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World Journal of Gastroenterology 2014年第28期20卷 9361-9373页

作者： Tara c mueller Marc A Burmeister Jeannine Bachmann Marc E Martignoni Department of Surgery University Hospital Rechts der IsarTechnical University of Munich Braun Melsungen AG/Department of Anesthesiology University Hospital Hamburg Eppendorf

cachexia is frequently described in patients with pancreatic ductal adenocarcinoma(PDAc)and is associated with reduced survival and quality of ***,the therapeutic options of this multi-factorial and complex syndrome are *** is due to the fact that,despite extensive preclinical and clinical research,the underlying pathological mechanisms leading to PDAc-associated cachexia are still not fully ***,there is still a lack of consensus on the definition of cachexia,which complicates the standardization of diagnosis and treatment as well as the analysis of the current *** order to provide an efficient therapy for cachexia,an early and reliable diagnosis and consistent monitoring is required,which can be challenging especially in obese *** many substances have been tested in clinical and preclinical settings,so far none of them have been proven to have a long-term effect in ameliorating cancer-associated ***,recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancerassociated cachexia and ultimately improve patients’*** this current review,we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer *** strategy consists of nutritional,dietary,pharmacological,physical and psychological methods.

关键词： cachexia Pancreatic neoplasms Nutritional support

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欧洲纳米级零价铁修复地下水的应用

水文地质工程地质技术方法动态 2013年第1期 1-7页

作者： Nicole c. mueller 葛秀珍(翻译) Technology and Society Laboratory Empa Swiss Federal Laboratories for Materials Science and Technology Lerchenfeldstrasse 5 9014 St Gallen Switzerland

目标：处理污染的土壤和主要被有机氯污染（有机溶剂和杀虫剂）、无机阴离子或者金属污染的地下水，纳米级零价铁（NZVI）作为一种新方案脱颖而出。本文对欧洲NZVI的应用进行了简短的概述，提出了美国对比现状。此外，还讨论了技术上差... 详细信息

目标：处理污染的土壤和主要被有机氯污染（有机溶剂和杀虫剂）、无机阴离子或者金属污染的地下水，纳米级零价铁（NZVI）作为一种新方案脱颖而出。本文对欧洲NZVI的应用进行了简短的概述，提出了美国对比现状。此外，还讨论了技术上差异的原因。方法：本文的结果是基于大量的文献资料的回顾和专家研讨会中，欧洲和美国专家的讨论结果。经验评价是以SWOT（优势、劣势、机会、威胁）分析为基础。结果：欧洲和美国在NZVI应用的范围和使用的技术类型上有显著差异。在欧洲，到目前为止，仅进行三次NZVI的大规模修复，而这些在美国却广泛地应用，但是在欧洲却寥寥无几。欧洲基于经济约束和预警态度，提出了NZVI对含水层修复是否具有成本效益的方法。NZVI商业化的调整主要包括非技术方面的诸如公众可能的反弹情绪，事实上，这一技术很大程度上不被执政领导、政府和网站所有者所了解，而且缺乏长期使用经验。结论：尽管存在这些问题，但是，在目前领域应用该方法去除污染物是有前景的。迄今为止，没有报告报道该方法使用对环境的重大负面影响。因此，在欧洲这些试验将有助于推动该技术的发展。

关键词：纳米级零价铁(NZVI) 修复地下水氯化烃类

纸浆纤维质淤泥栽凤尾菇的矿物质与重金属含量

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食用菌 1985年第5期 18-19页

作者： J.c.mueller 徐崇敬

引言 1983～84年,温哥华不列颠哥伦比亚研究中心,研究了如何用纸浆厂淤泥栽凤尾菇,且已达到商品生产阶段。由于是利用工业废弃物作栽培材料,菇农都担心凤尾菇会污染重金属。为此,对典型的漂白牛皮纸浆厂纤维质淤泥及用其栽培的凤尾菇进... 详细信息

引言 1983～84年,温哥华不列颠哥伦比亚研究中心,研究了如何用纸浆厂淤泥栽凤尾菇,且已达到商品生产阶段。由于是利用工业废弃物作栽培材料,菇农都担心凤尾菇会污染重金属。为此,对典型的漂白牛皮纸浆厂纤维质淤泥及用其栽培的凤尾菇进行了分析,以确定其矿物质及重金属含量。本文总结了分析数据并进行了比较。

关键词：凤尾菇商品平菇纤维质牛皮纸浆重金属含量淤泥碎屑沉积物

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纸浆厂纤维渣栽培毛头鬼伞

食用菌 1986年第1期 21-22页

作者： J. c. mueller 屠薇

前言加拿大温哥华B.c研究所的生物工程小组,于1982年开始用造纸厂的纤维素渣作为主要基质,对外来食用菌品种进行了栽培研究。在英格兰伯明翰市阿斯顿大学***博士的建议下,工程小组首先对一种叫漏斗状的侧耳(Pleurotus sajorcaju)进行了... 详细信息

前言加拿大温哥华B.c研究所的生物工程小组,于1982年开始用造纸厂的纤维素渣作为主要基质,对外来食用菌品种进行了栽培研究。在英格兰伯明翰市阿斯顿大学***博士的建议下,工程小组首先对一种叫漏斗状的侧耳(Pleurotus sajorcaju)进行了研究。初试结果是非常令人鼓舞的,并已作了报道(mueller等,1983).目前漏斗状侧耳的栽培已进入了商业生产的阶段。随着漏斗状侧耳的栽培成功,我们又对毛头鬼伞(coprinus comatus)能否在造纸厂的纤维素残渣上栽培进行了研究,企图为菇农提供用纸浆废料作栽培基质,来生产另一商业性菇类产品.本文采用对比试验进行了总结。

关键词：毛头鬼伞纤维素纸厂纤维渣加工厂培养料黄豆粉

B型利钠肽在肺部疾病患者急性呼吸困难治疗中的作用

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 21-22页

作者： mueller c. Laule-Kilian K. Frana B. c. mueller 高登峰(译) 马超(校) 不详 Medizinische Klinik A Universitaetsklinik Petersgraben 4 CH-4031 Basel Switzerland

Background: In patients with pulmonary disease, it is often challenging to distinguish exacerbated pulmonary disease from congestive heart failure(cHF). The impact of B- type natriuretic peptide(BNP) measurements on the management of patients with pulmonary disease and acute dyspnea remains to be defined. Methods: This study evaluated the subgroup of 226 patients with a history of pulmonary disease included in the BASEL Study. Patients were randomly assigned to a diagnostic strategy with(n=119, BNP group) or without(n=107, clinical group) the use of BNP levels provided by a rapid bedside assay. Time to discharge and total cost of treatment were recorded as the primary end points. Results: Baseline characteristics were similar in patients assigned to the BNP and control groups. comorbidity was extensive, including coronary artery disease and hypertension in half of patients. The primary discharge diagnosis was cHF and exacerbated obstructive pulmonary disease in 39% and 33% , respectively. The use of BNP levels significantly reduced the need for hospital admission(81% vs 91% , P=.034). Median time to discharge was 9.0 days in the BNP group as compared with 12.0 days(P=.001) in the clinical group. Median total cost of treatment was ＄ 4841 in the BNP group as compared with ＄ 5671 in the clinical group(P=.008). Inhospital mortality was 8% in both groups. conclusions: cHF is a major cause of acute dyspnea in patients with a history of pulmonary disease. Used in conjunction with other clinical information, rapid measurement of BNP reduced time to discharge and total treatment cost of these patients.

关键词：肺部疾病史急性呼吸困难疾病患者 B型利钠肽治疗费用充血性心力衰竭冠状动脉疾病出院时间 BASEL BNP

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低氧性肝炎患者的肝肺综合征

世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 23-24页

作者： Fuhrmann V. Madl c. mueller c. 刘丽娜 Intensive care Unit 13H1 Department of Internal Medicine IV Medical University Vienna Vienna Austria

Background&Aims: The hepatopulmonary syndrome (HPS) is defined as the triad of liver disease, arterial deoxygenation, and widespread pulmonary vasodilatation. Hypoxic hepatitis, also known as ischemic hepatitis, is the leading cause of acute liver impairment in hospitals. It is unknown whether HPS occurs in hypoxic hepatitis. We assessed the prevalence and clinical consequences of HPS in patients with hypoxic hepatitis. Methods: Forty-four patients with hypoxic hepatitis were screened prospectively for HPS using established criteria: (1) presence of hepatic disease, (2) increased alveolar-arterial difference for the partial pressure of oxygen greater than the age-related threshold, and (3) intrapulmonary vasodilatation detected via contrast-enhanced echocardiography. Sixty-two critically ill patients with different cardiopulmonary diseases but without hepatic disease were screened for prevalence of intrapulmonary vasodilatation as a control group. Results: criteria of HPS were fulfilled in 18 patients with hypoxic hepatitis. HPS-positive patients had a significantly decreased partial pressure of arterial oxygen (P = .001) and partial pressure of arterial oxygen/fraction of inspired oxygen ratio (P = .034) at the time of diagnosis of HPS, a significant decreased area under the curve of the partial pressure of arterial oxygen/fraction of inspired oxygen ratio during the first 48 hours after diagnosis of hypoxic hepatitis (P = .009), and a significantly increased peak serum aspartate transaminase level (P = .028), compared with patients without HPS. complete resolution of intrapulmonary vasodilatation was observed during follow-up evaluation. contrast-enhanced echocardiography was negative for intrapulmonary vasodilatation in all 62 control patients. conclusions: Intrapulmonary vasodilatation indicating HPS frequently occurs in patients with hypoxic hepatitis. It is reversible after normalization of the hepatic dysfunction. clinicians should consider intrapulmonary vas

关键词：肝肺综合征低氧肝脏疾病急性肝损伤扩张情况血管扩张动脉低氧血症动脉血氧分压动脉氧分压

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宫颈癌患者行腹膜外淋巴结清扫术后的评估

世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 30-31页

作者： Denschlag D. Gabriel B. mueller-Lantzsch c. 刘亦恒 Dept. of Obstetrics and Gynecology University of Freiburg School of Medicine Hugstetter Strasse 55 D79106 Freiburg German

*** presence of nodal metastases is an important prognostic factor in patients with cervical cancer. To adjust our therapy to the anatomic extent of the disease, we performed a surgical staging with extraperitoneal lymph node dissection (EPLND). The goal of our study was to evaluate the clinical outcome and side effects of the combined treatment approach of EPLND and either radical hysterectomy in case of early stage cervical cancer (FIGO Ia/b and IIa) and negative nodes, or pelvic radiotherapy/extended field radiotherapy with concomitant chemotherapy in case of positive nodes or advanced stage cervical cancer (FIGO IIb, III, and IVa). Patients and methods. Fifty- nine patients with primarily diagnosed invasive cervical cancer underwent EPLND. The value of this procedure as a diagnostic tool for evaluating the extent of disease was determined. Additionally, treatment- related complications and clinical outcomes were monitored. Results. A total of 983 lymph nodes were removed during EPLND (mean 16.7). According to the results of EPLND, radical hysterectomy was abandoned due to histopathologically confirmed lymph node involvement by frozen section in 11 out of 36 patients with early stage cervical cancer (31% ). The most common adverse effects directly related to surgery in general (EPLND or combined EPLND and radical hysterectomy) were lymph cysts in seven patients (12% ). Only in the group of patients who received EPLND followed by radical hysterectomy, 2 out of 25 patients (8% ) developed a severe ileus postoperatively (WHO Grade 3 toxicity). The treatment approach of combined EPLND followed by radio- and chemotherapy was without major complications (WHO Grade 3 or 4 toxicity). After a mean follow up of 28 months (range 6- 60), 44 out of 58 patients (one patient lost to follow up) are without evidence of disease (76% ), 2 patients have progressive disease (3% ), and 12 patients died of their disease (21% ). Using Kaplan- Meier analysis, the estimated 5- y

关键词：早期宫颈癌淋巴囊肿手术分期临床结局淋巴结转移淋巴结清扫术组织病理学癌晚期扩展范围诊断工具

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巴氏消毒器的设计

食用菌 1984年第5期 47-47,46页

作者： J.c.mueller J.R.Gawley 闵三弟

成功的蘑菇栽培,在接种前通常都要对培养基质进行灭菌或巴氏消毒。小量培养料的灭菌,可用高压灭菌锅,这是一般的实验室容易做到的。然而,对那些扩大到小规模或半商业规模需要的灭菌设备,在常规实验室里找不到。加拿大B.c研究室,在研究... 详细信息

成功的蘑菇栽培,在接种前通常都要对培养基质进行灭菌或巴氏消毒。小量培养料的灭菌,可用高压灭菌锅,这是一般的实验室容易做到的。然而,对那些扩大到小规模或半商业规模需要的灭菌设备,在常规实验室里找不到。加拿大B.c研究室,在研究纸浆渣栽培鲍鱼菇时,首先就遇到了这个问题。因此,决定设计和制造一种一次能消毒10～100公斤基质的装置。实践表明,这个装置性能非常好,现介绍如下。

关键词：巴氏消毒器空气流箱顶混合气金属网金属压制材料

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急性充血性心力衰竭的炎症和远期死亡率

世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 14-15页

作者： mueller c. Laule-Kilian K. christ A. 刘少伟(译) 马超(校) Medizinische Klinik A Universit&tsklinik Petersgraben 4 CH -4031 -Basel Switzerland 不详

Background: Systemic inflammation has long been recognized as a precipitator of acute congestive heart failure(cHF). The impact of inflammation on prognosis in acute cHF, however, is unknown. Methods: This study evaluated the prognostic role of inflammation among 214 consecutive patients presenting with acute cHF to the emergency department. Patients were stratified according to c-reactive protein(cRP) levels determined on admission. The primary end point was all-cause mortality during 24-month follow-up. Results: The median cRP level was 13.0 mg/L, with an intertertile range of 6.0 to 25.0 mg/L. Initial and long-term outcomes were significantly different to the detriment of patients with higher cRP levels. Patients in the highest cRP tertile significantly more often required admission to the intensive care unit(33%vs 14%in patients in the first tertile, P=.028) and died inhospital(15%vs 2%in patients in the first tertile, P=.027). cumulative 24-month mortality rates were 33.5%in the first, 42.4%in the second, and 53.6%in the third tertile(P=.0265 by log-rank test). After multivariate adjustment, cRP remained an independent predictor of death(hazard ratio 1.4, 95%cI 1.1-1.8 for each step up in tertile, P=.044). conclusions: Inflammation is a significant and independent predictor of long-term mortality in patients with acute cHF.

关键词：急性充血性心力衰竭全身炎症反应远期死亡率远期预后重症监护病室 P水平院内死亡率预测价值