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CapsNet-FR: Capsule Networks for Improved Recognition of Facial Features

Computers, Materials & Continua 2024年第5期79卷 2169-2186页

作者： Mahmood Ul Haq muhammad athar javed sethi Najib Ben Aoun Ala Saleh Alluhaidan Sadique Ahmad Zahid farid Department of Computer System Engineering University of Engineering&TechnologyPeshawar25000Pakistan College of Computer Science and Information Technology Al-Baha UniversityAlaqiq65779-7738Saudi Arabia REGIM-Lab:Research Groups in Intelligent Machines National School of Engineers of Sfax(ENIS)University of SfaxSfax3038Tunisia Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh84428Saudi Arabia EIAS:Data Science and Blockchain Laboratory College of Computer and Information SciencesPrince Sultan UniversityRiyadh11586Saudi Arabia Department of Computer Sciences Bahria University Karachi CampusKarachi541004Pakistan Department of Electrical Engineering Abasyn UniversityPeshawar25000Pakistan

Face recognition (FR) technology has numerous applications in artificial intelligence including biometrics, security,authentication, law enforcement, and surveillance. Deep learning (DL) models, notably convolutional neuralnetworks (CNNs), have shown promising results in the field of FR. However CNNs are easily fooled since theydo not encode position and orientation correlations between features. Hinton et al. envisioned Capsule Networksas a more robust design capable of retaining pose information and spatial correlations to recognize objects morelike the brain does. Lower-level capsules hold 8-dimensional vectors of attributes like position, hue, texture, andso on, which are routed to higher-level capsules via a new routing by agreement algorithm. This provides capsulenetworks with viewpoint invariance, which has previously evaded CNNs. This research presents a FR model basedon capsule networks that was tested using the LFW dataset, COMSATS face dataset, and own acquired photos usingcameras measuring 128 × 128 pixels, 40 × 40 pixels, and 30 × 30 pixels. The trained model outperforms state-ofthe-art algorithms, achieving 95.82% test accuracy and performing well on unseen faces that have been blurred orrotated. Additionally, the suggested model outperformed the recently released approaches on the COMSATS facedataset, achieving a high accuracy of 92.47%. Based on the results of this research as well as previous results, capsulenetworks perform better than deeper CNNs on unobserved altered data because of their special equivarianceproperties.

关键词： CapsNet face recognition artificial intelligence

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Sodium glucose cotransporter 2 inhibitors in the management of heart failure:Veni,Vidi,and Vici

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World Journal of Cardiology 2024年第10期16卷 550-563页

作者： Monika Bhandari Akshyaya Pradhan Pravesh Vishwakarma Abhishek Singh Rishi sethi Department of Cardiology King Georg’s Medical UniversityLucknow 226003Uttar PradeshIndia

Heart failure(HF)is a chronic disease associated with high morbidity and mortality ***-angiotensin-aldosterone system blockers(including angiotensin receptor/neprilysin inhibitors),beta-blockers,and mineralocorticoid receptor blockers remain the mainstay of pharmacotherapy for HF with reduced ejection fraction(HFrEF).However,despite the use of guideline-directed medical therapy,the mortality from HFrEF remains *** with preserved ejection fraction(HFpEF)comprises approximately half of the total incident HF cases;however,unlike HFrEF,there are no proven therapies for this *** glucose cotransporter-2 inhibitors(SGLT-2is)represent a new class of pharmacological agents approved for diabetes mellitus(DM)that inhibit SGLT-2 receptors in the kidney.A serendipitous finding from seminal trials of SGLT-2is in DM was the significant improvement in renal and cardiovascular(CV)*** importantly,the improvement in HF hospitalization(HHF)in the CV outcomes trials of SGLT-2is was *** mechanisms have been proposed for the pleiotropic effects of SGLT-2is beyond their glycemic ***,as patients with HF were not included in any of these trials,it can be considered as a primary ***,two landmark studies of SGLT-2is in patients with HFrEF,namely,an empagliflozin outcome trial in patients with chronic HF and a reduced ejection fraction(EMPEROR-Reduced)and dapagliflozin and prevention of adverse outcomes in HF(DAPA-HF),demonstrated significant improvement in HHF and CV mortality regardless of the presence of *** impressive results pitchforked these drugs as class I indications in patients with HFrEF across major ***,empagliflozin outcome trial in patients with chronic HF with preserved ejection fraction(EMPEROR-Preserved)and dapagliflozin evaluation to improve the lives of patients with preserved ejection fraction HF(DELIVER)trials successively confirmed that SGLT-2is also benefit patients w

