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Proteomics analysis of Trichoplusia ni midgut epithelial cell brush border membrane vesicles

Insect Science 2019年第3期26卷 424-440页

作者： muhammad afzal Javed Cathy Coutu David A. Theilmann Martin A. Erlandson Dwayne D. Hegedus Saskatoon Research and Development Centre Agriculture and Agri-Food Canada Saskatoon Saskatchewan Canada Summerland Research and Development Centre Agriculture and Agri-Food Canada Summerland British Columbia Canada Department of Food & Bio-Product Sciences University of Saskatchewan Saskatoon Saskatchewan Canada

The insect midgut epithelium is composed of columnar, goblet, and regenerative cells. Columnar epithelial cells are the most abundant and have membrane protrusions that form the brush border membrane (BBM) on their apical side. These increase surface area available for the transport of nutrients, but also provide opportunities for interaction with xenobiotics such as pathogens, toxins and host plant allelochemicals. Recent improvements in proteomic and bioinfbrmatics tools provided an opportunity to determine the proteome of the T. ni BBM in unprecedented detail. This study reports the identification of proteins from BBM vesicles (BBMVs) using single dimension polyacrylamide gel elec? trophoresis coupled with multi-dimensional protein identification technology. More than 3000 proteins were associated with the BBMV of which 697 were predicted to possess either a signal peptide, at least one transmembrane domain or a GPI-anchor signal. Of these, bioinfbrmatics analysis and manual curation predicted that 185 may be associated with the BBMV or epithelial cell plasma membrane. These are discussed with respect to their predicted functions, namely digestion, nutrient uptake, cell signaling, development, cell-cell interactions, and other functions. We believe this to be the most detailed proteomic analysis of the lepidopteran midgut epithelium membrane to date, which will provide information to better understand the biochemical, physiological and pathological processes taking place in the larval midgut.

关键词： brush border membrane vesicles midgut proteomic analysis Trichoplusiani

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SwCS: Section-Wise Content Similarity Approach to Exploit Scientific Big Data

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Computers, Materials & Continua 2021年第4期67卷 877-894页

作者： Kashif Irshad muhammad Tanvir afzal Sanam Shahla Rizvi Abdul Shahid Rabia Riaz Tae-Sun Chung Department of Computer Science Capital University of Science and TechnologyIslamabadPakistan Department of Computer Science NAMAL InstituteMianwali42250Pakistan Raptor Interactive(Pty)Ltd. Eco BoulevardWitch Hazel AveCenturion0157South Africa Institute of Computing Kohat University of Science and TechnologyPakistan Department of CS&IT University of Azad Jammu and KashmirMuzaffarabad13100Pakistan Department of Artificial Intelligence Ajou UniversityKorea

The growing collection of scientific data in various web repositories is referred to as Scientific Big Data,as it fulfills the four“V’s”of Big Data—volume,variety,velocity,and *** phenomenon has created new opportunities for startups;for instance,the extraction of pertinent research papers from enormous knowledge repositories using certain innovative methods has become an important task for researchers and ***,the content of the papers are compared to list the relevant papers from a *** conventional method results in a long list of papers that is often impossible to interpret ***,the need for a novel approach that intelligently utilizes the available data is ***,the primary element of the scientific knowledge base is a research article,which consists of various logical sections such as the Abstract,Introduction,Related Work,Methodology,Results,and ***,this study utilizes these logical sections of research articles,because they hold significant potential in finding relevant *** this study,comprehensive experiments were performed to determine the role of the logical sections-based terms indexing method in improving the quality of results(i.e.,retrieving relevant papers).Therefore,we proposed,implemented,and evaluated the logical sections-based content comparisons method to address the research objective with a standard method of indexing *** section-based approach outperformed the standard content-based approach in identifying relevant documents from all classified topics of computer ***,the proposed approach extracted 14%more relevant results from the entire *** the experimental results suggested that employing a finer content similarity technique improved the quality of results,the proposed approach has led the foundation of knowledge-based startups.

