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Sero-Epidemiological Survey of Crimean-Congo Hemorrhagic Fever among the Human Population of the Punjab Province in Pakistan

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Virologica Sinica 2020年第4期35卷 486-489页

作者： muhammad Furqan Shahid muhammad zubair shabbir Kamran Ashraf Muzaffar Ali Saima Yaqub Aziz Ul-Rahman Nageen Sardar Nadia Mukhtar Zarfishan Tahir Tahir Yaqub Department of Microbiology University of Veterinary and Animal SciencesLahore 54600Pakistan Quality Operation Laboratory University of Veterinary and Animal SciencesLahore 54600Pakistan Department of Parasitology University of Veterinary and Animal SciencesLahore 54600Pakistan Institute of Public Health Lahore 54600Pakistan

Dear Editor,Crimean-Congo hemorrhagic fever(CCHF),caused by the CCHF virus(CCHFV),is a tick-borne zoonotic infection characterized by myalgia,high-grade fever(>38℃),headache,nausea,bleeding from the body cavities,and in 10%–50%of cases,results in death(Swanepoel et al.1989).As CCHFV belongs to the Nairoviridae family,the virus can be transmitted to humans through the bite of infected ticks or by contact with the tissues or blood of infected animals(Bente et al.2013).

关键词： Population belongs Human

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Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers: Implications to emergence and its zoonotic potential towards public health

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Asian Pacific Journal of Tropical Medicine 2021年第2期14卷 64-72页

作者： muhammad zubair shabbir Ruth Helmus Nissly Abdul Ahad Masood Rabbani Levina Lim Shubhada K.Chothe Murugan Subbiah Aswathy Sebastian Istvan Albert Aziz Ul-Rahman Bhushan M Jayarao Suresh V.Kuchipudi University of Veterinary and Animal Sciences LahorePakistan Animal Diagnostic Laboratory Department of Veterinary and Biomedical Sciencesthe Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA Chattogram Veterinary and Animal Sciences University ChattogramBangladesh Bioinformatics Consulting Center the Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA Department of Veterinary and Animal Sciences Muhammad Nawaz Shareef University of AgricultureMultanPakistan

Objective:To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1(AOAV-1)isolates from poultry workers with respiratory ***:Using Illumina Mi Seq,whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates.A phylogenetic and comparative analysis of all coding genes was done using bioinformatics ***:Phylogenetic analysis and genetic distance estimation suggested a close relationship among human-and avian-originated velogenic strains of genotypeⅩⅢ,sub-genotypeⅩⅢ.*** substitutions in the significant structural and biological motifs were exclusively identified in the human-originated ***:To our knowledge,this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory *** findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.

关键词： Avian orthoavulavirus 1 Human originated strain Zoonotic potential Evolution GenotypeⅩⅢ Poultry workers

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