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Use of health-related quality of life tools in hepatobiliary surgery

Hepatobiliary & Pancreatic Diseases International 2008年第2期7卷 135-137页

作者： muhammad shafique sajid Mawara Iftikhar Jasmin Rimple Mirza Khurrum Baig Department of Surgery Worthing Hospital West Sussex BN11 2DH UK

BACKGROUND: The objective of this article is to review the literature and discuss the various tools used in hepatobiliary surgery for the measurement of health related quality of life (HR-QOL) and highlight various outcome variables that affect the HR-QOL among patients with common hepatobiliary disorders. DATA SOURCES: We reviewed HR-QOL articles published in the last 20 years on different hepatobiliary curative or palliative procedures in all languages. RESULTS: HR-QOL is a questionnaire tool which is utilized to assess the changes in the health status of patients after a hepatobiliary intervention. These surveys are of increasingly importance, as health care providers are challenged to justify treatment approaches and rationale for any surgical intervention. These HR-QOL tools are very helpful for the evaluation of subjective outcome of common hepatobiliary procedures like gastrointestinal quality of life index (GIQLI) for cholecystectomy, functional assessment in cancer therapy (FACT) for liver resection, short form 36 (SF-36) for liver transplantation, and quality of life questionnaire for patients with pancreatic cancer (QLQ-PAN). CONCLUSIONS: Use of validated and reliable health instruments in hepatobiliary surgery is directed at measuring the impact in a reproducible and valid fashion. Curative or palliative procedures should be offered to the patients of hepatobiliary disorders after the assessment by HR-QOL tools. Because the impairments of function that may occur after different operations vary considerably, an operation-specific assessment of HR-QOL for each type of surgical procedure is becoming an essential principle to follow in a successful healthcare system.

关键词： quality of life questionnaire hepatobiliary surgery hepatectomy

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Use of transanal minimally invasive surgery for endoscopic resection of rectal tumour:a technical note

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Gastroenterology Report 2015年第3期3卷 266-267页

作者： muhammad shafique sajid muhammad I.Bhatti MK Baigand William F.A.Miles Department of General Laparoscopic and Endoscopic Colorectal SurgeryWestern Sussex Hospitals NHS TrustWorthing HospitalUK Department of General Surgery Queen Elizabeth HospitalKing’s Lynn NHS Foundation TrustUK

Background:The aim of this article is to report and discuss a case of lower rectal cancer undergoing endoscopic transanal resection of tumour(ETART)using a transanal minimally invasive surgery(TAMIS)***:A technical note on a case *** innovative approach for ETART using ***:This is the first-ever case report of lower rectal cancer treated by ETART using a TAMIS *** procedure was completed successfully without any operative or peri-operative ***-operative flexible sigmoidoscopy confirmed a wide and patent rectal ***:Use of a TAMIS approach for ETART to remove lower rectal cancer for palliation can be technically very effective compared with conventional ETART,due to the potential advantages of avoiding contaminant fluid spillage,easy access,better visualization compared with conventional ETART,and being *** results from larger cohorts of patients undergoing TAMIS ETART are required before recommending the routine use of this ***,until then,this approach may be considered as an alternative to conventional ETART.

关键词： Rectal cancer endoscopic transanal resection of tumour(ETART) transanal minimally invasive surgery(TAMIS)

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Systematic review and meta-analysis of published randomized controlled trials comparing purse-string vs conventional linear closure of the wound following ileostomy(stoma)closure

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Gastroenterology Report 2015年第2期3卷 156-161页

作者： muhammad shafique sajid muhammad I.Bhatti William FA.Miles Department of General Endoscopic&Laparoscopic Colorectal SurgeryWestern Sussex Hospitals NHS Foundation TrustWorthing HospitalUK Department of General&Colorectal Surgery Queen Elizabeth Hospital King’s Lynn NHS Foundation TrustUK

Objective:The objective of this article is to systematically analyse the randomized,controlled trials comparing the effectiveness of purse-string closure(PSC)of an ileostomy wound with conventional linear closure(CLC).Methods:Randomized,controlled trials comparing the effectiveness of purse-string closure vs conventional linear closure(CLC)of ileostomy wound in patients undergoing ileostomy closure were analysed using RevMan-,and the combined outcomes were expressed as risk ratio(RR)and standardized mean difference(SMD).Results:Three randomized,controlled trials,recruiting 206 patients,were retrieved from medical electronic *** were 105 patients in the PSC group and 101 patients in the CLC *** was no heterogeneity among included *** of operation(SMD:-0.18;95%CI:-0.45,0.09;z=1.28;P<0.20)and length of hospital stay(SMD:0.01;95%CI:-0.26,0.28;z=0.07;P<0.95)was statistically similar following both approaches of ileostomy wound *** risk of surgical site infection(OR,0.10;95%CI:0.03,0.33;z=3.78;P<0.0001)was significantly reduced when ileostomy wound was closed using PSC ***:PSC technique for ileostomy wound is associated with a reduced risk of surgical site infection apparently without influencing the duration of operation and length of hospital stay.

