has firm genetic and very strong environmental influence; exhibiting a polygenic mode of *** single nucleotide polymorphisms(SNPs) in various genes including those of pro and antiinflammatory cytokines have been reported as a risk for T2 *** all the SNPs have been confirmed by unifying results in different studies and wide variations have been reported in various ethnic *** inter-ethnic variations can be explained by the fact that gene expression may be regulated by gene-gene,gene-environment and gene-nutrient *** review highlights the impact of these interactions on determining the role of single nucleotide polymorphism of IL-6,TNF-α,resistin and adiponectin in pathogenesis of T2 DM.

关键词： Cytokines Gene-environment interaction Diabetes mellitus Single nucleotide polymorphism Gene-gene interaction