关键词： Scientific big data ACM classification term indexing content similarity cosine similarity

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On the Reducibility of a Class of Linear Almost Periodic Differential Equations

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Communications in Mathematical Research 2019年第1期35卷 1-9页

作者： afzal muhammad Guo Shu-zheng Li Yong School of Mathematical Sciences Ocean University of ChinaQingdaoShandong266100 不详

In this paper, we use KAM methods to prove that there are positive measure Cantor sets such that for small perturbation parameters in these Cantor sets a class of almost periodic linear differential equations are redu... 详细信息

关键词： almost periodic reducibility KAM iteration

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Mini-organs with big impact:Organoids in liver cancer studies

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Oncology Research 2023年第5期31卷 677-688页

作者： muhammad BABAR KHAWAR YAJUN WANG ANEEQA MAJEED ALI afzal KABEER HANEEF HAIBO SUN Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhouChina Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research YangzhouChina Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowalPakistan Department of Oncology Haian Hospital of Traditional Chinese MedicineHaianChina Molecular Medicine and Cancer Therapeutics Lab Department of ZoologyFaculty of Sciences TechnologyUniversity of Central PunjabLahorePakistan Chinese Institute for Brain Research(CIBR) BeijingChina

Hepatocellular carcinoma,the most common primary liver cancer and a leading cause of death,is a difficult disease to treat due to its heterogeneous *** models,such as 2D culture and patient-derived xenografts,have not proven ***,the development of 3D culture techniques,such as organoids,which can mimic the tumor microenvironment(TME)and preserve heterogeneity and pathophysiological properties of tumor cells,offers new opportunities for treatment and *** also have the potential for biomarker detection and personalized medication,as well as genome editing using CRISPR/Cas9 to study the behavior of certain genes and therapeutic *** review explores to-the-date development of organoids with a focus on TME modeling in 3D organoid ***,it discusses gene editing using CRISPR/Cas9 in organoids,the challenges faced,and the prospects in the field of organoids.

关键词： Heterogeneity Tumor Organoid Liver Treatment Therapy

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Seed priming improves early seedling vigor, growth and productivity of spring maize

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Journal of Integrative Agriculture 2015年第9期14卷 1745-1754页

作者： Hafeez ur Rehman Hassan Iqbal Shahzad M A Basra Irfan afzal muhammad Farooq Abdul Wakeel WANG Ning Seed Physiology Laboratory Department of Crop PhysiologyUniversity of Agriculture Department of Agronomy University of Agriculture Institute of Soil and Environmental Sciences University of Agriculture Agricultural Information Institute Chinese Academy of Agricultural Sciences

Potential of seed priming treatments in improving the performance of early planted maize was evaluated against timely planting. Seeds of maize hybrid FH-810 were soaked in water (hydropriming), CaCl2 (2.2%, osmopriming), moringa leaf extracts (MLE 3.3%, osmopriming) and salicylic acid (SA, 50 mg L–1, hormonal priming) each for 18 h. Untreated and hydroprimed seeds were taken as control. Seeds primed with SA took less time in emergence and had high vigor in early planted maize. Amongst treatments, hormonal priming, reduced the electrical conductivity, increased the leaf relative and chlorophyl contents fol owed by osmopriming with CaCl2 at seedling stage. Likewise, plant height, grain rows and 1 000-grain weight, grain and biological yield and harvest index were also improved by seed priming;however hormonal priming and osmopriming with MLE were more effective in this regard. Improved yield performance by hormonal priming or osmopriming with MLE in early planting primarily owed to increased leaf area index, crop growth and net assimilation rates, and maintenance of green leaf area at maturity. In conclusion, osmopriming with MLE and hormonal priming with SA were the most economical treatments in improving productivity of early planted spring maize through stimulation of early seedling growth at low temperature.

关键词： low temperature membrane permeability organic stimulants moringa leaf extracts salicylic acid leaf area duration yield

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Noisy ECG Signal Data Transformation to Augment Classification Accuracy

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Computers, Materials & Continua 2022年第5期71卷 2191-2207页

作者： Iqra afzal Fiaz Majeed muhammad Usman Ali Shahzada Khurram Akber Abid Gardezi Shafiq Ahmad Saad Aladyan Almetwally M.Mostafa muhammad Shafiq Department of Information Technology University of GujratGujrat50700Pakistan Department of Computer Science University of GujratGujrat50700Pakistan Faculty of Computing The Islamia University of BahawalpurBahawalpur63100Pakistan Department of Computer Science COMSATS University IslamabadIslamabadPakistan Industrial Engineering Department College of EngineeringKing Saud UniversityP.O.Box 800Riyadh 11421Saudi Arabia Department of Information Systems College of Computer and Information SciencesKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38541Korea

