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Use of Impella cardiac axial flow pump for cardiogenic shock(A newer alternative)-How good is the evidence?

BIOCELL 2022年第5期46卷 1139-1150页

作者： RAFIQ AHMED BHAT SYED MANZOOR ALI YOOSUF ALI ASHRAF muhammad HUSSENBOCUS AKANKSHA RATHI JAVAID AKHTER BHAT ABDUL aleem khan SYED MAQBOOL RAJA SAQIB IQBAL MD MONOWARUL ISLAM YONGSHENG QU YOU ZHANG YUXIAO SUN WENTAO XIAO ABHISHEK TIBREWAL CHUANYU GAO Zhengzhou University People’s Hospital Department of CardiologyFuwai Central China Cardiovascular HospitalZhengzhouChina Department of Cardiology Super Speciality DivisionGovernment Medical CollegeSrinagarIndia Department of Rheumatology and Immunology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina Department of Community Medicine Vedanta Institute of Medical SciencesPalgharIndia State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjingChina Department of Orthopaedics Nanjing First HospitalNanjing Medical UniversityNanjingChina Department of Paediatrics Batra Hospital and Medical Research CentreNew DelhiIndia Zhengzhou University First Affiliated Hospital ZhengzhouChina Department of Community Medicine Institute of Biostatistics and EpidemiologyGurgaonIndia

The adverse outcomes of a ventricular heart failure(left,right or biventricular)caused by cardiogenic shock are aggravated by lung oedema and organ mal *** advances in medical sciences,revascularisation and mechanical hemodynamic support have proved ineffective in reducing the mortality rate in such patients.A thorough study of the data available about cardio-vascular diseases reveals that the application of conventional methods of treatment are least helpful to practically restore normal functions of heart when it experiences end-stage systolic ventricular ***,to overcome the challenges and find alternatives to address this issue,percutaneous ventricular support devices/machines were designed and successfully *** devices have revolutionized the treatment of ventricular heart failures and are now in use all over the *** this review paper a newer mechanical circulatory support(MCS)device,Impella,has been discussed and compared with a few other devices like Intra-aortic Balloon Pump(IABP),Extracorporeal Circulation(ECLS)and Veno-arterial Extracorporeal Membrane Oxygenation(VA-ECMO).This article studies the challenges being faced during the treatment of cardiogenic shock,and thoroughly discusses the use and effectiveness of Impella Cardiac Axial Pump in each *** can be said that mechanical circulatory support(MCS)device use during percutaneous coronary intervention(PCI)should be individualized based on multiple factors with a recommended use in patients with the greatest potential benefit and a relatively low risk of device-related *** current literature suggests that the outcomes of use of Impella and other mechanical circulatory support devices like IABP and VA-ECMO are *** there seem to be a few advantages of Impella over the others,sufficiently powered,multi-centric,randomised control trials are needed to establish its superiority.

关键词： Cardiogenic shock Hemodynamic support Impella Cardiac Axial Pump IABP VA-ECMO

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Locally Advanced Breast Cancer in Pakistani Women: What Is Different from Rest of the World and Why It Is Difficult to Manage

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Journal of Cancer Therapy 2022年第8期13卷 525-530页

作者： muhammad Khalid Noor Ul Wara Rao Farwa Batool Shamsi Tayaba Kanwal Sana Arshad muhammad Shahzeb Ameer Alam Sobia aleem M. Ahsan Iqbal Oncology/CCU Allied Hospital Faisalabad Faisalabad Medical University Faisalabad Pakistan Department of Pathology Faisalabad Medical University (FMU) Faisalabad Pakistan Department of PB & Genetics University of Agriculture Faisalabad Pakistan

Locally Advance Breast Cancer refers to a heterogeneous group of breast cancer with locally extensive disease, which may or may not involve the nodes, without any distant metastases. The study was conducted at Faisalabad Medical University (FMU), Oncology, Allied Hospital Faisalabad (Pakistan). Data of 100 patients with LABC was collected. Demographics were recorded in the form of age, socio-economic status. In clinical data, time of presentation, family history of breast cancer, the presenting symptom in the form of lump, ulceration and other skin changes were noted. Histo-pathological variables including tumor size, histopathology, Bloom & Richardson grading, estrogen receptor (ER), progesterone receptor status (PR) and HER2 status. Results showed that after following a standard trimodality treatment approach in LABC patients, 30 percent died within two years. Disease free survival for more than two years was observed in only 25% of patients. Whereas, 70% patients had eventful (Recurrence/metastases) survival. This poor outcome was observed due to lack of health care facilities, awareness and poor socioeconomic status.