关键词： Heart failure with preserved ejection fraction Gliflozins Diuresis Natriuresis N terminal-pro brain natriuretic peptide Heart failure hospitalization

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SQL or NoSQL—Practical Aspect and Rational behind Choosing Data Stores

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Journal of Computer and Communications 2024年第8期12卷 1-20页

作者： Sourabh sethi Sarah Panda Digital Experience Infosys Limited New York USA Research and Incubation Microsoft Inc. Seattle USA

Data storage solutions are a crucial aspect of any application, significantly impacting data management and system performance. This article explores the rationale behind utilizing both SQL and NoSQL databases, addressing key questions about when each type is preferable. The background emphasizes the importance of selecting the appropriate database technology to meet specific application requirements. The purpose of this research is to provide a comprehensive guide for choosing between SQL and NoSQL databases based on various factors, including workload characteristics, scalability needs, and consistency requirements. To achieve this, we examine different strategies for implementing SQL and NoSQL databases in large-scale distributed applications and systems. The research method involves a comparative analysis of the features, advantages, and limitations of both database types. We specifically focus on scenarios involving read-heavy versus write-heavy systems and the trade-offs between availability and consistency. The results of this research indicate that SQL databases, with their relational structure and ACID compliance, are ideal for applications requiring complex queries and data integrity. In contrast, NoSQL databases, offering schema flexibility and horizontal scalability, are better suited for managing extensive datasets and high-velocity data ingestion. In conclusion, the selection of a database depends on the specific needs of the application. SQL databases are preferred for transactional systems with complex relationships, while NoSQL databases excel in scenarios demanding flexibility and scalability. The study provides insights into hybrid approaches, leveraging both database types to optimize system performance.

关键词： SQLData Stores NO-SQLData Stores ACID BASE RUM Conjecture

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Transforming Digital Experiences: The Evolution of Digital Experience Platforms (DXPs) from Monoliths to Microservices: A Practical Guide

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Journal of Computer and Communications 2024年第2期12卷 142-155页

作者： Sourabh sethi Sarah Panda Infosys Limited New York NY USA Microsoft Inc. Seattle WA USA

The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures into Microservices, emphasizing business capability and subdomain decomposition. Concrete insights, challenges, and solutions encountered during this transformation process are presented. The research contributes valuable insights into the challenges and benefits of adopting Microservices in DXPs. Results highlight the importance of architectural patterns and strategic scaling dimensions for improved performance and scalability. The case study on Backbase’s Engagement Banking Platform showcases successful implementation, providing flexibility, integration, and efficient development in the evolving DXP landscape.

关键词： Digital Experience Platforms (DXPs) Microservices Software Evolution Distributed Systems Architectural Patterns

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Dosage and utilization of dexamethasone in the management of COVID-19: A critical review

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World Journal of Virology 2024年第3期13卷 107-114页

作者： Imran sethi Asim Shaikh Musa sethi Hira Khalid Chohan Sheraz Younus Syed A Khan Salim Surani Department of Critical Care Medicine Marion General HospitalMarionIN 46952United States Department of Medicine Aga Khan UniversityKarachi 74200SindhPakistan Department of Medicine Eman SchoolFishersIN 46038United States Department of Internal Medicine Dow University of Health ScienceKarachi 74200SindhPakistan Department of Hospital Medicine Franciscan HealthIndianapolisIN 46237United States Department of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine and Pharmacology Texas A and M UniversityCollege StationTX 77843United States

BACKGROUND The severe respiratory manifestations observed in severe coronavirus disease 2019(COVID-19)cases are often associated with an excessive inflammatory ***,a synthetic glucocorticoid,exerts its anti-inflammatory effects by inhibiting the transcription of pro-inflammatory genes and suppressing the activity of various immune *** mechanism has implications for mitigating the cytokine storm observed in severe COVID-19 *** on in the pandemic,the Recovery Collaborative working group showed a mortality benefit of using dexamethasone in decreasing mortality in patients with COVID-19 requiring respiratory ***,the optimal dosage of corticosteroids remains *** studies that compare different doses of dexamethasone in COVID-19 exist,but the results are *** To review the latest evidence regarding dosage,safety,and efficacy of dexamethasone in severe *** We followed preferred reporting items for systematic reviews and meta-analysis guidelines.A detailed literature search was conducted across PubMed,Google Scholar,and Medline to include publications up to March *** keywords included“COVID-19”“SARS-CoV-2”“dexamethasone”“corticosteroid”“steroid”and“glucocorticoid”-along with their *** employed the Cochrane Risk of Bias Tool and the Newcastle-Ottawa scale to evaluate the integrity and potential of bias in the included studies.A meta-analysis was conducted using a random-effects model,assessing pooled odds ratios and mean differences,with heterogeneity gauged by the I2 statistic and theχ^(2) *** No statistical differences were found in 28-day all-cause mortality[pooled odds ratio(OR)=1.109,95%CI:0.918-1.340],60-day all-cause mortality(OR=0.873,95%CI:0.744-1.024;I2=47.29%),mean length of hospital stay(mean difference=-0.08 days,95%CI:-0.001 to 0.161)and adverse events(OR=0.877,95%CI:0.707-1.087).CONCLUSION Differing doses of corticosteroids have no clinical implication

关键词： COVID-19 Steroids Corticosteroids Steroid dosage Critical care Corona virus

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Climate change and the emergence and exacerbation of infectious diseases:A review

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World Journal of Virology 2024年第4期13卷 24-30页

作者： Amal Ali Asim Shaikh Imran sethi Salim Surani Department of Medicine Aga Khan UniversityKarachi 74800SindhPakistan Department of Medicine Dow Medical CollegeKarachi 74200SindhPakistan Department of Critical Care Medicine Marion General HospitalMarionIN 46952United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States Department of Medicine Aga Khan UniversityNairobi 30270Nairobi CityKenya

Experts expressed severe concerns over the possibility of increasing burden of infectious diseases as the planet’s climate began to change years *** have been increased rates of climate-related catastrophes and as global temperatures rise,emergence of certain viruses has become a serious *** are susceptible to changing temperatures as they exhibit innate responses to thermal stress to increase *** change impacts virus reservoirs,increasing transmission rates of ***-borne diseases have already witnessed increasing numbers compared to *** non-endemic areas are encountering their first-ever infectious disease cases due to increasing ***-borne diseases are undergoing transformations provoking a heightened ***-borne illnesses are expected to increase owing to warmer *** is important to recognize that climate change has a multivariable impact on the transmission of *** climate change comes the potential of increasing interspecies interactions promoting *** factors must be considered,and an informed strategy must be *** and mitigation strategies are required to curb these diseases from *** significant evidence that climate change affects infectious diseases,gaps in research *** conducted this review to identify the potential role climate change plays in the emergence of new viruses.

关键词： Climate change Infectious disease Emergence Catastrophe Vector-borne disease

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Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman muhammad Aziz Ayrton Bangolo Vignesh K Nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali Rohan Kumar Priya Goyal Sanya Satheesha Fnu Nivedita Nicole Tesoro Tanni sethi Gurpreet Singh Areej Belal Alina Intisar Hirra Khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

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Efficacy of a Diabetes Specific Nutritional Supplement (DSNS) on Glycemic Response in Prediabetic Adults: A Two-Armed, Open-Labelled Randomized Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 612-643页

作者： Deepti Khanna Kejal Joshi Reddy Hema S. Gopalan Jaladhi Bhatt Jayanti Gupta Simran sethi Parth Joshi Manoj Pareek Department of R&D Hindustan Unilever Limited Gurugram India Mumbai India Cliantha Research Ahmedabad India

It is well known that Diabetes Specific Nutritional Supplements (DSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose Response (ABGR) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGR of DSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of DSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DSNS with lifestyle counselling (DSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). DSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that DSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： Diabetes Specific Nutritional Supplement Prediabetes Acute Blood Glucose Response Incremental Area under Curve Lifestyle Counselling

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Regional anesthesia for orthopedic procedures:What orthopedic surgeons need to know

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World Journal of Orthopedics 2022年第1期13卷 11-35页

作者： Ihab Kamel muhammad F Ahmed Anish sethi Department of Anesthesiology Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPA 19140United States

Regional anesthesia is an integral component of successful orthopedic *** anesthesia is commonly used for surgical anesthesia while peripheral nerve blocks are often used for postoperative *** evaluation for regional anesthesia should include neurological,pulmonary,cardiovascular,and hematological *** blocks include spinal,epidural,and combined spinal *** extremity peripheral nerve blocks include interscalene,supraclavicular,infraclavicular,and *** extremity peripheral nerve blocks include femoral nerve block,saphenous nerve block,sciatic nerve block,iPACK block,ankle block and lumbar plexus *** choice of regional anesthesia is a unanimous decision made by the surgeon,the anesthesiologist,and the patient based on a risk-benefit *** choice of the regional block depends on patient cooperation,patient positing,operative structures,operative manipulation,tourniquet use and the impact of postoperative motor blockade on initiation of physical *** anesthesia is safe but has an inherent risk of failure and a relatively low incidence of complications such as local anesthetic systemic toxicity(LAST),nerve injury,falls,hematoma,infection and allergic *** should be used for regional anesthesia procedures to improve the efficacy and minimize *** treatment guidelines and rescue medications(intralipid)should be readily available during the regional anesthesia administration.

关键词： Orthopedic surgery Regional anesthesia Spinal Epidural Combined spinal epidural Peripheral nerve blocks Neuraxial blocks Upper extremity Lower extremity Interscalene Supraclavicular Infraclavicular Axillary Femoral Fascia iliaca Popliteal Sciatic Saphenous Adductor canal Lumbar plexus Brachial plexus Ankle iPACK Complication Local anesthetic systemic toxicity Nerve injury Block failure Continuous nerve block catheters

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Innovation in pathogenesis and management of aortic aneurysm

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World Journal of Experimental Medicine 2024年第2期14卷 35-45页

作者： Maryam Barkhordarian Hadrian Hoang-Vu Tran Aiswarya Menon Sai Priyanka Pulipaka Izage Kianifar Aguilar Axel Fuertes Shraboni Dey Angel Ann Chacko Tanni sethi Ayrton Bangolo Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States

Aortic aneurysm(AA)refers to the persistent dilatation of the aorta,exceeding three *** the pathophysiology of this condition is important for its prevention and management,given its responsibility for more than 25000 deaths in the United *** are classified based on their location or *** pathophysiologic pathways including inflammation,the immune system and atherosclerosis have been implicated in its *** markers such as transforming growth factorβ,interleukin-1β,tumor necrosis factor-α,matrix metalloproteinase-2 and many more may contribute to this *** genetic disorders such as Marfan syndrome,Ehler-Danlos syndrome and Loeys-Dietz syndrome have also been associated with this *** years has seen the investigation of novel management of AA,exploring the implication of different immune suppressors,the role of radiation in shrinkage and prevention,as well as minimally invasive and newly hypothesized surgical *** this narrative review,we aim to present the new contributing factors involved in pathophysiology of *** also highlighted the novel management methods that have demonstrated promising benefits in clinical outcomes of the AA.

关键词： Aortic aneurysm Abdominal aneurysm Thoracic aneurysm Immunotherapy Surgical management Pathophysiology Inflammation and molecular pathways

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