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Journal of Rare Earths 2021年第4期39卷 440-445页

作者： Irshad Ahmad muhammad Shoaib Akhtar Mian Faisal Manzoor muhammad wajid muhammad Noman Ejaz Ahmed Mukhtar Ahmad Waheed Qamar Khan Anwar M.Rana Department of Physics.Bahauddin Zakariya University Multan60800Pakistan School of Computer and Communication Lanzhou University of Technology.Lanzhou730050China Department of Physics University of Agriculture Faisalabad38040Pakistan Institute of Advanced Materials Bahauddin Zakariya UniversityMultan6800Pakistan

Yttrium and cerium co-doped ZnO nanoparticles were synthesized by combustion route and characterized using X-ray diffraction(XRD),scanning electron microscopy(SEM),Brunauer-Emmett-Teller(BET),energy dispersive spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS),UV-visible diffuse reflectance spectroscopy(UV-vis DRS),photoluminescence(PL)and electrochemical impedance spectroscopy(EIS)*** introduction of yttrium ions has efficiently increased the relative percentage of Ce^(3+)ions in *** and cerium co-doped ZnO shows efficient photo activity for hydrogen evolution(10.61 mmol/((g·h))higher than previously reported optimal value for rare earth codoped ZnO *** remarkably increased hydrogen evolution can be ascribed to the synergy between electronic anchoring effect of Y^(3+)/Y^(2+)and Ce^(4+)/Ce^(3+)redox *** report presents new idea for the synthesis of efficient photocatalyst using economical route and ion anchoring *** hydrogen evolution was also tested using Na_(2)S and Na_(2)SO_(3)as electron donors under visible light *** synthesized photocatalysts also exhibit high stability.

关键词： ZnO H_(2)evolution Na_(2)SO_(3) PL Stability Rare earths

Synthesis and applications of fungal mycelium-based advanced functional materials

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Journal of Bioresources and Bioproducts 2021年第1期6卷 1-10页

作者： Sehrish Manan muhammad wajid Ullah Mazhar Ul-Islam Omar Mohammad Atta Guang Yang Department of Biomedical Engineering Huazhong University of Science and TechnologyWuhan 430074China Department of Chemical Engineering College of EngineeringDhofar UniversitySalalahSultanate of Oman

Over the last couple of decades,the introduction of living systems to material science for the synthesis of functional materials from biological resources is receiving immense *** is also in accordance with the need for green and sustainable development of new *** example,the growing concerns of the degradation of synthetic plastics are shifting the direction of materials-related research to the use of polymeric materials acquired from renewable *** example,the fungal mycelium-based materials are produced by growing the vegetative part of mushroom-forming fungi on different organic *** fungi are known for their ability to degrade agricultural wastes such as straws and *** mycelium-based composites having tailored structural,physical,chemical,mechanical,and biological properties are relying on the strain,feeding substrate,and the manufacturing *** mycelium cell wall mainly contains the chitin,glucans,proteins,and lipids,whose concentrations depend upon the feeding substrate that ultimately defines the final properties of the synthesized *** mycelium-based functional materials with tunable properties are synthesized by selecting the desired components and the synthesis *** pure and composites of stiff,elastic,porous,less dense,fast-growing,and low-cost mycelium-derived materials with efficient antimicrobial,antioxidant,and skin whitening properties pave their way in various applications such as construction,packaging,medicine,and *** review describes the synthesis and structural organization of mycelium-based *** further discusses the effect of different factors on the material ***,it summarizes different applications of mycelium-based materials in medicine,cosmetics,packaging,and construction fields.

关键词： Mycelium Material science Biomedical Cosmetics Packaging Construction

Plant extract-loaded bacterial cellulose composite membrane for potential biomedical applications

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Journal of Bioresources and Bioproducts 2021年第1期6卷 26-32页

作者： Atiya Fatima Sumayia Yasir MohdShariq Khan Sehrish Manan muhammad wajid Ullah Mazhar Ul-Islam Department of Chemical Engineering College of EngineeringDhofar UniversitySalalahSultanate of Oman Department of Biomedical Engineering Huazhong University of Science and TechnologyWuhan 430074China

