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Bioengineering liver tissue by repopulation of decellularised scaffolds

World Journal of Hepatology 2023年第2期15卷 151-179页

作者： Zeeshan afzal Emmanuel Laurent Huguet Department of Surgery Addenbrookes HospitalNIHR Comprehensive Biomedical Research and Academic Health Sciences CentreCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom

Liver transplantation is the only curative therapy for end stage liver disease,but is limited by the organ shortage,and is associated with the adverse consequences of *** of decellularised whole organ scaffolds with appropriate cells of recipient origin offers a theoretically attractive solution,allowing reliable and timely organ sourcing without the need for *** methodologies vary widely but seek to address the conflicting objectives of removing the cellular component of tissues whilst keeping the 3D structure of the extra-cellular matrix intact,as well as retaining the instructive cell fate determining biochemicals contained *** scaffold recellularisation has progressed from small rodent in vitro studies to large animal in vivo perfusion models,using a wide range of cell types including primary cells,cell lines,foetal stem cells,and induced pluripotent stem *** these models,a limited but measurable degree of physiologically significant hepatocyte function has been reported with demonstrable ammonia metabolism in *** repopulation and function have been restricted by challenges relating to the culture and propagations of cholangiocytes,though advances in organoid culture may help address *** vasculature repopulation has enabled sustainable blood perfusion in vivo,but with cell types that would limit clinical applications,and which have not been shown to have the specific functions of liver sinusoidal endothelial *** cell groups such as Kupffer cells and stellate cells have not been *** by repopulation of decellularised scaffolds has significantly progressed,but there remain significant experimental challenges to be addressed before therapeutic applications may be envisaged.

关键词： Regenerative Bioengineering Scaffolds Liver Decellularisation Recellularisation

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Managing Health Treatment by Optimizing Complex Lab-Developed Test Configurations: A Health Informatics Perspective

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Computers, Materials & Continua 2023年第6期75卷 6251-6267页

作者： Uzma afzal Tariq Mahmood Ali Mustafa Qamar Ayaz H.Khan Department of Computer Science Federal Urdu University of Arts Science and TechnologyKarachiPakistan Department of Computer Science Institute of Business AdministrationKarachiPakistan Department of Computer Science College of ComputerQassim UniversityBuraydahSaudi Arabia Computer Engineering Department King Fahd University of Petroleum and MineralsDhahranSaudi Arabia SDAIA-KFUPM Joint Research Center for Artificial Intelligence Dhahran31261Saudi Arabia

A complex Laboratory Developed Test(LDT)is a clinical test developed within a single *** is typically configured from many fea-ture constraints from clinical repositories,which are part of the existing Lab-oratory Information Management System(LIMS).Although these clinical repositories are automated,support for managing patient information with test results of an LDT is also integrated within the existing ***,the support to configure LDTs design needs to be made available even in standard LIMS *** manual configuration of LDTs is a complex process and can generate configuration inconsistencies because many constraints between features can remain *** is a risky process and can lead patients to undergo unnecessary *** proposed an optimized solution(opt-LDT)based on Genetic Algorithms to automate the configuration and resolve the inconsistencies in ***-LDT encodes LDT configuration as an optimization problem and generates a consistent configuration that satisfies the constraints of the *** tested and validated opt-LDT for a local secondary care hospital in a real healthcare *** results,averaged over ten runs,show that opt-LDT resolves 90%of inconsistencies while taking between 6 and 6.5 s for each ***,positive feedback based on a subjective questionnaire from clinicians regarding the performance,acceptability,and efficiency of opt-LDT motivates us to present our results for regulatory approval.

关键词： Artificial intelligence health informatics evolutionary algorithms genetic algorithms feature selection laboratory developed test

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Impact of marshy area reclamation by various vegetations on soil-nematode community structure in Dachigam National Park

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Soil Ecology Letters 2023年第3期5卷 123-133页

作者： Humira Nesar Shahid afzal Zarrin Imran Wasim Ahmad Nematode Biodiversity Research Lab Department of ZoologyAligarh Muslim UniversityAligarh 202002India