In this era of electronic health,healthcare data is very important because it contains information about human *** addition,the Internet of Things(IoT)revolution has redefined modern healthcare systems and management by providing continuous *** this case,the data related to the heart is more important and requires proper *** the analysis of heart data,Electrocardiogram(ECG)is *** this work,machine learning techniques,such as adaptive boosting(AdaBoost)is used for detecting normal sinus rhythm,atrial fibrillation(AF),and noise in ECG signals to improve the classification *** proposed model uses ECG signals as input and provides results in the form of the presence or absence of disease AF,and classifies other signals as normal,other,or *** article derives different features from the signal using Maximal Information Coefficient(MIC)and minimum Redundancy Maximum Relevance(mRMR)technique,and then classifies them based on their *** the ECG contains some kind of noise and irregular data streams so the purpose of this study is to remove artifacts from the ECG signal by deploying the method of Second-Order-Section(SOS)(filter)and correctly classify *** features were extracted to improve the detection of ECG *** with existing methods,this work gives promising results and can help improve the classification accuracy of the ECG signals.

关键词： ECG atrial fibrillation adaptive boosting heart rate variability

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Anxiolytic potential of ursolic acid derivative-a stearoyl glucoside isolated from Lantana camara L.(verbanaceae)

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Asian Pacific Journal of Tropical Medicine 2013年第6期6卷 433-437页

作者： Imran Kazmi muhammad afzal Babar Ali Zoheir A.Damanhouri Aftab Ahmaol Firoz Anwar Siddhartha Institute of Pharmacy Dehra DunUttarakhand.India Buraydah Colleges College of Dental Medicines and PharmacyBuraydahAl-QassimP.O.31717Saudia Arabia Department of Pharmacology Faculty of MedicineKing Abdulaziz University.Jeddah.Saudi Arabia Health Information Technology Department Jeddah Community CollegeKing Abdulaziz UniversityJeddah 21589Kingdom of Saudi Arabia

Objective:To investigate the anxiolytic activity of newly isolated compound by our lab called ursolic acid stearoyl glucoside(UASG) from the leaves of Lantana camam(L camam).Methods: Column chromatography was used to isolate *** potential was experimentally proved and demonstrated through Elevated plus-maze,Open field and light and dark test. Results:The UASG showed marked increased in time spent(%) and number of frequent movements made by animals in open arm of elevated plus-maze *** light and dark model,UASG produced marked increase in time spent by animal,number of crossing and reduced duration of immobility in light ***:UASG showed significant increase in number of rearing,assisted rearing and number of square crossed in open field established test *** showed its anxiolytic effect in dose dependent manner.

关键词： Lantana camara USAG CNS disorder Anxiolytic

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Seed Priming Influence on Early Crop Growth, Phenological Development and Yield Performance of Linola (Linum usitatissimum L.)

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Journal of Integrative Agriculture 2014年第5期13卷 990-996页

作者： Hafeez ur Rehman muhammad Qaiser Nawaz Shahzad Maqsood Ahmed Basra Irfan afzal Azra Yasmeen Fayyaz ul-Hassan Seed Physiology Laboratory Department of Crop Physiology University of Agriculture Faisalabad Soil Salinity Research Institute Pindi Bhatian College of Agriculture Bahuddin Zakriya University Department of Agronomy PMAS University of Arid Agriculture

Reduced early crop growth and limited branching are amongst yield limiting factors of linola. Field response of seed priming treatments viz. 50 mmol L^-1 salicylic acid （SA）, 2.2% CaCl2 and 3.3% moringa leaf extract （MLE） including untreated dry and hydropriming controls was evaluated on early crop growth and yield performance of linola. Osmopriming with CaCl2 reduced emergence time and produced the highest seedling fresh and dry weights including Chl. a contents. Osmopriming with CaCl2 reduced crop branching and flowering and maturity times and had the maximum plant height, number of branches, tillers, pods and seeds per pod followed by MLE. Increase in seed weight, biological and seed yields was 9.30, 34.16 and 39.49%, harvest index （4.12%） and oil contents （13.39%） for CaCl2 osmopriming. Positive relationship between emergence and seedling vigor traits, 100-seed weight, seed yield with maturity time, 100-seed weight and seed yield were found. The study concludes that seed osmopriming with CaC12 or MLE can play significant role to improve early crop growth and seed yields of linola.

