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Urban 8rowth： Chanses, manasement, and problems in larse cities of Southeast China

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Frontiers of Architectural Research 2016年第3期5卷 290-300页

作者： rong du Urban & Architectural Heritage Conservation Key Laboratory of Moe The School of Architecture Southeast University Nanjing 210096 China

Compared with medium-sized cities, megacities play an increasingly important role in the rapid urbanization process in China. Owing to the expanding scale of large cities, urban sprawl leads to unsustainable practices that cause ecological, social, and environmental problems. Urban planning and land use planning are major driving forces of land use and land cover change in China. However, the goals of these two types of planning are different, and coordinating them is a challenge for local government decision makers. Thus, we use the SLEUTH model to simulate the implementation scenarios of future urban growth in Nanjing in the Jiangsu province of China. Using the scientific simulation data of the model, we contrasted the alternative futures of the two planning types for local government decision makers to achieve sustainable urban planning. The objective of our study is to explore the problems and possible solutions for urban management in the context of a megacity in China. The results of our study confirm the value of SLEUTH, which provides extensive exploratory knowledge in evaluating the effects of possible local government decisions.

关键词： Urban growth Urban planning Land use planning SLEUTH Mesacity Nanjing

Meso-scale Discovery Assay Detects the Changes of Plasma Cytokine Levels in Mice after Low or High LET Ionizing Irradiation

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Biomedical and Environmental Sciences 2021年第7期34卷 540-551页

作者： JIA rong CHEN Ya Xiong du Ya rong HU Bu rong Key Laboratory of Space Radiobiology of Gansu Province&CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000GansuChina School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100039China Department of Radiation Medicine School of Public Health and ManagementWenzhou Medical UniversityWenzhou 325035ZhejiangChina

Objective To obtain precise data on the changes in the levels of 29 cytokines in mice after high or low linear energy transfer(LET)irradiation and to develop an accurate model of radiation exposure based on the cytokine levels after *** Plasma samples harvested from mice at different time points after carbon-ion or X-ray irradiation were analyzed using meso-scale discovery(MSD),a high-throughput and sensitive electrochemiluminescence measurement *** estimation equations were set up using multiple linear regression *** The relative levels of IL-6 at 1 h,IL-5 and IL-6 at 24 h,and IL-5,IL-6 and IL-15 at 7 d after irradiation with two intensities increased *** minimum measured levels of IL-5,IL-6 and IL-15 were up to 4.0076 pg/mL,16.4538 pg/mL and 0.4150 pg/mL,*** addition,dose estimation models were established and *** The MSD assay can provide more accurate data regarding the changes in the levels of the cytokines IL-5,IL-6 and *** cytokines could meet the essential criteria for radiosensitive biomarkers and can be used as radiation *** prediction models can conveniently and accurately estimate the exposure dose in irradiated organism.

关键词： MSD assay Low or high LET irradiation Mouse plasma Cytokines Dose estimation model

Energy of Long-Lifetime Configurations in Zero-Temperature Dynamics

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Communications in Theoretical Physics 2009年第4期51卷 671-674页

作者： rong Yong-Hui KONG Xiang-mu College of Physics and Engineering Qufu Normal University Qufu 273165 China

Using Monte Carlo method with zero-temperature dynamics, we investigate energy evolution of Ising spin configuration on a square lattice. The energies of some configurations exhibit long duration before those configurations reach the final state -- ground state or frozen stripe state. For ground-state dynamical realization, the duration occurs when the energy per spin is 4/L, where L is the lattice size. For stripe-state dynamical realization, the energy is slightly higher than 2/L when the duration appears in the last evolution stage. In addition, it is found that the average energy per spin in final state is approximately 2/3L.

关键词： Ising model zero-temperature dynamics Monte Carlo method

Flu Universal Vaccines: New Tricks on an Old Virus

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Virologica Sinica 2021年第1期36卷 13-24页

作者： Ruikun du Qinghua Cui Lijun rong College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Qingdao Academy of Chinese Medicinal Sciences Shandong University of Traditional Chinese MedicineQingdao 266122China Experimental Center Shandong University of Traditional Chinese MedicineJinan 250355China Department of Microbiology and Immunology College of MedicineUniversity of Illinois at ChicagoChicagoIL 60612USA

Conventional influenza vaccines are based on predicting the circulating viruses year by year,conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating *** necessitates development of universal influenza vaccines that provide broader and lasting protection against pan-influenza *** discovery of the highly conserved immunogens(epitopes)of influenza viruses provides attractive targets for universal vaccine *** we review the current understanding with broadly protective immunogens(epitopes)and discuss several important considerations to achieve the goal of universal influenza vaccines.

关键词： Influenza virus Universal vaccine Conserved epitopes Broadly protection

Intermittent Fault Diagnosability of Interconnection Networks

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Journal of Computer Science & Technology 2017年第6期32卷 1279-1287页

作者： Jia-rong Liang Hao Feng Xiaojiang du School of Computer and Electronic Information Guangxi University Nanning 530004 China Department of Computer and Information Sciences Temple University Philadelphia PA 19122 U.S.A.

An interconnection network＇s diagnosability is an important metric for measuring its self-diagnostic capability. Permanent fault and intermittent fault are two different fault models that exist in an interconnection network. In this paper, we focus on the problem pertaining to the diagnosability of interconnection networks in an intermittent fault situation. First, we study a class of interconnection networks called crisp three-cycle networks, in which the Chin-number （the number of common vertices each pair of vertices share） is no more than one. Necessary and sufficient conditions are derived for the diagnosability of crisp three-cycle networks under the PMC （Preparata, Metze, and Chien） model. A simple check can show that many well-known intereonnection networks are crisp three-cycle networks. Second, we prove that an intereonnection network S is a ti-fault diagnosable system without repair if and only if its minimum in-degree is greater than ti under the BGM （Barsi, Grandoni, and Masetrini） model. Finally, we extend the necessary and sufficient conditions to determine whether an interconnection network S is ti-fault diagnosable without repair under the MM （Maeng and Malek） model from the permanent fault situation to the intermittent fault situation.

关键词： diagnosability intermittent fault PMC(Preparata,Metze,and Chien)model BGM(Barsi,Grandoni,and Masetrini)model MM(Maeng and Malek)model

Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening du Hao You Junfeng Huang mudong Tu Hua Li Yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin du Jinlong Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury