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Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： mu-Hsien Lee Cheng-Hui Lin Chi-Huan Wu Yung-kuan Tsou Kai-Feng Sung Sheng-Fu Wang Nai-Jen liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

Preparation of MMA-BA-DMAEMA Nanosized Latex

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Chinese Chemical Letters 2003年第8期14卷 863-865页

作者： Yu yang liu mu jie yang Department of Polymer Science and Engineering ZhejiangUniversityHangzhou 310027

The terpolymer latex of methyl methacrylate (MMA)/butyl acrylate (BA)/ dimethyl aminoethyl methacrylate (DMAEMA) with diameter of less than 100 nm was prepared by seeding semi-continuous emulsion copolymerization using APS (ammonium persulfate) / TMEDA (N,N,N, N-tetramethylethylenediamine) as the redox initiators and SDS (sodium dodecylsulfate) and OP (P-octylpolyethylene glycol phenylether) as co-emulsifiers. The factors that influenced the process stability of the copolymerization and the particle size of the latex were investigated. The addition of aqueous ammonia as coagulation inhibitor provided better process stability of the copoly- merization. The addition of acetic acid as the acidification agent caused a remarkable reduction of the latex particle size.

关键词： Emulsion copolymerization dimethylaminoethyl methacrylate stablity nanosize.

Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis

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Cancer Biology & Medicine 2022年第9期19卷 1397-1409页

作者： Haoran mu Dongqing Zuo jie Chen Zhigang liu Zhuo Wang liu yang Qihui Shi Yingqi Hua Shanghai Bone Tumor Institute and Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Key Laboratory of Systems Biomedicine(Ministry of Education) Shanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Medical Epigenetics and the International Co-laboratory of Medical Epigenetics and Metabolism(MOST) Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer(SMHC)and Institute of Fudan-Minhang Academic Health System Minhang HospitalFudan UniversityShanghai 201199China Shanghai Engineering Research Center of Biomedical Analysis Reagents Shanghai 201203China

Objective:Osteosarcoma(OS)is an aggressive,highly metastatic,relatively drug-resistant bone tumor with poor long-term survival *** presence and persistence of circulating tumor cells(CTCs)in the peripheral blood are believed to be associated with treatment inefficiency and distant metastases.A blood-based CTC test is thus greatly needed for monitoring disease progression and predicting clinical ***,traditional methods cannot detect CTCs from tumors of mesenchymal origin such as OS,and research on CTC detection in mesenchymal tumors has been hindered for ***:In this study,we developed a CTC test based on hexokinase 2,a metabolic function-associated marker,for the detection and surveillance of OS CTCs,and subsequently explored its clinical *** patients with OS were enrolled as the training cohort for serial CTC *** CTC counting,in combination with therapy evaluation and post-treatment follow-up,was used to establish a model for predicting post-chemotherapy evaluation and disease-free survival,and the model was further validated with a cohort of 8 patients with ***:Two dynamic CTC number patterns were identified,and the resulting predictive model exhibited 92%consistency with the clinical *** model suggested that a single CTC test has similar predictive power to serial CTC *** the validation cohort,the single CTC test exhibited 100%and 87.5%consistency with therapy response and disease-free survival,***:Our non-invasive test for detection and surveillance of CTCs enables accurate prediction of therapy efficiency and prognosis,and may be clinically valuable for avoiding inefficient therapy and prolonging survival.

关键词： Circulating tumor cells osteosarcoma hexokinase 2 single-cell sequencing mesenchymal tumor

Selectively enhancing radiosensitivity of cancer cells via in situ enzyme-instructed peptide self-assembly

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Acta Pharmaceutica Sinica B 2020年第12期10卷 2374-2383页

作者： yang Gao jie Gao Ganen mu Yumin Zhang Fan Huang Wenxue Zhang Chunhua Ren Cuihong yang Jianfeng liu Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Radiation Oncology Department Tianjin Medical University General HospitalTianjin 300052China

The radiotherapy modulators used in clinic have disadvantages of high toxicity and low *** the first time,we used the in situ enzyme-instructed self-assembly(EISA)of a peptide derivative(Nap-GDFDFpYSV)to selectively enhance the sensitivity of cancer cells with high alkaline phosphatase(ALP)expression to ionizing radiation(IR).Compared with the in vitro pre-assembled control formed by the same molecule,assemblies formed by in situ EISA in cells greatly sensitized the ALPhigh-expressing cancer cells to y-rays,with a remarkable sensitizer enhancement *** results indicated that the enhancement was a result of fixing DNA damage,arresting cell cycles and inducing cell ***,in vitro pre-formed assemblies mainly localized in the lysosomes after incubating with cells,while the assemblies formed via in situ EISA scattered in the cell *** accumulation of these molecules in cells could not be inhibited by endocytosis *** believed that this molecule entered cancer cells by diffusion and then in situ self-assembled to form nanofibers under the catalysis of endogenous *** study provides a successful example to utilize intracellular in situ EISA of small molecules to develop selective tumor radiosensitizers.

关键词： In situ enzyme-instructed self-assembly(EISA) Pre-assembly Alkaline phosphatase(ALP) Peptide Cancer radiotherapy Nanofiber Histone deacetylases inhibitor(HDACI) Radiosensitizer

Functional characterization of a low-density lipoprotein receptor in the lepidopteran model,Bombyx mori

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Insect Science 2022年第5期29卷 1262-1274页

作者： Gui-Yun Li Xiao-Jing liu Gang-Qi Fang jie yang Shuai Zhan mu-Wang Li Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of BiotechnologyJiangsu University of Science and TechnologyZhenjiangJiangsuChina CAS Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghaiChina The Key Laboratory of Silkworm and mulberry Genetic Improvement Ministry of AgricultureSericultural Research InstituteChinese Academy of Agricultural SciencesZhenjiangJiangsuChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

The growth and development of metabolous insects are mainly regulated by ecdysone and juvenile *** a member of the low-density lipoprotein receptor(LDLR)family,megalin(mgl)is involved in the lipoprotein transport of cholesterol which is an essential precursor for the synthesis of *** extensive studies in mammals,the function of mgl is still largely unknown in *** this study,we characterize the function of mgl in the silkworm Bombyx mori,the model species of *** find that mgl is broadly present in the genomes of lepidopteran species and evolved with divergence between lepidopterans and *** expression pattern suggests a ubiquitous role of mgl in the growth and development in the *** further perform clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-based mutagenesis of Bmmgl and find that both the development and the silk production of the silkworm are seriously affected by the disruption of *** results not only explore the function of mgl in Lepidoptera but also add to our understanding of how cholesterol metabolism is involved in the development of insects.

关键词： Bombyx mori cholesterol CRISPR/Cas9 development megalin silkworm

Uneven Evolution of Microstructure,Magnetic Properties and Coercivity Mechanism of Mo-Substituted Nd-Ce-Fe-B Alloys

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Acta Metallurgica Sinica(English Letters) 2021年第4期34卷 590-596页

作者： Li-Li Zhang jie Song Sajjad Ur Rehman Jia-jie Li Lei Wang mu-Nan yang Ren-Hui liu Qing-Zheng Jiang Zhen-Chen Zhong Jiangxi Key Laboratory for Rare Earth Magnetic Materials and Devices/Institute for Rare Earth Magnetic Materials and Devices Jiangxi University of Science and TechnologyGanzhou341000China Fujian Changting Golden Gragon Rare-Earth Co. LtdChangting366300China

The purpose of this paper is to study the influence of Mo addition on the phase morphologies,microstructures and magnetic properties of the designated *** is found out that the coercivity H_(cj) increases unevenly from 12.2 kOe for(Nd_(0.8)Ce_(0.2))_(13)Fe_(82)B_(5) to the maximum value of 13.3 kOe for(Nd_(0.8)Ce_(0.2))_(13)Fe_(80)B_(5)Mo_(2).The transmission electron microscopy images demonstrate that the grain size decreases with the addition of Mo,which indicates that Mo has grain refinement *** correlative analysis gives rise to the conclusion that the coercivity mechanism of the investigated alloys is dominated by pinning *** in all,the enhancement of the magnetic properties is mainly attributed to the synergistic impact of grain refinement,pinning effects and the micro structural *** research may shed light on the potential development and application of rare earth-based counterpart magnets.

关键词： Mo-doped Nd-Ce-Fe-B alloy Magnetic properties Melt-spun ribbons Microstructure Coercivity mechanism

Dissecting the genome of star fruit(Averrhoa carambola L.)

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Horticulture Research 2020年第1期7卷 1626-1635页

作者： Yannan Fan Sunil Kumar Sahu Ting yang Weixue mu Jinpu Wei Le Cheng Jinlong yang Ranchang mu jie liu Jianming Zhao Yuxian Zhao Xun Xu Xin liu Huan liu State Key Laboratory of Agricultural Genomics China National GeneBankBGIShenzhen518120 ShenzhenChina BGI-Yunnan BGI-Shenzhen650106 KunmingChina Forestry Bureau of Ruili Yunnan Dehong678600 RuiliChina Chinese Academy of Forestry BeijingChina Guangdong Provincial Key Laboratory of Genome Read and Write 518120 ShenzhenChina BGI-Fuyang BGI-Shenzhen236009 FuyangChina Department of Biology University of CopenhagenCopenhagenDenmark

Averrhoa carambola is commonly known as star fruit because of its peculiar shape,and its fruit is a rich source of minerals and *** is also used in traditional medicines in countries such as India,China,the Philippines,and Brazil for treating various ailments,including fever,diarrhea,vomiting,and skin ***,we present the first draft genome of the Oxalidaceae family,with an assembled genome size of 470.51 *** total,24,726 protein-coding genes were identified,and 16,490 genes were annotated using various well-known *** phylogenomic analysis confirmed the evolutionary position of the Oxalidaceae *** on the gene functional annotations,we also identified enzymes that may be involved in important nutritional pathways in the star fruit ***,the data from this first sequenced genome in the Oxalidaceae family provide an essential resource for nutritional,medicinal,and cultivational studies of the economically important star-fruit plant.

关键词： vitamin Brazil cultivation

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不同栽培模式对韭菜采后贮藏品质及风味影响

食品科学 2025年第2期46卷 204-213页

作者：周新原陶杰杰刘明池左进华武占会郑鄢燕康欣娜梁浩牟建楼陈婕季延海北京市农林科学院蔬菜研究所农产品加工与食品营养研究所北京100097 国家蔬菜工程技术研究中心北京100097 农业农村部华北都市农业重点实验室北京100097 河北农业大学食品科技学院河北保定071001 石家庄市农林科学研究院河北石家庄050041

为探究不同栽培模式(水培、土培和基质培)对韭菜采后贮藏品质及风味物质的影响,采用水培、土培和基质培3种栽培方式种植‘航研791’韭菜,采后放入20℃、相对湿度80%~85%的冷库中贮藏,测定其贮藏期间生理品质和风味物质的变化。结果表明... 详细信息

为探究不同栽培模式(水培、土培和基质培)对韭菜采后贮藏品质及风味物质的影响,采用水培、土培和基质培3种栽培方式种植‘航研791’韭菜,采后放入20℃、相对湿度80%~85%的冷库中贮藏,测定其贮藏期间生理品质和风味物质的变化。结果表明:土培和基质培栽培方式能够较好地维持韭菜在贮藏期间的质量损失率和腐烂率,水培韭菜则质量损失率和腐烂率都较高,与水培相比,土培和基质培韭菜能够较好地维持VC和可溶性蛋白含量,具有较高的膳食纤维含量,土培还能促进纤维素、半纤维素、果胶和木质素含量的积累,基质培韭菜的木质素呈下降趋势,水培韭菜在贮藏过程中纤维素含量呈下降趋势,木质素含量则基本不变。韭菜的风味物质主要是醛类、醇类、酯类、醚类、杂环类化合物等,α-松油醇、丁酸异戊酯、水杨酸甲酯和苯乙醛等物质是3种韭菜贮藏前后的主要风味物质。土培韭菜能够在贮藏过程中更好地维持韭菜的品质和风味物质,耐贮性最强,其在贮藏过程中品质劣变以衰老为主,基质培次之,水培韭菜则耐贮性最差,品质劣变以软化腐烂为主。

关键词：不同栽培方式韭菜贮藏品质挥发性风味物质

One-step growth of the interconnected carbon nanotubes/graphene hybrids from cuttlebone-derived bi-functional catalyst for lithium-ion batteries

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Journal of Materials Science & Technology 2023年第18期149卷 205-213页

作者： Yan Zhong kuan Deng jie Zheng Tingting Zhang Peng liu Xingbin Lv Wen Tian Junyi Ji School of Chemical Engineering Sichuan UniversityChengdu 610065China College of Chemistry and Environment Southwest Minzu UniversityChengdu 610041China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

Carbon nanotubes/graphene hybrid materials with excellent physicochemical properties can be widely ap-plied in the fields of energy storage,electrocatalysis,sensing,*** the self-stacking and achiev-ing covalent interaction between carbon nanotubes and graphene are important to ensure a stable hi-erarchical architecture and effective mass ***,we propose a one-step strategy to synthesize 3D interconnected carbon nanotubes/graphene hybrids on the easy-to-remove biomass-derived *** calcined natural cuttlebone as bi-functional catalyst precursor can simultaneously grow carbon nan-otubes and graphene by one-step chemical vapor deposition without the addition of extra metal catalysts,while the interconnected structure can act as the porous template for graphene *** simultane-ous growth process can obtain covalent bonding between carbon nanotubes and graphene,while the crystalline quality and interlayer space can be adjusted by different carbon sources and growth parame-ters(e.g.,temperature).The one-step grown carbon nanotubes/graphene hybrids with seamless interfaces and hierarchical interconnected 3D structure can effectively enhance the electron transfer as well as the electrolyte infiltration *** utilized as lithium-ion batteries(LIBs)anode,a high specific ca-pacity(544 mAh g^(-1) at 0.1 A g^(-1)),good rate capability(200 mAh g^(-1) at 6.4 A g^(-1) with an ultrashort charge time of 113 s),and excellent cyclic stability can be *** simple and one-step carbon nanotubes/graphene hybrids fabrication strategy can be easily scale-up and applied in various fields.

关键词： Cuttlebone biomass Carbon nanotube/graphene hetero-junction Bi-functional catalyst Chemical vapor deposition Lithium-ion batteries