Marshy areas are ecologically important and sensitive areas which are under immense pressure,such as reclamation by various terrestrial ***,how these vegetation types disrupt the stability of nematode community is *** present study determined how the soil nematode community responded to shifting environmental states by using nematode abundances,nematode indices and metabolic footprints as *** this context,we selected three types of reclaimed vegetation around a marshy land(MR)in Dachigam National Park,Kashmir,which includes grassland(GL),forest(FR)and cropland(CL)to investigate the soil nematode ***,Plectus,Eudorylaimus,and Aphelenchus proved more sensitive to reclamation *** revealed decrease in total nematode and bacterivore *** reduced diversity in CL,whereas no effect was observed in the GL and FR as compared to *** index indicated shift from fungal decomposition to bacterial decomposition pathway in *** nematode faunal profile depicted grassland(GL)as the most structured ecosystem compared to MR,FR,and *** results suggest that vegetation type regulates the structure,function,and stability of the soil food web,which has significant implications for managing the vegetation cover in a sustainable manner in the Dachigam National Park.

关键词： nematodes diversity vegetation habitat reclamation

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Effects of hooked-collar on the local scour around a lenticular bridge pier

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International Journal of Sediment Research 2023年第1期38卷 1-11页

作者： Rashid Farooq Amir Hossein Azimi muh.mmad Atiq Ur Rehman Tariq afzal Ahmed Department of Civil Engineering International Islamic University Department of Civil Engineering Lakehead University College of Engineering and Science Victoria University Department of Civil Engineering University of Engineering and Technology James Watt School of Engineering University of Glasgow

This paper presents the results of comprehensive laboratory experiments to investigate the effects of hooked-collar on the scour development around a vertical pier with a lenticular cross section. The flow around the pier was uniform, steady, and under the clear-water condition. The axial scour profiles for cases without and with a lenticular hooked-collar were measured and the effects of hooked-collar dimensions and elevation from the bed were examined. To compute the efficiency of hooked-collar for scour prevention, the results of local scour for a bridge pier without a collar and a bridge pier with a plain collar, without a hooked wall, were used as benchmark data sets. A wide range of hooked-collar geometries such as the ratio of collar width to the pier width, Wc/Wp, ranging from 1.5 to 3.5, the ratio of hooked-collar wall height to the pier width, Hc/Wp, ranging from 0.15 to 0.6, and the ratio of collar elevation to the pier width, Ec/Wp, of-0.5, 0, and 0.5 were tested. The experimental results indicated that the equilibrium scour depth decreased with the ratio of hooked-collar to the pier width when Wcis twice the pier width, Wp. For Wc/Wp> 2, the scour depth was similar to the tests with an infinitely large pier width. In addition, the scour depth consistently reduced as the hooked-collar wall height, Hc, to the pier width, Wp, approached 0.3. The highest scour reduction efficiency was achieved when the hooked-collar being placed on the bed surface. Empirical models were developed for prediction of maximum scour depth near the lenticular bridge pier with a modified collar. The results showed that the volume of scour hole around a lenticular pier increased non-linearly with the maximum scour depth and it was independent of the hooked-collar geometry.

关键词： Local scour Erosion Collar Hooked-collar Lenticular pier Scour countermeasure Steady flow

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Catalyst-free ultrasound assisted novel one pot pseudo five component synthesis of aryl-bis-[1H-pyrazol-5-ol-4-yl]methanes,het(aryl)-bis-[1H-pyrazol-5-ol-4-yl]methanes and their 1-phenyl derivatives in aqueous medium

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Green Synthesis and Catalysis 2022年第2期3卷 190-193页

作者： Sudha S Mohamed afzal Pasha Department of Chemistry and Biochemistry Jyoti Nivas College AutonomousBengaluru 560095India Department of Studies in Chemistry Jnanabharathi CampusBangalore UniversityBengaluru 560056India

An efficient,catalyst-free and eco-friendly ultrasound-assisted novel one-pot pseudo-five-component synthesis of aryl-bis-[1H-pyrazol-5-ol-4yl]methanes,het(aryl)-bis-[1H-pyrazol-5-ol-4yl]methanes and their 1-phenyl derivatives in water is *** products were obtained in excellent yield in shorter duration with high purity,by simple *** synthetic methodology has been optimized and discussed herein.