关键词： Oncology Breast Cancer in Pakistani Women LABC

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基于热模拟实验的富有机质泥页岩成岩作用及演化特征

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沉积学报 2016年第6期34卷 1208-1216页

作者：栾国强董春梅马存飞林承焰张津营吕夏霏 muhammad aleem Zahid 中国石油大学(华东)地球科学与技术学院山东青岛266580 山东省油藏地质重点实验室山东青岛266580 中石油油气储层重点实验室中国石油大学(华东)研究室山东青岛266580 中国石油大学(北京)地球科学学院北京102200 Faculty of Marine Sciences Lasbela University

富有机质泥页岩蕴含丰富的油气资源,但成岩研究基础薄弱,已成为制约页岩油气勘探开发进程的重要因素。通过开展成岩热模拟实验,结合扫描电镜观察、流体成分测试及有机酸测试等实验测试手段,全面描述实验过程中所发生的水—岩化学反应,... 详细信息

富有机质泥页岩蕴含丰富的油气资源,但成岩研究基础薄弱,已成为制约页岩油气勘探开发进程的重要因素。通过开展成岩热模拟实验,结合扫描电镜观察、流体成分测试及有机酸测试等实验测试手段,全面描述实验过程中所发生的水—岩化学反应,试图揭示泥页岩成岩过程及成岩演化规律。研究结果显示,有机质热演化过程中存在一个较宽的有机酸生成窗口,对孔隙流体性质具有重要影响;长石和方解石存在接力溶蚀现象,长石溶蚀高峰过后紧接着出现方解石溶蚀高峰,但方解石溶蚀窗较窄,此后出现方解石重新沉淀结晶;黏土矿物转化及长石的溶蚀过程中会产生大量自生微晶石英,成链状或簇状胶结泥页岩骨架。泥页岩地层作为一个相对封闭体系,各类成岩作用之间相互关联,相互影响,构成错综复杂的成岩体系,进一步增加其成岩作用研究难度。

关键词：泥页岩成岩作用模拟实验

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Genes and Transcriptional Factors in Chili Plant with Aspect to Metabolism and Resistance against Virus, Bacteria and Fungi： A Review

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Journal of Agricultural Science and Technology(B) 2014年第7期4卷 509-517页

作者： Arfan Ali muhammad Sarmad Iftikhar muhammad Munawar Muqadas aleem Sajed Ali Saira Azam Idrees Ahmad Nasir Tayyab Husnain Umair Majid muhammad Sameer Akram Tajasar Kamran Shehzad Bajwa Tahir Rehman Samiullah National Centre of Excellence in Molecular Biology University of the Punjab Lahore 53700 Pakistan Department of Plant Breeding and Genetics University of Agriculture Faisalabad 38000 Pakistan

These days, there is a lot of discussion about genetically modified plants. There are different schools of thoughts in public, and some people adjusted while others are reluctant to accept genetically modified organism foods. Many vegetables are transformed and are used in daily life. Chili is one of those which is genetically modified and used in our food. Race specific genes can be used more efficiently for disease resistance and improving metabolic pathways. Different genes and transcriptional factors are available in Capsicum for this purpose. We can optimize and use the better expressed genes while engineering the chili plants, Genetic modifications causing significant changes are related with metabolism, which cause disease resistance.

关键词： Transcriptional factors chili plant metabolism resistance in chilies.

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Actin-depolymerizing factor from Eimeria tenella promotes immunogenic function of chicken dendritic cells

Actin-depolymerizing factor from Eimeria tenella promotes im...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Shakeel Ahmed Lakho muhammad Haseeb Jianmei Huang Zhang Yang muhammad Waqqas Hasan muhammad Tahir aleem muhammad Ali Memon XiaoKai Song RuoFeng Yan Lixin Xu 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University

Dendritic cells play a crucial role in inducing antigen-specific immunity to *** host-parasite interaction,host immune response to the parasite molecules is considered essential for recognizing novel antigens for control ***,in the present study,chicken dendritic cells(DCs)(ChDCs),derived from spleens were used to evaluate their capacity to proliferate and differentiate autologous T lymphocytes in response to actin-depolymerizing factor from Eimeria tenella(EtADF).Immunoblot analysis showed that recombinant EtADF protein(rEtADF) was able to interact with rat anti-rEtADF *** immunofluorescence test confirmed rEtADF binding on ChDCs *** *** revealed that phenotypes for MHCII,CD1.1,CD11 c,CD80,and CD86 were increased in ChDCs after rEtADF ***-PCR results indicated that ChDCs triggered TLR signaling in response to rEtADF,and suppressed Wnt *** levels of CD83,CCL5,and CCR7 in ChDCs were improved following rEtADF *** addition,rEtADF promoted DC-directed T cell proliferation and differentiation of naive T cells into CD3/CD4T cells in DC/T cell co-incubation *** analysis of rEtADF-pulsed ChDCs showed increased levels of IL-12 and IFN-γ,while IL-10 and TGF-β remained ***,rEtADF-treated ChDCs enhanced production of IFN-γ when incubated with T cells,and IL-4 secretion remained *** findings indicted that rEtADF could facilitate the polarization of Th1 immune cells by triggering both host DCs and T *** findings provide useful insights into future work aimed at anticoccidial vaccine strategies.

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Assessment of Heritable Variation and Best Combining Genotypes for Grain Yield and Its Attributes in Bread Wheat

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American Journal of Plant Sciences 2018年第8期9卷 1688-1698页

作者： Nusrat Parveen Amna Kanwal Etlas Amin Fariha Shahzadi Saba aleem Mehvish Tahir Abia Younas Rasheda Aslam Nafeesa Aslam Iqra Ghafoor Mehvish Makhdoom muhammad Amin Shakir muhammad Najeebullah Vegetable Research Institute AARI Faisalabad Pakistan Wheat Research Institute AARI Faisalabad Pakistan Rice Research Institute Kala Shah Kako Pakistan Cotton Research Station AARI Faisalabad Pakistan Department of Plant breeding and Genetics University of Agriculture Faisalabad Pakistan Livestock Production Research Institute Bahadernagar Farm Okara Pakistan

Grain yield in wheat is the resultant of several plant attributes. It is very important to assess heritable variation involved in the inheritance of these attributes in addition to find the best combining genotypes. For this purpose, the present study involving 5 × 5 full diallel analysis was performed. Twenty F1 hybrids along with their parents (9797, 9801, 9802, Chakwal-50 and Chakwal-86) were planted in field using randomized complete block design (RCBD) with three replications in the research area of Department of Plant Breeding and Genetics, University of Agriculture, Faisalabad during 2015-2016. Plant characters like plant height, flag leaf area, spike length, No. of fertile tillers per plant, No. of grains per spike, No. of spikelets per spike, 1000 grain weight and grain yield per plant were studied in this experiment. Mean squares due to general combining ability (GCA) were highly significant for all the traits except for spike length for which GCA effects were significant. Mean squares due to specific combining ability (SCA) and reciprocal combining ability (RCA) were highly significant for all the characters studied. GCA variance was higher than the SCA variance for spike length and No. of grains per spike exhibiting the predominant role of additive genetic variation in the inheritance of these traits. However, for the characters like plant height, flag leaf area, No. of fertile tillers per plant, No. of spikelets per spike, 1000 grain weight and grain yield per plant, the value of SCA variance was higher than the value of GCA variance showing non additive gene action for these traits. The variety Chakwal-50 proved to be the best general combiner for plant height, spike length, No. of spikelets per spike, No. of grains per spike and grain yield per plant. The cross, 9802 × Chakwal-86 was the best specific combination for grain yield and most of the yield attributes. The good general and specific combiners are important breeding resources for the initiatio

关键词： Wheat Combining Ability Yield Diallel Additive Genetic Variation

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Standardization of Famacha? system for natural parasites infected goat by comparing mucosa color

Standardization of Famacha? system for natural parasites inf...

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中国畜牧兽医学会兽医寄生虫学分会第一届青年科学家学术论坛

作者： Mubashar Hassan Zafar Iqbal Zia ud Din Sindhu Awais Ali Ahmad Aftab Shaukat Shahid Ali Rajput muhammad Tahir aleem muhammad Mohsin State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural University Deparment of Veterinary Parasitology University of Agriculture Faisalabad Department of Clinical Veterinary Medicine College of Veterinary MedicineHuazhong Agricultural University Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural University College of veterinary science Preventive Veterinary MedicineNanjing Agriculture University College of Life Sciences Fujian Agriculture and Forestry University

Haemonchus contortus is the most significant blood sucking abomasal *** has been playing a vital role to control ***,ability of *** to develop resistance against anthelmintics has led to scientists to control this rapid perpetual rate FAMACHA0 system has been introduced for selective and targeted use of the *** system works on scoring of the eye mucosal color,red to pale,with increasing anemic condition of the *** this study,sensitivity of FAMACHA was evaluated by faecal egg counts(FEC),packed cell volume(PCV) and haemoglobin(Hb) concentration in three breeds of goat ***,Pak Angora and *** Nachi and Pak Angora goats FEC values were concordant with FAMCAHA score but PCV and Hb values were in negative *** Beetal goats,FEC and PCV values were concordant to FAMACHA but Hb concentration was in negative *** conclusion,FAMCAHA system is not found competent in selective and targeted treatment system.

关键词： FAMACHA Haemonchus contortus goats color meter Diagnosis

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Immunogenicity and Protective Efficacy of Probiotics with EtIMP1C against Eimeria tenella Challenge

Immunogenicity and Protective Efficacy of Probiotics with Et...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： muhammad Mohsin Lina Li Xiaohang Huang muhammad Tahir aleem Yusuf Jibril Habib Akram Ismael Shehata muhammad Zeeshan Afzal Rao Zahid Abbas Asghar Abbas Guangwen Yin College of Animal Sciences (College of Bee Science) Fujian Agriculture and Forestry University College of Life Science Fujian Agriculture and Forestry University Department of Parasitology University of Agriculture MOE Joint International Research Laboratory of Animal Health and Food Safety College of Veterinary MedicineNanjing Agricultural University Department of Pathology University of Agriculture

Coccidiosis is an endemic problem in broilers inflicting disastrous losses to worldwide poultry *** are generally effective in controlling the infectious diseases;the subunit vaccines effectiveness can hopefully be improved with concurrent use of probiotics as assessed in this experiment using an Eimeria tenella *** mapped protein-1(IMP 1)is a novel immunogenic protein of Apicomplexans,including in Eimeria *** performance of the cumulative effect of probiotics and EtIMP1 C(Part of Eimeria tenella immune mapped protein1) was evaluated based on various parameters such as an intestinal lesion,oocyst scores,feed conversion ratio,and organ *** were also analyzed on both immunological and hematological *** EtIMP1 C and probiotics administered group showed less intestinal lesion,decreased oocyst shedding,satisfactory feed conversion ratio(FCR) and improved hematological parameters as compared to EtIMP1 C emulsified with FCA ***,there was no statistically significant difference between the two groups(P>0.05),in aspect of lesion and oocyst scores,as well as immunological and hematological *** experimental work showed that probiotics could be a good hope due to its antioxidant,immunomodulatory and growth promoting effect against poultry coccidiosis alone or in combination with vaccines,including IMP1 C based vaccine,but further studies are required to formulate its dose with the vaccine as well as a different strain of probiotics effect against coccidiosis.

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Glyceraldehyde-3-phosphate dehydrogenase from Eimeria acervulina modulates the functions of chicken dendritic cells to boost Th1 type immune response and stimulates autologous CD4+T cells differentiation in-vitro

Glyceraldehyde-3-phosphate dehydrogenase from Eimeria acervu...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Shakeel Ahmed Lakho muhammad Haseeb Jianmei Huang Zhang Yang muhammad Waqqas Hasan muhammad Tahir aleem muhammad Ali-Ul-Husnain Naqvi muhammad Ali Memon XiaoKai Song RuoFeng Yan Lixin Xu 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University

Dendritic cells(DCs) play a pivotal role to amplify antigen-specific immune *** that sensitize T cells via antigen-presentation by DCs could enhance the capacity of host immunity to fight *** this study,we tested the immunogenic profiles of chicken DCs towards Glyceraldehyde-3-phosphate dehydrogenase from Eimeria acervulina(EaGAPDH).Immunoblot analysis showed that recombinant EaGAPDH(rEaGAPDH) protein was successfully recognized by rat sera generated against *** and internalisation of rEaGAPDH by chicken splenic-derived DCs(chSPDCs) was confirmed by immunofluorescence *** cytometry revealed that chSPDCs upregulated MHCII,CD 1.1,CD11 c,CD80,and CD86 cell-surface ***,mRNA expressions of DC maturation biomarkers(CCL5,CCR7,and CD83) and TLR signalling genes(TLR15 and MyD88) were also upregulated whereas those of Wnt signalling were non-significant compared to negative *** treatment induced IL-12 and IFN-γ secretion in chSPDCs but had no effect on IL-10 and TGF-β.Likewise,DC-T cell co-culture promoted IFN-γ secretion and the level of IL-4 was *** of T cells and their differentiation into CD3+/CD4+T cells were triggered in chSPDCs-T cells co-culture *** together,rEaGAPDH could promote Th1 polarization by activating both host DCs and T cells and sheds new light on the role of this important molecule which might contribute to the development of new DCs-based immunotherapeutic strategies against coccidiosis.

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The immunogenic maturation of goat monocyte-derived dendritic cells and upregulation of toll-like receptors by five antigens of Haemonchus contortus in-vitro

The immunogenic maturation of goat monocyte-derived dendriti...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： muhammad Waqqas Hasan muhammad Haseeb muhammad Ehsan Javaid Ali Gadahi Qiangqiang Wang muhammad Ali Memon muhammad Tahir aleem Shakeel Ahmed Lakho Ruo Feng Yan Li Xin Xu Xiao Kai Song 李祥瑞 College of Veterinary Medicine Nanjing Agricultural University

Previously,it was found that several proteins of Haemonchus contortus were involved in the stimulation of the host immune ***,the information about the selection of superlative antigens with immunogenic efficacies on host DCs is *** the current study,the stimulatory effects of five recombinant proteins(elongation factor-1α,arginine kinase,ES-15,ES-24,and ADP-ribosylation factor 1) of *** on the maturation of goat monocyte-derived dendritic cells(md-DCs) were *** proteins were purified separately in *** expression and incubated with isolated goat peripheral blood mononuclear cells(PBMC).Immunofluorescence assay(IFA) results confirmed the binding of these molecules to the md-DC’s surface as compared to control *** the flow cytometry analysis,recombinant proteins induced md-DC stimulation via the up-regulation of the expression of the costimulatory molecule(CD80) and MHC-Ⅱ.Quantitative RT-PCR data showed a significant increase in the expression of specific genes of the WNT and toll-like receptor(TLR) signaling *** result of ELISA indicated the higher levels of cytokine(IL-10,IL-12,IFN-y,and TNF-α) secretion in the md-DC compared to the negative(pET-32 a His-Tag) and blank(PBS)control *** data gives valuable support in the selection of potential antigens for future studies on the immunomodulation of the host against the infection of ***.

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