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Porcine acute liver failure model established by two-phase surgery and treated with hollow fiber bioartificial liver support system

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World Journal of Gastroenterology 2005年第35期11卷 5468-5474页

作者： Yi Gao Ning mu xiao-Ping Xu Yan Wang Department of Hepatobiliary Surgery Zhujiang Hospital Southern MedicalUniversity Guanzhou 510282 Guangdong Province China

AIM： To establish a highly reproducible animal model of acute liver failure （ALF）, for assessing the effect of bioartificial liver support system （BALSS）. METHODS： A two-phase complete liver devascularization procedure was performed in eight Ioco-hybrid pigs. Blood biochemical index and liver biopsy were studied every 2 h after surgery, and survival time was recorded. The BALSS constructed with high volume recirculating technique was a hollow fiber circulating system consisting of a hepatocyte reactor-hollow fiber module inoculated with microcarrieradhering hepatocytes, and a double pump, heparinized, thermostabilized, micro-capsulized activated carbonadsorbing plasmapheresis system. Twelve pigs undergoing two-phase surgery were randomized into： control group （perfused without hepatocytes, n = 6） and treatment group （perfused with hepatocytes, n = 6）. Intergroup liver biochemical indexes, survival time, and liver pathological changes were analyzed at regular intervals. RESULTS： Two-phase surgery was performed in all the experimental pigs, and there was no obvious difference between their biochemical indexes. After 3 h of phase II surgery, ammonia （Amm） increased to （269＋37）μmol/L. After 5 h of the surgery, fibrinogen （Fib） decreased to （1.5±0.2） g/L. After 7 h of the surgery, ALT, AST, Tbil and PT were （7.6±1.8） nka/L, （40±5） nka/L, （55±8）μmol/L and （17.5±1.7） nka/L respectively. After 9 h of surgery, ALB and Cr were （27±4） g/L and （87±9）μmol/L. After 13 h of surgery, BUN was （3.5±0.9） μmol/L. All the above values were different from those determined before surgery. Survival time of pigs averaged 13.5±1.4 h. ALF pigs in the other group were treated with BALSS. The comparison analysis between the treated and control animals showed the changes of Tbil, PT, AIb, BUN, Cr, Fib, and Amm （P〈0.01）, but there was no change of ALT and AST. The survival time was statistically different （P〈0.01）, and there was no significant difference in histological ***： The po

关键词： Acute liver failure Animal model Bioartificialliver Micro-capsulized activated carbon adsorbing Porcinehepatocyte

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Solving the multi-discrete Logarithm Problems over a Group of Elliptic Curves with Prime Order

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Acta Mathematica Sinica,English Series 2005年第6期21卷 1443-1450页

作者： Jun Quan LI mu Lan LIU Liang Liang xiao Academy of Mathematics and Systems Science Key Laboratory of Mathematics Mechanization Chinese Academy of Sciences Beijing 100080 P. R. China

In this paper, we discuss the expected number of steps in solving multi-discrete logarithm problems over a group of elliptic curves with prime order by using Pollard＇s rho method and parallel collision search algorithm. We prove that when using these algorithms to compute discrete logarithms, the knowledge gained through computing many logarithms does not make it easier for finding other logarithms. Hence in an elliptic cryptosystem, it is safe for many users to share the same curve, with different private keys.

关键词： Pollard's rho method Parallel collision search algorithm Elliptic curve Discrete logarithm Distinguished point

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UAV-Assisted Dynamic Monitoring of Wheat Uniformity toward Yield and Biomass Estimation

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Plant Phenomics 2024年第3期6卷 610-620页

作者： Yandong Yang Qing Li yue mu Haitao Li Hengtong Wang Seishi Ninomiya Dong Jiang Academy for Advanced Interdisciplinary Studies Collaborative Innovation Center for Modern Crop Production Co-Sponsored by Province and MinistryState Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjing 210095China College of Agriculture National Technique Innovation Center for Regional Wheat ProductionKey Laboratory of Crop EcophysiologyMinistry of AgricultureNanjing Agricultural UniversityNanjing 210095China Graduate School of Agricultural and Life Sciences The University of TokyoNishi-TokyoTokyo 188-0002Japan

Crop uniformity is a comprehensive indicator used to describe crop growth and is important for assessing crop yield and biomass ***,there is still a lack of continuous monitoring of uniformity throughout the growing season to explain their effects on yield and ***,this paper proposed a wheat uniformity quantification method based on unmanned aerial vehicle imaging technology to monitor and analyze the dynamic changes in wheat *** leaf area index(LAI),soil plant analysis development(SPAD),and fractional vegetation cover were estimated from hyperspectral images,while plant height was estimated by a point cloud model from RGB *** on these 4 agronomic parameters,a total of 20 uniformity indices covering multiple growing stages were *** changing trends in the uniformity indices were consistent with the results of visual *** uniformity indices strongly correlated with yield and biomass were selected to construct multiple linear regression models for estimating yield and *** results showed that Pielou's index of LAI had the strongest correlation with yield and biomass,with correlation coefficients of-0.760 and-0.801,*** accuracies of the yield(coefficient of determination[R^(2)]=0.616,root mean square error[RMSE]=1.189 Mg/ha)and biomass estimation model(R^(2)=0.798,RMSE=1.952 Mg/ha)using uniformity indices were better than those of the models using the mean values of the 4 agronomic ***,the proposed uniformity monitoring method can be used to effectively evaluate the temporal and spatial variations in wheat uniformity and can provide new insights into the prediction of yield and biomass.

关键词： yield dynamic biomass estimation monitoring toward uav-assisted uniformity wheat

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Quantum classifier with parameterized quantum circuit based on the isolated quantum system

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The Journal of China Universities of Posts and Telecommunications 2022年第4期29卷 21-31页

作者： Shi Jinjing Wang Wenxuan xiao Zimeng mu Shuai Li Qin School of Computer Science and Engineering Central South UniversityChangsha 410083China School of Computer Science and School of Cyberspace Science Xiangtan UniversityXiangtan 411301China

It is a critical challenge for quantum machine learning to classify the datasets *** article develops a quantum classifier based on the isolated quantum system(QC-IQS)to classify nonlinear and multidimensional ***,a model of QC-IQS is presented by creating parameterized quantum circuits(PQCs)based on the decomposing of unitary operators with the Hamiltonian in the isolated quantum ***,a parameterized quantum classification algorithm(QCA)is designed to calculate the classification results by updating the loss function until it ***,the experiments on nonlinear random number datasets and Iris datasets are designed to demonstrate that the QC-IQS model can handle and generate accurate classification results on different kinds of *** experimental results reveal that the QC-IQS is adaptive and learnable to handle different types of ***,QC-IQS compensates the issue that the accuracy of previous quantum classifiers declines when dealing with diverse *** promotes the process of novel data processing with quantum machine learning and has the potential for more comprehensive applications in the future.

关键词： quantum classifier quantum classification isolated quantum system parameterized quantum circuit Hamiltonian

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Single Goss grain growth by isothermal annealing in rolled Fe–Al–Ga–Nb C sheets

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Rare Metals 2023年第10期42卷 3537-3544页

作者： Yang-Yang Liu Ji-Heng Li xiao-Long Li Xing mu xiao-Qian Bao Xue-Xu Gao State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing100083China

The(Fe_(82)Al_(13.5)Ga_(4.5))_(99.9)(NbC)_(0.1) sheets with strong Goss texture and large magnetostriction were prepared by rolling and isothermal annealing *** Goss grain growth was observed in sheets undergoing isothermal annealing at 1050 ℃ for 1 h using Ar as protecting *** annealing time increasing to 8 h at1050℃,a largest magnetostriction of 154×10^(-6) is obtained in sheet and a large λ_(//)(the maximum magnetostriction with magnetic field parallel to rolling direction)of 160×10^(-6) along the rolling direction is also *** fact that a λ_(//) of 160×10^(-6) along RD can be achieved with only 4.5 at% Ga in the Fe-18 at%(Al,Ga) sheet is of practical *** with previous studies in Fe-Al and Fe-Ga sheets,this paper provides a more efficient approach to prepare strong Goss textured *** this way,a slow continuous heating process,sulfur-induced surface energy control and high-temperature annealing above 1200 ℃ are no more *** shows a good prospect for industrial production of high-performance magnetostrictive alloy sheets.