Bacterial cellulose(BC)has been extensively explored as biomaterial for various biomedical applications owing to its non-toxic nature and unique structural morphology and impressive physicochemical and mechanical ***,its high production cost and lack of antimicrobial activity have restricted its large-scale production and therapeutic ***,the current study is aimed to devise a strategy for low-cost BC production and develop its composite with bioactive materials to bless it with antimicrobial ***,5 mm thick reticulated fibrous and highly porous BC was produced by utilizing the wasted rotten tomatoes as the production *** produced bacterial cellulose waste(BCW)(i.e.,produced from wastes)was ex-situ modified with bioactive plant extract(PE)obtained from Euclea schimperi,and the bactericidal activity of the developed BCW/PE was evaluated against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli through disc diffusion and colony forming unit(CFU)count *** BCW/PE composite showed high bactericidal activities against *** and produced clear inhibition zone whereas negligible activity was observed against ***,indicating its bactericidal activity mainly against the Gram-positive ***,this study illustrates that there is a huge potential for developing valuable biomaterials from food wastes and utilizing their liquid holding capabilities for value-added applications in medical and pharmaceutical fields.

关键词： Bacterial cellulose Food waste Plant extract Bactericidal activity Biomedical application

Bacterial cellulose/glycolic acid/glycerol composite membrane as a system to deliver glycolic acid for anti-aging treatment

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Journal of Bioresources and Bioproducts 2021年第2期6卷 129-141页

作者： Bricard Mbituyimana Lin Mao Sanming Hu muhammad wajid Ullah Kun Chen Lina Fu Weiwei Zhao Zhijun Shi Guang Yang Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Head and Neck Surgery&Communication Sciences School of MedicineDuke UniversityDurham 27710United States School of Mechanical and Electronic Engineering Wuhan Universit of TechnologyWuhan 430070China

Glycolic acid(GA),as an anti-aging skincare ingredient,plays a pivotal role in anti-aging ***,its benefits could be overshadowed due to its side effects including skin burning and irritation when *** cellulose(BC)is a highly pure form of cellulose,biosynthesized in the form of a swollen membrane by several kinds of bacteria that was demonstrated to modulate the release of model drugs owing to its porous and 3D fibrous network structure,and glycerol(GL),as a plasticizer,could enhance the controlled drug ***,we report a topical controlled drug delivery system based on BC membrane,GA and GL for controlling sustainable release of GA to reduce its side effects on the skin,while maintaining its prolonged and maximum therapeutic *** results showed that the incorporation of GL increased the malleability and flexibility of BC/GA/GL membrane,as compared with BC/GA *** addition,the GL enhanced the control of the GA delivery,as evidenced by a higher swelling capacity and thereby a slower release of the GA from BC/GA/GL *** importantly,in vitro study indicated that both BC/GA and BC/GA/GL membranes could effectively stimulate endogenous collagen synthesis in NIH3T3 cells owing to the release of GA,and that BC/GA/GL membrane is more conducive to a long-term cell adhesion,spreading,and proliferation of NIH3T3 and HaCaT cells due to its lower and sustainable release of GA than BC/GA *** study suggests the BC/GL/GA composite membrane holds great promise as an appealing platform to control the release of GA to greatly promote renewal of skin cells for effective anti-aging treatment.

关键词： Bacterial cellulose Glycolic acid Glycerol Biocompatibility Controlled drug release

Immobilized thrombin on X-ray radiopaque polyvinyl alcohol/chitosan embolic microspheres for precise localization and topical blood coagulation

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Bioactive Materials 2021年第7期6卷 2105-2119页

作者： Xiaohong Li Xiongfa Ji Kun Chen muhammad wajid Ullah Basen Li Jiameng Cao Lin Xiao Jun Xiao Guang Yang Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan430074China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou510006China Department of Orthopaedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Trans-catheter arterial embolization(TAE)plays an important role in treating various *** available embolic agents lack X-ray visibility and do not prevent the reflux phenomenon,thus hindering their application for TAE ***,we aim to develop a multifunctional embolic agent that combines the X-ray radiopacity with local procoagulant *** barium sulfate nanoparticles(BaSO4 NPs)were synthesized and loaded into the polyvinyl alcohol/chitosan(PVA/CS)to prepare the radiopaque BaSO4/PVA/CS microspheres(MS).Thereafter,thrombin was immobilized onto the BaSO4/PVA/CS MS to obtain the thrombin@BaSO4/PVA/CS *** prepared BaSO4/PVA/CS MS were highly spherical with diameters ranging from 100 to 300μ*** vitro CT imaging showed increased X-ray visibility of BaSO4/PVA/CS MS with the increased content of BaSO4 NPs in the PVA/CS *** biocompatibility assessments demonstrated that the MS were non-cytotoxic and possessed permissible hemolysis *** biofunctionalized thrombin@BaSO4/PVA/CS MS showed improved hemostatic capacity and facilitated hemostasis in ***,in vivo study performed on a rabbit ear embolization model confirmed the excellent X-ray radiopaque stability of the BaSO4/PVA/CS ***,both the BaSO4/PVA/CS and thrombin@BaSO4/PVA/CS MS achieved superior embolization effects with progressive ischemic necrosis on the ear tissue and induced prominent ultrastructural changes in the endothelial *** findings of this study suggest that the developed MS could act as a radiopaque and hemostatic embolic agent to improve the embolization efficiency.

关键词： BaSO_(4) Polyvinyl alcohol/chitosan Radiopacity Thrombin Coagulation Embolization

Implantable versatile oxidized bacterial cellulose membrane for postoperative HNSCC treatment via photothermal-boosted immunotherapy

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Nano Research 2023年第1期16卷 951-963页

作者： Jun-Jie Zhou Xiao-Hong Li Peng-Yu He Fu-Yu Qi muhammad wajid Ullah Shu-Jin Li Yuan-Tong Liu Lin-Lin Bu Guang Yang Zhi-Jun Sun The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral Maxillofacial Head Neck Oncology School&Hospital of StomatologyWuhan UniversityWuhan 430079China Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and Technology Wuhan UniversityWuhan 430079China Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Biofuels Institute School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China

The recurrence of head and neck squamous cell carcinoma(HNSCC)after surgical resection continues to pose a major challenge to cancer *** HNSCC exhibits a low response rate to immune checkpoint blockade(ICB),while photothermal therapy(PTT)can increase the infiltration of immune cells to make tumors more susceptible to cancer *** this regard,we designed and constructed a novel multifunctional nanocomposite comprised of oxidized bacterial cellulose(OBC),thrombin(TB),and gold nanocages(AuNCs)containing anti-programmed death 1(PD-1)antibody(αPD-1@AuNCs),which allows the combination of therapies with remarkable postoperative antitumor immunity to control local tumor ***αPD-1@AuNCs displayed high light-to-heat conversion efficiency and induced pyroptosis under near infrared(NIR)irradiation,which activated a potent antitumor immune *** importantly,the therapeutic system could induce tumor pyroptosis and enhance antitumor immune response by increasing T-cell infiltration and reducing the immune suppressive cells,when combined with local ICB therapy,which effectively avoided the tumor recurrence in a HNSCC postoperative mice ***,the newly developed multifunctional nanocomposites could be a promising candidate for the treatment of postoperative HNSCC.

关键词： head and neck squamous cell carcinoma(HNSCC) oxidized bacterial cellulose pyroptosis immunotherapy postoperative treatment

Cryogenic 3D Printing of Bacterial Cellulose—based Scaffolds for Tissue Engineering and Regenerative Medicine Applications

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Cryogenic 3D Printing of Bacterial Cellulose—based Scaffold...

In situ Development of Cellulose-Based Nanocomposites Using a Cell-Free System for Potential Biomedical Applications

中国化学会第一届全国纤维素学术研讨会

作者： muhammad wajid Ullah Manjila Adhikari Omar Mohammad Atta Vincent Ikenna Iloh Stezhka Yulia Guang Yang Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology

＜正＞Three—dimensional printing is an advanced and innovative technology that has received growing interest and revolutionized the tissue engineering and regenerative medicine fields. It refers to printing of bioink （i.e., viable cells and polymer solution） in a premeditated layer—by—layer stacking pattern. A bioink should demonstrate low viscosity, stiffness, and crosslinking,

关键词： Bacterial cellulose Bioink Cryogenic printing Characterization Biomedical Applications

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In situ Development of Cellulose-Based Nanocomposites Using ...

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

第十一届全国高聚物分子与结构表征学术研讨会

作者： muhammad wajid Ullah Omar Mohammad Atta Manjila Adhikari Vincent Ikenna Iloh Stezhka Yulia Guang Yang Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and Technology

＜正＞Bacterial cellulose has received immense considerations owing to its excellent structural, physico-chemical, mechanical, and biological properties. However, its broad spectrum applications have been limited by few limitations associated with its production and lack of antimicrobial, magnetic, antioxidant, and conducting properties and limited biocompatibility. The shortcomings associated with its production can be overcome by a cell-free system that offers several advantages compared to microbial system.

关键词： Cellulose Cell-free system Nanocomposites Characterization Antibacterial activity

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： K.muhammad M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： muhammad Junaid Eun Jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics