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High Ba-Sr adakitic charnockite suite from the Nagercoil Block,southern India:Vestiges of Paleoproterozoic arc and implications for Columbia to Gondwana

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Geoscience Frontiers 2021年第3期12卷 577-596页

作者： Pin Gao M.Santosh Cheng-Xue Yang Sanghoon Kwon mu.ramkumar School of Earth Sciences and Resources China University of Geosciences(Beijing)29 Xueyuan RoadBeijing 100083PR China Department of Earth Sciences University of AdelaideAdelaideSA 5005Australia Department of Earth Sciences Yonsei UniversitySeoul 03772Republic of Korea Department of Geology Periyar UniversitySalem 636011India

The Nagercoil block is the southernmost crustal segment of the Southern Granulite Terrane(SGT)in India and is mainly composed of charnockitic rocks and felsic gneisses(charnockite suite).In this study,we present petrologic,geochemical,zircon U-Pb,REE,and Hf isotopic studies on the charnockites and leucogneiss from the Nagercoil *** on field investigations and petrologic studies,the charnockites can be divided into garnet-bearing and garnet-absent anhydrous granulite facies rocks with *** charnockites and leucogneiss show transition from adakites to non-adakitic magmatic rocks,with enrichment in LREEs(light rare earth elements)and LILEs(large ion lithophile elements),and depletion in HREEs(heavy rare earth elements)and HFSEs(high field strength elements).Some of the charnockites and the leucogneiss show typical HSA(high silica adakite)characters,(high SiO_(2),Al_(2)O_(3),Ba-Sr,La/Yb,and Sr/Y).The HSA is considered to have formed from the interaction of slab derived melts and peridotitic mantle *** high Ba-Sr features were possibly inherited from subducted oceanic crust melting under high thermal gradient during *** magmas were underplated and subjected to fractional *** grains from the charnockite and leucogneiss show zoned magmatic cores surrounded by structureless metamorphic *** zircon grains from the charnockites show ages ranging from 1983±8.8 Ma to 2046±14 Ma,and the metamorphic domains show an age range of 502±14 Ma to 547±8.7 *** from the leucogneiss yielded magmatic and metamorphic ages of 1860±20 Ma and 575.6±8.8 *** charnockites and leucogneiss show two prominent age peaks at 1987 Ma and 568 *** REE data of the zircon grains show LREE depletion and HREE enrichment,with the metamorphic grains showing more depletion in *** Hf isotopic data of the magmatic cores of zircon grains from the charnockite yieldedε_(Hf)(t)values from-1.17 to 0.46 with T_(DM)and T_(DM)~C and age

关键词： Charnockite Adakitic rocks High Ba-Sr granitoids Geochemistry and zircon geochronology Nagercoil block Columbia and Gondwana supercontinents

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Episodic dolomitization of Paleozoic limestones in the Kinta Valley,Malaysia:Implications on porosity evolution and reservoir properties

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Energy Geoscience 2021年第4期2卷 298-307页

作者： Poon Xin Hui mu.ramkumar R.Nagarajan Manoj J.Mathew T.F.Ng South East Asia Carbonate Research Laboratory(SEACaRL) Universiti Teknologi PETRONASBandar Seri Iskandar31750TronohPerakMalaysia Department of Geology Periyar University636011SalemIndia Department of Applied Geology Curtin UniversityMalaysia98009MiriSarawakMalaysia Shale Gas Research Group Institute of Hydrocarbon RecoveryUniversiti Teknologi PETRONAS31750TronohPerakMalaysia Department of Geology University of MalayaKuala LumpurMalaysia

Carbonates undergo a variety of physical,mineralogical,chemical changes during depositional and postdepositional stages that are of interest to exploration geologists and *** over,about 60%of hydrocarbon reserves occur in carbonates with the dominant proportion associated with dolomitic reservoirs,in particular fault-associated dolomites which appear to be proven hydrocarbon *** as the critical diagenetic process thus plays an important role in determining reservoir characteristics and in designing exploration *** buried Paleozoic dolomites exhibit relatively higher porosity than their counterparts,Paleozoic ***-associated dolomites are usually targets of hydrocarbon exploration due to their good reservoir *** heterogeneity in carbonate reservoirs due to varied porosity types and distribution makes reservoir characterization a daunting ***,the key elements that control porosity development and evolution in these dolomites remain *** the influence of multiphase dolomitization,associated diagenetic events,hydrothermal alteration and their causative thermo-tectonic events on porosity evolution and reservoir quality is essential to understanding the critical processes and controlling factors that result in diverse impacts on reservoir *** this paper,an attempt is made to characterize dolomitization in homogeneous carbonate mud and its relationship with porosity evolution and reservoir *** the field,six facies types excluding host limestone are recognized,which are in turn characterized into seven petrographically recognizable phases,namely the host limestone,early replacement dolomite,sucrosic dolomite,metamorphosed dolomite,late replacement dolomite,brecciated limestone and dolomite and late stage *** analyses reveal the dominance of stoichiometric dolomites,followed by calcareous dolomites and magnesium *** all the field-based f

关键词： Dolomitization Porosity evolution Paleozoic Kinta Valley Malaysia

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High resolution facies architecture and digital outcrop modeling of the Sandakan formation sandstone reservoir, Borneo:Implications for reservoir characterization and flow simulation

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Geoscience Frontiers 2019年第3期10卷 957-971页

作者： Numair A.Siddiqui mu.ramkumar Abdul Hadi A.Rahman Manoj J.Mathew M.Santosh Chow W.Sum David Menier Department of Petroleum Geosciences Universiti Teknologi PETRONAS Department of Geology Periyar University Institute of Oceanography and Environment Universiti Malaysia Terengganu Department of Earth Sciences University of Adelaide School of Earth Sciences and Resources China University of Geosciences Beijing Laboratoire Géosciences Océan UMR CNRS 6538Campus de Tohannic

Advances in photogrammetry have eased the acquisition of high-resolution digital information from outcrops, enabling faster, non-destructive data capturing and improved reservoir modeling. Geocellular models for flow dynamics with in the virtual outcrop in siliciclastic deposits at different sets of sandstone facies architecture remain, however, a challenge. Digital maps of bedding, lithological contrast, spatial-temporal variations of bedding and permeability characteristics make it more easy to understand flow tortuosity in a particular architecture. An ability to precisely model these properties can improve reservoir characterization and flow modeling at different scales. Here we demonstrate the construction of realistic 2 D sandstone facies based models for a pragmatic simulation of flow dynamics using a combination of digital point clouds dataset acquired from LiDAR and field investigation of the Sandakan Formation, Sabah, ***, we present methods for enhancing the accuracy of outcrop digital datasets for producing high resolution flow simulation. A well-exposed outcrop from the Sandakan Formation, Sabah, northwest Borneo having a lateral extent of 750 m was chosen in order to implement our research approach. Sandstone facies and its connectivity are well constrained by outcrop observations, data from air-permeability measurements, bilinear interpolation of permeability, grid construction and water vector analysis for flow *** proportions were then enumerated in terms of static digital outcrop model(DOM) and facies model based on sandstone facies bedding characteristics. Flow simulation of water vector analysis through each of the four sandstone facies types show persistent spatial correlation of permeability that align with either cross-bedded orientation or straight with more dispersion high quality sandstone(porosity 21.25%-41.2%and permeability 1265.20-5986.25 mD) and moderate quality sandstone(porosity 10.44%-28.75% and permeabili

关键词： Siliciclastic sandstone facies Connectivity Heterogeneity Digital outcrop model Flow dynamics

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Advances in sediment geochemistry and chemostratigraphy for reservoir characterization

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Energy Geoscience 2021年第4期2卷 308-326页

作者： mu.ramkumar R.Nagarajan M.Santosh Department of Geology Periyar UniversitySalem636011India Department of Applied Geology Curtin UniversityMalaysia Curtin Malaysia Research Institute Curtin UniversityMalaysia School of Earth Sciences and Resources China University of Geosciences BeijingBeijingChina Department of Earth Sciences University of AdelaideAdelaideSA5005Australia

Sedimentary sequences preserve the records of changes in major controls of sedimentation namely,tectonics,climate,relative sea level and sediment production and *** potential to characterize these changes in spatial and temporal scales has led to the development of the branch of *** study of sedimentary sequences commenced from recognizing identical/contrasting geochemical features across major geochronological boundaries,and evolved into one of the essential tools in exploration,characterization,and well development *** incorporates applications on continuous,real-time geochemical mapping and direction of lateral drilling,and machine learning,among *** the sedimentary systems operate on a variety of temporal scales that range from few hours(tidal cycles)to few tens of millions of years,within which many perturbations such as catastrophic and diagenetic events take place,that lead to unique geochemical signature which can be correlated at appropriate spatial and temporal *** application of chemostratigraphic technique in hydrocarbon exploration and reservoir characterization has gained momentum in recent years,particularly with the advent of developments in analytical *** has also led to the integration of a variety of data from field sedimentary structures,mineralogy,major,trace and isotopic chemical compositions of whole rock,selected components of rocks,organic and inorganic components of oil and gas,etc.,for reservoir characterization more accurately than *** geochemical fingerprinting of oil and gas reservoir components plays a major role in the identification of source rocks,discrimination of oil families,characterization of reservoir,source,and seal segments in petroleum *** trends indicate the relevance and growing applications of machine learning techniques,artificial intelligence in real-time assessment,monitoring and planning of hydrocarbon

关键词： Biomarker Chemostratigraphy Geochemical fingerprinting Machine learning Oil family Stratigraphic correlation

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India at crossroads for energy

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Geoscience Frontiers 2021年第6期12卷 356-360页

作者： mu.ramkumar M.Santosh Manoj J.Mathew Numair A.Siddiqui Department of Geology Periyar UniversitySalem636011India School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing100083China Department of Earth Science University of AdelaideAdelaideSAAustralia Shale Gas Research Group Institute of Hydrocarbon RecoveryUniversiti Teknologi PETRONAS32610Seri IskandarMalaysia Department of Geosciences Universiti Teknologi PetronasTronohMalaysia

As one of the fastest growing economies and further larger consumer of energy in the world, there has been a paradigm shift in India’s energy demand. Here we evaluate the growth of Indian economy its, diversification of agriculture-based economy to industrial production, service and digital-technology based economy and deepening of income sources, although the dependence on foreign sources for energy demands has not markedly *** situation has placed India at the crossroads for energy sufficiency, especially under the highly fluid and changing geopolitical, strategic, environmental and economic scenarios of the World order. We attempt to understand the issue from geological perspective and address some of the impediments.

关键词： Economy Energy sources Technology Geological impediments India

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Reservoir characterization and enhanced oil recovery: Preface

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Energy Geoscience 2021年第4期2卷 285-286页

作者： mu.ramkumar R.Nagarajan M.Santosh Department of Geology Periyar UniversitySalem636011India Department of Applied Geology Faculty of Engineering and ScienceCurtin UniversityMalaysia Curtin Malaysia Research Institute Curtin UniversityMalaysia China University of Geosciences Beijing No.29 Xueyuan RoadHaidian DistrictBeijing100083PR China

A systematic and thorough understanding of the reservoir facies,commencing from exploration methods,identification,and precise characterization and predicting applicable analogues are essential tasks that form the cru... 详细信息

关键词： reservoir facies exploration

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