关键词： stoma closure ileostomy closure purse-string wound closure linear wound closure

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Systematic review of oncological outcomes following laparoscopic vs open total mesorectal excision

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World Journal of Gastrointestinal Endoscopy 2014年第5期6卷 209-219页

作者： muhammad shafique sajid Adil Ahamd William FA Miles Mirza Khurrum Baig Department of General Endoscopic and Laparoscopic Colorectal Surgery Western Sussex Hospitals NHS Trust Worthing Hospital

AIM: To systematically analyze the randomized trials comparing the oncological and clinical effectiveness of laparoscopic total mesorectal excision(LTME) vs open total mesorectal excision(OTME) in the management of rectal ***: Published randomized, controlled trials comparing the oncological and clinical effectiveness of LTME vs OTME in the management of rectal cancer were retrieved from the standard electronic medical databases. The data of included randomized, controlled trials was extracted and then analyzed according to the principles of meta-analysis using RevMan? statistical software. The combined outcome of the binary variables was expressed as odds ratio(OR) and the combined outcome of the continuous variables waspresented in the form of standardized mean difference(SMD). RESULTS: Data from eleven randomized, controlled trials on 2143 patients were retrieved from the electronic databases. There was a trend towards the higher risk of surgical site infection(OR = 0.66; 95%CI: 0.44-1.00; z = 1.94; P < 0.05), higher risk of incomplete total mesorectal resection(OR = 0.62; 95%CI: 0.43-0.91; z = 2.49; P < 0.01) and prolonged length of hospital stay(SMD,-1.59; 95%CI:-0.86--0.25; z = 4.22; P < 0.00001) following OTME. However, the oncological outcomes like number of harvested lymph nodes, tumour recurrence and risk of positive resection margins were statistically similar in both groups. In addition, the clinical outcomes such as operative complications, anastomotic leak and all-cause mortality were comparable between both approaches of mesorectal ***: LTME appears to have clinically and oncologically measurable advantages over OTME in patients with primary rectal cancer in both short term and long term follow ups.

关键词： Total mesorectal excision Anterior resection Abdominoperineal resection Rectal cancer Oncological outcomes

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Graphene photodetectors integrated with silicon and perovskite quantum dots

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Microsystems & Nanoengineering 2024年第3期10卷 21-33页

作者： Kashif Abbas Peirui Ji Naveed Ullah Shareen shafique Ze Zhang muhammad Faizan Ameer Shenghan Qin Shuming Yang State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Microelectronic Science and Engineering Laboratory of Clean Energy Storage and ConversionSchool of Physical Science and TechnologyNingbo Collaborative Innovation Center of Nonlinear Calamity System of Ocean and AtmosphereNingbo UniversityNingbo 315211China

Photodetectors(PDs)play a crucial role in imaging,sensing,communication systems,***(Gr),a leading two-dimensional material,has demonstrated significant potential for photodetection in recent ***,its relatively weak interaction with light poses challenges for practical *** integration of silicon(Si)and perovskite quantum dots(PQDs)has opened new avenues for Gr in the realm of next-generation *** review provides a comprehensive investigation of Gr/Si Schottky junction PDs and Gr/PQD hybrid PDs as well as their *** operating principles,design,fabrication,optimization strategies,and typical applications of these devices are studied and *** these discussions,we aim to illuminate the current challenges and offer insights into future directions in this rapidly evolving field.

关键词： quantum discussions summarized

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Numerical Analysis of Bacterial Meningitis Stochastic Delayed Epidemic Model through Computational Methods

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 311-329页

作者： Umar shafique Mohamed Mahyoub Al-Shamiri Ali Raza Emad Fadhal muhammad Rafiq Nauman Ahmed Department of Mathematics National College of Business Administration and EconomicsLahore54660Pakistan Department of Mathematics Applied CollegeMahayl AssirKing Khalid UniversityAbha62529Saudi Arabia Department of Physical Sciences The University of ChenabGujrat50700Pakistan Department of Mathematics&Statistics College of ScienceKing Faisal UniversityP.O.Box 400Al-Ahsa31982Saudi Arabia Department of Computer Science and Mathematics Lebanese American UniversityBeirut1102-2801Lebanon Department of Mathematics Faculty of Science and TechnologyUniversity of Central PunjabLahore54000Pakistan Department of Mathematics and Statistics University of LahoreLahore54000Pakistan

Based on theWorld Health Organization(WHO),Meningitis is a severe infection of the meninges,the membranes covering the brain and spinal *** is a devastating disease and remains a significant public health *** study investigates a bacterial meningitis model through deterministic and stochastic ***-compartment population dynamics explain the concept,particularly the susceptible population,carrier,infected,and *** model predicts the nonnegative equilibrium points and reproduction number,i.e.,the Meningitis-Free Equilibrium(MFE),and Meningitis-Existing Equilibrium(MEE).For the stochastic version of the existing deterministicmodel,the twomethodologies studied are transition probabilities and non-parametric ***,positivity,boundedness,extinction,and disease persistence are studiedrigorouslywiththe helpofwell-known *** and nonstandard techniques such as EulerMaruyama,stochastic Euler,stochastic Runge Kutta,and stochastic nonstandard finite difference in the sense of delay have been presented for computational analysis of the stochastic ***,standard methods fail to restore the biological properties of the model,so the stochastic nonstandard finite difference approximation is offered as an efficient,low-cost,and independent of time step *** addition,the convergence,local,and global stability around the equilibria of the nonstandard computational method is studied by assuming the perturbation effect is *** simulations and comparison of the methods are presented to support the theoretical results and for the best visualization of results.

关键词： Bacterial Meningitis disease stochastic delayed model stability analysis extinction and persistence computational methods

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A Framework to Assess Possible Sources of Stakeholder Exploitation:A Developing Country Case

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International Journal of Disaster Risk Science 2024年第1期15卷 32-44页

作者： Kamran shafique Syed Shams Tapan Sarker School of Business University of Southern QueenslandSpringfeldQLD 4300Australia Business School University of QueenslandSt LuciaQLD 4072Australia

Solving complex post-disaster reconstruction challenges requires the altruistic involvement of heterogeneous stakeholder ***,small,more organized groups,such as government parastatals,private developers,and contractors often exploit large,unorganized groups,such as affected communities,leaving them more vulnerable to future *** on data collected from a case study in Pakistan,this study proposed a framework to assess,anticipate,and mitigate the exploitation of vulnerable stakeholders in post-disaster reconstruction *** framework draws on influential management theories and utilizes reciprocal relationships between stakeholder attributes(power,legitimacy,and urgency),participation,and *** study also argued for non-binary treatment of stakeholder *** framework will allow practitioners to address issues around the exploitation of stakeholder interests in future post-disaster reconstruction projects.

关键词： Collective action Pakistan Post-disaster reconstruction-Stakeholder participation Stakeholder exploitation

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A novel medical image data protection scheme for smart healthcare system

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 821-836页

作者： Mujeeb Ur Rehman Arslan shafique muhammad Shahbaz Khan Maha Driss Wadii Boulila Yazeed Yasin Ghadi Suresh Babu Changalasetty Majed Alhaisoni Jawad Ahmad School of Computer Science and Informatics Cyber Technology InstituteDe Montfort UniversityLeicesterUK Department of Biomedical Engineering University of GlasgowGlasgowUK School of Computing Engineering and the Built EnvironmentEdinburgh Napier UniversityEdinburghUK Robotics and Internet‐of‐Things Laboratory Prince Sultan UniversityRiyadhSaudi Arabia Department of Computer Science Al Ain UniversityAl AinUnited Arab Emirates Department of Computer Engineering College of Computer Science King Khalid UniversityAbhaSaudi Arabia Computer Sciences Department College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadhSaudi Arabia

The Internet of Multimedia Things(IoMT)refers to a network of interconnected multimedia devices that communicate with each other over the ***,smart healthcare has emerged as a significant application of the IoMT,particularly in the context of knowledge‐based learning *** healthcare systems leverage knowledge‐based learning to become more context‐aware,adaptable,and auditable while maintain-ing the ability to learn from historical *** smart healthcare systems,devices capture images,such as X‐rays,Magnetic Resonance *** security and integrity of these images are crucial for the databases used in knowledge‐based learning systems to foster structured decision‐making and enhance the learning abilities of ***,in knowledge‐driven systems,the storage and transmission of HD medical images exert a burden on the limited bandwidth of the communication channel,leading to data trans-mission *** address the security and latency concerns,this paper presents a lightweight medical image encryption scheme utilising bit‐plane decomposition and chaos *** results of the experiment yield entropy,energy,and correlation values of 7.999,0.0156,and 0.0001,*** validates the effectiveness of the encryption system proposed in this paper,which offers high‐quality encryption,a large key space,key sensitivity,and resistance to statistical attacks.

关键词： data analysis medical image processing security

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Factors influencing the diagnostic accuracy and management in acute surgical patients

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World Journal of Gastrointestinal Surgery 2014年第11期6卷 229-234页

作者： muhammad shafique sajid William FA Miles Thaddeus Hollingsworth Mike Mc Glue Department of General Laparoscopic and Endoscopic Colorectal SurgeryWestern Sussex Hospitals NHS Foundation TrustWorthing Hospital Worthing West Sussex BN11 2DHUnited Kingdom The American University of the Caribbean School of Medicine FL 33134United States

AIM:To evaluate the diagnostic accuracy(DA) in acute surgical patients admitted to a District General ***: The case notes of all acute surgical patients admitted under the surgical team for a period of two weeks were reviewed for the data pertaining to the admission diagnoses, relevant investigations and final diagnoses confirmed by either surgery or various other diagnostic modalities. The diagnostic pathway was recorded from the source of referral [general practitioner(GP), A and E, in-patient] to the correct final diagnosis by the surgical team. RESULTS: Forty-one patients(23 males) with acute surgical admissions during two weeks of study period were evaluated. The mean age of study group was 61.05 ± 23.24 years. There were 111 patient-doctor encounters. Final correct diagnosis was achieved in 85.4% patients. The DA was 46%, 44%, 50%, 33%,61%, 61%, and 75% by GP, A and E, in-patient referral, surgical foundation year-1, surgical senior house officer(SHO), surgical registrar, and surgical consultant respectively. The percentage of clinical consensus diagnosis was 12%. Surgery was performed in 48.8% of patients. Sixty-seven percent of GP-referred patients, 31% of A and E-referred, and 25% of the in-patient referrals underwent surgery. Surgical SHO made the most contributions to the primary diagnostic ***: Approximately 85% of acute surgical patients can be diagnosed accurately along the diagnostic pathway. Patients referred by a GP are more likely to require surgery as compared to other referral sources. Surgical consultant was more likely to make correct surgical diagnosis, however it is the surgical SHO that contributes the most correct diagnoses along the diagnostic pathway.

关键词： Diagnostic accuracy Diagnostic error Misdiagnosis Premature closure

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Focus on current and emerging treatment options for glioma:A comprehensive review

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World Journal of Clinical Oncology 2024年第4期15卷 482-495页

作者： Brandon Lucke-Wold Burhanuddin Sohail Rangwala muhammad Ashir shafique Mohammad Arham Siddiq muhammad Saqlain Mustafa Fnu Danish Rana muhammad Umer Nasrullah Noor Zainab Abdul Haseeb Department of Neurosurgery University of FloridaGainesvilleFL 32608United States Department of Neurosurgery Jinnah Sindh Medical UniversityKarachi 75510Pakistan Department of Neurosurgery Army Medical CollegeRawalpindi 46000Pakistan

This comprehensive review delves into the current updates and challenges associated with the management of low-grade gliomas(LGG),the predominant primary tumors in the central nervous *** a general incidence rate of 5.81 per 100000,gliomas pose a significant global concern,necessitating advancements in treatment techniques to reduce mortality and *** review places a particular focus on immunotherapies,discussing promising agents such as Zotiraciclib and ***,a CDK9 inhibitor,has demonstrated efficacy in glioblastoma treatment in preclinical and clinical studies,showing its potential as a therapeutic ***,a viral immunotherapy,induces inflammation in glioblastoma and displays positive outcomes in both adult and pediatric *** of immunotherapy extends to Pembrolizumab,Nivolumab,and Entrectinib,revealing the challenges and variabilities in patient *** promising preclinical data,the monoclonal antibody Depatuxizumab has proven ineffective in glioblastoma treatment,emphasizing the critical need to understand resistance *** review also covers the success of radiation therapy in pediatric LGG,with evolving techniques,such as proton therapy,showing potential improvements in patient quality of *** treatment is discussed in the context of achieving a balance between preserving the patient’s quality of life and attaining gross total resection,with the extent of surgical resection significantly influencing the survival *** addition to advancements in cancer vaccine development,this review highlights the evolving landscape of LGG treatment,emphasizing a shift toward personalized and targeted *** research is essential for refining strategies and enhancing outcomes in the management of LGG.

关键词： Low-grade gliomas Monoclonal antibody Lerapolturev Glioblastoma CDK9 inhibitor

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