关键词： linseed oil quality stand establishment CaCl2

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An LSTM Based Forecasting for Major Stock Sectors Using COVID Sentiment

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Computers, Materials & Continua 2021年第4期67卷 1191-1206页

作者： Ayesha Jabeen Sitara afzal Muazzam Maqsood Irfan Mehmood Sadaf Yasmin muhammad Tabish Niaz Yunyoung Nam Department of Computer Science COMSATS University IslamabadAttock CampusPakistan Department of Media Design and Technology Faculty of Engineering&InformaticsUniversity of BradfordBradfordBD71AZUK Department of Smart Device Engineering School of Intelligent Mechatronics EngineeringSejong UniversitySeoulKorea Department of Computer Science&Engineering Soonchunhyang UniversityAsan36538Korea

Stock market forecasting is an important research area,especially for better business decision *** stock predictions continue to be significant for business *** short-term stock market forecasting is usually based on historical market data analysis such as stock prices,moving averages,or daily ***,major events’news also contains significant information regarding market *** effective stock market forecasting system helps investors and analysts to use supportive information regarding the future direction of the stock *** research proposes an efficient model for stock market *** current proposed study explores the positive and negative effects of coronavirus events on major stock sectors like the airline,pharmaceutical,e-commerce,technology,and *** use the Twitter dataset for calculating the coronavirus sentiment with a Long Short-Term Memory(LSTM)model to improve stock *** LSTM has the advantage of analyzing relationship between time-series data through memory *** performance of the system is evaluated by Mean Absolute Error(MAE),Mean Squared Error(MSE),and Root Mean Squared Error(RMSE).The results show that performance improves by using coronavirus event sentiments along with the LSTM prediction model.

关键词： Business intelligence decision making stock prediction long short-term memory COVID-19 event sentiment

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Electronic-property dependent interactions between tetracycline and graphene nanomaterials in aqueous solution

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Journal of Environmental Sciences 2018年第4期30卷 286-294页

作者： Lin He Fei-fei Liu Mengyao Zhao Zhen Qi Xuefei Sun muhammad Zaheer afzal Xiaomin Sun Yanhui Li Jingcheng Hao Shuguang Wang Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong University Insistute of Marine Science and Technology Shandong University Environment Research Institute Shandong University Laboratory of Fiber Materials and Modern Textile The Growing Base for State Key Laboratory Qingdao University Key Laboratory of Colloid and Interface Chemistry Ministry of Education Shandong University

Understanding the interactions between graphene nanomaterials（GNMs） and antibiotics in aqueous solution is critical to both the engineering applications of GNMs and the assessment of their potential impact on the fate and transport of antibiotics in the aquatic environment. In this study, adsorption of one common antibiotic, tetracycline, by graphene oxide（GO） and reduced graphene oxide（RGO） was examined with multi-walled carbon nanotubes（MWCNTs） and graphite as comparison. The results showed that the tetracycline adsorption capacity by the four selected carbonaceous materials on the unit mass basis followed an order of GO ＆gt; RGO ＆gt; MWCNTs ＆gt; graphite. Upon normalization by surface area,graphite, RGO and MWCNTs had almost the same high tetracycline adsorption affinity while GO exhibited the lowest. We proposed π-electron-property dependent interaction mechanisms to explain the observed different adsorption behaviors. Density functional theory（DFT） calculations suggested that the oxygen-containing functional groups on GO surface reduced its π-electron-donating ability, and thus decreased the π-based interactions between tetracycline and GO surface. Comparison of adsorption efficiency at different p H indicated that electrostatic interaction also played an important role in tetracycline-GO interactions. Site energy analysis confirmed a highly heterogeneous distribution of the binding sites and strong tetracycline binding affinity of GO surface.

关键词： Graphene oxide Reduced graphene oxide Tetracycline Adsorption DFT calculation π-Based interaction

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