关键词： Fe–Al–Ga sheet Isothermal annealing Goss texture Magnetostriction

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Docking MOF crystals on graphene support for highly selective electrocatalytic peroxide production

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Nano Research 2022年第1期15卷 145-152页

作者： xiaofeng Huang Peter Oleynikov Hailong He Alvaro Mayoral Linqin mu Feng Lin yue-Biao Zhang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Chemistry Virginia TechBlacksburgVA 24061USA

Tailoring the reaction kinetics is the central theme of designer electrocatalysts,which enables the selective conversion of abundant and inert atmospheric species into useful *** we show a supporting effect in tuning the electrocatalytic kinetics of oxygen reduction reaction(ORR)from four-electron to two-electron mechanism by docking metalloporphyrin-based metal-organic frameworks(MOFs)crystals on graphene support,leading to highly selective peroxide production with faradaic efficiency as high as 93.4%.A magic angle of 38.1°tilting for the co-facial alignment was uncovered by electron diffraction tomography,which is attributed to the maximization of n-n interaction for mitigating the lattice and symmetry mismatch between MOF and *** facilitated electron migration and oxygen chemisorption could be ascribed to the supportive effect of graphene that disperses of the electron state of the active center,and ultimately regulates rate-determining step.

关键词： metal-organic frameworks nanocomposites support effect oxygen reduction reaction peroxide selectivity

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Superatom-assembled boranes,carboranes,and low-dimensional boron nanomaterials based on aromatic icosahedral B_(12)and C_(2)B_(10)

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Nano Research 2024年第7期17卷 6734-6740页

作者： Qiao-Qiao Yan Yan-Fang Wei Qiang Chen yue-Wen mu Si-Dian Li Institute of Molecular Science Shanxi UniversityTaiyuan 030006China

Using the experimentally known aromatic icosahedral superatoms I_(h)B_(12)H_(12)2−and D_(5d)1,12-C_(2)B_(10)H_(12)as building blocks and based on extensive density functional theory calculations,we predict herein a series of core–shell superpolyhedral boranes and carboranes in a bottom-up approach,including the high-symmetry Th B_(12)@B_(152)H_(72)2−(2),C2h C_(2)B_(10)@B_(152)H_(72)(3),D_(3d)B_(12)@B_(144)H_(66)(4),I_(h)B_(12)@C_(24)B_(12)0H_(72)2−(6),and D_(5d)C_(2)B_(10)@C_(24)B_(12)0H_(72)(7).More interestingly,the superatom-assembled linear D2h B_(36)H_(32)^(2−)(8),close-packed planar D_(3d)B_(84)H_(60)^(2−)(10),and nearly close-packed core−shell D_(3d)B_(12)@B144H_(6)6(4)can be extended periodically to form the one-dimensional(1D)α-rhombohedral borane nanowire B_(12)H_(10)(Pmmm)(9),two-dimensional(2D)α-rhombohedral monolayer borophane B_(12)H_(6)(P m1)(11),and the experimentally known three-dimensional(3D)α-rhombohedral boron(R m)(12)which can be viewed as an assembly of the monolayer B_(12)H_(6)(11)staggered in vertical direction,setting up a bottom-up strategy to form low-dimensional boron-based nanomaterials from their borane“seeds”via partial or complete *** bonding analyses indicate that the high stability of these nanostructures originates from the spherical aromaticity of their icosahedral B_(12)or C_(2)B_(10)structural units which possess the universal skeleton electronic configuration of 1S21P61D101F8 following the Wade’s n+1 *** infrared(IR)and Raman spectra of the most-concerned neutral B_(12)@B144H_(6)6(4)and C_(2)B_(10)@C_(24)B_(12)0H_(72)(7)are computationally simulated to facilitate their experimental characterizations.

关键词： superatom-assembling bottom-up approach density functional theory superpolyhedral boranes superpolyhedral carboranes borophanes

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Primary cutaneous anaplastic large cell lymphoma with overexpressed Ki-67 transitioning into systemic anaplastic large cell lymphoma:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6889-6894页

作者： Hai-Xi mu xiao-Qiong Tang Department of Hematology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

BACKGROUND Primary cutaneous anaplastic large cell lymphoma(PC-ALCL)differs from systemic anaplastic large cell lymphoma(sALCL)in cell biological behavior,clinical features,treatment,and ***-ALCL has been reported to rarely transition into sALCL,but the underlying mechanism is not *** we report such a case with certain characteristics that shed light on *** SUMMARY Herein,we report a 43-year-old male with symptoms of a skin nodule and histologically confirmed PC-ALCL with high expression of *** three months of observation,two skin nodules re-appeared with muscle layer involvement and was histologically confirmed as *** months after receiving six cycles of CHOP regimen,the patient had pain in the chest and back,cough,shortness of breath,and night *** was confirmed as relapse of sALCL by immunohistochemistry and several organs,such as the lung were involved as shown by positron emission tomography/computed *** four cycles of DICE plus chidamide regimens followed by auto-hematopoietic stem cell transplantation(ASCT),complete remission(CR)duration was achieved for twelve months while the patient was on maintenance with chidamide(20 mg)*** This case had significantly high expression of Ki-67 when diagnosed as PC-ALCL initially and then transitioned into sALCL,which is ***-ASCT combined with demethylation drugs effectively maintained CR and prolonged progression free survival.

关键词： Cutaneous lymphoma Anaplastic large cell lymphoma Ki-67 Auto hematopoietic stem cell transplantation Case report

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An Adaptive Parameter-Free Optimal Number of Market Segments Estimation Algorithm Based on a New Internal Validity Index

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 197-232页

作者： Jianfang Qi yue Li Haibin Jin Jianying Feng Dong Tian Weisong mu College of Information and Electrical Engineering China Agricultural UniversityBeijing100083China Key Laboratory of Viticulture and Enology Ministry of AgricultureBeijing100083China Institute of Population Research Peking UniversityBeijing100871China

An appropriate optimal number of market segments(ONS)estimation is essential for an enterprise to achieve successful market segmentation,but at present,there is a serious lack of attention to this issue in market *** our study,an independent adaptive ONS estimation method BWCON-NSDK-means++is proposed by integrating a newinternal validity index(IVI)Between-Within-Connectivity(BWCON)and a newstable clustering algorithmNatural-SDK-means++(NSDK-means++)in a novel ***,to complete the evaluation dimensions of the existing IVIs,we designed a connectivity formula based on the neighbor relationship and proposed the BWCON by integrating the connectivity with other two commonly considered measures of compactness and ***,considering the stability,number of parameters and clustering performance,we proposed the NSDK-means++to participate in the integrationwhere the natural neighbor was used to optimize the initial cluster centers(ICCs)determination strategy in the SDK-means++.At last,to ensure the objectivity of the estimatedONS,we designed a BWCON-based ONS estimation framework that does not require the user to set any parameters in advance and integrated the NSDK-means++into this framework forming a practical ONS estimation tool BWCON-NSDK-means++.The final experimental results showthat the proposed BWCONand NSDK-means++are significantlymore suitable than their respective existing models to participate in the integration for determining theONS,and the proposed BWCON-NSDK-means++is demonstrably superior to the BWCON-KMA,BWCONMBK,BWCON-KM++,BWCON-RKM++,BWCON-SDKM++,BWCON-Single linkage,BWCON-Complete linkage,BWCON-Average linkage and BWCON-Ward linkage in terms of the ONS ***,as an independentmarket segmentation tool,the BWCON-NSDK-means++also outperforms the existing models with respect to the inter-market differentiation and sub-market size.

关键词： Optimal number of market segments internal validity index cluster connectivity SDK-means++ market segmentation

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Differentiation of a Miniature Inverted Transposable Element （MITE） System in Asian Rice Cultivars and Its Inference for a Diphyletic Origin of Two Subspecies of Asian Cultivated Rice

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Journal of Integrative Plant Biology 2006年第3期48卷 260-267页

作者： Hao Hu Jie mu Hong-Ji Zhang yue-Zhi Tao Bin Han National Center for Gene Research Shanghai Institutes of Biological Sciences the Chinese Academy of Sciences Shanghai 200233 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China

In the present study, we report a survey on a Miniature Inverted Transposable Element （MITE） system known as mPing in 102 varieties of Asian cultivated rice （Oryza sativa L.）. We found that mPing populations could be generalized Into two families, mPing-1 and mPing-2, according to their sequence structures. Further analysis showed that these two families of mPing had significant bias in their distribution pattern in two subspecies of rice, namely O. sativa ssp. japonica and indica. 0. sativa japonica has a higher proportion of mPing-1 as a general trait, whereas 0. sativa indica has a higher proportion of roPing-2. We also examined the mPing system In a doubled haploid （DH） cross-breeding population of jingxi 17 （japonica） and zhaiyeqing 8 （indica） varieties and observed that the mPing system was not tightly linked to major subspecies-determining genes. Furthermore, we checked the mPing system in 28 accessions of Asian common wild rice O. rufipogon and found the roPing system in 0. rufipogon. The distribution pattern of the roPing system in O. rufipogon indicated a diphyletlc origin of the Asian cultivated rice O. sativa species. We did not find the mPing system in another 20 Oryza species. These results substantiated a previous hypothesis that O. ruflpogon and O. nivara species were the closest relatives of O. sativa and that the two extant subspecies of O. sativa were evolved independently from corresponding ecotypes of O. ruflpogon.

关键词： diphyletic indica japonica Miniature Inverted Transposable Element (MITE) mPing rice.

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