关键词： Bis pyrozolyl-methanes Ethyl acetoacetate Aromatic/het(aryl)aldehydes Hydrazine/phenyl hydrazine One-pot multi-component synthesis Ultrasound

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Construction of oxygen defective ZnO/ZnFe_(2)O_(4) yolk-shell composite with photothermal effect for tetracycline degradation:Performance and mechanism insight

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Chinese Chemical Letters 2023年第1期34卷 452-456页

作者： Ke Zhang Hongyang Cao afzal Dar Danqing Li Lina Zhou Chuanyi Wang School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021China

Oxygen vacancy induced photothermal effect is of great significant but lack of adequate attentions for environmental *** this paper,green recyclable ZnO/ZnFe_(2)O_(4) with oxygen vacancy was prepared by a solvothermal-calcination *** UV-vis light capture ability of ZnO/ZnFe_(2)O_(4) microspheres is improved with the multiple light reflections due to the yolk-shell structure,and the oxygen vacancy expands the absorption range of photocatalyst and enhances photothermal *** optimized photocatalyst can heat the solution from room temperature to 70°C within 60 min of visible light illumination,and the light to heat conversion efficiency is achieved by 61.3%.Compared with the degradation efficiency at 20°C,photothermal catalysis achieves a stable degradation in 80 min,and the degradation efficiency is increased by 41.5%.This can be attributed to the fact that light induced thermal energy accelerates the migration of electrons and holes,and promotes the diffusion of free radicals by heating active centers in *** active species contributing to the degradation,in order of importance,are the superoxide radical,hydroxyl radical,hole and *** light-to-thermal assisted photocatalysis with ZnO/ZnFe_(2)O_(4) provides a new sight for the pollution control in the future practical applications.

关键词： Photocatalysis Photothermal Oxygen vacancy Yolk-shell Tetracycline

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Binary Oriented Feature Selection for Valid Product Derivation in Software Product Line

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Computers, Materials & Continua 2023年第9期76卷 3653-3670页

作者： muh.mmad Fezan afzal Imran Khan Javed Rashid Mubbashar Saddique Heba G.Mohamed Department of CS&SE International Islamic UniversityIslamabad44000Pakistan Information Technology Services University of OkaraOkara56300Pakistan Departmet of Computer Science MLC LabOkara56300Pakistan Department of Computer Science&Engineering University of Engineering&Technology LahoreNarowal CampusNarowal51601Pakistan Department of Electrical Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Software Product Line(SPL)is a group of software-intensive systems that share common and variable resources for developing a particular *** feature model is a tree-type structure used to manage SPL’s common and variable features with their different relations and problem of Crosstree Constraints(CTC).CTC problems exist in groups of common and variable features among the sub-tree of feature models more diverse in Internet of Things(IoT)devices because different Internet devices and protocols are ***,managing the CTC problem to achieve valid product configuration in IoT-based SPL is more complex,time-consuming,and ***,the CTC problem needs to be considered in previously proposed approaches such as Commonality VariabilityModeling of Features(COVAMOF)andGenarch+tool;therefore,invalid products are *** research has proposed a novel approach Binary Oriented Feature Selection Crosstree Constraints(BOFS-CTC),to find all possible valid products by selecting the features according to cardinality constraints and cross-tree constraint problems in the featuremodel of ***-CTC removes the invalid products at the early stage of feature selection for the product ***,this research developed the BOFS-CTC algorithm and applied it to,IoT-based feature *** findings of this research are that no relationship constraints and CTC violations occur and drive the valid feature product configurations for the application development by removing the invalid product *** accuracy of BOFS-CTC is measured by the integration sampling technique,where different valid product configurations are compared with the product configurations derived by BOFS-CTC and found 100%*** BOFS-CTC eliminates the testing cost and development effort of invalid SPL products.

关键词： Software product line feature model internet of things crosstree constraints variability management

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Acupuncture enhances brain function in patients with mild cognitive impairment: evidence from a functional-near infrared spectroscopy study

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Neural Regeneration Research 2022年第8期17卷 1850-1856页

作者： M.N.afzal Khan Usman Ghafoor Ho-Ryong Yoo Keum-Shik Hong School of Mechanical Engineering Pusan National UniversityBusanKorea Department of Neurology Disorders Dunsan HospitalDaejeon UniversityDaejeonKorea

Mild cognitive impairment(MCI)is a precursor to Alzheimer’s *** is imperative to develop a proper treatment for this neurological disease in the aging *** observational study investigated the effects of acupuncture therapy on MCI *** healthy individuals and eleven MCI patients were recruited for this ***-and deoxy-hemoglobin signals in the prefrontal cortex during working-memory tasks were monitored using functional near-infrared *** acupuncture treatment,working-memory experiments were conducted for healthy control(HC)and MCI groups(MCI-0),followed by 24 sessions of acupuncture for the MCI *** acupuncture sessions were initially carried out for 6 weeks(two sessions per week),after which experiments were performed again on the MCI group(MCI-1).This was followed by another set of acupuncture sessions that also lasted for 6 weeks,after which the experiments were repeated on the MCI group(MCI-2).Statistical analyses of the signals and classifications based on activation maps as well as temporal features were *** highest classification accuracies obtained using binary connectivity maps were 85.7%HC ***-0,69.5%HC ***-1,and 61.69%HC *** classification accuracies using the temporal features mean from 5 seconds to 28 seconds and maximum(i.e,max(5:28 seconds))values were 60.6%HC ***-0,56.9%HC ***-1,and 56.4%HC *** results reveal that there was a change in the temporal characteristics of the hemodynamic response of MCI patients due to *** was reflected by a reduction in the classification accuracy after the therapy,indicating that the patients’brain responses improved and became comparable to those of healthy subjects.A similar trend was reflected in the classification using the image *** results indicate that acupuncture can be used for the treatment of MCI patients.

关键词： acupuncture Alzheimer’s disease cognition convolutional neural network functional connectivity functional-near infrared spectroscopy hemodynamic response linear discriminant analysis mild cognitive impairment

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Multifaceted roles of extracellular RNAs in different diseases

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Military Medical Research 2023年第3期10卷 359-368页

作者： Abdullah muh.mmad sohail muh.mmad Babar Khawar Ali afzal Ali Hassan Sara Shahzaman Ahmed Ali Molecular Medicine and Cancer Therapeutics Lab Department of ZoologyFaculty of SciencesUniversity of Central PunjabLahorePakistan Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowalPakistan

Extracellular RNAs(exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There has been immense work carried out since the discovery of exRNAs in circulation and other biological fluids to catalog and determine whether exRNAs may be utilized as indicators for health and illness. In this review, we aim to understand the current state of exRNAs in relation to various diseases and their potential as biomarkers. We will also review current issues and challenges faced in using exRNAs, with clinical and lab trials, that can be used as viable markers for different diseases.

关键词： Extracellular RNAs(exRNAs) Extracellular vehicles(EVs) Cancer Biomarkers Exosomes

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The Relationship between Fe Mineralization and Magnetic Basement Faults using Multifractal Modeling in the Esfordi and Behabad Areas(BMD), Central Iran

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Acta Geologica Sinica(English Edition) 2022年第2期96卷 591-606页

作者： Masoumeh NABILOU Peyman afzal Mehran ARIAN Ahmad ADib Hassan KHEYROLLAHI Mohammad FOUDAZI Parviz ANSARIRAD Department of Earth Sciences Science and Research BranchIslamic Azad UniversityTehranIran Department of Petroleum and Mining Engineering South Tehran BranchIslamic Azad UniversityTehranIran Division of Airborne Geophysics Explorartion DepartmentGeological Survey of IranTehranIran Department of Geology Eslamshar BranchIslamic Azad UniversityTehranIran Farhangian University TehranIran

Multifractal modeling is a mathematical method for the separation of a high potential mineralized background from a non-mineralized background. The Concentration-Distance to Fault structures(C-DF) fractal model and the distribution of the known iron(Fe) deposits/mines seen in the Esfordi and Behabad 1:100,000 sheets from the Bafq region of central Iran are used to distinguish Fe mineralization based on their distance to magnetic basement structures and surface faults, separately, using airborne geophysical data and field surveys. Application of the C-DF fractal model for the classification of Fe mineralizations in the Esfordi and Behabad areas reveals that the main ones show a correlation with their distance from magnetic basement structures. Accordingly, the distances of Fe mineralizations with grades of Fe higher than 55%(43% < Fe ≤ 60%) are located at a distance of less than 1 km, whereas for surfacial faults with grades of 43% ≤ Fe ≤ 60%, the distances are 3162< DF ≤ 4365 m from the faults. Thus, there is a positive relationship between Fe mineralization and magnetic basement structures. Also, the proximity evidence of Precambrian high-grade Fe mineralization related to magnetic basement structures indicates syn-rifting tectonic events. Finally, this C-DF fractal model can be used for exploration of magmatic and hydrothermal ore deposits.

关键词： Fe mineralization prospecting Concentration-Distance to Fault model(C-DF) fractals Bafq Iran

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